NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|237820711|ref|NP_059997|]
View 

lymphocyte antigen 6K isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 41-126 4.27e-44

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467080  Cd Length: 86  Bit Score: 140.53  E-value: 4.27e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237820711  41 VWCHVCERENTFECQNPRRCKWTEPYCVIAAVKIFPRFFMVAKQCSAGCAAMERPKPEEKRFLLEEPMPFFYLKCCKIRY 120
Cdd:cd23550    1 LTCHVCEVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPVVEVPPPPPKSFVLEKPMPFLYIKCCRENL 80


                 ....*.
gi 237820711 121 CNLEGP 126
Cdd:cd23550   81 CNEEGP 86
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 41-126 4.27e-44

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467080  Cd Length: 86  Bit Score: 140.53  E-value: 4.27e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237820711  41 VWCHVCERENTFECQNPRRCKWTEPYCVIAAVKIFPRFFMVAKQCSAGCAAMERPKPEEKRFLLEEPMPFFYLKCCKIRY 120
Cdd:cd23550    1 LTCHVCEVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPVVEVPPPPPKSFVLEKPMPFLYIKCCRENL 80


                 ....*.
gi 237820711 121 CNLEGP 126
Cdd:cd23550   81 CNEEGP 86
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 41-126 4.27e-44

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467080  Cd Length: 86  Bit Score: 140.53  E-value: 4.27e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237820711  41 VWCHVCERENTFECQNPRRCKWTEPYCVIAAVKIFPRFFMVAKQCSAGCAAMERPKPEEKRFLLEEPMPFFYLKCCKIRY 120
Cdd:cd23550    1 LTCHVCEVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPVVEVPPPPPKSFVLEKPMPFLYIKCCRENL 80


                 ....*.
gi 237820711 121 CNLEGP 126
Cdd:cd23550   81 CNEEGP 86
TFP_LU_ECD_GML cd23555
extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like ...
 43-126 9.35e-09

extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like protein (GML) and similar proteins; GML may play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467085  Cd Length: 87  Bit Score: 50.07  E-value: 9.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237820711  43 CHVCERENTFECQNPRRCKWTEPYCVIAAVKIFPRFFMVAKQCSAGCAAMER-PKPEEKRFLLEEPMPFFYLKCCKIRYC 121
Cdd:cd23555    3 CHSCAVINTFNCPAHRTCPYDIRRCMTVAIRVNSRELLVYKNCTKNCTFVYAeEQPPEAPRKIPKTNSFYFVMCCSSMFC 82


                 ....*
gi 237820711 122 NLEGP 126
Cdd:cd23555   83 NEGGP 87
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 43-122 8.05e-04

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 36.62  E-value: 8.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237820711  43 CHVCEreNTFECQNPRRCKWTEPYCVIaAVKIFPRFFMVAKQCSAGCAAMERPKPEEkrflleepMPFFYLKCCKIRYCN 122
Cdd:cd23542    8 CHVCN--SSSNCTNPVNCEGSERYCKT-TTVVQPSGNLVKKGCAETCPPSTSRQQVG--------SGISSVTCCQGDLCN 76
TFP_LU_ECD_SLURP2 cd23561
extracellular domain (ECD) found in Secreted Ly-6/uPAR-related protein 2 (SLURP-2) and similar ...
 41-122 3.12e-03

extracellular domain (ECD) found in Secreted Ly-6/uPAR-related protein 2 (SLURP-2) and similar proteins; SLURP-2 (also called Lynx1, or secreted Ly-6/uPAR domain-containing protein 2, or secreted LY6/PLAUR domain-containing protein 2) binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. It may regulate keratinocytes proliferation, differentiation, and apoptosis. In vitro SLURP-2 moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs and strongly inhibits alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. It may act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner. SLURP-2 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467091  Cd Length: 75  Bit Score: 34.92  E-value: 3.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237820711  41 VWCHVCERENTfeCQNPRRCKWTEPYCVIAAVKI---FPRFFMVAKQCSAGCaamerpkPEEKRFLLEepmPFFYLKCCK 117
Cdd:cd23561    1 IWCHQCTGFGG--CSHGSRCPRDSTHCVTTATRVlsnTEDLPLVTKMCHIGC-------PDIPSLGLG---PYVSIACCQ 68


                 ....*
gi 237820711 118 IRYCN 122
Cdd:cd23561   69 TSLCN 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH