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Conserved domains on  [gi|19923479|ref|NP_057253|]
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suppressor of fused homolog isoform 1 [Homo sapiens]

Protein Classification

suppressor of fused domain protein( domain architecture ID 10523852)

suppressor of fused domain protein similar to Homo sapiens suppressor of fused homolog, a negative regulator in the hedgehog/smoothened signaling pathway

CATH:  3.30.1360.230
Gene Ontology:  GO:1990788|GO:0008013|GO:0019901|GO:0007165|GO:0003714

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SUFU_C pfam12470
Suppressor of Fused Gli/Ci N terminal binding domain; This domain family is found in ...
 253-473 3.97e-93

Suppressor of Fused Gli/Ci N terminal binding domain; This domain family is found in eukaryotes, and is typically between 192 and 219 amino acids in length. The family is found in association with pfam05076. There is a conserved HGRHFT sequence motif. This family is the C terminal domain of the Suppressor of Fused protein (Su(fu)). Su(fu) is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding these proteins and preventing their translocation to the nucleus. The C terminal domain is only found in eukaryotic Su(fu) proteins; it is not present in bacterial homologs. The C terminal domain binds to the N terminal of Gli/Ci while the N terminal of Su(fu) binds to the C terminal of Gli/Ci. This dual binding mechanism is likely an evolutionary advancement in this signalling cascade which is not present in bacterial homologs.


:

Pssm-ID: 463598  Cd Length: 200  Bit Score: 280.84  E-value: 3.97e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923479   253 ERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQ----PRRLSGK----DTEQIRETLRR------GLEI 318
Cdd:pfam12470   1 EQVEEGIEKEGSNLSGVSAKCTWKELKKKSETKLAERSQELSEKceenNRRISECnisrEEEQIKQELLEssgssdGLNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923479   319 NSKPVLPPinpqrqnglahdrapsrkdslesdsstaiipheliRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYK 398
Cdd:pfam12470  81 INNPQAPS-----------------------------------RTRTLEGVHLTFNLEAGKLLPLALKGRIRHGRHFTFK 125

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19923479   399 SITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPEEFKLPKEYSWPEKKLKVSI 473
Cdd:pfam12470 126 AVLGDTAVTFVAESVTGSFVSEEHPYAALGPWLQVLIPNDLVPRMLEDLEELTSPDELKLPKTYEWPDKNLKITI 200
SUFU pfam05076
Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila ...
 64-240 4.26e-54

Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.


:

Pssm-ID: 461543  Cd Length: 171  Bit Score: 179.04  E-value: 4.26e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923479    64 GPDPLDYVSMYRNVGSPsanipeHWHYISFGLSDLYGDnrVHEFTGTDgpSGFGFELTFRLKR--ETGESAPPTWPAELM 141
Cdd:pfam05076   1 GDDPLDILSIPDTPEPG------HWHYVTLGLSDLPMD--EPEDLEED--SGPRAELTFRLPKdeESLADEPPTWPLNLL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923479   142 QGLARYVFQSENTFCSGDHVSWHSPLD-NSESRIQHMLLTE---DPQMQPVQTPFG-VVTFLQIVGVCTEELHSAQQWNG 216
Cdd:pfam05076  71 QNLARYPFKEGTWLGPGHTIPNGGPIPlAENTDLTGLLLVEpldDEELGALETPGGkKVNFLQLVPITEEELEYALEKGA 150

                         170       180
                  ....*....|....*....|....
gi 19923479   217 QGILELLRtvpiAGGPWLITDMRR 240
Cdd:pfam05076 151 DALLELLL----EEGPIDITDLNR 170
 
Name Accession Description Interval E-value
SUFU_C pfam12470
Suppressor of Fused Gli/Ci N terminal binding domain; This domain family is found in ...
 253-473 3.97e-93

Suppressor of Fused Gli/Ci N terminal binding domain; This domain family is found in eukaryotes, and is typically between 192 and 219 amino acids in length. The family is found in association with pfam05076. There is a conserved HGRHFT sequence motif. This family is the C terminal domain of the Suppressor of Fused protein (Su(fu)). Su(fu) is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding these proteins and preventing their translocation to the nucleus. The C terminal domain is only found in eukaryotic Su(fu) proteins; it is not present in bacterial homologs. The C terminal domain binds to the N terminal of Gli/Ci while the N terminal of Su(fu) binds to the C terminal of Gli/Ci. This dual binding mechanism is likely an evolutionary advancement in this signalling cascade which is not present in bacterial homologs.


Pssm-ID: 463598  Cd Length: 200  Bit Score: 280.84  E-value: 3.97e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923479   253 ERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQ----PRRLSGK----DTEQIRETLRR------GLEI 318
Cdd:pfam12470   1 EQVEEGIEKEGSNLSGVSAKCTWKELKKKSETKLAERSQELSEKceenNRRISECnisrEEEQIKQELLEssgssdGLNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923479   319 NSKPVLPPinpqrqnglahdrapsrkdslesdsstaiipheliRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYK 398
Cdd:pfam12470  81 INNPQAPS-----------------------------------RTRTLEGVHLTFNLEAGKLLPLALKGRIRHGRHFTFK 125

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19923479   399 SITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPEEFKLPKEYSWPEKKLKVSI 473
Cdd:pfam12470 126 AVLGDTAVTFVAESVTGSFVSEEHPYAALGPWLQVLIPNDLVPRMLEDLEELTSPDELKLPKTYEWPDKNLKITI 200
SUFU pfam05076
Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila ...
 64-240 4.26e-54

Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.


Pssm-ID: 461543  Cd Length: 171  Bit Score: 179.04  E-value: 4.26e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923479    64 GPDPLDYVSMYRNVGSPsanipeHWHYISFGLSDLYGDnrVHEFTGTDgpSGFGFELTFRLKR--ETGESAPPTWPAELM 141
Cdd:pfam05076   1 GDDPLDILSIPDTPEPG------HWHYVTLGLSDLPMD--EPEDLEED--SGPRAELTFRLPKdeESLADEPPTWPLNLL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923479   142 QGLARYVFQSENTFCSGDHVSWHSPLD-NSESRIQHMLLTE---DPQMQPVQTPFG-VVTFLQIVGVCTEELHSAQQWNG 216
Cdd:pfam05076  71 QNLARYPFKEGTWLGPGHTIPNGGPIPlAENTDLTGLLLVEpldDEELGALETPGGkKVNFLQLVPITEEELEYALEKGA 150

                         170       180
                  ....*....|....*....|....
gi 19923479   217 QGILELLRtvpiAGGPWLITDMRR 240
Cdd:pfam05076 151 DALLELLL----EEGPIDITDLNR 170
 
Name Accession Description Interval E-value
SUFU_C pfam12470
Suppressor of Fused Gli/Ci N terminal binding domain; This domain family is found in ...
 253-473 3.97e-93

Suppressor of Fused Gli/Ci N terminal binding domain; This domain family is found in eukaryotes, and is typically between 192 and 219 amino acids in length. The family is found in association with pfam05076. There is a conserved HGRHFT sequence motif. This family is the C terminal domain of the Suppressor of Fused protein (Su(fu)). Su(fu) is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding these proteins and preventing their translocation to the nucleus. The C terminal domain is only found in eukaryotic Su(fu) proteins; it is not present in bacterial homologs. The C terminal domain binds to the N terminal of Gli/Ci while the N terminal of Su(fu) binds to the C terminal of Gli/Ci. This dual binding mechanism is likely an evolutionary advancement in this signalling cascade which is not present in bacterial homologs.


Pssm-ID: 463598  Cd Length: 200  Bit Score: 280.84  E-value: 3.97e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923479   253 ERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQ----PRRLSGK----DTEQIRETLRR------GLEI 318
Cdd:pfam12470   1 EQVEEGIEKEGSNLSGVSAKCTWKELKKKSETKLAERSQELSEKceenNRRISECnisrEEEQIKQELLEssgssdGLNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923479   319 NSKPVLPPinpqrqnglahdrapsrkdslesdsstaiipheliRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYK 398
Cdd:pfam12470  81 INNPQAPS-----------------------------------RTRTLEGVHLTFNLEAGKLLPLALKGRIRHGRHFTFK 125

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19923479   399 SITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLEDLTSPEEFKLPKEYSWPEKKLKVSI 473
Cdd:pfam12470 126 AVLGDTAVTFVAESVTGSFVSEEHPYAALGPWLQVLIPNDLVPRMLEDLEELTSPDELKLPKTYEWPDKNLKITI 200
SUFU pfam05076
Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila ...
 64-240 4.26e-54

Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.


Pssm-ID: 461543  Cd Length: 171  Bit Score: 179.04  E-value: 4.26e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923479    64 GPDPLDYVSMYRNVGSPsanipeHWHYISFGLSDLYGDnrVHEFTGTDgpSGFGFELTFRLKR--ETGESAPPTWPAELM 141
Cdd:pfam05076   1 GDDPLDILSIPDTPEPG------HWHYVTLGLSDLPMD--EPEDLEED--SGPRAELTFRLPKdeESLADEPPTWPLNLL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923479   142 QGLARYVFQSENTFCSGDHVSWHSPLD-NSESRIQHMLLTE---DPQMQPVQTPFG-VVTFLQIVGVCTEELHSAQQWNG 216
Cdd:pfam05076  71 QNLARYPFKEGTWLGPGHTIPNGGPIPlAENTDLTGLLLVEpldDEELGALETPGGkKVNFLQLVPITEEELEYALEKGA 150

                         170       180
                  ....*....|....*....|....
gi 19923479   217 QGILELLRtvpiAGGPWLITDMRR 240
Cdd:pfam05076 151 DALLELLL----EEGPIDITDLNR 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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