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Conserved domains on  [gi|7706667|ref|NP_057230|]
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trafficking protein particle complex subunit 4 isoform 1 [Homo sapiens]

Protein Classification

trafficking protein particle complex subunit 4( domain architecture ID 13000952)

trafficking protein particle complex subunit 4 is a core component of the transport protein particle (TRAPP) complexes and one of the essential subunits for guanine nucleotide exchange factor (GEF) activity for Rab1 GTPase

CATH:  3.30.450.70
Gene Ontology:  GO:0030008|GO:0006888
PubMed:  9564032|27066478|18801063|22669257|20966969

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 4-205 1.55e-74

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


:

Pssm-ID: 341446  Cd Length: 127  Bit Score: 221.24  E-value: 1.55e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706667    4 FSVYVVNKAGGLIYQldsyapraeaeKTFSYPLdlllklhdervlvafgqrdgirvghavlaingmdvngrytadgkevl 83
Cdd:cd14856   1 YSLYIINKAGGLIYQ-----------KDFSDAL----------------------------------------------- 22

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706667   84 eylgnpanypvsirfgrPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQ 163
Cdd:cd14856  23 -----------------AKLSSNDYLRLASTFHGLHAIAAQLSPVPGSSGIELLETDTFRLHCFQTLTGIKFVLVADPKQ 85

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 7706667  164 AGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLA 205
Cdd:cd14856  86 PGLDALLRRVYELYADYVLKNPFYELEMPIRCELFDENLQKL 127
 
Name Accession Description Interval E-value
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 4-205 1.55e-74

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341446  Cd Length: 127  Bit Score: 221.24  E-value: 1.55e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706667    4 FSVYVVNKAGGLIYQldsyapraeaeKTFSYPLdlllklhdervlvafgqrdgirvghavlaingmdvngrytadgkevl 83
Cdd:cd14856   1 YSLYIINKAGGLIYQ-----------KDFSDAL----------------------------------------------- 22

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706667   84 eylgnpanypvsirfgrPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQ 163
Cdd:cd14856  23 -----------------AKLSSNDYLRLASTFHGLHAIAAQLSPVPGSSGIELLETDTFRLHCFQTLTGIKFVLVADPKQ 85

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 7706667  164 AGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLA 205
Cdd:cd14856  86 PGLDALLRRVYELYADYVLKNPFYELEMPIRCELFDENLQKL 127
Sybindin pfam04099
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ...
 97-209 6.07e-62

Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses.


Pssm-ID: 282019  Cd Length: 134  Bit Score: 189.45  E-value: 6.07e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706667     97 RFGRPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQ-AGIDSLLRKIYE 175
Cdd:pfam04099  21 RPKKTKLTTNEYKLLAGMLHSLHSISSKISPLPGSSGIESLETDTFKLHCLETLTGIKFVLVTDPGTgINRDSLLRKYYE 100

                          90       100       110
                  ....*....|....*....|....*....|....
gi 7706667    176 IYSDFALKNPFYSLEMPIRCELFDQNLKLALEVA 209
Cdd:pfam04099 101 LYSDYVLKNPFYSLGMPIRCELFDEKLDQYVRSL 134
TRS23 COG5122
Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];
99-207 1.38e-36

Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227451  Cd Length: 134  Bit Score: 125.01  E-value: 1.38e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706667   99 GRPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRKIYEIYS 178
Cdd:COG5122  24 GETELNSNEYLILASTLHGVSAILTQTIPLPGSSGRLVLYFRNFVMTIFQTTTGTKFVFVAEKRTVNALFQLQKIYSLYS 103

                        90       100
                ....*....|....*....|....*....
gi 7706667  179 DFALKNPFYSLEMPIRCELFDQNLKLALE 207
Cdd:COG5122 104 DYVTKNPFYSPEMPIQCSLFDEHLKRMFE 132
 
Name Accession Description Interval E-value
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 4-205 1.55e-74

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341446  Cd Length: 127  Bit Score: 221.24  E-value: 1.55e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706667    4 FSVYVVNKAGGLIYQldsyapraeaeKTFSYPLdlllklhdervlvafgqrdgirvghavlaingmdvngrytadgkevl 83
Cdd:cd14856   1 YSLYIINKAGGLIYQ-----------KDFSDAL----------------------------------------------- 22

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706667   84 eylgnpanypvsirfgrPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQ 163
Cdd:cd14856  23 -----------------AKLSSNDYLRLASTFHGLHAIAAQLSPVPGSSGIELLETDTFRLHCFQTLTGIKFVLVADPKQ 85

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 7706667  164 AGIDSLLRKIYEIYSDFALKNPFYSLEMPIRCELFDQNLKLA 205
Cdd:cd14856  86 PGLDALLRRVYELYADYVLKNPFYELEMPIRCELFDENLQKL 127
Sybindin pfam04099
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ...
 97-209 6.07e-62

Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses.


Pssm-ID: 282019  Cd Length: 134  Bit Score: 189.45  E-value: 6.07e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706667     97 RFGRPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQ-AGIDSLLRKIYE 175
Cdd:pfam04099  21 RPKKTKLTTNEYKLLAGMLHSLHSISSKISPLPGSSGIESLETDTFKLHCLETLTGIKFVLVTDPGTgINRDSLLRKYYE 100

                          90       100       110
                  ....*....|....*....|....*....|....
gi 7706667    176 IYSDFALKNPFYSLEMPIRCELFDQNLKLALEVA 209
Cdd:pfam04099 101 LYSDYVLKNPFYSLGMPIRCELFDEKLDQYVRSL 134
TRS23 COG5122
Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];
99-207 1.38e-36

Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227451  Cd Length: 134  Bit Score: 125.01  E-value: 1.38e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706667   99 GRPRLTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRKIYEIYS 178
Cdd:COG5122  24 GETELNSNEYLILASTLHGVSAILTQTIPLPGSSGRLVLYFRNFVMTIFQTTTGTKFVFVAEKRTVNALFQLQKIYSLYS 103

                        90       100
                ....*....|....*....|....*....
gi 7706667  179 DFALKNPFYSLEMPIRCELFDQNLKLALE 207
Cdd:COG5122 104 DYVTKNPFYSPEMPIQCSLFDEHLKRMFE 132
TRAPPC1_MUM2 cd14855
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ...
 97-202 2.30e-24

Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341445  Cd Length: 132  Bit Score: 93.38  E-value: 2.30e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706667   97 RFGRPRLTSNE----KLMLAsMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGIDSLLRK 172
Cdd:cd14855  20 RPKQSSNGKSEeeeqKLMFG-LLFSLKSFVRKISPTDDTCGFHSYTTNKYKLHYYETPTGLKFVLLTDPNVGDLRDVLQQ 98

                        90       100       110
                ....*....|....*....|....*....|.
gi 7706667  173 IY-EIYSDFALKNPFYSLEMPIRCELFDQNL 202
Cdd:cd14855  99 IYsNIYVEYVVKNPLYPPGEPITSELFRSKL 129
TRAPPC_longin-like cd14853
Longin-like domains of Trafficking protein particle complex; Longin-like domains of a ...
 103-203 7.43e-21

Longin-like domains of Trafficking protein particle complex; Longin-like domains of a subfamily of core components of the trafficking protein particle complex (TRAPP), including TRAPPC2, TRAPPC4, TRAPPC1 and a TRAPPC2L, whose function is not known. TRAPP complexes are required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341443  Cd Length: 132  Bit Score: 84.46  E-value: 7.43e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706667  103 LTSNEKLMLASMFHSLFAIGSQLSPEQGSSGIEMLETDTFKLHCYQTLTGIKFVVLADPRQAGI-DSLLRKIYEIYSDFA 181
Cdd:cd14853  27 DNEEEYKLLAGMLHSVRSINSKLSPNVEKYLKLSDKTNEYKVHAYVTATGLKFVMLTDVLMDRIeDVLKNFFSDLYVLYV 106

                        90       100
                ....*....|....*....|....
gi 7706667  182 LKNPFYSLEM--PIRCELFDQNLK 203
Cdd:cd14853 107 KKNPNPFYEPnsPIRSRLFDSKVQ 130
TRAPPC2_sedlin cd14825
Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 ...
 140-205 3.75e-08

Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 (TRAPPC2), also known as Sedlin (SEDL) or TRS20, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. In humans, deletions or point mutations in the SEDL gene cause the genetic disease spondyloepiphyseal dysplasia tarda (SEDT), an X-linked skeletal disorder.


Pssm-ID: 341429  Cd Length: 135  Bit Score: 50.61  E-value: 3.75e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706667  140 DTFK---LHCYQTLTGIKFVVLADPRQ-AGIDSLLRKIYEIYSDFALkNPFYSLEMPIRCELFDQNLKLA 205
Cdd:cd14825  62 DRFNewsVSAFVTAGNIRFLLLHDNKNdDGIKNFFQEVYELYVKILM-NPFYEPNTPIRSPAFDRRVRAL 130
Sedlin_N pfam04628
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ...
 147-205 1.19e-07

Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region.


Pssm-ID: 335859  Cd Length: 129  Bit Score: 48.80  E-value: 1.19e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7706667    147 YQTLTGIKFVVLADPRQ---AGIDSLLRKIYEIYSDFALkNPFYSLEMPIRCELFDQNLKLA 205
Cdd:pfam04628  66 YVTNSHIKFILVHESSTksdENIKQFFQEVHELYVKTLM-NPFYKPNDPIRSPAFDKKVRKL 126
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 89-203 6.03e-07

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341444  Cd Length: 135  Bit Score: 47.20  E-value: 6.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706667   89 PANYPVSIRFGRPRLTSNEKLMLAsMFHSLFAIGSQLSPEQGSSGI-EM-----LETDTFKLHCYQTLTGIKFVVL---- 158
Cdd:cd14854   8 KQNNPLYLRTFPSGEDNDLKLHYI-AHSSLDVVEEKLSASKKGGDTsDMylgllYPTEDYKVYGYVTNTKVKFILVledt 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 7706667  159 -ADPRQAGIDSLLRKIYEIYSDfALKNPFYSLEMPIRCELFDQNLK 203
Cdd:cd14854  87 nTPLRDNDVRTLFRRLHNAYVD-AVSNPFYPPGTPITSKKFDRRVD 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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