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Conserved domains on  [gi|157743245|ref|NP_055946|]
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WD repeat-containing protein 43 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11456769)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
20-300 1.42e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 1.42e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  20 AFSPHSQaYFALASTDGHLRVWETANNRLHQEYvpSAHlSGTCTCLAWaparlqakeSPQRKkrkseavgmsnqtdLLAL 99
Cdd:COG2319  127 AFSPDGK-TLASGSADGTVRLWDLATGKLLRTL--TGH-SGAVTSVAF---------SPDGK--------------LLAS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245 100 GTAVGSILLYSTVKGELHSKLisGGHDNRVNCIQWHQDSGCLYSCSDDKHIVEWNVQTCKVKCKWKGDNSSVSSLCISPD 179
Cdd:COG2319  180 GSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245 180 GKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLMFTtirpPNesqpfdgitGLYFLSGAvHDRLLNVWQVRSenke 257
Cdd:COG2319  258 GRLLASGSadGTVRLWDLATGELLRTLTGHSGGVNSVAFS----PD---------GKLLASGS-DDGTVRLWDLAT---- 319

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 157743245 258 KSAVMSFTVTDEPVYiDLTLSENKEepvKLAVVCRDGQVHLFE 300
Cdd:COG2319  320 GKLLRTLTGHTGAVR-SVAFSPDGK---TLASGSDDGTVRLWD 358
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 473-577 6.59e-27

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


:

Pssm-ID: 461125  Cd Length: 106  Bit Score: 105.32  E-value: 6.59e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  473 NDFEMLNKVLQTRNVNLIKKTVLRMPLHTIIPLLQELTKRLQGHPNSAVLMVQWLKCVLTVHASYLSTLPDLVPQLGTLY 552
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 157743245  553 QLMESRVKTFQKLSHLH-GKLILLIT 577
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNlGALDYLLS 106
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
20-300 1.42e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 1.42e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  20 AFSPHSQaYFALASTDGHLRVWETANNRLHQEYvpSAHlSGTCTCLAWaparlqakeSPQRKkrkseavgmsnqtdLLAL 99
Cdd:COG2319  127 AFSPDGK-TLASGSADGTVRLWDLATGKLLRTL--TGH-SGAVTSVAF---------SPDGK--------------LLAS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245 100 GTAVGSILLYSTVKGELHSKLisGGHDNRVNCIQWHQDSGCLYSCSDDKHIVEWNVQTCKVKCKWKGDNSSVSSLCISPD 179
Cdd:COG2319  180 GSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245 180 GKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLMFTtirpPNesqpfdgitGLYFLSGAvHDRLLNVWQVRSenke 257
Cdd:COG2319  258 GRLLASGSadGTVRLWDLATGELLRTLTGHSGGVNSVAFS----PD---------GKLLASGS-DDGTVRLWDLAT---- 319

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 157743245 258 KSAVMSFTVTDEPVYiDLTLSENKEepvKLAVVCRDGQVHLFE 300
Cdd:COG2319  320 GKLLRTLTGHTGAVR-SVAFSPDGK---TLASGSDDGTVRLWD 358
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 473-577 6.59e-27

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 105.32  E-value: 6.59e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  473 NDFEMLNKVLQTRNVNLIKKTVLRMPLHTIIPLLQELTKRLQGHPNSAVLMVQWLKCVLTVHASYLSTLPDLVPQLGTLY 552
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 157743245  553 QLMESRVKTFQKLSHLH-GKLILLIT 577
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNlGALDYLLS 106
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-272 1.21e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.12  E-value: 1.21e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  19 CAFSPHSQaYFALASTDGHLRVWETANNRLHQEYVpsAHLSGtCTCLAWAPARlqakespqrkkrkseavgmsnqtDLLA 98
Cdd:cd00200   57 VAASADGT-YLASGSSDKTIRLWDLETGECVRTLT--GHTSY-VSSVAFSPDG-----------------------RILS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  99 LGTAVGSILLYSTVKGELHSKLisGGHDNRVNCIQWHQDSGCLYSCSDDKHIVEWNVQTCKVKCKWKGDNSSVSSLCISP 178
Cdd:cd00200  110 SSSRDKTIKVWDVETGKCLTTL--RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245 179 DGKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLMFTTIRppnesqpfdgitglYFLSGAVHDRLLNVWQVRSenk 256
Cdd:cd00200  188 DGEKLLSSSsdGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG--------------YLLASGSEDGTIRVWDLRT--- 250

                        250
                 ....*....|....*.
gi 157743245 257 eKSAVMSFTVTDEPVY 272
Cdd:cd00200  251 -GECVQTLSGHTNSVT 265
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-154 4.65e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 4.65e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 157743245   124 GHDNRVNCIQWHQDSGCLYSCSDDKHIVEWN 154
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
124-154 4.05e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 4.05e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 157743245  124 GHDNRVNCIQWHQDSGCLYSCSDDKHIVEWN 154
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
20-300 1.42e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 1.42e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  20 AFSPHSQaYFALASTDGHLRVWETANNRLHQEYvpSAHlSGTCTCLAWaparlqakeSPQRKkrkseavgmsnqtdLLAL 99
Cdd:COG2319  127 AFSPDGK-TLASGSADGTVRLWDLATGKLLRTL--TGH-SGAVTSVAF---------SPDGK--------------LLAS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245 100 GTAVGSILLYSTVKGELHSKLisGGHDNRVNCIQWHQDSGCLYSCSDDKHIVEWNVQTCKVKCKWKGDNSSVSSLCISPD 179
Cdd:COG2319  180 GSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245 180 GKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLMFTtirpPNesqpfdgitGLYFLSGAvHDRLLNVWQVRSenke 257
Cdd:COG2319  258 GRLLASGSadGTVRLWDLATGELLRTLTGHSGGVNSVAFS----PD---------GKLLASGS-DDGTVRLWDLAT---- 319

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 157743245 258 KSAVMSFTVTDEPVYiDLTLSENKEepvKLAVVCRDGQVHLFE 300
Cdd:COG2319  320 GKLLRTLTGHTGAVR-SVAFSPDGK---TLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
20-253 2.24e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 2.24e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  20 AFSPHSQaYFALASTDGHLRVWETANNRLHQEYvpsAHLSGTCTCLAWaparlqakeSPQRKkrkseavgmsnqtdLLAL 99
Cdd:COG2319  211 AFSPDGK-LLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRSVAF---------SPDGR--------------LLAS 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245 100 GTAVGSILLYSTVKGELHSKLisGGHDNRVNCIQWHQDSGCLYSCSDDKHIVEWNVQTCKVKCKWKGDNSSVSSLCISPD 179
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTL--TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157743245 180 GKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLMFTtirpPNesqpfdgitGLYFLSGAvHDRLLNVWQVRS 253
Cdd:COG2319  342 GKTLASGSddGTVRLWDLATGELLRTLTGHTGAVTSVAFS----PD---------GRTLASGS-ADGTVRLWDLAT 403
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 473-577 6.59e-27

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 105.32  E-value: 6.59e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  473 NDFEMLNKVLQTRNVNLIKKTVLRMPLHTIIPLLQELTKRLQGHPNSAVLMVQWLKCVLTVHASYLSTLPDLVPQLGTLY 552
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 157743245  553 QLMESRVKTFQKLSHLH-GKLILLIT 577
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNlGALDYLLS 106
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-272 1.21e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.12  E-value: 1.21e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  19 CAFSPHSQaYFALASTDGHLRVWETANNRLHQEYVpsAHLSGtCTCLAWAPARlqakespqrkkrkseavgmsnqtDLLA 98
Cdd:cd00200   57 VAASADGT-YLASGSSDKTIRLWDLETGECVRTLT--GHTSY-VSSVAFSPDG-----------------------RILS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  99 LGTAVGSILLYSTVKGELHSKLisGGHDNRVNCIQWHQDSGCLYSCSDDKHIVEWNVQTCKVKCKWKGDNSSVSSLCISP 178
Cdd:cd00200  110 SSSRDKTIKVWDVETGKCLTTL--RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245 179 DGKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLMFTTIRppnesqpfdgitglYFLSGAVHDRLLNVWQVRSenk 256
Cdd:cd00200  188 DGEKLLSSSsdGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG--------------YLLASGSEDGTIRVWDLRT--- 250

                        250
                 ....*....|....*.
gi 157743245 257 eKSAVMSFTVTDEPVY 272
Cdd:cd00200  251 -GECVQTLSGHTNSVT 265
WD40 COG2319
WD40 repeat [General function prediction only];
65-299 9.61e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 9.61e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  65 LAWAPARLQAKESPQRKKRKSEAVGMSNQTDLLALGTAVGSILLYSTVKGELHSKLisGGHDNRVNCIQWHQDSGCLYSC 144
Cdd:COG2319   61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL--TGHTGAVRSVAFSPDGKTLASG 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245 145 SDDKHIVEWNVQTCKVKCKWKGDNSSVSSLCISPDGKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLMFTtirpP 222
Cdd:COG2319  139 SADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSddGTVRLWDLATGKLLRTLTGHTGAVRSVAFS----P 214

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157743245 223 NesqpfdgitGLYFLSGAvHDRLLNVWQVRSenkeKSAVMSFTVTDEPVYiDLTLSENKEepvKLAVVCRDGQVHLF 299
Cdd:COG2319  215 D---------GKLLASGS-ADGTVRLWDLAT----GKLLRTLTGHSGSVR-SVAFSPDGR---LLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 91-313 3.02e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 3.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  91 SNQTDLLALGTAVGSILLYSTVKGELHSKLIsgGHDNRVNCIQWHQDSGCLYSCSDDKHIVEWNVQTCKVKCKWKGDNSS 170
Cdd:cd00200   18 SPDGKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245 171 VSSLCISPDGKMLLSAGR--TIKLWVLETKEVYRHFTGHATPVSSLMFTtirppnesqPFDGitglyFLSGAVHDRLLNV 248
Cdd:cd00200   96 VSSVAFSPDGRILSSSSRdkTIKVWDVETGKCLTTLRGHTDWVNSVAFS---------PDGT-----FVASSSQDGTIKL 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157743245 249 WQVRSEnkekSAVMSFTVTDEPVYiDLTLSENKEepvKLAVVCRDGQVHLFEhILNGYCKKPLTS 313
Cdd:cd00200  162 WDLRTG----KCVATLTGHTGEVN-SVAFSPDGE---KLLSSSSDGTIKLWD-LSTGKCLGTLRG 217
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-193 1.93e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.32  E-value: 1.93e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  19 CAFSPHSQAYFAlASTDGHLRVWETANNRLHQEYvpSAHlSGTCTCLAWaparlqakeSPQRKKrkseavgmsnqtdlLA 98
Cdd:cd00200  141 VAFSPDGTFVAS-SSQDGTIKLWDLRTGKCVATL--TGH-TGEVNSVAF---------SPDGEK--------------LL 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  99 LGTAVGSILLYSTVKGELHSKLIsgGHDNRVNCIQWHQDSGCLYSCSDDKHIVEWNVQTCKVKCKWKGDNSSVSSLCISP 178
Cdd:cd00200  194 SSSSDGTIKLWDLSTGKCLGTLR--GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271

                        170
                 ....*....|....*..
gi 157743245 179 DGKMLLSAG--RTIKLW 193
Cdd:cd00200  272 DGKRLASGSadGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
65-300 9.66e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 9.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245  65 LAWAPARLQAKESPQRKKRKSEAVGMSNQTDLLALGTAVGSILLYSTVKGELHSKLIsgGHDNRVNCIQWHQDSGCLYSC 144
Cdd:COG2319   19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL--GHTAAVLSVAFSPDGRLLASA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245 145 SDDKHIVEWNVQTCKVKCKWKGDNSSVSSLCISPDGKMLLSAG--RTIKLWVLETKEVYRHFTGHATPVSSLMFTtirpP 222
Cdd:COG2319   97 SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSadGTVRLWDLATGKLLRTLTGHSGAVTSVAFS----P 172

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157743245 223 NesqpfdgitGLYFLSGAvHDRLLNVWQVRSENKEKsavmSFTVTDEPVYiDLTLSENKEepvKLAVVCRDGQVHLFE 300
Cdd:COG2319  173 D---------GKLLASGS-DDGTVRLWDLATGKLLR----TLTGHTGAVR-SVAFSPDGK---LLASGSADGTVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-312 3.53e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 3.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245 164 WKGDNSSVSSLCISPDGKMLLSAGR--TIKLWVLETKEVYRHFTGHATPVSSLMFTTirppnesqpfdgiTGLYFLSGAV 241
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGdgTIKVWDLETGELLRTLKGHTGPVRDVAASA-------------DGTYLASGSS 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157743245 242 hDRLLNVWQVRSENKeksaVMSFTVTDEPVYiDLTLSENKeepvKLAVVC-RDGQVHLFEhILNGYCKKPLT 312
Cdd:cd00200   72 -DKTIRLWDLETGEC----VRTLTGHTSYVS-SVAFSPDG----RILSSSsRDKTIKVWD-VETGKCLTTLR 132
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-154 4.65e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 4.65e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 157743245   124 GHDNRVNCIQWHQDSGCLYSCSDDKHIVEWN 154
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
124-154 4.05e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 4.05e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 157743245  124 GHDNRVNCIQWHQDSGCLYSCSDDKHIVEWN 154
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 157-193 4.58e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 4.58e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 157743245   157 TCKVKCKWKGDNSSVSSLCISPDGKMLLSAG--RTIKLW 193
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSddGTIKLW 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 91-214 8.21e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 8.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743245   91 SNQTDLLALGTAVGSILLYstvkgelhsklisgghdnRVNciqWHQdsgclyscsddkhivEWNVQTCKVKCKwkgdnss 170
Cdd:pfam12894   4 CPTMDLIALATEDGELLLH------------------RLN---WQR---------------VWTLSPDKEDLE------- 40

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 157743245  171 VSSLCISPDGKMLLSAGR--TIKLWVLETKEVYRHFTGHATPVSSL 214
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSdgTVRLLDAENGKIVHHFSAGSDLITCL 86
WD40 pfam00400
WD domain, G-beta repeat;
159-193 1.23e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 157743245  159 KVKCKWKGDNSSVSSLCISPDGKMLLSAG--RTIKLW 193
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSddGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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