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Conserved domains on  [gi|9632146|ref|NP_048968|]
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Histone H3K27 methylase [Paramecium bursaria Chlorella virus 1]

Protein Classification

SET domain-containing protein( domain architecture ID 14410642)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:0008168|GO:1904047
PubMed:  12372294|17013555|16086857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 5-111 1.57e-46

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


:

Pssm-ID: 380938  Cd Length: 112  Bit Score: 145.47  E-value: 1.57e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    5 RVIVKKSPLGGYGVFARKSFEKGELVEECLCIVR----HNDDWGTALEDYLFSRK-NMSAMALGFGAIFNHSKDPNARHE 79
Cdd:cd10540   1 RLEVKPSTLKGRGVFATRPIKKGEVIEEAPVIVLpkeeYQHLCKTVLDHYVFSWGdGCLALALGYGSMFNHSYTPNAEYE 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 9632146   80 LTAGLKRMRIFTIKPIAIGEEITISYGDDYWL 111
Cdd:cd10540  81 IDFENQTIVFYALRDIEAGEELTINYGDDLWD 112
 
Name Accession Description Interval E-value
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 5-111 1.57e-46

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 145.47  E-value: 1.57e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    5 RVIVKKSPLGGYGVFARKSFEKGELVEECLCIVR----HNDDWGTALEDYLFSRK-NMSAMALGFGAIFNHSKDPNARHE 79
Cdd:cd10540   1 RLEVKPSTLKGRGVFATRPIKKGEVIEEAPVIVLpkeeYQHLCKTVLDHYVFSWGdGCLALALGYGSMFNHSYTPNAEYE 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 9632146   80 LTAGLKRMRIFTIKPIAIGEEITISYGDDYWL 111
Cdd:cd10540  81 IDFENQTIVFYALRDIEAGEELTINYGDDLWD 112
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1-110 6.40e-26

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 93.87  E-value: 6.40e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    1 MFNDRVIVKKSPLGGYGVFARKSFEKGELVEECLCIVRHNDDW------GTALEDYLFS----RKNMSAMALGFGAIFNH 70
Cdd:COG2940   3 MLHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAerrephKEPLHTYLFEldddGVIDGALGGNPARFINH 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 9632146   71 SKDPNArhELTAGLKRMRIFTIKPIAIGEEITISYGDDYW 110
Cdd:COG2940  83 SCDPNC--EADEEDGRIFIVALRDIAAGEELTYDYGLDYD 120
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 5-110 2.22e-23

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 87.39  E-value: 2.22e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146       5 RVIVKKSPLGGYGVFARKSFEKGELVEECLCIVRHND---------DWGTALEDYLF---SRKNMSAMALG-FGAIFNHS 71
Cdd:smart00317   2 KLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEeaeerpkayDTDGAKAFYLFdidSDLCIDARRKGnLARFINHS 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 9632146      72 KDPNARHELTA--GLKRMRIFTIKPIAIGEEITISYGDDYW 110
Cdd:smart00317  82 CEPNCELLFVEvnGDDRIVIFALRDIKPGEELTIDYGSDYA 122
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 15-106 1.16e-16

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 69.86  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146     15 GYGVFARKSFEKGELV---EECLCIVRHNDDWGTALED----------YLFSRKNMSAMAL--------GFGAIFNHSKD 73
Cdd:pfam00856   1 GRGLFATEDIPKGEFIgeyVEVLLITKEEADKRELLYYdklelrlwgpYLFTLDEDSEYCIdaralyygNWARFINHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 9632146     74 PNARHELT--AGLKRMRIFTIKPIAIGEEITISYG 106
Cdd:pfam00856  81 PNCEVRVVyvNGGPRIVIFALRDIKPGEELTIDYG 115
 
Name Accession Description Interval E-value
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 5-111 1.57e-46

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 145.47  E-value: 1.57e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    5 RVIVKKSPLGGYGVFARKSFEKGELVEECLCIVR----HNDDWGTALEDYLFSRK-NMSAMALGFGAIFNHSKDPNARHE 79
Cdd:cd10540   1 RLEVKPSTLKGRGVFATRPIKKGEVIEEAPVIVLpkeeYQHLCKTVLDHYVFSWGdGCLALALGYGSMFNHSYTPNAEYE 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 9632146   80 LTAGLKRMRIFTIKPIAIGEEITISYGDDYWL 111
Cdd:cd10540  81 IDFENQTIVFYALRDIEAGEELTINYGDDLWD 112
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1-110 6.40e-26

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 93.87  E-value: 6.40e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    1 MFNDRVIVKKSPLGGYGVFARKSFEKGELVEECLCIVRHNDDW------GTALEDYLFS----RKNMSAMALGFGAIFNH 70
Cdd:COG2940   3 MLHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAerrephKEPLHTYLFEldddGVIDGALGGNPARFINH 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 9632146   71 SKDPNArhELTAGLKRMRIFTIKPIAIGEEITISYGDDYW 110
Cdd:COG2940  83 SCDPNC--EADEEDGRIFIVALRDIAAGEELTYDYGLDYD 120
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 5-110 2.22e-23

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 87.39  E-value: 2.22e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146       5 RVIVKKSPLGGYGVFARKSFEKGELVEECLCIVRHND---------DWGTALEDYLF---SRKNMSAMALG-FGAIFNHS 71
Cdd:smart00317   2 KLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEeaeerpkayDTDGAKAFYLFdidSDLCIDARRKGnLARFINHS 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 9632146      72 KDPNARHELTA--GLKRMRIFTIKPIAIGEEITISYGDDYW 110
Cdd:smart00317  82 CEPNCELLFVEvnGDDRIVIFALRDIKPGEELTIDYGSDYA 122
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 7-115 2.15e-19

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 77.03  E-value: 2.15e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    7 IVKKSPLGGYGVFARKSFEKGELV--EECLCIVRHNddwgtALEDYLFSRKNMSAMaLGFGAIFNHSKDPNARHELTaGL 84
Cdd:cd20071   2 VRESEGSKGRGLVATRDIEPGELIlvEKPLVSVPSN-----SFSLTDGLNEIGVGL-FPLASLLNHSCDPNAVVVFD-GN 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 9632146   85 KRMRIFTIKPIAIGEEITISYGDDYWLSRPR 115
Cdd:cd20071  75 GTLRVRALRDIKAGEELTISYIDPLLPRTER 105
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 8-110 8.93e-17

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 70.45  E-value: 8.93e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    8 VKKSPLGGYGVFARKSFEKGELVEECLCIVRHNDdwgTALEDYLFSRKNMSAMALGFGAIF-------------NHSKDP 74
Cdd:cd10522   7 IPNLSHNGLGLFAAETIAKGEFVGEYTGEVLDRW---EEDRDSVYHYDPLYPFDLNGDILVidagkkgnltrfiNHSDQP 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 9632146   75 NAR--HELTAGLKRMRIFTIKPIAIGEEITISYGDDYW 110
Cdd:cd10522  84 NLEliVRTLKGEQHIGFVAIRDIKPGEELFISYGPKYW 121
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 15-106 1.16e-16

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 69.86  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146     15 GYGVFARKSFEKGELV---EECLCIVRHNDDWGTALED----------YLFSRKNMSAMAL--------GFGAIFNHSKD 73
Cdd:pfam00856   1 GRGLFATEDIPKGEFIgeyVEVLLITKEEADKRELLYYdklelrlwgpYLFTLDEDSEYCIdaralyygNWARFINHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 9632146     74 PNARHELT--AGLKRMRIFTIKPIAIGEEITISYG 106
Cdd:pfam00856  81 PNCEVRVVyvNGGPRIVIFALRDIKPGEELTIDYG 115
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 15-110 2.69e-16

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 69.62  E-value: 2.69e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146   15 GYGVFARKSFEKGELVEE-CLCIVRHNDD----WGTALEDY--LFS-RKNMSAMALGFGAIFNHSKDPNARHELTaGLKR 86
Cdd:cd10524  19 GAKIIATKPIKKGEKIHElCGCIAELSEEeealLRPGGNDFsvMYSsRKKCSQLWLGPAAFINHDCRPNCKFVPT-GKST 97

                        90       100
                ....*....|....*....|....
gi 9632146   87 MRIFTIKPIAIGEEITISYGDDYW 110
Cdd:cd10524  98 ACVKVLRDIEPGEEITVYYGDNYF 121
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 5-106 1.06e-15

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 66.12  E-value: 1.06e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    5 RVIVKKSPLGGYGVFARKSFEKGELVeeclcivrhnddwgtaledylfsrknmsamalGFGAIFNHSKDPNARHELT--A 82
Cdd:cd08161   1 EIRPSTIPGAGFGLFATRDIPKGEVI--------------------------------GLARFINHSCEPNCEFEEVyvG 48

                        90       100
                ....*....|....*....|....
gi 9632146   83 GLKRMRIFTIKPIAIGEEITISYG 106
Cdd:cd08161  49 GKPRVFIVALRDIKAGEELTVDYG 72
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 5-107 9.96e-09

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 49.16  E-value: 9.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    5 RVIVKKSPLGGYGVFARKSFEKGELVEE-CLCIVRHND-DWGTALED-----YLFSRKNMSAM-ALGFGAIF---NHSKD 73
Cdd:cd10519   2 RLLLGKSDVAGWGLFLKEPIKKDEFIGEyTGELISQDEaDRRGKIYDkynssYLFNLNDQFVVdATRKGNKIrfaNHSSN 81

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 9632146   74 PN--ARHELTAGLKRMRIFTIKPIAIGEEITISYGD 107
Cdd:cd10519  82 PNcyAKVMMVNGDHRIGIFAKRDIEAGEELFFDYGY 117
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 15-108 1.12e-08

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 49.56  E-value: 1.12e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146   15 GYGVFARKSFEKGELVEECLCIVRHNDDWGTALEDY------------LFSRKNMSAMALG-FGAIFNHSKDPNARHELT 81
Cdd:cd10531  11 GWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERLDEYeelgksnfyilsLSDDVVIDATRKGnLSRFINHSCEPNCETQKW 90

                        90       100
                ....*....|....*....|....*....
gi 9632146   82 A--GLKRMRIFTIKPIAIGEEITISYGDD 108
Cdd:cd10531  91 IvnGEYRIGIFALRDIPAGEELTFDYNFV 119
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 4-105 2.51e-08

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 48.75  E-value: 2.51e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    4 DRVIVKKSPLGGYGVFARKSFEKGELV-EECLCIVRHN---------DDWGTAlEDYLF---SRKNMSAMALGFGAIF-N 69
Cdd:cd10518  14 ERLRVGKSGIHGWGLFAKRPIAAGEMViEYVGEVIRPIvadkrekryDEEGGG-GTYMFridEDLVIDATKKGNIARFiN 92

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 9632146   70 HSKDPN--ARHELTAGLKRMRIFTIKPIAIGEEITISY 105
Cdd:cd10518  93 HSCDPNcyAKIITVDGEKHIVIFAKRDIAPGEELTYDY 130
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 67-107 8.63e-08

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 48.60  E-value: 8.63e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 9632146   67 IFNHS-KDPNARHELTAGLKRMRIFTIKPIAIGEEITISYGD 107
Cdd:cd10527 182 MLNHSpDAPNVRYEYDEDEGSFVLVATRDIAAGEEVFISYGP 223
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 5-105 2.46e-06

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 43.34  E-value: 2.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    5 RVIVKKSPLGGYGVFARKSFEKGELVEECLCIVRHNDDWGTALEDYLFS-RKNMSAMALGFGAIF------------NHS 71
Cdd:cd19172   3 KVEVFRTEKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYAREgNRHYYFMALKSDEIIdatkkgnlsrfiNHS 82

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 9632146   72 KDPNARHE--LTAGLKRMRIFTIKPIAIGEEITISY 105
Cdd:cd19172  83 CEPNCETQkwTVNGELRVGFFAKRDIPAGEELTFDY 118
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 5-109 4.66e-06

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 42.56  E-value: 4.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    5 RVIVKKSPL-GGYGVFARKSFEKGELVEECLC-IVRHND-------DWGTAlEDYLFS-RKNMSAMALGFGAI---FNHS 71
Cdd:cd19168   2 AVVLGKSQLeCGLGLFAAEDIKEGEFVIEYTGeLISHDEgvrrehrRGDVS-YLYLFEeQEGIWVDAAIYGNLsryINHA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 9632146   72 KDPNARHELTA------GLKRMRIFTIKPIAIGEEITISYGDDY 109
Cdd:cd19168  81 TDKVKTGNCMPkimyvnHEWRIKFTAIKDIKIGEELFFNYGDNF 124
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 52-107 1.05e-05

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 42.35  E-value: 1.05e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9632146   52 FSRKNMSAMALGFG-----AIFNHSKDPNArhELTAGLKRMRIFTIKPIAIGEEITISYGD 107
Cdd:cd19203 125 FTICDAEMQEVGVGlypsaSLLNHSCDPNC--VIVFNGPHLLLRAIREIEVGEELTISYID 183
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 1-105 1.19e-05

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 41.99  E-value: 1.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    1 MFNDRVIVKKSPLGGYGVFARKSFEKGELVEE--------CLCIVRHNDDWGTALEDYLFsRKN----MSAMALGFGAIF 68
Cdd:cd19170  11 TAKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEyagevirsVLTDKREKYYESKGIGCYMF-RIDddevVDATMHGNAARF 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 9632146   69 -NHSKDPNARHELTA--GLKRMRIFTIKPIAIGEEITISY 105
Cdd:cd19170  90 iNHSCEPNCYSRVVNidGKKHIVIFALRRILRGEELTYDY 129
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 15-110 1.30e-05

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 42.33  E-value: 1.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146   15 GYGVFARKSFEKG--------ELVEECLCIVRHNDDwgtaledYLFSRKNMSAM-----ALGFGAI---FNHSKDPNAR- 77
Cdd:cd10543 102 GWGVRALQDIPKGtfvceyigELISDSEADSREDDS-------YLFDLDNKDGEtycidARRYGNIsrfINHLCEPNLIp 174

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 9632146   78 ------HEltaGLKRMRI--FTIKPIAIGEEITISYGDDYW 110
Cdd:cd10543 175 vrvfveHQ---DLRFPRIafFASRDIKAGEELGFDYGEKFW 212
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 4-105 1.44e-05

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 41.55  E-value: 1.44e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    4 DRVIVKKSPLGGYGVFARKSFEKGELVEECLCIV----------RHNDDWGTA-----LEDYLFSRKNMSAMALGFgaiF 68
Cdd:cd19206  14 EAVGVYRSPIHGRGLFCKRNIDAGEMVIEYSGNVirsiltdkreKYYDSKGIGcymfrIDDSEVVDATMHGNAARF---I 90

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 9632146   69 NHSKDPN--ARHELTAGLKRMRIFTIKPIAIGEEITISY 105
Cdd:cd19206  91 NHSCEPNcySRVINIDGQKHIVIFAMRKIYRGEELTYDY 129
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 15-105 1.49e-05

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 41.51  E-value: 1.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146   15 GYGVFARKSFEKGELVEECLC-IVRHNDDWGTALEDYlFSRKNMSAMALGFGAIF------------NHSKDPNARHE-- 79
Cdd:cd19174  11 GWGVRTKEPIKAGQFIIEYVGeVVSEQEFRRRMIEQY-HNHSHHYCLNLDSGMVIdgyrmgnearfvNHSCDPNCEMQkw 89

                        90       100
                ....*....|....*....|....*.
gi 9632146   80 LTAGLKRMRIFTIKPIAIGEEITISY 105
Cdd:cd19174  90 SVNGVYRIGLFALKDIPAGEELTYDY 115
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 59-106 5.15e-05

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 40.74  E-value: 5.15e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 9632146   59 AMAL-GFGAIFNHSKDPNARHELTAGLkrMRIFTIKPIAIGEEITISYG 106
Cdd:cd10536 144 ATAIyPTLSLLNHSCDPNTIRSFYGNT--IVVRATRPIKKGEEITICYG 190
SET_SETD4 cd19177
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
 68-106 9.77e-05

SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.


Pssm-ID: 380954 [Multi-domain]  Cd Length: 245  Bit Score: 39.98  E-value: 9.77e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 9632146   68 FNHSKDPNARHELTAGLKRMRIFTIKPIAIGEEITISYG 106
Cdd:cd19177 192 LNHSPDVNVKAGFNKSGKCYEIRTGTDYKKGEEVFISYG 230
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 4-109 1.21e-03

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 36.25  E-value: 1.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    4 DRVIVKKSPLGGYGVFARKSFEKGELVEECL-CIVRhnDDWGTALED---------YLFSRKNM----SAMALGFGAIFN 69
Cdd:cd19171  14 SNVYLARSRIQGLGLYAARDIEKHTMVIEYIgEIIR--NEVANRREKiyesqnrgiYMFRIDNDwvidATMTGGPARYIN 91

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 9632146   70 HSKDPNARHELTAGLKRMRIFTI--KPIAIGEEITISYGDDY 109
Cdd:cd19171  92 HSCNPNCVAEVVTFDKEKKIIIIsnRRIAKGEELTYDYKFDF 133
SET_Suv4-20 cd19186
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 54-110 1.64e-03

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation.


Pssm-ID: 380963  Cd Length: 142  Bit Score: 35.89  E-value: 1.64e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 9632146   54 RKNMSAMALGFGAIFNHSKDPNARHeLTAGLKRMRIFTIKPIAIGEEITISYGDDYW 110
Cdd:cd19186  67 RKNCAQLWLGPAAFINHDCRPNCKF-VSTGRDTACVQVLRDIEPGEEITCFYGEDFF 122
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 15-108 3.30e-03

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 34.97  E-value: 3.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146   15 GYGVFARKSFEKGELV----------EECLCIVRHNDDWGTAlEDYLFSRKNMSAMALG----FGAIFNHSKDPNARHE- 79
Cdd:cd19211  13 GWGLIAKRDIKKGEFVneyvgelideEECMARIKHAHENDIT-HFYMLTIDKDRIIDAGpkgnYSRFMNHSCQPNCETQk 91

                        90       100       110
                ....*....|....*....|....*....|
gi 9632146   80 -LTAGLKRMRIFTIKPIAIGEEITISYGDD 108
Cdd:cd19211  92 wTVNGDTRVGLFAVCDIPAGTELTFNYNLD 121
SET_SMYD5 cd10521
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 69-115 5.09e-03

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins; SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis.


Pssm-ID: 380919 [Multi-domain]  Cd Length: 282  Bit Score: 34.98  E-value: 5.09e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 9632146   69 NHSKDPNARHELTAGLKRMRIFTIKPIAIGEEITISYGDDYWLSRPR 115
Cdd:cd10521 213 NHSCVPNAEITFPENNFTLSLKALRDIQEGEEICISYLDECQRERSR 259
SET_KMT5B cd19184
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) ...
 53-110 6.19e-03

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins; KMT5B (also termed lysine N-methyltransferase 5B, lysine-specific methyltransferase 5B, suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1 or Suv4-20h1) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380961  Cd Length: 144  Bit Score: 34.24  E-value: 6.19e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 9632146   53 SRKNMSAMALGFGAIFNHSKDPNARHeLTAGLKRMRIFTIKPIAIGEEITISYGDDYW 110
Cdd:cd19184  65 TRKNCAQLWLGPAAFINHDCRPNCKF-VSTGRDTACVKALRDIEPGEEISCYYGDGFF 121
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 4-105 7.06e-03

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 34.23  E-value: 7.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    4 DRVIVKKSPLGGYGVFARKSFEKGELVEECLCIV--------RHNDDWGTALEDYLFSRKN---MSAMALGFGAIF-NHS 71
Cdd:cd19207  14 EAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVirsvltdkREKFYDSKGIGCYMFRIDDfdvVDATMHGNAARFiNHS 93

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 9632146   72 KDPN--ARHELTAGLKRMRIFTIKPIAIGEEITISY 105
Cdd:cd19207  94 CEPNcySRVIHVEGQKHIVIFALRKIYRGEELTYDY 129
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 5-106 7.73e-03

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 34.27  E-value: 7.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9632146    5 RVIVKKSPLGGYGVFARKSFEKGELVEECLCIVRHNDD-------WGTALEDYLFSRKNMSAMALGFGAIF--------- 68
Cdd:cd10538  90 RLQVFRTSKKGWGVRSLEFIPKGSFVCEYVGEVITTSEadrrgkiYDKSGGSYLFDLDEFSDSDGDGEELCvdatfcgnv 169

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 9632146   69 ----NHSKDPN--------ARHELTagLKRMRIFTIKPIAIGEEITISYG 106
Cdd:cd10538 170 srfiNHSCDPNlfpfnvviDHDDLR--YPRIALFATRDILPGEELTFDYG 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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