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Conserved domains on  [gi|73915092|ref|NP_038347|]
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glutathione hydrolase 1 proenzyme precursor [Homo sapiens]

Protein Classification

gamma-glutamyltransferase family protein( domain architecture ID 10470232)

gamma-glutamyltransferase family protein exhibits gamma-glutamyltranspeptidase and/or cephalosporin acylase and/or glutathione hydrolase activity, all involving the hydrolytic splitting of a peptide-like C-N bond

EC:  3.-.-.-
Gene Ontology:  GO:0016787
MEROPS:  T3
PubMed:  11563810|22527720
SCOP:  4000420

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
55-564 0e+00

Gamma-glutamyltranspeptidase;


:

Pssm-ID: 425991  Cd Length: 499  Bit Score: 663.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092    55 RDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFNS---SEQSQKGGLS 131
Cdd:pfam01019   1 LDILRKGGNAVDAAVAAALCLGVVEPHSSGIGGGGFMLIYDAKTGKVLVIDARETAPAAATKDMFDGkgdSKLSLTGGLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   132 VAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRKVLREGERLTLP 211
Cdd:pfam01019  81 VGVPGEVAGLAEAHKRYGRLPWADLLEPAIKLARDGFPVSPALARALARAEERLRADPGLRKIFLPTGRVLKAGELLKQP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   212 QLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAElIEHPLNISLGDVVLYMPSAPLSGPVLALILN 291
Cdd:pfam01019 161 ALAKTLELIAEEGPDAFYRGELAQQLVADLQANGGIITAEDLANYRVK-IREPLSADYGGYTVYSPPPSSGGIALLQILN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   292 ILKGYNFSrESVESPEqkglTYHRIVEAFRFAYAKRTL-LGDPKFVDVteVVRNMTSEFFAAQLRAQISDDTTHPISYYk 370
Cdd:pfam01019 240 ILEGFDLS-SLLNSAE----YLHLLIEAMKLAYADRTRyLGDPDFVPV--PVENLLSPEYAKERAKLINPNAAFPSSYA- 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   371 pefytPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSItNEFGVPPSPANFIQPGKQPL 450
Cdd:pfam01019 312 -----PEDGGTTHFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLNNEMDDFSTPPG-NAFGLDPSPANAIAPGKRPL 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   451 SSMCPTImVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQlLPNVTTVERNIDQAVTAALETR 530
Cdd:pfam01019 386 SSMAPTI-VLDDGKPVLVVGAPGGSRIISAVLQVIVNVLDLGLDLQQAVDAPRIHHQ-LPDVLEVEPGFPEEVLAELEAR 463
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 73915092   531 HHHTQIASTFIAVVQAIV--RTAGGWAAASDSRKGG 564
Cdd:pfam01019 464 GHKVKVVEDSSSVGAIQIvrRTGGVLYAASDPRRDG 499
 
Name Accession Description Interval E-value
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
55-564 0e+00

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 663.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092    55 RDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFNS---SEQSQKGGLS 131
Cdd:pfam01019   1 LDILRKGGNAVDAAVAAALCLGVVEPHSSGIGGGGFMLIYDAKTGKVLVIDARETAPAAATKDMFDGkgdSKLSLTGGLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   132 VAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRKVLREGERLTLP 211
Cdd:pfam01019  81 VGVPGEVAGLAEAHKRYGRLPWADLLEPAIKLARDGFPVSPALARALARAEERLRADPGLRKIFLPTGRVLKAGELLKQP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   212 QLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAElIEHPLNISLGDVVLYMPSAPLSGPVLALILN 291
Cdd:pfam01019 161 ALAKTLELIAEEGPDAFYRGELAQQLVADLQANGGIITAEDLANYRVK-IREPLSADYGGYTVYSPPPSSGGIALLQILN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   292 ILKGYNFSrESVESPEqkglTYHRIVEAFRFAYAKRTL-LGDPKFVDVteVVRNMTSEFFAAQLRAQISDDTTHPISYYk 370
Cdd:pfam01019 240 ILEGFDLS-SLLNSAE----YLHLLIEAMKLAYADRTRyLGDPDFVPV--PVENLLSPEYAKERAKLINPNAAFPSSYA- 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   371 pefytPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSItNEFGVPPSPANFIQPGKQPL 450
Cdd:pfam01019 312 -----PEDGGTTHFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLNNEMDDFSTPPG-NAFGLDPSPANAIAPGKRPL 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   451 SSMCPTImVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQlLPNVTTVERNIDQAVTAALETR 530
Cdd:pfam01019 386 SSMAPTI-VLDDGKPVLVVGAPGGSRIISAVLQVIVNVLDLGLDLQQAVDAPRIHHQ-LPDVLEVEPGFPEEVLAELEAR 463
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 73915092   531 HHHTQIASTFIAVVQAIV--RTAGGWAAASDSRKGG 564
Cdd:pfam01019 464 GHKVKVVEDSSSVGAIQIvrRTGGVLYAASDPRRDG 499
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
51-562 1.13e-169

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


Pssm-ID: 440174  Cd Length: 507  Bit Score: 490.72  E-value: 1.13e-169
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  51 SKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFNS--SEQSQKG 128
Cdd:COG0405  10 SQAGLEILRAGGNAVDAAVAAAAALAVVEPHSSGIGGGGFALIYDAKDGKVTALDGRGTAPAAATPDMYLDagDEIPVRG 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092 129 GLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRKVLREGERL 208
Cdd:COG0405  90 PLAVGVPGTVAGWEAAHERYGTLPLAELLAPAIRLAEDGFPVSPRLAALLAAAAERLARDPGAAAIFLPDGRPPKAGDIL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092 209 TLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEhPLNISLGDVVLY-MPsAPLSGPVLA 287
Cdd:COG0405 170 RQPDLAATLRRIAEEGADAFYRGEIAEAIVAAVQAAGGLLTLEDLAAYRAEWRE-PLSGTYRGYTVYsMP-PPSQGIALL 247
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092 288 LILNILKGYNFSRESVESPEqkglTYHRIVEAFRFAYAKR-TLLGDPKFVDVTevVRNMTSEFFAAQLRAQISDDTTHPi 366
Cdd:COG0405 248 QILNILEGFDLAALGPDSAE----YVHLLAEAMKLAFADRdRYLGDPDFVDVP--VEGLLSPAYAAERAALIDPDRATP- 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092 367 SYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSpsitnefgvPPSPANFIQPG 446
Cdd:COG0405 321 SPRPGDPTGPESGDTTHLSVVDRDGNAVSLTQSIYGGFGSGVVVPGTGFLLNNRGDDFSL---------DPGHPNALAPG 391
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092 447 KQPLSSMCPTiMVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAA 526
Cdd:COG0405 392 KRPRSTMSPT-IVLKDGKPVLVFGSPGGSRIPQTVLQVLLNVLDFGMNPQEAVDAPRWHHQGLPDTLELEPRFPPAVIAA 470
                       490       500       510
                ....*....|....*....|....*....|....*..
gi 73915092 527 LETRHHHTQIASTFIAVVQAIVRTAGG-WAAASDSRK 562
Cdd:COG0405 471 LRARGHKVEVVPDWSGGAQAILRDPDGvLEGAADPRR 507
PLN02198 PLN02198
glutathione gamma-glutamylcysteinyltransferase
28-569 3.34e-137

glutathione gamma-glutamylcysteinyltransferase


Pssm-ID: 177849  Cd Length: 573  Bit Score: 410.62  E-value: 3.34e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   28 SASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIyNSTTRKAEVINAR 107
Cdd:PLN02198  21 AAQKRQQSIVASHGAVATDDGRCSVIGMNVLREGGNAIDASVAAALCLGVVSPASSGIGGGAFTLI-KLANGEEIAYDSR 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  108 EVAPRLAFATMF-NSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIE 186
Cdd:PLN02198 100 ETAPLSATENMYgGNVELKKKGALSVGVPGEVAGLFTAWKQHGKLPWKRLVRPAEKLAAEGFKISKYLYMQMNATRSDIL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  187 QQPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLN 266
Cdd:PLN02198 180 ADKGLSDLFVSNGELKKPGTICHNPKLALTLRLIGEYGPKAFYNGTVGVNLVRDIQKSGGIITLKDLQSYRVKVKEPLSA 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  267 ISLGDVVLYMPSAPLSGPVLALILNILKGYNFSrESVESPeqkgLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMT 346
Cdd:PLN02198 260 DILGYRVLGMPPPSSGGAAMMLILNILAQYGIP-SGVSGP----LGVHRLIEALKHAFAVRMNLGDPDFVDVTKVVSDML 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  347 SEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSS 426
Cdd:PLN02198 335 SPKFAQDLKSKINDNKTFDPKHYGGRWNQIDDHGTSHLSIIDSERNAVSMTSTINGYFGALMLSPSTGIVLNNEMDDFSI 414
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  427 PsiTNEFGV----PPSPANFIQPGKQPLSSMCPTIMVgQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEP 502
Cdd:PLN02198 415 P--MKSGGNldvpPPAPANFIRPGKRPLSSMTPTIVL-KDGKVKAAVGASGGANIIAGTTEVYLNHFFLKMDPLSSVLAP 491
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  503 RLHNQLLPNVTTVER---------NIDQAVTAALETRHHHTQ-IASTFIA--VVQAIVRTAGGWA---AASDSRKGGEPA 567
Cdd:PLN02198 492 RIYHQLIPNRASYENwttvyndhfEIPKATRVVLEKKGHVLSpIAGGTIAqfIVQESGENSGGRSelvAVSDPRKGGFPS 571

                 ..
gi 73915092  568 GY 569
Cdd:PLN02198 572 GY 573
g_glut_trans TIGR00066
gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of ...
43-561 4.22e-127

gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of this family have antibiotic synthesis or resistance activities. In the case of a cephalosporin acylase from Pseudomonas sp., the enzyme was shown to retain some gamma-glutamyltranspeptidase activity. Other, more distantly related proteins have ggt-related activities and score below the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 129176  Cd Length: 516  Bit Score: 382.58  E-value: 4.22e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092    43 VAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFNS- 121
Cdd:TIGR00066   3 VASLHALASEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGLGGGGFMLISGKKTKDTTAIDFRERAPAKATRDMFLDk 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   122 -----SEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLC-EVF 195
Cdd:TIGR00066  83 sgnplPGKSLTGGLAIGVPGTVAGLEAALKKYGTLPLKDLIEPAIKLARNGFPINEALADTLELYEEVLLTTKEDSkDIF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   196 CRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAElIEHPLNISL-GDVVL 274
Cdd:TIGR00066 163 NPTGKPLKEGDTLVQKDLAKSLELIAENGPDAFYKGDIAESIIDTLQKNGGIMTKKDLAAYDVE-IRKPLSGDYrGYQVY 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   275 YMPSAPLSGPVLALILNILKGYNFSRESVESPEQkgltYHRIVEAFRFAYAKRT-LLGDPKFVDVTevVRNMTSEFFAAQ 353
Cdd:TIGR00066 242 TTPPPSSGGIHLLQALNILENFDLSQYGDGSAET----YQLLAEAMKLSYADRSrYLGDPEFVDVP--LEELLDKRYAKE 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   354 LRAQISDDTTHPISYYKPEFYTPDDG-GTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSspsitne 432
Cdd:TIGR00066 316 LAQSIKINKVDPKSTIYPGAYQPNEGsQTTHFSVVDRDGNAVSLTTTINLEFGSGVHAPDTGILLNNEMDDFS------- 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   433 fgVPPSPANFIQPGKQPLSSMCPTIMVgQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNV 512
Cdd:TIGR00066 389 --LKPGGANAVEPNKRPLSSMAPTIVL-KDGKPDLVVGSPGGSRIITTVLQTIVRHIDYGMPLAEAVSEPRIHHQWLPDE 465
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 73915092   513 TTVERNIDQAVTAALETR-HHHTQIASTFIAVVQAIVRTAGGWA-AASDSR 561
Cdd:TIGR00066 466 LRLEKGFPDDVLQLLKDMgHKVTLKEVFPMGVVQAIRVDPEGWLyGVSDPR 516
 
Name Accession Description Interval E-value
G_glu_transpept pfam01019
Gamma-glutamyltranspeptidase;
55-564 0e+00

Gamma-glutamyltranspeptidase;


Pssm-ID: 425991  Cd Length: 499  Bit Score: 663.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092    55 RDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFNS---SEQSQKGGLS 131
Cdd:pfam01019   1 LDILRKGGNAVDAAVAAALCLGVVEPHSSGIGGGGFMLIYDAKTGKVLVIDARETAPAAATKDMFDGkgdSKLSLTGGLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   132 VAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRKVLREGERLTLP 211
Cdd:pfam01019  81 VGVPGEVAGLAEAHKRYGRLPWADLLEPAIKLARDGFPVSPALARALARAEERLRADPGLRKIFLPTGRVLKAGELLKQP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   212 QLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAElIEHPLNISLGDVVLYMPSAPLSGPVLALILN 291
Cdd:pfam01019 161 ALAKTLELIAEEGPDAFYRGELAQQLVADLQANGGIITAEDLANYRVK-IREPLSADYGGYTVYSPPPSSGGIALLQILN 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   292 ILKGYNFSrESVESPEqkglTYHRIVEAFRFAYAKRTL-LGDPKFVDVteVVRNMTSEFFAAQLRAQISDDTTHPISYYk 370
Cdd:pfam01019 240 ILEGFDLS-SLLNSAE----YLHLLIEAMKLAYADRTRyLGDPDFVPV--PVENLLSPEYAKERAKLINPNAAFPSSYA- 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   371 pefytPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSItNEFGVPPSPANFIQPGKQPL 450
Cdd:pfam01019 312 -----PEDGGTTHFSVVDRDGNAVSFTSTINLGFGSGVVVPGTGILLNNEMDDFSTPPG-NAFGLDPSPANAIAPGKRPL 385
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   451 SSMCPTImVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQlLPNVTTVERNIDQAVTAALETR 530
Cdd:pfam01019 386 SSMAPTI-VLDDGKPVLVVGAPGGSRIISAVLQVIVNVLDLGLDLQQAVDAPRIHHQ-LPDVLEVEPGFPEEVLAELEAR 463
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 73915092   531 HHHTQIASTFIAVVQAIV--RTAGGWAAASDSRKGG 564
Cdd:pfam01019 464 GHKVKVVEDSSSVGAIQIvrRTGGVLYAASDPRRDG 499
Ggt COG0405
Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];
51-562 1.13e-169

Gamma-glutamyltranspeptidase [Amino acid transport and metabolism];


Pssm-ID: 440174  Cd Length: 507  Bit Score: 490.72  E-value: 1.13e-169
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  51 SKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFNS--SEQSQKG 128
Cdd:COG0405  10 SQAGLEILRAGGNAVDAAVAAAAALAVVEPHSSGIGGGGFALIYDAKDGKVTALDGRGTAPAAATPDMYLDagDEIPVRG 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092 129 GLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRKVLREGERL 208
Cdd:COG0405  90 PLAVGVPGTVAGWEAAHERYGTLPLAELLAPAIRLAEDGFPVSPRLAALLAAAAERLARDPGAAAIFLPDGRPPKAGDIL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092 209 TLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEhPLNISLGDVVLY-MPsAPLSGPVLA 287
Cdd:COG0405 170 RQPDLAATLRRIAEEGADAFYRGEIAEAIVAAVQAAGGLLTLEDLAAYRAEWRE-PLSGTYRGYTVYsMP-PPSQGIALL 247
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092 288 LILNILKGYNFSRESVESPEqkglTYHRIVEAFRFAYAKR-TLLGDPKFVDVTevVRNMTSEFFAAQLRAQISDDTTHPi 366
Cdd:COG0405 248 QILNILEGFDLAALGPDSAE----YVHLLAEAMKLAFADRdRYLGDPDFVDVP--VEGLLSPAYAAERAALIDPDRATP- 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092 367 SYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSpsitnefgvPPSPANFIQPG 446
Cdd:COG0405 321 SPRPGDPTGPESGDTTHLSVVDRDGNAVSLTQSIYGGFGSGVVVPGTGFLLNNRGDDFSL---------DPGHPNALAPG 391
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092 447 KQPLSSMCPTiMVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAA 526
Cdd:COG0405 392 KRPRSTMSPT-IVLKDGKPVLVFGSPGGSRIPQTVLQVLLNVLDFGMNPQEAVDAPRWHHQGLPDTLELEPRFPPAVIAA 470
                       490       500       510
                ....*....|....*....|....*....|....*..
gi 73915092 527 LETRHHHTQIASTFIAVVQAIVRTAGG-WAAASDSRK 562
Cdd:COG0405 471 LRARGHKVEVVPDWSGGAQAILRDPDGvLEGAADPRR 507
PLN02198 PLN02198
glutathione gamma-glutamylcysteinyltransferase
28-569 3.34e-137

glutathione gamma-glutamylcysteinyltransferase


Pssm-ID: 177849  Cd Length: 573  Bit Score: 410.62  E-value: 3.34e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   28 SASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIyNSTTRKAEVINAR 107
Cdd:PLN02198  21 AAQKRQQSIVASHGAVATDDGRCSVIGMNVLREGGNAIDASVAAALCLGVVSPASSGIGGGAFTLI-KLANGEEIAYDSR 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  108 EVAPRLAFATMF-NSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIE 186
Cdd:PLN02198 100 ETAPLSATENMYgGNVELKKKGALSVGVPGEVAGLFTAWKQHGKLPWKRLVRPAEKLAAEGFKISKYLYMQMNATRSDIL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  187 QQPVLCEVFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLN 266
Cdd:PLN02198 180 ADKGLSDLFVSNGELKKPGTICHNPKLALTLRLIGEYGPKAFYNGTVGVNLVRDIQKSGGIITLKDLQSYRVKVKEPLSA 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  267 ISLGDVVLYMPSAPLSGPVLALILNILKGYNFSrESVESPeqkgLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMT 346
Cdd:PLN02198 260 DILGYRVLGMPPPSSGGAAMMLILNILAQYGIP-SGVSGP----LGVHRLIEALKHAFAVRMNLGDPDFVDVTKVVSDML 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  347 SEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSS 426
Cdd:PLN02198 335 SPKFAQDLKSKINDNKTFDPKHYGGRWNQIDDHGTSHLSIIDSERNAVSMTSTINGYFGALMLSPSTGIVLNNEMDDFSI 414
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  427 PsiTNEFGV----PPSPANFIQPGKQPLSSMCPTIMVgQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEP 502
Cdd:PLN02198 415 P--MKSGGNldvpPPAPANFIRPGKRPLSSMTPTIVL-KDGKVKAAVGASGGANIIAGTTEVYLNHFFLKMDPLSSVLAP 491
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  503 RLHNQLLPNVTTVER---------NIDQAVTAALETRHHHTQ-IASTFIA--VVQAIVRTAGGWA---AASDSRKGGEPA 567
Cdd:PLN02198 492 RIYHQLIPNRASYENwttvyndhfEIPKATRVVLEKKGHVLSpIAGGTIAqfIVQESGENSGGRSelvAVSDPRKGGFPS 571

                 ..
gi 73915092  568 GY 569
Cdd:PLN02198 572 GY 573
g_glut_trans TIGR00066
gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of ...
43-561 4.22e-127

gamma-glutamyltranspeptidase; Also called gamma-glutamyltranspeptidase (ggt). Some members of this family have antibiotic synthesis or resistance activities. In the case of a cephalosporin acylase from Pseudomonas sp., the enzyme was shown to retain some gamma-glutamyltranspeptidase activity. Other, more distantly related proteins have ggt-related activities and score below the trusted cutoff. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 129176  Cd Length: 516  Bit Score: 382.58  E-value: 4.22e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092    43 VAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMFNS- 121
Cdd:TIGR00066   3 VASLHALASEIGEDILKEGGNAFDAAVAVGLALAVVEPFMTGLGGGGFMLISGKKTKDTTAIDFRERAPAKATRDMFLDk 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   122 -----SEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLC-EVF 195
Cdd:TIGR00066  83 sgnplPGKSLTGGLAIGVPGTVAGLEAALKKYGTLPLKDLIEPAIKLARNGFPINEALADTLELYEEVLLTTKEDSkDIF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   196 CRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAElIEHPLNISL-GDVVL 274
Cdd:TIGR00066 163 NPTGKPLKEGDTLVQKDLAKSLELIAENGPDAFYKGDIAESIIDTLQKNGGIMTKKDLAAYDVE-IRKPLSGDYrGYQVY 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   275 YMPSAPLSGPVLALILNILKGYNFSRESVESPEQkgltYHRIVEAFRFAYAKRT-LLGDPKFVDVTevVRNMTSEFFAAQ 353
Cdd:TIGR00066 242 TTPPPSSGGIHLLQALNILENFDLSQYGDGSAET----YQLLAEAMKLSYADRSrYLGDPEFVDVP--LEELLDKRYAKE 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   354 LRAQISDDTTHPISYYKPEFYTPDDG-GTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSspsitne 432
Cdd:TIGR00066 316 LAQSIKINKVDPKSTIYPGAYQPNEGsQTTHFSVVDRDGNAVSLTTTINLEFGSGVHAPDTGILLNNEMDDFS------- 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   433 fgVPPSPANFIQPGKQPLSSMCPTIMVgQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNV 512
Cdd:TIGR00066 389 --LKPGGANAVEPNKRPLSSMAPTIVL-KDGKPDLVVGSPGGSRIITTVLQTIVRHIDYGMPLAEAVSEPRIHHQWLPDE 465
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 73915092   513 TTVERNIDQAVTAALETR-HHHTQIASTFIAVVQAIVRTAGGWA-AASDSR 561
Cdd:TIGR00066 466 LRLEKGFPDDVLQLLKDMgHKVTLKEVFPMGVVQAIRVDPEGWLyGVSDPR 516
PLN02180 PLN02180
gamma-glutamyl transpeptidase 4
43-568 1.15e-112

gamma-glutamyl transpeptidase 4


Pssm-ID: 177836  Cd Length: 639  Bit Score: 349.36  E-value: 1.15e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   43 VAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRKAEVINAREVAPRLAFATMF-NS 121
Cdd:PLN02180  85 VAADDARCSEIGASVLRRGGHAVDAAVAITLCIGVVNPMSSGIGGGSFLIVSSQKDSKAEAFDMRETAPLAASKDMYkND 164
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  122 SEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRKV 201
Cdd:PLN02180 165 ASAKSLGALSMGVPGEIAGLYEAWKRYGRLPWKPLFEPAIELARDGFVVHPYLGKAISSHAAMILKDPGLRSVFSRNGQV 244
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  202 LREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPsaPL 281
Cdd:PLN02180 245 LKPGETCYNPELAQSLETISEQGPGAFYNGTIGEKLVKDVKKAGGIITMDDLRSYEVLVTDAMSVDVMGYTIHGMP--PP 322
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  282 SGPVL--ALILNILKGYNfsreSVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQIS 359
Cdd:PLN02180 323 SGGTLgfSMVIDILDSYS----NLYTASGRELGLHRLIEAMKHMFAARMDLGDPEFVNITNAMNQMLSKAHAEEIQKRIF 398
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  360 DDTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSP 439
Cdd:PLN02180 399 DNTTFPPEYYLNRWSQLRDQGTSHFCIVDADRNSVSMTSTVNYGFGAGVLSPSTGIVLNNEMDDFSTPAEITPDMLPPAP 478
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  440 ANFIQPGKQPLSSMCPtIMVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVER-- 517
Cdd:PLN02180 479 TNFIEPNKRPLSSMTP-LVITKDGEFVAALGGAGGMHIIPAVLQVFLNCFVLNMKPKEAVESARIYHRLIPNVVSYENft 557
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  518 -------NIDQAVTAALETRHHHTQIASTFiAVVQAIVRT------------------------AGGWAAASDSRKGGEP 566
Cdd:PLN02180 558 aingdhiGVSEDTKMFLAERGHELKALSGG-AIVQLIVQSfkeekeeemiieigrkigkkskplKGLLTAVCDPRKDGKP 636

                 ..
gi 73915092  567 AG 568
Cdd:PLN02180 637 AA 638
ggt PRK09615
gamma-glutamyltranspeptidase; Reviewed
41-569 5.81e-91

gamma-glutamyltranspeptidase; Reviewed


Pssm-ID: 181992  Cd Length: 581  Bit Score: 291.04  E-value: 5.81e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092   41 AAVAADAKQcskIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIyNSTTRKAEVINAREVAPRLAFATMF- 119
Cdd:PRK09615  53 ASVDATATQ---VGVDILKQGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLL-RTKNGNTTAIDFREMAPAKATRDMFl 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  120 -----NSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALEN-KRTVIEQQPVLCE 193
Cdd:PRK09615 129 ddqgnPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTyGSEVLPNHENSKA 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  194 VFCRDRKVLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAelIEH-PLNISL-GD 271
Cdd:PRK09615 209 IFWKEGEPLKKGDKLVQANLAKSLEMIAENGPDAFYKGTIADQIAQEMQKNGGLITKEDLAAYKA--VERtPISGDYrGY 286
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  272 VVLYMPSAPLSGPVLALILNILKGYNFSRESVESPEQKGLtyhrIVEAFRFAYAKRT-LLGDPKFVDVTevVRNMTSEFF 350
Cdd:PRK09615 287 QVYSMPPPSSGGIHIVQILNILENFDMKKYGFGSADAMQI----MAEAEKYAYADRSeYLGDPDFVKVP--WQALTNKAY 360
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  351 AAQLRAQISDDTTHPISYYKPEFYTP-DDGGTAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSS-PS 428
Cdd:PRK09615 361 AKSIADQIDINKAKPSSEIRPGKLAPyESNQTTHFSVVDKDGNAVAVTYTLNTTFGTGIVAGNSGILLNNQMDDFSAkPG 440
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73915092  429 ITNEFGVPPSPANFIQPGKQPLSSMCPTIMVgQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVEEPRLHNQL 508
Cdd:PRK09615 441 VPNVYGLVGGDANAVGPNKRPLSSMSPTIVV-KDGKTWLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQW 519
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 73915092  509 LPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGE-PAGY 569
Cdd:PRK09615 520 LPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDlTAGY 581
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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