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Conserved domains on  [gi|32483367|ref|NP_036513|]
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origin recognition complex subunit 3 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ORC3_N pfam07034
Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus ...
18-344 0e+00

Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication. This domain is predicted to contain an AAA+ fold but lack the residues important for ATP hydrolysis, thus, it is called AAA+ like.


:

Pssm-ID: 462070  Cd Length: 330  Bit Score: 529.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367    18 KKRKISLPIEDYFNKGKNEPEDSKLRFETYQLIWQQMKSENERLQEELNKNLFDNLIEFLQKSHSgfQKNSRDLGGQIKL 97
Cdd:pfam07034   1 KKKKKRVSAEDYFSSLLGDEETSQLRFKTYQRLWEQIKSHIERLQSELNKNLLDSLVEFVRKCHA--TAKSDDWGSQMRS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367    98 REIPTAALVLGVNVTDHDLTFGSLTEALQNNVTPYVVSLQAKDCPDMKHFLQKLISQLMDCCVDIKSKEE----ESVHVT 173
Cdd:pfam07034  79 SEIPTAALLLGVNVPDHDLTFSSLTELLQSSVTPHVVSLQSRDCKALKHALQKVLSQLMGCEVDVDSDEEeeeeESDTKS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   174 QRKTHYSMDSLSSWYMTVTQKTDPKMLSKKRTTSS-QWQSPPVVVILKDMESFATKVLQDFIIISSQHLHEFPLILIFGI 252
Cdd:pfam07034 159 LRKSQCSMRALCSWYAEVTRKTSPRSRPKKRASSArKIQSPPVVVIFKDLESFSAKVLQDFILILSSYLSELPLVFVFGV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   253 ATSPIIIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFPFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSL 332
Cdd:pfam07034 239 ATSPSAVHRMLPHSVSSLLCIELFQSLSCTSHLAEVLDKVLLTPQFPFKLSGKVLQVLTHIFLYHDFSVQNFIKGLQLAL 318
                         330
                  ....*....|..
gi 32483367   333 LEHFYSQPLSVL 344
Cdd:pfam07034 319 LEHFYSQPLSVL 330
ORC3_ins pfam19675
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ...
355-585 2.55e-145

Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ORC subunit 3 (ORC3) located between the N-terminal AAA+-like subunit and the C-terminal winged- helix (WH) DNA-binding domain. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This domain insertion forms a bi-lobed alpha-helical protuberance that engages a short alpha-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits, which constitute the ORC core.


:

Pssm-ID: 466140  Cd Length: 233  Bit Score: 423.42  E-value: 2.55e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   355 INFLSNNQCENIRRLPSFRRYVEKQASEKQVALLTNERYLKEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKYPLGRQ 434
Cdd:pfam19675   1 INSLSHDQCENIRRLPSFRRYVEKQASEKQIALLTNDRYLKEETQKLLEDLHIYHENYFPVLRCLHVFTSSLPKYPLGKQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   435 IRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLD--ETKEEED 512
Cdd:pfam19675  81 IRELYCTCLEKNIWETEEYASALQLLRMLAKDELVTLLQKCVEILKSSKGKDLGSTAKKLEEFLAQFQKLDgcENNEEEV 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32483367   513 ASGSQPKGLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAH 585
Cdd:pfam19675 161 TSGSQKKLQQKTDLYHLQKTLLEMKESRRSKKLTKFEVLREKVVDFIDSLVRKYLLPPETQPLHEVVYFSAAH 233
ORC_WH_C pfam18137
Origin recognition complex winged helix C-terminal; This is the C-terminal winged-helix (WH) ...
596-708 9.52e-40

Origin recognition complex winged helix C-terminal; This is the C-terminal winged-helix (WH) DNA-binding domain of the origin recognition complex present in Drosophila melanogaster. The WH domain is responsible for recognizing origin sequences.


:

Pssm-ID: 436299  Cd Length: 131  Bit Score: 142.44  E-value: 9.52e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   596 RIALHTALNNPYYYLKNEALK-SEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKM------------ 662
Cdd:pfam18137   1 RSTIESALLNPEDYLRCECCDdSEEELSLASLPDTSILFKLYLEAGRLINLYDWYQAFKEVLEKEEELvrlreaakegkd 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 32483367   663 -----DANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTW 708
Cdd:pfam18137  81 kdaekDADEEDDEEWEKELQARFLRALAELQYLGFIKHTKRKTDHVEKTIW 131
 
Name Accession Description Interval E-value
ORC3_N pfam07034
Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus ...
18-344 0e+00

Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication. This domain is predicted to contain an AAA+ fold but lack the residues important for ATP hydrolysis, thus, it is called AAA+ like.


Pssm-ID: 462070  Cd Length: 330  Bit Score: 529.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367    18 KKRKISLPIEDYFNKGKNEPEDSKLRFETYQLIWQQMKSENERLQEELNKNLFDNLIEFLQKSHSgfQKNSRDLGGQIKL 97
Cdd:pfam07034   1 KKKKKRVSAEDYFSSLLGDEETSQLRFKTYQRLWEQIKSHIERLQSELNKNLLDSLVEFVRKCHA--TAKSDDWGSQMRS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367    98 REIPTAALVLGVNVTDHDLTFGSLTEALQNNVTPYVVSLQAKDCPDMKHFLQKLISQLMDCCVDIKSKEE----ESVHVT 173
Cdd:pfam07034  79 SEIPTAALLLGVNVPDHDLTFSSLTELLQSSVTPHVVSLQSRDCKALKHALQKVLSQLMGCEVDVDSDEEeeeeESDTKS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   174 QRKTHYSMDSLSSWYMTVTQKTDPKMLSKKRTTSS-QWQSPPVVVILKDMESFATKVLQDFIIISSQHLHEFPLILIFGI 252
Cdd:pfam07034 159 LRKSQCSMRALCSWYAEVTRKTSPRSRPKKRASSArKIQSPPVVVIFKDLESFSAKVLQDFILILSSYLSELPLVFVFGV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   253 ATSPIIIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFPFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSL 332
Cdd:pfam07034 239 ATSPSAVHRMLPHSVSSLLCIELFQSLSCTSHLAEVLDKVLLTPQFPFKLSGKVLQVLTHIFLYHDFSVQNFIKGLQLAL 318
                         330
                  ....*....|..
gi 32483367   333 LEHFYSQPLSVL 344
Cdd:pfam07034 319 LEHFYSQPLSVL 330
ORC3_ins pfam19675
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ...
355-585 2.55e-145

Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ORC subunit 3 (ORC3) located between the N-terminal AAA+-like subunit and the C-terminal winged- helix (WH) DNA-binding domain. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This domain insertion forms a bi-lobed alpha-helical protuberance that engages a short alpha-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits, which constitute the ORC core.


Pssm-ID: 466140  Cd Length: 233  Bit Score: 423.42  E-value: 2.55e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   355 INFLSNNQCENIRRLPSFRRYVEKQASEKQVALLTNERYLKEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKYPLGRQ 434
Cdd:pfam19675   1 INSLSHDQCENIRRLPSFRRYVEKQASEKQIALLTNDRYLKEETQKLLEDLHIYHENYFPVLRCLHVFTSSLPKYPLGKQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   435 IRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLD--ETKEEED 512
Cdd:pfam19675  81 IRELYCTCLEKNIWETEEYASALQLLRMLAKDELVTLLQKCVEILKSSKGKDLGSTAKKLEEFLAQFQKLDgcENNEEEV 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32483367   513 ASGSQPKGLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAH 585
Cdd:pfam19675 161 TSGSQKKLQQKTDLYHLQKTLLEMKESRRSKKLTKFEVLREKVVDFIDSLVRKYLLPPETQPLHEVVYFSAAH 233
Orc3 cd20704
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit ...
42-344 4.63e-91

Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit of the heterohexameric origin recognition complex (ORC) that is essential for coordinating replication onset. ORC binds to the origin of replication, binds CDC6, and recruits the hexameric MCM2-7 ring to the DNA, which leads to the assembly of the pre-replicative complex (pre-RC). Five of the 6 ORC subunits (Orc 1-5) retain AAA+ (ATPases associated with a variety of cellular activities) folds, but Orc3, as well as Orc2, lost their ATP-binding signatures.


Pssm-ID: 412052 [Multi-domain]  Cd Length: 387  Bit Score: 289.08  E-value: 4.63e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367  42 LRFETYQLIWQQMKSENERLQEELNKNLFDNLIEFLQKSHSGFQKNSRDlggqiklREIPTAALVLGVNVTDHDLTFGSL 121
Cdd:cd20704   1 LRYEAYEKAWSKCESRIQEILEELNAKVLDDLVEFVRNAYSDFLPGLPY-------GEIPTALLLTGVNISDHDLLFSQL 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367 122 TEALQNNVTPYVVSLQAKDCPDMKHFLQKLISQLMDCcvdikskeeesvhvtqrkthysmdslsswymtvtqktdpkmls 201
Cdd:cd20704  74 LERLLQSVTPHVVRLTSKDCPNLKSALKSLISQFIGQ------------------------------------------- 110
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367 202 kkrttssqwqspPVVVILKDMESFATKVLQDFIIISSQHLHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSC 281
Cdd:cd20704 111 ------------PLVVILEDFESFDPSVLQDLILILSSYLDRLPFVLIFGIATSVEAFHKRLPRSTLSLLRIEKFQLPSS 178
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32483367 282 KEHLTTVLDKLLLTTQFPFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVL 344
Cdd:cd20704 179 SDYLERVLEKVLLDPDPPLKLGPKVLEFLLDRFLRHDFSVDSFISALKYAYMEHFYANPLSIL 241
ORC_WH_C pfam18137
Origin recognition complex winged helix C-terminal; This is the C-terminal winged-helix (WH) ...
596-708 9.52e-40

Origin recognition complex winged helix C-terminal; This is the C-terminal winged-helix (WH) DNA-binding domain of the origin recognition complex present in Drosophila melanogaster. The WH domain is responsible for recognizing origin sequences.


Pssm-ID: 436299  Cd Length: 131  Bit Score: 142.44  E-value: 9.52e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   596 RIALHTALNNPYYYLKNEALK-SEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKM------------ 662
Cdd:pfam18137   1 RSTIESALLNPEDYLRCECCDdSEEELSLASLPDTSILFKLYLEAGRLINLYDWYQAFKEVLEKEEELvrlreaakegkd 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 32483367   663 -----DANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTW 708
Cdd:pfam18137  81 kdaekDADEEDDEEWEKELQARFLRALAELQYLGFIKHTKRKTDHVEKTIW 131
 
Name Accession Description Interval E-value
ORC3_N pfam07034
Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus ...
18-344 0e+00

Origin recognition complex (ORC) subunit 3 N-terminus; This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication. This domain is predicted to contain an AAA+ fold but lack the residues important for ATP hydrolysis, thus, it is called AAA+ like.


Pssm-ID: 462070  Cd Length: 330  Bit Score: 529.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367    18 KKRKISLPIEDYFNKGKNEPEDSKLRFETYQLIWQQMKSENERLQEELNKNLFDNLIEFLQKSHSgfQKNSRDLGGQIKL 97
Cdd:pfam07034   1 KKKKKRVSAEDYFSSLLGDEETSQLRFKTYQRLWEQIKSHIERLQSELNKNLLDSLVEFVRKCHA--TAKSDDWGSQMRS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367    98 REIPTAALVLGVNVTDHDLTFGSLTEALQNNVTPYVVSLQAKDCPDMKHFLQKLISQLMDCCVDIKSKEE----ESVHVT 173
Cdd:pfam07034  79 SEIPTAALLLGVNVPDHDLTFSSLTELLQSSVTPHVVSLQSRDCKALKHALQKVLSQLMGCEVDVDSDEEeeeeESDTKS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   174 QRKTHYSMDSLSSWYMTVTQKTDPKMLSKKRTTSS-QWQSPPVVVILKDMESFATKVLQDFIIISSQHLHEFPLILIFGI 252
Cdd:pfam07034 159 LRKSQCSMRALCSWYAEVTRKTSPRSRPKKRASSArKIQSPPVVVIFKDLESFSAKVLQDFILILSSYLSELPLVFVFGV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   253 ATSPIIIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFPFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSL 332
Cdd:pfam07034 239 ATSPSAVHRMLPHSVSSLLCIELFQSLSCTSHLAEVLDKVLLTPQFPFKLSGKVLQVLTHIFLYHDFSVQNFIKGLQLAL 318
                         330
                  ....*....|..
gi 32483367   333 LEHFYSQPLSVL 344
Cdd:pfam07034 319 LEHFYSQPLSVL 330
ORC3_ins pfam19675
Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ...
355-585 2.55e-145

Origin recognition complex subunit 3 insertion domain; This is the large domain insertion of ORC subunit 3 (ORC3) located between the N-terminal AAA+-like subunit and the C-terminal winged- helix (WH) DNA-binding domain. ORC3 is a component of the origin recognition complex (ORC) that binds origins of replication, required to assemble the pre-replication complex necessary to initiate DNA replication. This domain insertion forms a bi-lobed alpha-helical protuberance that engages a short alpha-helix formed at the ORC6 C-terminal, allowing its binding to ORC1-5 subunits, which constitute the ORC core.


Pssm-ID: 466140  Cd Length: 233  Bit Score: 423.42  E-value: 2.55e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   355 INFLSNNQCENIRRLPSFRRYVEKQASEKQVALLTNERYLKEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKYPLGRQ 434
Cdd:pfam19675   1 INSLSHDQCENIRRLPSFRRYVEKQASEKQIALLTNDRYLKEETQKLLEDLHIYHENYFPVLRCLHVFTSSLPKYPLGKQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   435 IRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLD--ETKEEED 512
Cdd:pfam19675  81 IRELYCTCLEKNIWETEEYASALQLLRMLAKDELVTLLQKCVEILKSSKGKDLGSTAKKLEEFLAQFQKLDgcENNEEEV 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32483367   513 ASGSQPKGLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAH 585
Cdd:pfam19675 161 TSGSQKKLQQKTDLYHLQKTLLEMKESRRSKKLTKFEVLREKVVDFIDSLVRKYLLPPETQPLHEVVYFSAAH 233
Orc3 cd20704
Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit ...
42-344 4.63e-91

Origin recognition complex subunit 3; Origin recognition complex subunit 3 (Orc3) is a subunit of the heterohexameric origin recognition complex (ORC) that is essential for coordinating replication onset. ORC binds to the origin of replication, binds CDC6, and recruits the hexameric MCM2-7 ring to the DNA, which leads to the assembly of the pre-replicative complex (pre-RC). Five of the 6 ORC subunits (Orc 1-5) retain AAA+ (ATPases associated with a variety of cellular activities) folds, but Orc3, as well as Orc2, lost their ATP-binding signatures.


Pssm-ID: 412052 [Multi-domain]  Cd Length: 387  Bit Score: 289.08  E-value: 4.63e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367  42 LRFETYQLIWQQMKSENERLQEELNKNLFDNLIEFLQKSHSGFQKNSRDlggqiklREIPTAALVLGVNVTDHDLTFGSL 121
Cdd:cd20704   1 LRYEAYEKAWSKCESRIQEILEELNAKVLDDLVEFVRNAYSDFLPGLPY-------GEIPTALLLTGVNISDHDLLFSQL 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367 122 TEALQNNVTPYVVSLQAKDCPDMKHFLQKLISQLMDCcvdikskeeesvhvtqrkthysmdslsswymtvtqktdpkmls 201
Cdd:cd20704  74 LERLLQSVTPHVVRLTSKDCPNLKSALKSLISQFIGQ------------------------------------------- 110
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367 202 kkrttssqwqspPVVVILKDMESFATKVLQDFIIISSQHLHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSC 281
Cdd:cd20704 111 ------------PLVVILEDFESFDPSVLQDLILILSSYLDRLPFVLIFGIATSVEAFHKRLPRSTLSLLRIEKFQLPSS 178
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 32483367 282 KEHLTTVLDKLLLTTQFPFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVL 344
Cdd:cd20704 179 SDYLERVLEKVLLDPDPPLKLGPKVLEFLLDRFLRHDFSVDSFISALKYAYMEHFYANPLSIL 241
ORC_WH_C pfam18137
Origin recognition complex winged helix C-terminal; This is the C-terminal winged-helix (WH) ...
596-708 9.52e-40

Origin recognition complex winged helix C-terminal; This is the C-terminal winged-helix (WH) DNA-binding domain of the origin recognition complex present in Drosophila melanogaster. The WH domain is responsible for recognizing origin sequences.


Pssm-ID: 436299  Cd Length: 131  Bit Score: 142.44  E-value: 9.52e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32483367   596 RIALHTALNNPYYYLKNEALK-SEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKM------------ 662
Cdd:pfam18137   1 RSTIESALLNPEDYLRCECCDdSEEELSLASLPDTSILFKLYLEAGRLINLYDWYQAFKEVLEKEEELvrlreaakegkd 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 32483367   663 -----DANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTW 708
Cdd:pfam18137  81 kdaekDADEEDDEEWEKELQARFLRALAELQYLGFIKHTKRKTDHVEKTIW 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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