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Conserved domains on  [gi|6754934|ref|NP_036180|]
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osteomodulin precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-320 1.89e-29

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.50  E-value: 1.89e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   96 LNLQFNDIEAVTANSFINATHLKEINLSHNKIksqkidygvFAKLSNLQQLHLEHNNLEEFPFPLP--KSLERLLLGYNE 173
Cdd:COG4886  77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE---------LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQ 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  174 ISILPTnAMDGLVNVTMLDLCYNHLSDsmLKEkTLSKMEKLMQLNLCNNRLESMP--LGLPSSLMYLSLENNSISSIPDN 251
Cdd:COG4886 148 LTDLPE-PLGNLTNLKSLDLSNNQLTD--LPE-ELGNLTNLKELDLSNNQITDLPepLGNLTNLEELDLSGNQLTDLPEP 223

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754934  252 yFDKLPKLHALRISHNKLEDIPyDIFNLSNLIELNVGHNKLKQafyIP-----RNLEHLYLQNNEIESINVTMI 320
Cdd:COG4886 224 -LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTD---LPplanlTNLKTLDLSNNQLTDLKLKEL 292
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-94 5.23e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 5.23e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 6754934      61 GCAKECFCPtnfPTSMYCDNRKLKTIPI-IPMHIQ 94
Cdd:smart00013   1 ACPAPCNCS---GTAVDCSGRGLTEVPLdLPPDTT 32
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-320 1.89e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.50  E-value: 1.89e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   96 LNLQFNDIEAVTANSFINATHLKEINLSHNKIksqkidygvFAKLSNLQQLHLEHNNLEEFPFPLP--KSLERLLLGYNE 173
Cdd:COG4886  77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE---------LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQ 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  174 ISILPTnAMDGLVNVTMLDLCYNHLSDsmLKEkTLSKMEKLMQLNLCNNRLESMP--LGLPSSLMYLSLENNSISSIPDN 251
Cdd:COG4886 148 LTDLPE-PLGNLTNLKSLDLSNNQLTD--LPE-ELGNLTNLKELDLSNNQITDLPepLGNLTNLEELDLSGNQLTDLPEP 223

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754934  252 yFDKLPKLHALRISHNKLEDIPyDIFNLSNLIELNVGHNKLKQafyIP-----RNLEHLYLQNNEIESINVTMI 320
Cdd:COG4886 224 -LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTD---LPplanlTNLKTLDLSNNQLTDLKLKEL 292
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
68-302 7.62e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 85.90  E-value: 7.62e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934    68 CPTNFPTSMYCDNRKLKTIP-IIPMHIQQLNLQFNDIEAVTANSFINathLKEINLSHNKIKSqkidygVFAKLSN-LQQ 145
Cdd:PRK15370 175 CLKNNKTELRLKILGLTTIPaCIPEQITTLILDNNELKSLPENLQGN---IKTLYANSNQLTS------IPATLPDtIQE 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   146 LHLEHNNLEEFPFPLPKSLERLLLGYNEISILPTNAMDGLvnvTMLDLCYNHLsdSMLKEKTLSkmeKLMQLNLCNNRLE 225
Cdd:PRK15370 246 MELSINRITELPERLPSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSI--RTLPAHLPS---GITHLNVQSNSLT 317

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6754934   226 SMPLGLPSSLMYLSLENNSISSIPDNYfdkLPKLHALRISHNKLEDIPYDIfnLSNLIELNVGHNKLKQafyIPRNL 302
Cdd:PRK15370 318 ALPETLPPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQITVLPETL--PPTITTLDVSRNALTN---LPENL 386
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 140-267 8.77e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.26  E-value: 8.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  140 LSNLQQLHLEHNNLEEFPF--PLPKsLERLLLGYNEISILptNAMDGLVNVTMLDLCYNHL--SDSMLKE----KTLSkm 211
Cdd:cd21340  45 LTNLTHLYLQNNQIEKIENleNLVN-LKKLYLGGNRISVV--EGLENLTNLEELHIENQRLppGEKLTFDprslAALS-- 119

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6754934  212 EKLMQLNLCNNRLESM-PLGLPSSLMYLSLENNSISSIPD--NYFDKLPKLHALRISHN 267
Cdd:cd21340 120 NSLRVLNISGNNIDSLePLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
96-153 1.00e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.00e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 6754934     96 LNLQFNDIEAVTANSFINATHLKEINLSHNKIKSqkIDYGVFAKLSNLQQLHLEHNNL 153
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-94 5.23e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 5.23e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 6754934      61 GCAKECFCPtnfPTSMYCDNRKLKTIPI-IPMHIQ 94
Cdd:smart00013   1 ACPAPCNCS---GTAVDCSGRGLTEVPLdLPPDTT 32
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-320 1.89e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.50  E-value: 1.89e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   96 LNLQFNDIEAVTANSFINATHLKEINLSHNKIksqkidygvFAKLSNLQQLHLEHNNLEEFPFPLP--KSLERLLLGYNE 173
Cdd:COG4886  77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE---------LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQ 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  174 ISILPTnAMDGLVNVTMLDLCYNHLSDsmLKEkTLSKMEKLMQLNLCNNRLESMP--LGLPSSLMYLSLENNSISSIPDN 251
Cdd:COG4886 148 LTDLPE-PLGNLTNLKSLDLSNNQLTD--LPE-ELGNLTNLKELDLSNNQITDLPepLGNLTNLEELDLSGNQLTDLPEP 223

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6754934  252 yFDKLPKLHALRISHNKLEDIPyDIFNLSNLIELNVGHNKLKQafyIP-----RNLEHLYLQNNEIESINVTMI 320
Cdd:COG4886 224 -LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTD---LPplanlTNLKTLDLSNNQLTDLKLKEL 292
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-344 1.96e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.10  E-value: 1.96e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   96 LNLQFNDIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLSNLQQLHLEHNNleefPFPLPKSLERLLLGYNEIS 175
Cdd:COG4886  51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLT 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  176 ILPtNAMDGLVNVTMLDLCYNHLSDSmlkEKTLSKMEKLMQLNLCNNRLESMP--LGLPSSLMYLSLENNSISSIPDNyF 253
Cdd:COG4886 127 DLP-EELANLTNLKELDLSNNQLTDL---PEPLGNLTNLKSLDLSNNQLTDLPeeLGNLTNLKELDLSNNQITDLPEP-L 201

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  254 DKLPKLHALRISHNKLEDIPYDIFNLSNLIELNVGHNKLKQAFYIPR--NLEHLYLQNNEIESInvtmicpsPDPVHHHH 331
Cdd:COG4886 202 GNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNltNLEELDLSNNQLTDL--------PPLANLTN 273

                       250
                ....*....|...
gi 6754934  332 LTYLRVDQNKLKE 344
Cdd:COG4886 274 LKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-344 3.12e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.00  E-value: 3.12e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   68 CPTNFPTSMYCDNRKLKTIPIIPMHIQQLNLQFNDIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLSNLQQLH 147
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  148 LEHNNLEEFPFPLPKSLERLLLGYNeisilptNAMDGLVNVTMLDLCYNHLSDSmlkEKTLSKMEKLMQLNLCNNRLESM 227
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDL 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  228 PLGLPS--SLMYLSLENNSISSIPDNyFDKLPKLHALRISHNKLEDIPYDIFNLSNLIELNVGHNKLKQafyIP------ 299
Cdd:COG4886 152 PEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD---LPeplanl 227

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 6754934  300 RNLEHLYLQNNEIESInvtmicpsPDPVHHHHLTYLRVDQNKLKE 344
Cdd:COG4886 228 TNLETLDLSNNQLTDL--------PELGNLTNLEELDLSNNQLTD 264
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
68-302 7.62e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 85.90  E-value: 7.62e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934    68 CPTNFPTSMYCDNRKLKTIP-IIPMHIQQLNLQFNDIEAVTANSFINathLKEINLSHNKIKSqkidygVFAKLSN-LQQ 145
Cdd:PRK15370 175 CLKNNKTELRLKILGLTTIPaCIPEQITTLILDNNELKSLPENLQGN---IKTLYANSNQLTS------IPATLPDtIQE 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   146 LHLEHNNLEEFPFPLPKSLERLLLGYNEISILPTNAMDGLvnvTMLDLCYNHLsdSMLKEKTLSkmeKLMQLNLCNNRLE 225
Cdd:PRK15370 246 MELSINRITELPERLPSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSI--RTLPAHLPS---GITHLNVQSNSLT 317

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6754934   226 SMPLGLPSSLMYLSLENNSISSIPDNYfdkLPKLHALRISHNKLEDIPYDIfnLSNLIELNVGHNKLKQafyIPRNL 302
Cdd:PRK15370 318 ALPETLPPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQITVLPETL--PPTITTLDVSRNALTN---LPENL 386
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-316 3.41e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 3.41e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   74 TSMYCDNRKLKTIP--IIPM-HIQQLNLQFNDIEAVTAnSFINATHLKEINLSHNKIKSQKidyGVFAKLSNLQQLHLEH 150
Cdd:COG4886 139 KELDLSNNQLTDLPepLGNLtNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLP---EPLGNLTNLEELDLSG 214

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  151 NNLEEFPFPLP--KSLERLLLGYNEISILPtnAMDGLVNVTMLDLCYNHLSDSmlkeKTLSKMEKLMQLNLCNNRLESMP 228
Cdd:COG4886 215 NQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL----PPLANLTNLKTLDLSNNQLTDLK 288

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  229 L-----GLPSSLMYLSLENNSISSIPDNYFDKLPKLHALRISHNKLEDIPYDIFNLSNLIELNVGHNKLKQAFYIPRNLE 303
Cdd:COG4886 289 LkelelLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                       250
                ....*....|...
gi 6754934  304 HLYLQNNEIESIN 316
Cdd:COG4886 369 LGLLGLLEATLLT 381
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 92-310 5.30e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.40  E-value: 5.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934    92 HIQQLNLQFNDIEAVTANSFINATHLKEINLSHNKIkSQKIDYGVFAKLSNLQQLHLEHNNleeFPFPLPKS----LERL 167
Cdd:PLN00113  70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNN---FTGSIPRGsipnLETL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   168 LLG--------YNEISI--------LPTNAMDG-----LVNVTMLD---LCYNHLSDSMLKEktLSKMEKLMQLNLCNNR 223
Cdd:PLN00113 146 DLSnnmlsgeiPNDIGSfsslkvldLGGNVLVGkipnsLTNLTSLEfltLASNQLVGQIPRE--LGQMKSLKWIYLGYNN 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   224 LE-SMP--LGLPSSLMYLSL-ENNSISSIPDNyFDKLPKLHALRISHNKLED-IPYDIFNLSNLIELNVGHNKLKQAfyI 298
Cdd:PLN00113 224 LSgEIPyeIGGLTSLNHLDLvYNNLTGPIPSS-LGNLKNLQYLFLYQNKLSGpIPPSIFSLQKLISLDLSDNSLSGE--I 300

                        250
                 ....*....|....*...
gi 6754934   299 P------RNLEHLYLQNN 310
Cdd:PLN00113 301 PelviqlQNLEILHLFSN 318
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 140-267 8.77e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.26  E-value: 8.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  140 LSNLQQLHLEHNNLEEFPF--PLPKsLERLLLGYNEISILptNAMDGLVNVTMLDLCYNHL--SDSMLKE----KTLSkm 211
Cdd:cd21340  45 LTNLTHLYLQNNQIEKIENleNLVN-LKKLYLGGNRISVV--EGLENLTNLEELHIENQRLppGEKLTFDprslAALS-- 119

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6754934  212 EKLMQLNLCNNRLESM-PLGLPSSLMYLSLENNSISSIPD--NYFDKLPKLHALRISHN 267
Cdd:cd21340 120 NSLRVLNISGNNIDSLePLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
96-153 1.00e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.00e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 6754934     96 LNLQFNDIEAVTANSFINATHLKEINLSHNKIKSqkIDYGVFAKLSNLQQLHLEHNNL 153
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 92-292 8.52e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.55  E-value: 8.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934    92 HIQQLNLQFNDIEAVTANSFINATHLKEINLSHNKIkSQKIDYGvFAKLSNLQQLHLEHNNL----EEFPFPLPkSLERL 167
Cdd:PLN00113 381 NLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF-SGELPSE-FTKLPLVYFLDISNNNLqgriNSRKWDMP-SLQML 457

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   168 LLGYNEIS-ILPTNAmdGLVNVTMLDLCYNHLSDSMlkEKTLSKMEKLMQLNLCNNRLES-MPLGLPS--SLMYLSLENN 243
Cdd:PLN00113 458 SLARNKFFgGLPDSF--GSKRLENLDLSRNQFSGAV--PRKLGSLSELMQLKLSENKLSGeIPDELSSckKLVSLDLSHN 533

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 6754934   244 SIS-SIPDNyFDKLPKLHALRISHNKLE-DIPYDIFNLSNLIELNVGHNKL 292
Cdd:PLN00113 534 QLSgQIPAS-FSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
141-319 8.98e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.40  E-value: 8.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   141 SNLQQLHLEHNNLEEFPFPLPKSLERLLLGYNEISILPTNAMdglVNVTMLDLCYNHLSDSmlkEKTLSKMEKLMQLNLc 220
Cdd:PRK15370 178 NNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQ---GNIKTLYANSNQLTSI---PATLPDTIQEMELSI- 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   221 nNRLESMPLGLPSSLMYLSLENNSISSIPDNyfdkLPK-LHALRISHNKLEDIPYdifnlsnlielnvghnklkqafYIP 299
Cdd:PRK15370 251 -NRITELPERLPSALQSLDLFHNKISCLPEN----LPEeLRYLSVYDNSIRTLPA----------------------HLP 303

                        170       180
                 ....*....|....*....|
gi 6754934   300 RNLEHLYLQNNEIESINVTM 319
Cdd:PRK15370 304 SGITHLNVQSNSLTALPETL 323
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 89-312 8.87e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 8.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934    89 IPMHIQQL-NLQF-----NDIEAVTANSFINATHLKEINLSHNKIKSQKIDygVFAKLSNLQQLHLEHNNLE-EFPFPLp 161
Cdd:PLN00113 252 IPSSLGNLkNLQYlflyqNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPE--LVIQLQNLEILHLFSNNFTgKIPVAL- 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   162 KSLERLllgynEISILPTNAMDGLV--------NVTMLDLCYNHLSDSMlkEKTLSKMEKLMQLNLCNNRLES-MP--LG 230
Cdd:PLN00113 329 TSLPRL-----QVLQLWSNKFSGEIpknlgkhnNLTVLDLSTNNLTGEI--PEGLCSSGNLFKLILFSNSLEGeIPksLG 401

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   231 LPSSLMYLSLENNSISSIPDNYFDKLPKLHALRISHNKLE-DIPYDIFNLSNLIELNVGHNK----LKQAFYiPRNLEHL 305
Cdd:PLN00113 402 ACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKffggLPDSFG-SKRLENL 480


                 ....*..
gi 6754934   306 YLQNNEI 312
Cdd:PLN00113 481 DLSRNQF 487
LRR_8 pfam13855
Leucine rich repeat;
213-269 9.08e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 9.08e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6754934    213 KLMQLNLCNNRLESMP----LGLPSsLMYLSLENNSISSIPDNYFDKLPKLHALRISHNKL 269
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDdgafKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
233-292 1.44e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 1.44e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6754934    233 SSLMYLSLENNSISSIPDNYFDKLPKLHALRISHNKLEDI-PYDIFNLSNLIELNVGHNKL 292
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
141-198 2.67e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 2.67e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6754934    141 SNLQQLHLEHNNLEEFP---FPLPKSLERLLLGYNEISILPTNAMDGLVNVTMLDLCYNHL 198
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
141-348 4.52e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.09  E-value: 4.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   141 SNLQQLHLEHNNLEEFPfPLPKSLERLLLGYNEISILPTnAMDGLVNVTMLDLCYNHLSdsmlkektlSKMEKLMQLNLC 220
Cdd:PRK15387 222 AHITTLVIPDNNLTSLP-ALPPELRTLEVSGNQLTSLPV-LPPGLLELSIFSNPLTHLP---------ALPSGLCKLWIF 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   221 NNRLESMPLgLPSSLMYLSLENNSISSIPdnyfdKLP-KLHALRISHNKLEDIPYdifNLSNLIELNVGHNKLKQAFYIP 299
Cdd:PRK15387 291 GNQLTSLPV-LPPGLQELSVSDNQLASLP-----ALPsELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTLP 361

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 6754934   300 RNLEHLYLQNNEIESINVTMICPSPDPVHHHHLTYLRVDQNKLKEPISS 348
Cdd:PRK15387 362 SELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLPSELKELMVS 410
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 136-342 5.59e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.20  E-value: 5.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  136 VFAKLSNLQQLHLEHNNL--EEFPF-----PLPKSLERLLLGYNEISILPTN---AMDGL---VNVTMLDLCYNHLS-DS 201
Cdd:cd00116  18 LLPKLLCLQVLRLEGNTLgeEAAKAlasalRPQPSLKELCLSLNETGRIPRGlqsLLQGLtkgCGLQELDLSDNALGpDG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  202 MLKEKTLSKMEKLMQLNLCNNRLESMPL-----GLPSSLMYLS---LENNSISSIP----DNYFDKLPKLHALRISHNKL 269
Cdd:cd00116  98 CGVLESLLRSSSLQELKLNNNGLGDRGLrllakGLKDLPPALEklvLGRNRLEGAScealAKALRANRDLKELNLANNGI 177

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6754934  270 ED--IPYdifnlsnlielnvghnkLKQAFYIPRNLEHLYLQNNEIESINVTMICPSPDpvHHHHLTYLRVDQNKL 342
Cdd:cd00116 178 GDagIRA-----------------LAEGLKANCNLEVLDLNNNGLTDEGASALAETLA--SLKSLEVLNLGDNNL 233
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-303 7.08e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 7.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   94 QQLNLQFNDIEAVTAnSFINATHLKEINLSHNKIKsqkiDYGVFAKLSNLQQLHLEHNNLEEFPFPLP-KSLERLLLGYN 172
Cdd:COG4886 208 EELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNN 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  173 EISILPTNAMDGLVNVTMLDLcYNHLSDSMLKEKTLSKMEKLMQLNLCNNRLESMPLGLPSSLMYLSLENNSISSIPDNY 252
Cdd:COG4886 283 QLTDLKLKELELLLGLNSLLL-LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 6754934  253 FDKLPKLHALRISHNKLEDIPYDIFNLSNLIELNVGHNKLKQAFYIPRNLE 303
Cdd:COG4886 362 LLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 93-342 4.19e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 4.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934    93 IQQLNLQFNDIEAVTANSFInaTHLKEINLSHNKIkSQKI--DYGVF---------------------AKLSNLQQLHLE 149
Cdd:PLN00113 120 LRYLNLSNNNFTGSIPRGSI--PNLETLDLSNNML-SGEIpnDIGSFsslkvldlggnvlvgkipnslTNLTSLEFLTLA 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   150 HNNLE-EFPFPLP--KSLERLLLGYNEISILPTNAMDGLVNVTMLDLCYNHLSDSMlkektlskmeklmqlnlcnnrleS 226
Cdd:PLN00113 197 SNQLVgQIPRELGqmKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPI-----------------------P 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   227 MPLGLPSSLMYLSLENNSIS-SIPDNYFDkLPKLHALRISHNKLE-DIPYDIFNLSNLIELNVGHNKLKQAfyIPRNLEH 304
Cdd:PLN00113 254 SSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGK--IPVALTS 330

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 6754934   305 L-YLQNNEIESINVTMICPSpDPVHHHHLTYLRVDQNKL 342
Cdd:PLN00113 331 LpRLQVLQLWSNKFSGEIPK-NLGKHNNLTVLDLSTNNL 368
LRRNT smart00013
Leucine rich repeat N-terminal domain;
61-94 5.23e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 5.23e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 6754934      61 GCAKECFCPtnfPTSMYCDNRKLKTIPI-IPMHIQ 94
Cdd:smart00013   1 ACPAPCNCS---GTAVDCSGRGLTEVPLdLPPDTT 32
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 93-224 5.89e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.25  E-value: 5.89e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   93 IQQLNLQFNDIEAVTANSFINA----THLKEINLSHNKIKsqkiDYGVFAklsnLQQlHLEHNnleefpfplpKSLERLL 168
Cdd:COG5238 266 VETLYLSGNQIGAEGAIALAKAlqgnTTLTSLDLSVNRIG----DEGAIA----LAE-GLQGN----------KTLHTLN 326

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754934  169 LGYNEIS----ILPTNAMDGLVNVTMLDLCYNHLSDSMLKE--KTLSKMEKLMQLNLCNNRL 224
Cdd:COG5238 327 LAYNGIGaqgaIALAKALQENTTLHSLDLSDNQIGDEGAIAlaKYLEGNTTLRELNLGKNNI 388
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 93-246 3.10e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 3.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934    93 IQQLNLQFNDIEAVTANSFINATHLKEINLSHNKIKSQKIDYgvFAKLSNLQQLHLEHNNLE-EFPfplpkslerllLGY 171
Cdd:PLN00113 477 LENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDE--LSSCKKLVSLDLSHNQLSgQIP-----------ASF 543

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6754934   172 NEISILptnamdglvnvTMLDLCYNHLSDSMlkEKTLSKMEKLMQLNLCNNRLESmplGLPSSLMYLSLENNSIS 246
Cdd:PLN00113 544 SEMPVL-----------SQLDLSQNQLSGEI--PKNLGNVESLVQVNISHNHLHG---SLPSTGAFLAINASAVA 602
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 211-315 3.60e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 3.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  211 MEKLMQLNLCNNRLESMP-LGLPSSLMYLSLENNSISSIPDnyFDKLPKLHALRISHNKLEDIPydifNLSNLielnvgh 289
Cdd:cd21340   1 LKRITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE----NLENL------- 67

                        90       100
                ....*....|....*....|....*.
gi 6754934  290 nklkqafyipRNLEHLYLQNNEIESI 315
Cdd:cd21340  68 ----------VNLKKLYLGGNRISVV 83
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
82-251 6.37e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.15  E-value: 6.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934    82 KLKTIPIIPMHIQQLNLQFNDIEAVTANSfinaTHLKEINLSHNKIKSqkidygVFAKLSNLQQLHLEHNNLEEFPfPLP 161
Cdd:PRK15387 293 QLTSLPVLPPGLQELSVSDNQLASLPALP----SELCKLWAYNNQLTS------LPTLPSGLQELSVSDNQLASLP-TLP 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   162 KSLERLLLGYNEISILPTNAmdglvnvtmldlcyNHLSDSMLKEKTLSKM----EKLMQLNLCNNRLESMPLgLPSSLMY 237
Cdd:PRK15387 362 SELYKLWAYNNRLTSLPALP--------------SGLKELIVSGNRLTSLpvlpSELKELMVSGNRLTSLPM-LPSGLLS 426

                        170
                 ....*....|....
gi 6754934   238 LSLENNSISSIPDN 251
Cdd:PRK15387 427 LSVYRNQLTRLPES 440
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 142-302 1.06e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   142 NLQQLHLEHNNLE-EFPFPLP--KSLERLLLGYNEIS----------------ILPTNAMDGLVN--------VTMLDLC 194
Cdd:PLN00113 381 NLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSgelpseftklplvyflDISNNNLQGRINsrkwdmpsLQMLSLA 460

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   195 YNHLSDSMlkeKTLSKMEKLMQLNLCNNRL-ESMPLGLP--SSLMYLSLENNSISS-IPDNyFDKLPKLHALRISHNKLE 270
Cdd:PLN00113 461 RNKFFGGL---PDSFGSKRLENLDLSRNQFsGAVPRKLGslSELMQLKLSENKLSGeIPDE-LSSCKKLVSLDLSHNQLS 536

                        170       180       190
                 ....*....|....*....|....*....|...
gi 6754934   271 -DIPYDIFNLSNLIELNVGHNKLKQAfyIPRNL 302
Cdd:PLN00113 537 gQIPASFSEMPVLSQLDLSQNQLSGE--IPKNL 567
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 197-316 1.27e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 1.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  197 HLSdsmLKEKTLSKMEKLMQ------LNLCNNRLESMP-LGLPSSLMYLSLENNSISSIPDnyFDKLPKLHALRISHNKL 269
Cdd:cd21340   6 HLY---LNDKNITKIDNLSLcknlkvLYLYDNKITKIEnLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6754934  270 EDI----------------------------PYDIFNLSN-LIELNVGHNKLK--QAFYIPRNLEHLYLQNNEIESIN 316
Cdd:cd21340  81 SVVeglenltnleelhienqrlppgekltfdPRSLAALSNsLRVLNISGNNIDslEPLAPLRNLEQLDASNNQISDLE 158
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
217-317 6.37e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.07  E-value: 6.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934   217 LNLCNNRLESMPLGLPSSLMYLSLENNSISSIPdnyfDKLPKLHALRISHNKLEDIPydiFNLSNLIELNVGHNKLKQAF 296
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLP----ALPPELRTLEVSGNQLTSLP---VLPPGLLELSIFSNPLTHLP 278

                         90       100
                 ....*....|....*....|.
gi 6754934   297 YIPRNLEHLYLQNNEIESINV 317
Cdd:PRK15387 279 ALPSGLCKLWIFGNQLTSLPV 299
LRR_8 pfam13855
Leucine rich repeat;
163-224 1.05e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754934    163 SLERLLLGYNEISILPTNAMDGLVNVTMLDLCYNHLSDsmLKEKTLSKMEKLMQLNLCNNRL 224
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 115-153 1.78e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.78e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6754934    115 THLKEINLSHNKIKsqkiDYGVFAKLSNLQQLHLEHNNL 153
Cdd:pfam12799   1 PNLEVLDLSNNQIT----DIPPLAKLPNLETLDLSGNNK 35
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 107-224 9.87e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.72  E-value: 9.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754934  107 TANSFINATHLKEINLSHNKIKSQKIDYGV--FAKLSNLQQLHLEHNNLEE-------FPFPLPKSLERLLLGYNEISIL 177
Cdd:cd00116 157 LAKALRANRDLKELNLANNGIGDAGIRALAegLKANCNLEVLDLNNNGLTDegasalaETLASLKSLEVLNLGDNNLTDA 236

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6754934  178 PTNAMD-----GLVNVTMLDLCYNHLSDS---MLKEkTLSKMEKLMQLNLCNNRL 224
Cdd:cd00116 237 GAAALAsallsPNISLLTLSLSCNDITDDgakDLAE-VLAEKESLLELDLRGNKF 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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