|
Name |
Accession |
Description |
Interval |
E-value |
| UCH |
pfam00443 |
Ubiquitin carboxyl-terminal hydrolase; |
52-363 |
5.05e-54 |
|
Ubiquitin carboxyl-terminal hydrolase;
Pssm-ID: 425685 [Multi-domain] Cd Length: 310 Bit Score: 180.33 E-value: 5.05e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 52 VGLHNIGQTCCLNSLLQVFMMNMDFRMILKRITVPRSAEERKRSVPF--QLLLLLEKMQD-SRQKAVLPTELVQCLQKYN 128
Cdd:pfam00443 1 TGLVNLGNTCYMNSVLQSLFSIPPFRDYLLRISPLSEDSRYNKDINLlcALRDLFKALQKnSKSSSVSPKMFKKSLGKLN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 129 VPL--FVQHDAAQLYLTIWNLTKDQITDTDLTERLQG---LFTIWTQESLICVGCTAESSRRSKLLTLSLPLFDKDA-KP 202
Cdd:pfam00443 81 PDFsgYKQQDAQEFLLFLLDGLHEDLNGNHSTENESLitdLFRGQLKSRLKCLSCGEVSETFEPFSDLSLPIPGDSAeLK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 203 LKTLEDALRCFVQPKELASSDMC-CESCGEKTPWKQVLKLTHLPQTLTIHLMRFSARNSRTEKICHSVNFPQSLDFSQVL 281
Cdd:pfam00443 161 TASLQICFLQFSKLEELDDEEKYyCDKCGCKQDAIKQLKISRLPPVLIIHLKRFSYNRSTWEKLNTEVEFPLELDLSRYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 282 PTEEDlgdTKEQSEIHYELFAVIAHVGMADFGHYCAYIRNPVDGKWFCFNDSHVCWVTWKDVQCTygnhryrwrETAYLL 361
Cdd:pfam00443 241 AEELK---PKTNNLQDYRLVAVVVHSGSLSSGHYIAYIKAYENNRWYKFDDEKVTEVDEETAVLS---------SSAYIL 308
|
..
gi 188035917 362 VY 363
Cdd:pfam00443 309 FY 310
|
|
| Peptidase_C19 |
cd02257 |
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ... |
53-363 |
1.73e-52 |
|
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239072 [Multi-domain] Cd Length: 255 Bit Score: 174.59 E-value: 1.73e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 53 GLHNIGQTCCLNSLLQVFMMNM-DfrmilkritvprsAEErkrsvpFqLLLLLEKMQDSRQKAVlptelvqclqkynvpl 131
Cdd:cd02257 1 GLNNLGNTCYLNSVLQALFSEQqD-------------AHE------F-LLFLLDKLHEELKKSS---------------- 44
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 132 fvqhdaaqlyltiwnltKDQITDTDLTERLQGLFTIWTQESLICVGCTAESSRRSKLLTLSLPLFDKDAKPlKTLEDALR 211
Cdd:cd02257 45 -----------------KRTSDSSSLKSLIHDLFGGKLESTIVCLECGHESVSTEPELFLSLPLPVKGLPQ-VSLEDCLE 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 212 CFVQPKELASSDMCCESCGEKTPWKQVLKLTHLPQTLTIHLMRFSA-RNSRTEKICHSVNFPQSLDFSQVLpTEEDLGDT 290
Cdd:cd02257 107 KFFKEEILEGDNCYKCEKKKKQEATKRLKIKKLPPVLIIHLKRFSFnEDGTKEKLNTKVSFPLELDLSPYL-SEGEKDSD 185
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 188035917 291 KEQSEIHYELFAVIAHVG-MADFGHYCAYIRNPVDGKWFCFNDSHVCWVTWKDVQCTYGNHryrwrETAYLLVY 363
Cdd:cd02257 186 SDNGSYKYELVAVVVHSGtSADSGHYVAYVKDPSDGKWYKFNDDKVTEVSEEEVLEFGSLS-----SSAYILFY 254
|
|
| peptidase_C19C |
cd02659 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
50-365 |
4.94e-49 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239124 [Multi-domain] Cd Length: 334 Bit Score: 168.20 E-value: 4.94e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 50 GLVGLHNIGQTCCLNSLLQVFMMNMDFR-MILKRITVPRSAEERKRSVPFQLLLLLEKMQDSRQKAVLPTELVQCLQKYN 128
Cdd:cd02659 1 GYVGLKNQGATCYMNSLLQQLYMTPEFRnAVYSIPPTEDDDDNKSVPLALQRLFLFLQLSESPVKTTELTDKTRSFGWDS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 129 VPLFVQHDAAQLYLTIWNLTKDQITDTDLTERLQGLF--TIWTQesLICVGCTAESSRRSKLLTLSLplfdkDAKPLKTL 206
Cdd:cd02659 81 LNTFEQHDVQEFFRVLFDKLEEKLKGTGQEGLIKNLFggKLVNY--IICKECPHESEREEYFLDLQV-----AVKGKKNL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 207 EDALRCFVQPKELASSDMC-CESCGEKTPWKQVLKLTHLPQTLTIHLMRFS---ARNSRtEKICHSVNFPQSLDFSQ--- 279
Cdd:cd02659 154 EESLDAYVQGETLEGDNKYfCEKCGKKVDAEKGVCFKKLPPVLTLQLKRFEfdfETMMR-IKINDRFEFPLELDMEPyte 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 280 --VLPTEEDLGDTKEQSEIhYELFAVIAHVGMADFGHYCAYIRNPVDGKWFCFNDSHVCWVTWKDV--QCTYGNHRYRWR 355
Cdd:cd02659 233 kgLAKKEGDSEKKDSESYI-YELHGVLVHSGDAHGGHYYSYIKDRDDGKWYKFNDDVVTPFDPNDAeeECFGGEETQKTY 311
|
330 340
....*....|....*....|
gi 188035917 356 ET----------AYLLVYTK 365
Cdd:cd02659 312 DSgprafkrttnAYMLFYER 331
|
|
| Peptidase_C19L |
cd02668 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
53-364 |
1.77e-40 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239133 [Multi-domain] Cd Length: 324 Bit Score: 145.26 E-value: 1.77e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 53 GLHNIGQTCCLNSLLQVFMMNMDFRMILKRITVPRSAEER--KRSVPF-------QLLLLLEKMQDSRQKAVLPTELVQC 123
Cdd:cd02668 1 GLKNLGATCYVNSFLQLWFMNLEFRKAVYECNSTEDAELKnmPPDKPHepqtiidQLQLIFAQLQFGNRSVVDPSGFVKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 124 LQKYNVplfVQHDAAQ---LYLTIWNLTKDQITDTDLTERLQGLFTIWTQESLICVGCTAESSRRSKLLTLSLPLfdkda 200
Cdd:cd02668 81 LGLDTG---QQQDAQEfskLFLSLLEAKLSKSKNPDLKNIVQDLFRGEYSYVTQCSKCGRESSLPSKFYELELQL----- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 201 KPLKTLEDALRCFVQPKELASSDM-CCESCGEKTPWKQVLKLTHLPQTLTIHLMRFS-ARNSRTEKICH-SVNFPQSLDF 277
Cdd:cd02668 153 KGHKTLEECIDEFLKEEQLTGDNQyFCESCNSKTDATRRIRLTTLPPTLNFQLLRFVfDRKTGAKKKLNaSISFPEILDM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 278 SQVLpTEEDLGDTKeqseihYELFAVIAHVGM-ADFGHYCAYIRNPVDGKWFCFNDSHVCWVTWKDVQC----------- 345
Cdd:cd02668 233 GEYL-AESDEGSYV------YELSGVLIHQGVsAYSGHYIAHIKDEQTGEWYKFNDEDVEEMPGKPLKLgnsedpakprk 305
|
330 340
....*....|....*....|
gi 188035917 346 -TYGNHRYRWReTAYLLVYT 364
Cdd:cd02668 306 sEIKKGTHSSR-TAYMLVYK 324
|
|
| Peptidase_C19R |
cd02674 |
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
134-364 |
2.77e-33 |
|
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239139 [Multi-domain] Cd Length: 230 Bit Score: 123.55 E-value: 2.77e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 134 QHDAAQLYLTIWNLTKDQITDTdlterLQGLFtiwtQESLICVGCTAESSRRSKLLTLSLPLFDKDAKPLK-TLEDALRC 212
Cdd:cd02674 22 QQDAQEFLLFLLDGLHSIIVDL-----FQGQL----KSRLTCLTCGKTSTTFEPFTYLSLPIPSGSGDAPKvTLEDCLRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 213 FVQPKELASSDM-CCESCGEKTPWKQVLKLTHLPQTLTIHLMRFSARNSRTEKICHSVNFP-QSLDFSQVLPTEEDLGDT 290
Cdd:cd02674 93 FTKEETLDGDNAwKCPKCKKKRKATKKLTISRLPKVLIIHLKRFSFSRGSTRKLTTPVTFPlNDLDLTPYVDTRSFTGPF 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 188035917 291 KeqseihYELFAVIAHVGMADFGHYCAYIRNPVDGKWFCFNDSHVcwvtwkdvqcTYGNHRYRWRETAYLLVYT 364
Cdd:cd02674 173 K------YDLYAVVNHYGSLNGGHYTAYCKNNETNDWYKFDDSRV----------TKVSESSVVSSSAYILFYE 230
|
|
| Peptidase_C19H |
cd02664 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
53-363 |
4.35e-32 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239129 [Multi-domain] Cd Length: 327 Bit Score: 122.99 E-value: 4.35e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 53 GLHNIGQTCCLNSLLQVFMMNMDFRMILKRITVPRSAEErkRSVPFQLLLLLEKMQDSRQKAVLPTELV--QCLQKYNVP 130
Cdd:cd02664 1 GLINLGNTCYMNSVLQALFMAKDFRRQVLSLNLPRLGDS--QSVMKKLQLLQAHLMHTQRRAEAPPDYFleASRPPWFTP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 131 LFvQHDAAQlYLTIwnltkdqitdtdLTERLQGLFTIWTQESLI----CVGC--TAESSRRSKLLTLSLPLfdkdakplk 204
Cdd:cd02664 79 GS-QQDCSE-YLRY------------LLDRLHTLIEKMFGGKLSttirCLNCnsTSARTERFRDLDLSFPS--------- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 205 tLEDALRCFVQPKELASSDMC-CESCGEKTPWKQVLKLTHLPQTLTIHLMRFS---ARNSRtEKICHSVNFPQSLDF--- 277
Cdd:cd02664 136 -VQDLLNYFLSPEKLTGDNQYyCEKCASLQDAEKEMKVTGAPEYLILTLLRFSydqKTHVR-EKIMDNVSINEVLSLpvr 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 278 ----SQVLPTEEDLGDTKEQSE-----IHYELFAVIAHVGMA-DFGHYCAYIRNPVD--------------------GKW 327
Cdd:cd02664 214 veskSSESPLEKKEEESGDDGElvtrqVHYRLYAVVVHSGYSsESGHYFTYARDQTDadstgqecpepkdaeendesKNW 293
|
330 340 350
....*....|....*....|....*....|....*..
gi 188035917 328 FCFNDSHVCWVTWKDVQctygNHRYRWR-ETAYLLVY 363
Cdd:cd02664 294 YLFNDSRVTFSSFESVQ----NVTSRFPkDTPYILFY 326
|
|
| Peptidase_C19E |
cd02661 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
53-363 |
2.47e-29 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239126 [Multi-domain] Cd Length: 304 Bit Score: 115.07 E-value: 2.47e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 53 GLHNIGQTCCLNSLLQVFMMnmdfrmilkriTVP-------RSAEERKRSVPFQLLLLLEKM-QDSRQ--KAVLPTELVQ 122
Cdd:cd02661 3 GLQNLGNTCFLNSVLQCLTH-----------TPPlanyllsREHSKDCCNEGFCMMCALEAHvERALAssGPGSAPRIFS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 123 CLQKYNVPLFV---QHDAAQL-----------YLTIWNLTKDQITDTDLTERLQGLFTIWTQESLICVGCTAESSRRSKL 188
Cdd:cd02661 72 SNLKQISKHFRigrQEDAHEFlrylldamqkaCLDRFKKLKAVDPSSQETTLVQQIFGGYLRSQVKCLNCKHVSNTYDPF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 189 LTLSLplfdkDAKPLKTLEDALRCFVQPKELASSDMC-CESCGEKTPWKQVLKLTHLPQTLTIHLMRFSarNSRTEKICH 267
Cdd:cd02661 152 LDLSL-----DIKGADSLEDALEQFTKPEQLDGENKYkCERCKKKVKASKQLTIHRAPNVLTIHLKRFS--NFRGGKINK 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 268 SVNFPQSLDFSQVlpteedLGDTKEQSEIhYELFAVIAHVGM-ADFGHYCAYIRNPvDGKWFCFNDSHVCWVTWKDVqct 346
Cdd:cd02661 225 QISFPETLDLSPY------MSQPNDGPLK-YKLYAVLVHSGFsPHSGHYYCYVKSS-NGKWYNMDDSKVSPVSIETV--- 293
|
330
....*....|....*..
gi 188035917 347 ygnhryrWRETAYLLVY 363
Cdd:cd02661 294 -------LSQKAYILFY 303
|
|
| COG5077 |
COG5077 |
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ... |
50-363 |
3.50e-29 |
|
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227409 [Multi-domain] Cd Length: 1089 Bit Score: 119.20 E-value: 3.50e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 50 GLVGLHNIGQTCCLNSLLQVFMMNMDFRMILKRItvPRSAEERKRSVPFQLLLLLEKMQDSRQkAVLPTELVQCLQKYNV 129
Cdd:COG5077 192 GYVGLRNQGATCYMNSLLQSLFFIAKFRKDVYGI--PTDHPRGRDSVALALQRLFYNLQTGEE-PVDTTELTRSFGWDSD 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 130 PLFVQHDAAQLYLTIWNLTKDQITDTDLTERLQGLFTIWTQESLICVGCTAESSRRSKLLTLSLplfdkDAKPLKTLEDA 209
Cdd:COG5077 269 DSFMQHDIQEFNRVLQDNLEKSMRGTVVENALNGIFVGKMKSYIKCVNVNYESARVEDFWDIQL-----NVKGMKNLQES 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 210 LRCFVQpKELASSDMC--CESCGEKTPWKQVLkLTHLPQTLTIHLMRFSARNSRTE--KICHSVNFPQSLDFSQVLPTEe 285
Cdd:COG5077 344 FRRYIQ-VETLDGDNRynAEKHGLQDAKKGVI-FESLPPVLHLQLKRFEYDFERDMmvKINDRYEFPLEIDLLPFLDRD- 420
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 286 dlGDTKEQSEIHYELFAVIAHVGMADFGHYCAYIRNPVDGKWFCFNDSHVCWVTWKDV-QCTYG-NHRYRWR-------- 355
Cdd:COG5077 421 --ADKSENSDAVYVLYGVLVHSGDLHEGHYYALLKPEKDGRWYKFDDTRVTRATEKEVlEENFGgDHPYKDKirdhsgik 498
|
330
....*....|
gi 188035917 356 --ETAYLLVY 363
Cdd:COG5077 499 rfMSAYMLVY 508
|
|
| Peptidase_C19D |
cd02660 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
170-364 |
5.95e-26 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239125 [Multi-domain] Cd Length: 328 Bit Score: 106.30 E-value: 5.95e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 170 QESLICVGCTAESSRRSKLLTLSLPLFDK----------DAKPLKTLEDALRCFVQPKELASSDMCCESCGEKTPWKQVL 239
Cdd:cd02660 132 QSSVTCQRCGGVSTTVDPFLDLSLDIPNKstpswalgesGVSGTPTLSDCLDRFTRPEKLGDFAYKCSGCGSTQEATKQL 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 240 KLTHLPQTLTIHLMRFS-ARNSRTEKICHSVNFPQSLDFSQVLPTEEdlGDTKE----QSEIHYELFAVIAHVGMADFGH 314
Cdd:cd02660 212 SIKKLPPVLCFQLKRFEhSLNKTSRKIDTYVQFPLELNMTPYTSSSI--GDTQDsnslDPDYTYDLFAVVVHKGTLDTGH 289
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 188035917 315 YCAYIRNPvDGKWFCFNDSHVCWVTWKDVQctygnhryrwRETAYLLVYT 364
Cdd:cd02660 290 YTAYCRQG-DGQWFKFDDAMITRVSEEEVL----------KSQAYLLFYH 328
|
|
| UBP12 |
COG5560 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
200-363 |
1.32e-25 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227847 [Multi-domain] Cd Length: 823 Bit Score: 108.43 E-value: 1.32e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 200 AKPLKTLEDALRCFVQPKELASSD-MCCESCGEKTPWKQVLKLTHLPQTLTIHLMRFSARNSRTEKICHSVNFP-QSLDF 277
Cdd:COG5560 671 AERTITLQDCLNEFSKPEQLGLSDsWYCPGCKEFRQASKQMELWRLPMILIIHLKRFSSVRSFRDKIDDLVEYPiDDLDL 750
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 278 SQVLpteedlgDTKEQSEIHYELFAVIAHVGMADFGHYCAYIRNPVDGKWFCFNDSHVCWVTWKDVQctygnhryrwRET 357
Cdd:COG5560 751 SGVE-------YMVDDPRLIYDLYAVDNHYGGLSGGHYTAYARNFANNGWYLFDDSRITEVDPEDSV----------TSS 813
|
....*.
gi 188035917 358 AYLLVY 363
Cdd:COG5560 814 AYVLFY 819
|
|
| Peptidase_C19A |
cd02657 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
53-363 |
5.54e-25 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239122 [Multi-domain] Cd Length: 305 Bit Score: 103.18 E-value: 5.54e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 53 GLHNIGQTCCLNSLLQVFMMNMDFRMILKRIT-VPRSAEERKRSVPFQLLLLLEKMqDSRQKAVLPTELVQCL------- 124
Cdd:cd02657 1 GLTNLGNTCYLNSTLQCLRSVPELRDALKNYNpARRGANQSSDNLTNALRDLFDTM-DKKQEPVPPIEFLQLLrmafpqf 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 125 -QKYNVPLFVQHDAAQLYLTIWN-LTKDQITDTDLTERLQGLFTIWTQESLICVGC-TAESSRRSKLLTLSLPLFDKDAK 201
Cdd:cd02657 80 aEKQNQGGYAQQDAEECWSQLLSvLSQKLPGAGSKGSFIDQLFGIELETKMKCTESpDEEEVSTESEYKLQCHISITTEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 202 plKTLEDALRCFVQPKELASSdmccESCGEKTPWKQVLKLTHLPQTLTIHLMRFSARNS--RTEKICHSVNFPQSLDFSQ 279
Cdd:cd02657 160 --NYLQDGLKKGLEEEIEKHS----PTLGRDAIYTKTSRISRLPKYLTVQFVRFFWKRDiqKKAKILRKVKFPFELDLYE 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 280 VLpteedlgdtkEQSEIhYELFAVIAHVGM-ADFGHYCAYIRNPVDGKWFCFNDSHVCWVTWKDVQCTYGNHRYrwrETA 358
Cdd:cd02657 234 LC----------TPSGY-YELVAVITHQGRsADSGHYVAWVRRKNDGKWIKFDDDKVSEVTEEDILKLSGGGDW---HIA 299
|
....*
gi 188035917 359 YLLVY 363
Cdd:cd02657 300 YILLY 304
|
|
| Peptidase_C19O |
cd02671 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
42-363 |
4.39e-23 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239136 [Multi-domain] Cd Length: 332 Bit Score: 98.43 E-value: 4.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 42 CSAWDSPHGLVGLHNIGQTCCLNSLLQVFMMNMDFRMILKRITVPRSAEERKRSVpfqlLLLLEKMQDSRQKAVLPTELV 121
Cdd:cd02671 15 CEKRENLLPFVGLNNLGNTCYLNSVLQVLYFCPGFKHGLKHLVSLISSVEQLQSS----FLLNPEKYNDELANQAPRRLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 122 QCLQKYNvPLF---VQHDAAQLYLTIWNLTKDQitdtdLTERLQGLFTIWTQesliCVGCTAESSRRSKLLTLSLPL--- 195
Cdd:cd02671 91 NALREVN-PMYegyLQHDAQEVLQCILGNIQEL-----VEKDFQGQLVLRTR----CLECETFTERREDFQDISVPVqes 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 196 ------FDKDAKP-----LKTLEDALRCFVQPKELASSD-MCCESCGEKTPWKQVLKLTHLPQTLTIHLMRFSARNSRTE 263
Cdd:cd02671 161 elskseESSEISPdpkteMKTLKWAISQFASVERIVGEDkYFCENCHHYTEAERSLLFDKLPEVITIHLKCFAANGSEFD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 264 KI--CHSVNFPQSLDFsqVLPTEEdlGDTKEQSEIhYELFAVIAHVGMA-DFGHYCAYIRnpvdgkWFCFNDSHVCWVTW 340
Cdd:cd02671 241 CYggLSKVNTPLLTPL--KLSLEE--WSTKPKNDV-YRLFAVVMHSGATiSSGHYTAYVR------WLLFDDSEVKVTEE 309
|
330 340
....*....|....*....|...
gi 188035917 341 KDVQCTYGNHRyRWRETAYLLVY 363
Cdd:cd02671 310 KDFLEALSPNT-SSTSTPYLLFY 331
|
|
| Peptidase_C19K |
cd02667 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
53-363 |
1.54e-22 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239132 [Multi-domain] Cd Length: 279 Bit Score: 95.92 E-value: 1.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 53 GLHNIGQTCCLNSLLQVFmmnmdfrmilkritvprsaeerkrsvpFQLLLLLEKMQDSrqkavlPTELVQCLQKYNVPL- 131
Cdd:cd02667 1 GLSNLGNTCFFNAVMQNL---------------------------SQTPALRELLSET------PKELFSQVCRKAPQFk 47
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 132 -FVQHDAAQL--YLTiwnltkdqitdTDLTERLQGLFTIWTQESLICVGCTAESSRRSKLLTLSLPLFDkDAKPLKTLED 208
Cdd:cd02667 48 gYQQQDSHELlrYLL-----------DGLRTFIDSIFGGELTSTIMCESCGTVSLVYEPFLDLSLPRSD-EIKSECSIES 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 209 ALRCFVQPKELASSDM-CCESCGEKTpwKQVLkLTHLPQTLTIHLMRFSA-RNSRTEKICHSVNFPQSLDFSQVLPTEED 286
Cdd:cd02667 116 CLKQFTEVEILEGNNKfACENCTKAK--KQYL-ISKLPPVLVIHLKRFQQpRSANLRKVSRHVSFPEILDLAPFCDPKCN 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 287 LGDTKEQSEihYELFAVIAHVGMADFGHYCAYI--RNPVD-------------------GKWFCFNDSHVCWVTWKDVQc 345
Cdd:cd02667 193 SSEDKSSVL--YRLYGVVEHSGTMRSGHYVAYVkvRPPQQrlsdltkskpaadeagpgsGQWYYISDSDVREVSLEEVL- 269
|
330
....*....|....*...
gi 188035917 346 tygnhryrwRETAYLLVY 363
Cdd:cd02667 270 ---------KSEAYLLFY 278
|
|
| Peptidase_C19B |
cd02658 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
53-336 |
1.28e-18 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239123 [Multi-domain] Cd Length: 311 Bit Score: 85.45 E-value: 1.28e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 53 GLHNIGQTCCLNSLLQV-----------FMMNMDFRMILKRITVPRSAEERK-----RSVPFQLLLLLEKMQDSRQKAVL 116
Cdd:cd02658 1 GLRNLGNSCYLNSVLQVlfsipsfqwryDDLENKFPSDVVDPANDLNCQLIKladglLSGRYSKPASLKSENDPYQVGIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 117 PTELVQCLQKYNvPLFV---QHDAAQ--LYLtIWNLTKD--QITDTDLTErlqgLFTIWTQESLICVGCTAESSRRSKLL 189
Cdd:cd02658 81 PSMFKALIGKGH-PEFStmrQQDALEflLHL-IDKLDREsfKNLGLNPND----LFKFMIEDRLECLSCKKVKYTSELSE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 190 TLSLPL-------FDKDAKPLK--TLEDALRCFVQPKELassDMCCESCGEKTPWKQVLKLTHLPQTLTIHLMRFSArns 260
Cdd:cd02658 155 ILSLPVpkdeateKEEGELVYEpvPLEDCLKAYFAPETI---EDFCSTCKEKTTATKTTGFKTFPDYLVINMKRFQL--- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 261 rtekichSVNF-PQSLDFSQVLPteEDLGDTKeqseihYELFAVIAHVGM-ADFGHYCAYIRNPVD--GKWFCFNDSHVC 336
Cdd:cd02658 229 -------LENWvPKKLDVPIDVP--EELGPGK------YELIAFISHKGTsVHSGHYVAHIKKEIDgeGKWVLFNDEKVV 293
|
|
| Peptidase_C19G |
cd02663 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
53-364 |
6.27e-18 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239128 [Multi-domain] Cd Length: 300 Bit Score: 83.13 E-value: 6.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 53 GLHNIGQTCCLNSLLQ-VFMMNMdfrmilkritvprsaeerkrsvpFQLL-LLLEKMQDSRQK--AVLPTELVQCLQKYN 128
Cdd:cd02663 1 GLENFGNTCYCNSVLQaLYFENL-----------------------LTCLkDLFESISEQKKRtgVISPKKFITRLKREN 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 129 vPLF---VQHDAAQLY---------------------LTIWNLTKDQITDTDLTERLQGLFTIWTQesliCVGCTAESSR 184
Cdd:cd02663 58 -ELFdnyMHQDAHEFLnfllneiaeildaerkaekanRKLNNNNNAEPQPTWVHEIFQGILTNETR----CLTCETVSSR 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 185 RSKLLTLSLplfdkDAKPLKTLEDALRCFVQPKELASSD-MCCESCGEKTPWKQVLKLTHLPQTLTIHLMRF--SARNSR 261
Cdd:cd02663 133 DETFLDLSI-----DVEQNTSITSCLRQFSATETLCGRNkFYCDECCSLQEAEKRMKIKKLPKILALHLKRFkyDEQLNR 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 262 TEKICHSVNFPQSLdfsQVLPTEEDlgdtKEQSEIHYELFAVIAHVGM-ADFGHYCAYIRnpVDGKWFCFNDSHVCWVTW 340
Cdd:cd02663 208 YIKLFYRVVFPLEL---RLFNTTDD----AENPDRLYELVAVVVHIGGgPNHGHYVSIVK--SHGGWLLFDDETVEKIDE 278
|
330 340
....*....|....*....|....
gi 188035917 341 KDVQCTYGNHRYrwRETAYLLVYT 364
Cdd:cd02663 279 NAVEEFFGDSPN--QATAYVLFYQ 300
|
|
| COG5533 |
COG5533 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
53-366 |
1.14e-17 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444284 [Multi-domain] Cd Length: 284 Bit Score: 82.16 E-value: 1.14e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 53 GLHNIGQTCCLNSLLQVFMMNMDfrmilkritvprSAEERKRSVPFQLLLLLEKMQDSRQ--KAVLPTELVQCLQKYNVP 130
Cdd:COG5533 1 GLPNLGNTCFMNSVLQILALYLP------------KLDELLDDLSKELKVLKNVIRKPEPdlNQEEALKLFTALWSSKEH 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 131 LFVQhdaaqlyltiwnlTKDQITDTDLTERLQGLF------TIWTQESLIcvGCTAESSRRSKL-----LTLSLPLFDKD 199
Cdd:COG5533 69 KVGW-------------IPPMGSQEDAHELLGKLLdelkldLVNSFTIRI--FKTTKDKKKTSTgdwfdIIIELPDQTWV 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 200 aKPLKTLEdalrCFVQPKELASSDMCCESCGEKTPWKQVLKLTH------LPQTLTIHLMRFSARNSRTeKICHSVNFPQ 273
Cdd:COG5533 134 -NNLKTLQ----EFIDNMEELVDDETGVKAKENEELEVQAKQEYevsfvkLPKILTIQLKRFANLGGNQ-KIDTEVDEKF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 274 SLDFSqvlpTEEDLGDTKEqseIHYELFAVIAHVGMADFGHYCAYIRnpVDGKWFCFNDSHVCWVTWKDVQCTYgnhryr 353
Cdd:COG5533 208 ELPVK----HDQILNIVKE---TYYDLVGFVLHQGSLEGGHYIAYVK--KGGKWEKANDSDVTPVSEEEAINEK------ 272
|
330
....*....|...
gi 188035917 354 wRETAYLLVYTKT 366
Cdd:COG5533 273 -AKNAYLYFYERI 284
|
|
| Peptidase_C19J |
cd02666 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
52-363 |
1.24e-17 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239131 [Multi-domain] Cd Length: 343 Bit Score: 82.92 E-value: 1.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 52 VGLHNIGQTCCLNSLLQVF---------MMNMD---FRMILKRITVPR------SAEERKRSVPF--QLLLLLEKMQDSR 111
Cdd:cd02666 2 AGLDNIGNTCYLNSLLQYFftikplrdlVLNFDeskAELASDYPTERRiggrevSRSELQRSNQFvyELRSLFNDLIHSN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 112 QKAVLPT-ELV----------QCLQkyNVpLFvQHDAAQLYLTIWNLTKDQITDTDLTERLQGLFTIWTQESLICVGCTA 180
Cdd:cd02666 82 TRSVTPSkELAylalrqqdvtECID--NV-LF-QLEVALEPISNAFAGPDTEDDKEQSDLIKRLFSGKTKQQLVPESMGN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 181 ESSRRSKLLT-LSLPLFDKDAKPL-------KTLEDAL-RCFVQpkelassdmccESCGEKTPWKQVLKltHLPQTLTIH 251
Cdd:cd02666 158 QPSVRTKTERfLSLLVDVGKKGREivvllepKDLYDALdRYFDY-----------DSLTKLPQRSQVQA--QLAQPLQRE 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 252 LMRFSARN-----SRTEKICHSVNFPQSldfSQVLPTEEDLGDTKEQSE--------IHYELFAVIAHVGMADFGHYCAY 318
Cdd:cd02666 225 LISMDRYElpssiDDIDELIREAIQSES---SLVRQAQNELAELKHEIEkqfddlksYGYRLHAVFIHRGEASSGHYWVY 301
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 188035917 319 IRNPVDGKWFCFNDSHVCWVTWKDV-QCTYGNhryrwRETAYLLVY 363
Cdd:cd02666 302 IKDFEENVWRKYNDETVTVVPASEVfLFTLGN-----TATPYFLVY 342
|
|
| Peptidase_C19F |
cd02662 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
53-363 |
1.69e-15 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239127 [Multi-domain] Cd Length: 240 Bit Score: 75.10 E-value: 1.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 53 GLHNIGQTCCLNSLLQVFmmnmdfrmilkritvprsaeerkrsvpfqlllllekmqdsrqkAVLPtELVQCLQKYNVplf 132
Cdd:cd02662 1 GLVNLGNTCFMNSVLQAL-------------------------------------------ASLP-SLIEYLEEFLE--- 33
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 133 vQHDAAQLYLtiwnltkdQITDTdLTERLQGLFTIWTQESLICVGCTAESS-RRSKLLTLSLPLFDKDAKPLKTLEDALR 211
Cdd:cd02662 34 -QQDAHELFQ--------VLLET-LEQLLKFPFDGLLASRIVCLQCGESSKvRYESFTMLSLPVPNQSSGSGTTLEHCLD 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 212 CFVQPKELasSDMCCESCGektpwkqvLKLTHLPQTLTIHLMR--FSARNSRTEKICHsVNFPQSLdfSQVLpteedlgd 289
Cdd:cd02662 104 DFLSTEII--DDYKCDRCQ--------TVIVRLPQILCIHLSRsvFDGRGTSTKNSCK-VSFPERL--PKVL-------- 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 290 tkeqseihYELFAVIAHVGMADFGHYCAYIRNPV--------------------DGKWFCFNDSHVCWVTWKDVQCTYGn 349
Cdd:cd02662 163 --------YRLRAVVVHYGSHSSGHYVCYRRKPLfskdkepgsfvrmregpsstSHPWWRISDTTVKEVSESEVLEQKS- 233
|
330
....*....|....
gi 188035917 350 hryrwretAYLLVY 363
Cdd:cd02662 234 --------AYMLFY 239
|
|
| Peptidase_C19M |
cd02669 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
33-335 |
3.08e-14 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239134 [Multi-domain] Cd Length: 440 Bit Score: 73.51 E-value: 3.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 33 RKRVLSRDLCSAWDSPhGLVGLHNIGQTCCLNSLLQVFMMNMDFRMILKRITVPRSAEERKRSVPFQLLLLLEKMQDSRQ 112
Cdd:cd02669 102 RDPKLSRDLDGKPYLP-GFVGLNNIKNNDYANVIIQALSHVKPIRNFFLLYENYENIKDRKSELVKRLSELIRKIWNPRN 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 113 -KAVL-PTELVQCLQKY---NVPLFVQHDAAQLYLTIWNLTKDQITDTD------LTERLQGLFTIWTQE---------- 171
Cdd:cd02669 181 fKGHVsPHELLQAVSKVskkKFSITEQSDPVEFLSWLLNTLHKDLGGSKkpnssiIHDCFQGKVQIETQKikphaeeegs 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 172 -SLICVGCTAESSRRSKLLTLSL-----PLF----DKDAKPLKTLEDALRCFVQPKELASSDMccescgektpwKQVLKL 241
Cdd:cd02669 261 kDKFFKDSRVKKTSVSPFLLLTLdlpppPLFkdgnEENIIPQVPLKQLLKKYDGKTETELKDS-----------LKRYLI 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 242 THLPQTLTIHLMRFSARNSRTEKICHSVNFPQS-LDFSQVLPTEEDLGdtkeQSEIHYELFAVIAHVGM-ADFGHYCAYI 319
Cdd:cd02669 330 SRLPKYLIFHIKRFSKNNFFKEKNPTIVNFPIKnLDLSDYVHFDKPSL----NLSTKYNLVANIVHEGTpQEDGTWRVQL 405
|
330
....*....|....*.
gi 188035917 320 RNPVDGKWFCFNDSHV 335
Cdd:cd02669 406 RHKSTNKWFEIQDLNV 421
|
|
| UCH_1 |
pfam13423 |
Ubiquitin carboxyl-terminal hydrolase; |
161-335 |
1.16e-13 |
|
Ubiquitin carboxyl-terminal hydrolase;
Pssm-ID: 463872 [Multi-domain] Cd Length: 305 Bit Score: 70.76 E-value: 1.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 161 LQGLFTIWTQESLICVGCTAESSRRSKLLTLSL----PLFDKDAKPLKT-----LEDALRCFVQPKelassdMCCESCGE 231
Cdd:pfam13423 128 LEQLFGIDAETTIRCSNCGHESVRESSTHVLDLiyprKPSSNNKKPPNQtfssiLKSSLERETTTK------AWCEKCKR 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 232 KTPWKQVLKLTHLPQTLTIHLMRFSARNSRTEKichSVNFpqsldfsqvLPTE----EDLGDTKEQSEIHYELFAVIAHV 307
Cdd:pfam13423 202 YQPLESRRTVRNLPPVLSLNAALTNEEWRQLWK---TPGW---------LPPEigltLSDDLQGDNEIVKYELRGVVVHI 269
|
170 180 190
....*....|....*....|....*....|....*.
gi 188035917 308 GMADF-GHYCAYIR-------NPVDGKWFCFNDSHV 335
Cdd:pfam13423 270 GDSGTsGHLVSFVKvadseleDPTESQWYLFNDFLV 305
|
|
| Peptidase_C19I |
cd02665 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
242-363 |
3.63e-12 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239130 [Multi-domain] Cd Length: 228 Bit Score: 65.27 E-value: 3.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 242 THLPQTLTIHLMRFSARNSRTEKICHSVNFPQSLdfsqvlpteedlgdtkeqSEIHYELFAVIAHVGMADFGHYCAYIRN 321
Cdd:cd02665 126 TELPPVLTFELSRFEFNQGRPEKIHDKLEFPQII------------------QQVPYELHAVLVHEGQANAGHYWAYIYK 187
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 188035917 322 PVDGKWFCFNDSHVCWVTWKDVQC-TYGNHRyrwRETAYLLVY 363
Cdd:cd02665 188 QSRQEWEKYNDISVTESSWEEVERdSFGGGR---NPSAYCLMY 227
|
|
| Peptidase_C19P |
cd02672 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
174-332 |
3.68e-04 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239137 [Multi-domain] Cd Length: 268 Bit Score: 41.73 E-value: 3.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 174 ICVGCTAESSrrSKLLTLSLPLfdkDAKPLKTLEDALRCFVQPKELASSDMC-CESCGEKTPWKQVLKLTHLPQT----L 248
Cdd:cd02672 89 FSCGTSRNSV--SLLYTLSLPL---GSTKTSKESTFLQLLKRSLDLEKVTKAwCDTCCKYQPLEQTTSIRHLPDIlllvL 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 249 TIHLMRFSarnsrTEKICHSVNFPQSLDFSQ-VLPTEEDLGDTKEQSEIH----YELFAVIAHVGMADFG-HYCAYIR-- 320
Cdd:cd02672 164 VINLSVTN-----GEFDDINVVLPSGKVMQNkVSPKAIDHDKLVKNRGQEsiykYELVGYVCEINDSSRGqHNVVFVIkv 238
|
170
....*....|....
gi 188035917 321 --NPVDGKWFCFND 332
Cdd:cd02672 239 neESTHGRWYLFND 252
|
|
| Peptidase_C19Q |
cd02673 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
54-343 |
7.65e-04 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239138 [Multi-domain] Cd Length: 245 Bit Score: 40.59 E-value: 7.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 54 LHNIGQTCCLNSLLQ----VFMMNMDFrmilkritvprsAEERKRSVPFQLLLLLEKMQDsrqkavlptelvqcLQKYNV 129
Cdd:cd02673 2 LVNTGNSCYFNSTMQalssIGKINTEF------------DNDDQQDAHEFLLTLLEAIDD--------------IMQVNR 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 130 PLFVqhdaaqlyltiwnltkdqiTDTDLTERLQGL--FTIWTQESLICVGCTAESSRRSKLLTLSLPLFDKDakpLKTLE 207
Cdd:cd02673 56 TNVP-------------------PSNIEIKRLNPLeaFKYTIESSYVCIGCSFEENVSDVGNFLDVSMIDNK---LDIDE 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188035917 208 DALRCFVQPKElasSDMCCESCGEKTPwKQVLKLTHLPQTLTIHLMRFSARNSrtekichsvnfpqsldfsqvlpTEEDL 287
Cdd:cd02673 114 LLISNFKTWSP---IEKDCSSCKCESA-ISSERIMTFPECLSINLKRYKLRIA----------------------TSDYL 167
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 188035917 288 GDTKE-----QSEI-HYELFAVIAHVG-MADFGHYCAYIRNPVDG-KWFCFNDSHVCWVTWKDV 343
Cdd:cd02673 168 KKNEEimkkyCGTDaKYSLVAVICHLGeSPYDGHYIAYTKELYNGsSWLYCSDDEIRPVSKNDV 231
|
|
| |
