NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|47059075|ref|NP_034684|]
View 

interleukin-1 alpha [Mus musculus]

Protein Classification

IL1_propep and beta-trefoil_IL1B domain-containing protein( domain architecture ID 10493286)

IL1_propep and beta-trefoil_IL1B domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_IL1A cd23295
beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, ...
 125-270 3.72e-80

beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, also called hematopoietin-1, is a potent inflammatory cytokine that activates the inflammatory process. It is produced by activated macrophages. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 alpha contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


:

Pssm-ID: 466777  Cd Length: 145  Bit Score: 238.00  E-value: 3.72e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059075 125 RYKLMKLVRQKFVMNDSLNQTIYQDVDKHyLSTTWLNDLQQEVKFDMYAYSSGGDDSKYPVTLKISDSQLFVSAQGEDQP 204
Cdd:cd23295   1 KYNFIRIIKQQFILNDALNQSIIRDPSQH-LKAAALQNLDEEVKFDIGAYKSLDDDYKIPVTLRISNTQLFVSAQGEDEP 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47059075 205 VLLKELPETPKLITGSETDLIFFWKSINSKNYFTSAAYPELFIATKEQSRVHLARGLPSMTDFQIS 270
Cdd:cd23295  80 VLLKEMPETPKTITGSETNLLFFWEEHGTKNFFSSAANPELFAATKQDELVHLARGLPSITDFQIL 145
IL1_propep pfam02394
Interleukin-1 propeptide; The Interleukin-1 cytokines are translated as precursor proteins. ...
 1-111 1.37e-45

Interleukin-1 propeptide; The Interleukin-1 cytokines are translated as precursor proteins. The N terminal approx. 115 amino acids form a propeptide that is cleaved off to release the active interleukin-1.


:

Pssm-ID: 426754  Cd Length: 106  Bit Score: 148.62  E-value: 1.37e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059075     1 MAKVPDLFEDLKNCYSENEDYSSAIDHLSLNqKSFYDASYGSLHETCTDQFVSLRTSETSKMSnfTFKESRVTVSATssn 80
Cdd:pfam02394   1 MAKVPELFEDLMACYSENEEFFEADGPLSLK-KSFQDLDLGPLHEDCMDKGIQLQISEQSKNS--SFKESVVVVVAV--- 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 47059075    81 gKILKKRRLSFSETFTEDDLQSITHDL--EETI 111
Cdd:pfam02394  75 -EKLKKRRLSCSQFFQDDDLEAIFSDIfeEEPI 106
 
Name Accession Description Interval E-value
beta-trefoil_IL1A cd23295
beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, ...
 125-270 3.72e-80

beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, also called hematopoietin-1, is a potent inflammatory cytokine that activates the inflammatory process. It is produced by activated macrophages. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 alpha contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466777  Cd Length: 145  Bit Score: 238.00  E-value: 3.72e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059075 125 RYKLMKLVRQKFVMNDSLNQTIYQDVDKHyLSTTWLNDLQQEVKFDMYAYSSGGDDSKYPVTLKISDSQLFVSAQGEDQP 204
Cdd:cd23295   1 KYNFIRIIKQQFILNDALNQSIIRDPSQH-LKAAALQNLDEEVKFDIGAYKSLDDDYKIPVTLRISNTQLFVSAQGEDEP 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47059075 205 VLLKELPETPKLITGSETDLIFFWKSINSKNYFTSAAYPELFIATKEQSRVHLARGLPSMTDFQIS 270
Cdd:cd23295  80 VLLKEMPETPKTITGSETNLLFFWEEHGTKNFFSSAANPELFAATKQDELVHLARGLPSITDFQIL 145
IL1 smart00125
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ...
 131-270 1.92e-59

Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin.


Pssm-ID: 128430  Cd Length: 147  Bit Score: 185.66  E-value: 1.92e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059075    131 LVRQKFVMNDSlNQTIYQDVDKHYLSTTWLN--DLQQEVKFDMYAYSSGGDDSKYPVTLKISDSQLFVSAQGE-DQPVLL 207
Cdd:smart00125   1 VISQECRLNDA-NQKSLVLSNPQYLKALHLNgqNLNQEVKFDMSFVQGEEDDSKIPVTLGISGTNLYLSCVKKgDEPTLQ 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47059075    208 KELPETPKLITgSETDLIFFWKS--INSKNYFTSAAYPELFIATK--EQSRVHLARGLPS--MTDFQIS 270
Cdd:smart00125  80 LEMVDPPKYPK-KEMEKRFVFEKheIGNKVEFESAAHPNWFISTSqeEDKPVFLGNGPPSqdITDFQME 147
IL1 pfam00340
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.
 158-269 7.23e-48

Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.


Pssm-ID: 395269  Cd Length: 119  Bit Score: 154.92  E-value: 7.23e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059075   158 TWLNDLQQEVKFDMYAYSSGGDDSKYPVTLKISDSQLFVSAQGEDQPVLLKELPETPKLITGSETDLIFFWKSINSKNY- 236
Cdd:pfam00340   1 LQGQNLNLEVKFDMSFYKGDSDDSKIPVTLGIKGKKLYLSCVNKDEPVLQLEEVNIPKLIKNKESDKRFFFIRSESKNYv 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 47059075   237 -FTSAAYPELFIATKEQ-----SRVHLARGLPSMTDFQI 269
Cdd:pfam00340  81 eFESAAYPGWFIATKQEedlpvFLVNTAGGQDSITDFQI 119
IL1_propep pfam02394
Interleukin-1 propeptide; The Interleukin-1 cytokines are translated as precursor proteins. ...
 1-111 1.37e-45

Interleukin-1 propeptide; The Interleukin-1 cytokines are translated as precursor proteins. The N terminal approx. 115 amino acids form a propeptide that is cleaved off to release the active interleukin-1.


Pssm-ID: 426754  Cd Length: 106  Bit Score: 148.62  E-value: 1.37e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059075     1 MAKVPDLFEDLKNCYSENEDYSSAIDHLSLNqKSFYDASYGSLHETCTDQFVSLRTSETSKMSnfTFKESRVTVSATssn 80
Cdd:pfam02394   1 MAKVPELFEDLMACYSENEEFFEADGPLSLK-KSFQDLDLGPLHEDCMDKGIQLQISEQSKNS--SFKESVVVVVAV--- 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 47059075    81 gKILKKRRLSFSETFTEDDLQSITHDL--EETI 111
Cdd:pfam02394  75 -EKLKKRRLSCSQFFQDDDLEAIFSDIfeEEPI 106
 
Name Accession Description Interval E-value
beta-trefoil_IL1A cd23295
beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, ...
 125-270 3.72e-80

beta-trefoil domain found in interleukin-1 alpha (IL-1 alpha) and similar proteins; IL-1 alpha, also called hematopoietin-1, is a potent inflammatory cytokine that activates the inflammatory process. It is produced by activated macrophages. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 alpha contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466777  Cd Length: 145  Bit Score: 238.00  E-value: 3.72e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059075 125 RYKLMKLVRQKFVMNDSLNQTIYQDVDKHyLSTTWLNDLQQEVKFDMYAYSSGGDDSKYPVTLKISDSQLFVSAQGEDQP 204
Cdd:cd23295   1 KYNFIRIIKQQFILNDALNQSIIRDPSQH-LKAAALQNLDEEVKFDIGAYKSLDDDYKIPVTLRISNTQLFVSAQGEDEP 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47059075 205 VLLKELPETPKLITGSETDLIFFWKSINSKNYFTSAAYPELFIATKEQSRVHLARGLPSMTDFQIS 270
Cdd:cd23295  80 VLLKEMPETPKTITGSETNLLFFWEEHGTKNFFSSAANPELFAATKQDELVHLARGLPSITDFQIL 145
IL1 smart00125
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ...
 131-270 1.92e-59

Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin.


Pssm-ID: 128430  Cd Length: 147  Bit Score: 185.66  E-value: 1.92e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059075    131 LVRQKFVMNDSlNQTIYQDVDKHYLSTTWLN--DLQQEVKFDMYAYSSGGDDSKYPVTLKISDSQLFVSAQGE-DQPVLL 207
Cdd:smart00125   1 VISQECRLNDA-NQKSLVLSNPQYLKALHLNgqNLNQEVKFDMSFVQGEEDDSKIPVTLGISGTNLYLSCVKKgDEPTLQ 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47059075    208 KELPETPKLITgSETDLIFFWKS--INSKNYFTSAAYPELFIATK--EQSRVHLARGLPS--MTDFQIS 270
Cdd:smart00125  80 LEMVDPPKYPK-KEMEKRFVFEKheIGNKVEFESAAHPNWFISTSqeEDKPVFLGNGPPSqdITDFQME 147
IL1 pfam00340
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.
 158-269 7.23e-48

Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18.


Pssm-ID: 395269  Cd Length: 119  Bit Score: 154.92  E-value: 7.23e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059075   158 TWLNDLQQEVKFDMYAYSSGGDDSKYPVTLKISDSQLFVSAQGEDQPVLLKELPETPKLITGSETDLIFFWKSINSKNY- 236
Cdd:pfam00340   1 LQGQNLNLEVKFDMSFYKGDSDDSKIPVTLGIKGKKLYLSCVNKDEPVLQLEEVNIPKLIKNKESDKRFFFIRSESKNYv 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 47059075   237 -FTSAAYPELFIATKEQ-----SRVHLARGLPSMTDFQI 269
Cdd:pfam00340  81 eFESAAYPGWFIATKQEedlpvFLVNTAGGQDSITDFQI 119
IL1_propep pfam02394
Interleukin-1 propeptide; The Interleukin-1 cytokines are translated as precursor proteins. ...
 1-111 1.37e-45

Interleukin-1 propeptide; The Interleukin-1 cytokines are translated as precursor proteins. The N terminal approx. 115 amino acids form a propeptide that is cleaved off to release the active interleukin-1.


Pssm-ID: 426754  Cd Length: 106  Bit Score: 148.62  E-value: 1.37e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059075     1 MAKVPDLFEDLKNCYSENEDYSSAIDHLSLNqKSFYDASYGSLHETCTDQFVSLRTSETSKMSnfTFKESRVTVSATssn 80
Cdd:pfam02394   1 MAKVPELFEDLMACYSENEEFFEADGPLSLK-KSFQDLDLGPLHEDCMDKGIQLQISEQSKNS--SFKESVVVVVAV--- 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 47059075    81 gKILKKRRLSFSETFTEDDLQSITHDL--EETI 111
Cdd:pfam02394  75 -EKLKKRRLSCSQFFQDDDLEAIFSDIfeEEPI 106
beta-trefoil_IL1 cd00100
beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of ...
 136-269 8.69e-20

beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of cytokines comprises 11 members, including 7 pro-inflammatory agonists (IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, IL-36gamma) and 4 defined or putative antagonists (IL-1R antagonist (IL-1Ra), IL-36Ra, IL-37, and IL-38) exerting anti-inflammatory activities. These members can have complimentary or distinct biological functions. All family members share a common structure at the C-terminus, which is comprised by of a typical beta-trefoil fold consisting of 12-beta-strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466776  Cd Length: 145  Bit Score: 83.14  E-value: 8.69e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059075 136 FVMNDSLNQTIYQDVDKhYLSTTWLNDLQQEVKFDMYAYSS--GGDDSKYPVTLKISDSQLFVSAQ--GEDQPVLLKELP 211
Cdd:cd00100   5 FVIRDSNDKSLYLRGNN-ELVAEDLSDVEKSAKITIYYYKSdsDEDFKGIPVVLNFTGTNCFLSCVkeGDKPSLQLEECN 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47059075 212 ETP-KLITGSETDLIFFWKSI-NSKNYFTSAAYPELFIATKEQSRVHLARGL--PSMTDFQI 269
Cdd:cd00100  84 KEElKNGDEEEWPFVFYMKAShDNTCRFESAAHPGWFICTKKDQPVGLTKELgkTEDTDFYF 145
beta-trefoil_IL1B cd23296
beta-trefoil domain found in interleukin-1 beta (IL-1 beta) and similar proteins; IL-1 beta, ...
 161-270 9.23e-11

beta-trefoil domain found in interleukin-1 beta (IL-1 beta) and similar proteins; IL-1 beta, also called catabolin, is a potent inflammatory cytokine that activates the inflammatory process. It was initially discovered as the major endogenous pyrogen. It induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. IL-1 beta promotes Th17 differentiation of T-cells and synergizes with IL12/interleukin-12 to induce IFN-gamma synthesis from T-helper 1 (Th1) cells. It plays a role in angiogenesis by inducing vascular endothelial growth factor (VEGF) production synergistically with tumor necrosis factor (TNF) and IL-6. IL-1 beta contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466778  Cd Length: 150  Bit Score: 58.78  E-value: 9.23e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059075 161 NDLQQEVKFDMYAY-SSGGDDSKYPVTLKISDSQLFVSAQGE-DQPVL-LKELPETPKLITGSETDLIFFwKSINSKNYF 237
Cdd:cd23296  33 PNSSQEVKLNMSFYrSPESNGGKIPVALGIKGKNLYLSCVKKgDKPTLqLEEVDPKNDSKSKDLKRFLFY-KIESIGSTT 111

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47059075 238 T--SAAYPELFIAT--KEQSRVHLA--RGLPSMTDFQIS 270
Cdd:cd23296 112 TfeSAAFPGWYISTsqAENQPVFLGnqKGQQRITDFTLQ 150
beta-trefoil_IL18 cd23298
beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called ...
 166-256 9.63e-04

beta-trefoil domain found in interleukin-18 (IL-18) and similar proteins; IL-18, also called Iboctadekin, or interferon gamma-inducing factor, or IFN-gamma-inducing factor, or interleukin-1 gamma, or IL-1 gamma, is a proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, it forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. IL-18 works synergistically with IL12/interleukin-12 to induce IFN-gamma synthesis from Th1 cells and natural killer (NK) cells. IL-18 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466780  Cd Length: 149  Bit Score: 38.73  E-value: 9.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059075 166 EVKFDMYAYSSGGDDSKYPVTLKI-SDSQLFVSAQGEDQPVLLKELpETPKLITGSETDLIFFWK--SINSKNY-FTSAA 241
Cdd:cd23298  37 DCKFTIQIYKDTSPPRGLPVALYVkKDGKTYVLCCEENKEIRFKEM-DLPDDIEGTKSDAIFYQKkfPGGTNKYkFESSL 115

                        90
                ....*....|....*
gi 47059075 242 YPELFIATKEQSRVH 256
Cdd:cd23298 116 YPGYFLAFEPENDLF 130
beta-trefoil_IL1RA cd23297
beta-trefoil domain found in interleukin-1 receptor antagonist protein (IL-1RA) and similar ...
 182-266 4.26e-03

beta-trefoil domain found in interleukin-1 receptor antagonist protein (IL-1RA) and similar proteins; IL-1RA, also called IL-1RN, or IRAP, or ICIL-1RA, or IL1 inhibitor, inhibits the activity of interleukin-1 (IL-1) by binding to receptor IL1R1 and preventing its association with the co-receptor IL1RAP for signaling. It has no IL-1 like activity. IL-1RN binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unknown. IL-1RN contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.


Pssm-ID: 466779  Cd Length: 149  Bit Score: 36.65  E-value: 4.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059075 182 KYPVTLKISDSQLFVSAQ-GEDQPVL------LKELPETPKlitgSETDLIFFWKSINSKNYFTSAAYPELFIATkeQSR 254
Cdd:cd23297  51 PLPVILGIHDGSRCLSCVkSGDEPRLqledvdITDLPRNGK----QSARFTFFRSYRDGLWRFESAAHPGWFLCT--SMR 124

                        90
                ....*....|..
gi 47059075 255 VHLARGLPSMTD 266
Cdd:cd23297 125 ADQPVSLTNMPD 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH