|
Name |
Accession |
Description |
Interval |
E-value |
| 4-S |
cd16029 |
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ... |
46-489 |
0e+00 |
|
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.
Pssm-ID: 293753 [Multi-domain] Cd Length: 393 Bit Score: 628.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHGS-VIRTPHLDALAAGGVVLDNYYVQPLCTPSRSQLLTGRYQIHLGLQHYLIMTCQPSCVP 124
Cdd:cd16029 1 PHIVFILADDLGWNDVGFHGSdQIKTPNLDALAADGVILNNYYVQPICTPSRAALMTGRYPIHTGMQHGVILAGEPYGLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 125 LDEKLLPQLLKEAGYATHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYTHEACAPIESLNgtrcaLDLRDGEEPA 204
Cdd:cd16029 81 LNETLLPQYLKELGYATHLVGKWHLGFYTWEYTPTNRGFDSFYGYYGGAEDYYTHTSGGANDYGN-----DDLRDNEEPA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 205 KEYNNIYSTNIFTKRATTVIANHPPEKPLFLYLAFQSVHDPLQVPEEYMEPY----GFIQDKHRRIYAGMVSLMDEAVGN 280
Cdd:cd16029 156 WDYNGTYSTDLFTDRAVDIIENHDPSKPLFLYLAFQAVHAPLQVPPEYADPYedkfAHIKDEDRRTYAAMVSALDESVGN 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 281 VTKALKSHGLWNNTVFIFSTDNGGQTRSG--GNNWPLRGRKGTLWEGGIRGTGFVASPLLK-QKGVKSRELMHITDWLPT 357
Cdd:cd16029 236 VVDALKAKGMLDNTLIVFTSDNGGPTGGGdgGSNYPLRGGKNTLWEGGVRVPAFVWSPLLPpKRGTVSDGLMHVTDWLPT 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 358 LVDLAGGSTNGTKPLDGFNMWKTISEGHPSPRVELLHNIDQDffdglpcpgknmtpakddsfplehsaFNTSIHAGIRYK 437
Cdd:cd16029 316 LLSLAGGDPDDLPPLDGVDQWDALSGGAPSPRTEILLNIDDI--------------------------TRTTGGAAIRVG 369
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 125656171 438 NWKLLTGHPgcgywfpppsqsnvseippvdpptktlwLFDINQDPEERHDVS 489
Cdd:cd16029 370 DWKLIVGKP----------------------------LFNIENDPCERNDLA 393
|
|
| AslA |
COG3119 |
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
35-508 |
1.41e-101 |
|
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 311.43 E-value: 1.41e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 35 SPARASGATQPPHVVFVLADDLGWNDLGFHGS-VIRTPHLDALAAGGVVLDNYYVQ-PLCTPSRSQLLTGRYQIHLGLQH 112
Cdd:COG3119 13 AAAAAAAAAKRPNILFILADDLGYGDLGCYGNpLIKTPNIDRLAAEGVRFTNAYVTsPVCSPSRASLLTGRYPHRTGVTD 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 113 YLIMTCQPscVPLDEKLLPQLLKEAGYATHMVGKWHLgmyrkeclptrrgfdtyfgyllgsedyytheacapieslngtr 192
Cdd:COG3119 93 NGEGYNGG--LPPDEPTLAELLKEAGYRTALFGKWHL------------------------------------------- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 193 caldlrdgeepakeynniYSTNIFTKRATTVIANH-PPEKPLFLYLAFQSVHDPLQVPEEYMEPYG-------------- 257
Cdd:COG3119 128 ------------------YLTDLLTDKAIDFLERQaDKDKPFFLYLAFNAPHAPYQAPEEYLDKYDgkdiplppnlaprd 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 258 ---FIQDKHRRIYAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGQTRSGGnnwpLRGRKGTLWEGGIRGTGFVA 334
Cdd:COG3119 190 lteEELRRARAAYAAMIEEVDDQVGRLLDALEELGLADNTIVVFTSDNGPSLGEHG----LRGGKGTLYEGGIRVPLIVR 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 335 SPLLKQKGVKSRELMHITDWLPTLVDLAGGSTNgtKPLDGFNMWKTISEGHPSPRvellhnidqdffdglpcpgknmtpa 414
Cdd:COG3119 266 WPGKIKAGSVSDALVSLIDLLPTLLDLAGVPIP--EDLDGRSLLPLLTGEKAEWR------------------------- 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 415 kdDSFPLEHSAFNTsiHAGIRYKNWKLLTGHPGCGYWfpppsqsnvseippvdpptktlWLFDINQDPEERHDVSREHPH 494
Cdd:COG3119 319 --DYLYWEYPRGGG--NRAIRTGRWKLIRYYDDDGPW----------------------ELYDLKNDPGETNNLAADYPE 372
|
490
....*....|....
gi 125656171 495 IVQNLLSRLQYYHE 508
Cdd:COG3119 373 VVAELRALLEAWLK 386
|
|
| ARS_like |
cd16146 |
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ... |
46-508 |
4.27e-101 |
|
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293765 [Multi-domain] Cd Length: 409 Bit Score: 310.64 E-value: 4.27e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHGS-VIRTPHLDALAAGGVVLDNYYVQPLCTPSRSQLLTGRYQIHLGLQH-YL---IMTcqp 120
Cdd:cd16146 1 PNVILILTDDQGYGDLGFHGNpILKTPNLDRLAAESVRFTNFHVSPVCAPTRAALLTGRYPFRTGVWHtILgreRMR--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 121 scvpLDEKLLPQLLKEAGYATHMVGKWHLGM---YRkeclPTRRGFDTYFGYLLG----SEDYYTHEACAPIESLNGTRc 193
Cdd:cd16146 78 ----LDETTLAEVFKDAGYRTGIFGKWHLGDnypYR----PQDRGFDEVLGHGGGgigqYPDYWGNDYFDDTYYHNGKF- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 194 aldlrdgeepaKEYNNiYSTNIFTKRATTVIANHpPEKPLFLYLAFQSVHDPLQVPEEYMEPY---GFIqDKHRRIYaGM 270
Cdd:cd16146 149 -----------VKTEG-YCTDVFFDEAIDFIEEN-KDKPFFAYLATNAPHGPLQVPDKYLDPYkdmGLD-DKLAAFY-GM 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 271 VSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGQTR-SGGNNWPLRGRKGTLWEGGIRGTGFVASPLLKQKGVKSRELM 349
Cdd:cd16146 214 IENIDDNVGRLLAKLKELGLEENTIVIFMSDNGPAGGvPKRFNAGMRGKKGSVYEGGHRVPFFIRWPGKILAGKDVDTLT 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 350 HITDWLPTLVDLAGGSTNGTKPLDGFNMWKTISEG--HPSPRVELLHNIDqdffdglpcpGKNMTPAKDdsfplehsafn 427
Cdd:cd16146 294 AHIDLLPTLLDLCGVKLPEGIKLDGRSLLPLLKGEsdPWPERTLFTHSGR----------WPPPPKKKR----------- 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 428 tsiHAGIRYKNWKLltghpgcgywfpppsqsnvseippVDPPTKTLWLFDINQDPEERHDVSREHPHIVQNLLSRLQYYH 507
Cdd:cd16146 353 ---NAAVRTGRWRL------------------------VSPKGFQPELYDIENDPGEENDVADEHPEVVKRLKAAYEAWW 405
|
.
gi 125656171 508 E 508
Cdd:cd16146 406 D 406
|
|
| GALNS_like |
cd16026 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
45-489 |
6.67e-99 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293750 [Multi-domain] Cd Length: 399 Bit Score: 304.49 E-value: 6.67e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 45 PPHVVFVLADDLGWNDLGFHGS-VIRTPHLDALAAGGVVLDNYYV-QPLCTPSRSQLLTGRYQIHLGLQHYLIMTCQPSC 122
Cdd:cd16026 1 KPNIVVILADDLGYGDLGCYGSpLIKTPNIDRLAAEGVRFTDFYAaAPVCSPSRAALLTGRYPVRVGLPGVVGPPGSKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 123 VPLDEKLLPQLLKEAGYATHMVGKWHLGMyRKECLPTRRGFDTYFGyLLGSEDYYTHeacaPIESLNGTRCALDLRDGEE 202
Cdd:cd16026 81 LPPDEITIAEVLKKAGYRTALVGKWHLGH-QPEFLPTRHGFDEYFG-IPYSNDMWPF----PLYRNDPPGPLPPLMENEE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 203 pAKEYNNIYS--TNIFTKRATTVIANHPpEKPLFLYLAFQSVHDPLQVPEEYmepygfiQDKHRR-IYAGMVSLMDEAVG 279
Cdd:cd16026 155 -VIEQPADQSslTQRYTDEAVDFIERNK-DQPFFLYLAHTMPHVPLFASEKF-------KGRSGAgLYGDVVEELDWSVG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 280 NVTKALKSHGLWNNTVFIFSTDNG---GQTRSGGNNWPLRGRKGTLWEGGIRGTGFVASPLLKQKGVKSRELMHITDWLP 356
Cdd:cd16026 226 RILDALKELGLEENTLVIFTSDNGpwlEYGGHGGSAGPLRGGKGTTWEGGVRVPFIAWWPGVIPAGTVSDELASTMDLLP 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 357 TLVDLAGGSTNGTKPLDGFNMWKTISEGHPSPRVELLHNidqdffdglpcpgknmtpakddsfplehsaFNTSIHAGIRY 436
Cdd:cd16026 306 TLAALAGAPLPEDRVIDGKDISPLLLGGSKSPPHPFFYY------------------------------YDGGDLQAVRS 355
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 125656171 437 KNWKLLtghpgcgywFPPPSQSNVSEIPPVDPPTKTLWLFDINQDPEERHDVS 489
Cdd:cd16026 356 GRWKLH---------LPTTYRTGTDPGGLDPTKLEPPLLYDLEEDPGETYNVA 399
|
|
| ARS_like |
cd16144 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
46-504 |
7.91e-93 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 289.83 E-value: 7.91e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHGS-VIRTPHLDALAAGGVVLDNYYV-QPLCTPSRSQLLTGRYQIHLGLQHYLIMTCQPSC- 122
Cdd:cd16144 1 PNIVLILVDDLGWADLGCYGSkFYETPNIDRLAKEGMRFTQAYAaAPVCSPSRASILTGQYPARLGITDVIPGRRGPPDn 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 123 -----------VPLDEKLLPQLLKEAGYATHMVGKWHLGMyRKECLPTRRGFDTYFGY-LLGSEDYYTHEACAPIESLNg 190
Cdd:cd16144 81 tklipppsttrLPLEEVTIAEALKDAGYATAHFGKWHLGG-EGGYGPEDQGFDVNIGGtGNGGPPSYYFPPGKPNPDLE- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 191 trcalDLRDGEepakeynniYSTNIFTKRATTVIANHPpEKPLFLYLAFQSVHDPLQVPEEYMEPY-----GFIQDKHRR 265
Cdd:cd16144 159 -----DGPEGE---------YLTDRLTDEAIDFIEQNK-DKPFFLYLSHYAVHTPIQARPELIEKYekkkkGLRKGQKNP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 266 IYAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGQTRSGGN---NWPLRGRKGTLWEGGIRGTGFVASPLLKQKG 342
Cdd:cd16144 224 VYAAMIESLDESVGRILDALEELGLADNTLVIFTSDNGGLSTRGGPptsNAPLRGGKGSLYEGGIRVPLIVRWPGVIKPG 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 343 VKSRELMHITDWLPTLVDLAGGSTNGTKPLDGFNMwktiseghpsprVELLHnidqdffdglpcpGKNMTPAKDDSF--- 419
Cdd:cd16144 304 SVSDVPVIGTDLYPTFLELAGGPLPPPQHLDGVSL------------VPLLK-------------GGEADLPRRALFwhf 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 420 PLEHSAFNTSiHAGIRYKNWKLLtghpgcgYWFpppsqsnvsEippvdppTKTLWLFDINQDPEERHDVSREHPHIVQNL 499
Cdd:cd16144 359 PHYHGQGGRP-ASAIRKGDWKLI-------EFY---------E-------DGRVELYNLKNDIGETNNLAAEMPEKAAEL 414
|
....*
gi 125656171 500 LSRLQ 504
Cdd:cd16144 415 KKKLD 419
|
|
| PAS_like |
cd16025 |
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ... |
44-488 |
1.88e-84 |
|
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293749 [Multi-domain] Cd Length: 402 Bit Score: 267.39 E-value: 1.88e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 44 QPPHVVFVLADDLGWNDLGFHGSVIRTPHLDALAAGGVVLDNYYVQPLCTPSRSQLLTGRYQIHLGL-QHYLIMTCQP-- 120
Cdd:cd16025 1 GRPNILLILADDLGFSDLGCFGGEIPTPNLDALAAEGLRFTNFHTTALCSPTRAALLTGRNHHQVGMgTMAELATGKPgy 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 121 -SCVPLDEKLLPQLLKEAGYATHMVGKWHLGMyrkeclptrrgfdtyfgyllgsEDYytheacapieslngtrcaldlrd 199
Cdd:cd16025 81 eGYLPDSAATIAEVLKDAGYHTYMSGKWHLGP----------------------DDY----------------------- 115
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 200 geepakeynniYSTNIFTKRATTVI-ANHPPEKPLFLYLAFQSVHDPLQVPEEYMEPY---------------------- 256
Cdd:cd16025 116 -----------YSTDDLTDKAIEYIdEQKAPDKPFFLYLAFGAPHAPLQAPKEWIDKYkgkydagwdalreerlerqkel 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 257 GFIQ-------------------DKHRR-------IYAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGqtrSGG 310
Cdd:cd16025 185 GLIPadtkltprppgvpawdslsPEEKKlearrmeVYAAMVEHMDQQIGRLIDYLKELGELDNTLIIFLSDNGA---SAE 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 311 NNW------PLRGRKGTLWEGGIRgTGFVASP--LLKQKGVKSRELMHITDWLPTLVDLAG----GSTNG--TKPLDGFN 376
Cdd:cd16025 262 PGWanasntPFRLYKQASHEGGIR-TPLIVSWpkGIKAKGGIRHQFAHVIDIAPTILELAGveypKTVNGvpQLPLDGVS 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 377 MwktiseghpsprvellhnidQDFFDGlpcpgkNMTPAKDDSFPLEHSAfntsiHAGIRYKNWKLLTGHPGcgywfppps 456
Cdd:cd16025 341 L--------------------LPTLDG------AAAPSRRRTQYFELFG-----NRAIRKGGWKAVALHPP--------- 380
|
490 500 510
....*....|....*....|....*....|...
gi 125656171 457 qsnvseippvdPPTKTLW-LFDINQDPEERHDV 488
Cdd:cd16025 381 -----------PGWGDQWeLYDLAKDPSETHDL 402
|
|
| sulfatase_like |
cd16022 |
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
46-376 |
4.77e-81 |
|
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 252.74 E-value: 4.77e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHGS-VIRTPHLDALAAGGVVLDNYYVQ-PLCTPSRSQLLTGRYQIHLGLQHYLIMTCQPscv 123
Cdd:cd16022 1 PNILLIMTDDLGYDDLGCYGNpDIKTPNLDRLAAEGVRFTNAYVAsPVCSPSRASLLTGRYPHRHGVRGNVGNGGGL--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 124 PLDEKLLPQLLKEAGYATHMVGKWHlgmyrkeclptrrgfdtyfgyllgsedyytheacapieslngtrcaldlrdgeep 203
Cdd:cd16022 78 PPDEPTLAELLKEAGYRTALIGKWH------------------------------------------------------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 204 akeynniystniftKRATTVIANHPPEKPLFLYLAFQSVHDPLqvpeeymepygfiqdkhrrIYAGMVSLMDEAVGNVTK 283
Cdd:cd16022 103 --------------DEAIDFIERRDKDKPFFLYVSFNAPHPPF-------------------AYYAMVSAIDDQIGRILD 149
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 284 ALKSHGLWNNTVFIFSTDNGGQTRSGGnnwpLRGRKGTLWEGGIRGTGFVASPLLKQKGVKSRELMHITDWLPTLVDLAG 363
Cdd:cd16022 150 ALEELGLLDNTLIVFTSDHGDMLGDHG----LRGKKGSLYEGGIRVPFIVRWPGKIPAGQVSDALVSLLDLLPTLLDLAG 225
|
330
....*....|...
gi 125656171 364 GSTNgtKPLDGFN 376
Cdd:cd16022 226 IEPP--EGLDGRS 236
|
|
| ARS_like |
cd16145 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
46-493 |
1.12e-79 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 255.60 E-value: 1.12e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHGS-VIRTPHLDALAAGGVVLDNYYV-QPLCTPSRSQLLTGRYQIHLGL-QHYLIMTCQPsc 122
Cdd:cd16145 1 PNIIFILADDLGYGDLGCYGQkKIKTPNLDRLAAEGMRFTQHYAgAPVCAPSRASLLTGLHTGHTRVrGNSEPGGQDP-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 123 VPLDEKLLPQLLKEAGYATHMVGKWHLGMYRKECLPTRRGFDTYFGYL--LGSEDYYtheacaPIESL-NGTRCALD--- 196
Cdd:cd16145 79 LPPDDVTLAEVLKKAGYATAAFGKWGLGGPGTPGHPTKQGFDYFYGYLdqVHAHNYY------PEYLWrNGEKVPLPnnv 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 197 --LRDGEEPAKEYNNIYSTNIFTKRATTVIANHpPEKPLFLYLAFQSVHDPLQVPEEYMEPYGFIQDKH---------RR 265
Cdd:cd16145 153 ipPLDEGNNAGGGGGTYSHDLFTDEALDFIREN-KDKPFFLYLAYTLPHAPLQVPDDGPYKYKPKDPGIyaylpwpqpEK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 266 IYAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGQTRSGGN--------NWPLRGRKGTLWEGGIRGTGFVASPL 337
Cdd:cd16145 232 AYAAMVTRLDRDVGRILALLKELGIDENTLVVFTSDNGPHSEGGSEhdpdffdsNGPLRGYKRSLYEGGIRVPFIARWPG 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 338 LKQKGVKSRELMHITDWLPTLVDLAGGSTngTKPLDGFNMWKTiseghpsprveLLhnidqdffdglpcpGKNmTPAKDD 417
Cdd:cd16145 312 KIPAGSVSDHPSAFWDFMPTLADLAGAEP--PEDIDGISLLPT-----------LL--------------GKP-QQQQHD 363
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 125656171 418 SFPLEhsaFNTSIHA-GIRYKNWKLLtghpgcgywfpppsqsnvsEIPPVDPPTKtlwLFDINQDPEERHDVSREHP 493
Cdd:cd16145 364 YLYWE---FYEGGGAqAVRMGGWKAV-------------------RHGKKDGPFE---LYDLSTDPGETNNLAAQHP 415
|
|
| ARS_like |
cd16142 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
46-488 |
4.82e-76 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293761 [Multi-domain] Cd Length: 372 Bit Score: 244.75 E-value: 4.82e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHGS----VIRTPHLDALAAGGVVLDNYYVQPLCTPSRSQLLTGRYQIHLGLqHYLIMTCQPS 121
Cdd:cd16142 1 PNILVILGDDIGWGDLGCYGGgigrGAPTPNIDRLAKEGLRFTSFYVEPSCTPGRAAFITGRHPIRTGL-TTVGLPGSPG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 122 CVPLDEKLLPQLLKEAGYATHMVGKWHLGMyRKECLPTRRGFDTYFGYLLGSEDYYTHEAcapieslngtrcALDlrdge 201
Cdd:cd16142 80 GLPPWEPTLAELLKDAGYATAQFGKWHLGD-EDGRLPTDHGFDEFYGNLYHTIDEEIVDK------------AID----- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 202 epakeynniystniFTKRattviaNHPPEKPLFLYLAFQSVHDPLQVPEEYMEpygfiQDKHRRIYAGMVSLMDEAVGNV 281
Cdd:cd16142 142 --------------FIKR------NAKADKPFFLYVNFTKMHFPTLPSPEFEG-----KSSGKGKYADSMVELDDHVGQI 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 282 TKALKSHGLWNNTVFIFSTDNGGQTRS--GGNNWPLRGRKGTLWEGGIRGTGFVASPLLKQKGVKSRELMHITDWLPTLV 359
Cdd:cd16142 197 LDALDELGIADNTIVIFTTDNGPEQDVwpDGGYTPFRGEKGTTWEGGVRVPAIVRWPGKIKPGRVSNEIVSHLDWFPTLA 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 360 DLAGgstnGTKPLDGFNMWKTISEGhpsprvellhnIDQ-DFFDGlpcpgknmtpaKDDSFPLEHSAFNTSIH-AGIRYK 437
Cdd:cd16142 277 ALAG----APDPKDKLLGKDRHIDG-----------VDQsPFLLG-----------KSEKSRRSEFFYFGEGElGAVRWK 330
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 125656171 438 NWKLLTghpgcgYWFPPPSQSNVSEIPPVDPPtktlWLFDINQDPEERHDV 488
Cdd:cd16142 331 NWKVHF------KAQEDTGGPTGEPFYVLTFP----LIFNLRRDPKERYDV 371
|
|
| Sulfatase |
pfam00884 |
Sulfatase; |
46-363 |
1.25e-72 |
|
Sulfatase;
Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 233.08 E-value: 1.25e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHGSVIR-TPHLDALAAGGVVLDNYYV-QPLCTPSRSQLLTGRYQIHLGLQhylimTCQPSCV 123
Cdd:pfam00884 1 PNVVLVLGESLRAPDLGLYGYPRPtTPFLDRLAEEGLLFSNFYSgGTLTAPSRFALLTGLPPHNFGSY-----VSTPVGL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 124 PLDEKLLPQLLKEAGYATHMVGKWHLGMYRKEClPTRRGFDTYFGYLLGSEDYYTHEACAPIESLNGtrcaldlrdgeep 203
Cdd:pfam00884 76 PRTEPSLPDLLKRAGYNTGAIGKWHLGWYNNQS-PCNLGFDKFFGRNTGSDLYADPPDVPYNCSGGG------------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 204 akeynniYSTNIFTKRATTVIANhpPEKPLFLYLAFQSVHDPLQVPEEYMEPYGF------IQDKHRRIYAGMVSLMDEA 277
Cdd:pfam00884 142 -------VSDEALLDEALEFLDN--NDKPFFLVLHTLGSHGPPYYPDRYPEKYATfkpsscSEEQLLNSYDNTLLYTDDA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 278 VGNVTKALKSHGLWNNTVFIFSTDNGGQTrSGGNNWPLRGRKGTLWEGGIRGTGFVASPLLKQKGVKSRELMHITDWLPT 357
Cdd:pfam00884 213 IGRVLDKLEENGLLDNTLVVYTSDHGESL-GEGGGYLHGGKYDNAPEGGYRVPLLIWSPGGKAKGQKSEALVSHVDLFPT 291
|
....*.
gi 125656171 358 LVDLAG 363
Cdd:pfam00884 292 ILDLAG 297
|
|
| ARS_like |
cd16143 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
46-489 |
4.80e-71 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293762 [Multi-domain] Cd Length: 395 Bit Score: 232.48 E-value: 4.80e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHG--SVIRTPHLDALAAGGVVLDNYYV-QPLCTPSRSQLLTGRYQIHLGLQHYLIMTCQPSC 122
Cdd:cd16143 1 PNIVIILADDLGYGDISCYNpdSKIPTPNIDRLAAEGMRFTDAHSpSSVCTPSRYGLLTGRYPWRSRLKGGVLGGFSPPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 123 VPLDEKLLPQLLKEAGYATHMVGKWHLGM--YRKECL-------------------PTRRGFDTYFGYllgsedyythea 181
Cdd:cd16143 81 IEPDRVTLAKMLKQAGYRTAMVGKWHLGLdwKKKDGKkaatgtgkdvdyskpikggPLDHGFDYYFGI------------ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 182 capieslngTRCALDLRdgeepakeynniystniFTKRATTVIANHP-PEKPLFLYLAFQSVHDPLQVPEEY-----MEP 255
Cdd:cd16143 149 ---------PASEVLPT-----------------LTDKAVEFIDQHAkKDKPFFLYFALPAPHTPIVPSPEFqgksgAGP 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 256 YG-FIQDkhrriyagmvslMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGQT--------RSGGN-NWPLRGRKGTLWEG 325
Cdd:cd16143 203 YGdFVYE------------LDWVVGRILDALKELGLAENTLVIFTSDNGPSPyadykeleKFGHDpSGPLRGMKADIYEG 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 326 GIRgTGFVAS-PLLKQKGVKSRELMHITDWLPTLVDLAGGSTNGTKPLDGFNMWKT-ISEGHPSPRVELLHNidqdffdg 403
Cdd:cd16143 271 GHR-VPFIVRwPGKIPAGSVSDQLVSLTDLFATLAAIVGQKLPDNAAEDSFSFLPAlLGPKKQEVRESLVHH-------- 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 404 lpcpgknmtpAKDDSFplehsafntsihaGIRYKNWKLLTGHPGCGYWfpPPSQSNVSEIPPVDpptktlwLFDINQDPE 483
Cdd:cd16143 342 ----------SGNGSF-------------AIRKGDWKLIDGTGSGGFS--YPRGKEKLGLPPGQ-------LYNLSTDPG 389
|
....*.
gi 125656171 484 ERHDVS 489
Cdd:cd16143 390 ESNNLY 395
|
|
| sulfatase_like |
cd16151 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-487 |
7.08e-63 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293770 [Multi-domain] Cd Length: 377 Bit Score: 210.15 E-value: 7.08e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHGSV-IRTPHLDALAAGGVVLDNYYVQPLCTPSRSQLLTGRYQIHLGLQHYlimtcqpscvP 124
Cdd:cd16151 1 PNIILIMADDLGYECIGCYGGEsYKTPNIDALAAEGVRFNNAYAQPLCTPSRVQLMTGKYNFRNYVVFG----------Y 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 125 LD--EKLLPQLLKEAGYATHMVGKWHLGMYR-KECLPTRRGFDTY--FGYLLGSEDYYTheacaPIESLNGtrcaldLRD 199
Cdd:cd16151 71 LDpkQKTFGHLLKDAGYATAIAGKWQLGGGRgDGDYPHEFGFDEYclWQLTETGEKYSR-----PATPTFN------IRN 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 200 GEEPaKEYNNIYSTNIFTKRATTVIANHpPEKPLFLYLAFQSVHDPLQV--PEEYMEPYGFIQDKHRRIYAGMVSLMDEA 277
Cdd:cd16151 140 GKLL-ETTEGDYGPDLFADFLIDFIERN-KDQPFFAYYPMVLVHDPFVPtpDSPDWDPDDKRKKDDPEYFPDMVAYMDKL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 278 VGNVTKALKSHGLWNNTVFIFSTDNG----GQTRSGGNNwpLRGRKGTLWEGGIRgTGFVAS-PLLKQKGVKSRELMHIT 352
Cdd:cd16151 218 VGKLVDKLEELGLRENTIIIFTGDNGthrpITSRTNGRE--VRGGKGKTTDAGTH-VPLIVNwPGLIPAGGVSDDLVDFS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 353 DWLPTLVDLAGGSTNGTKPLDGFNMWKTISeghpsprvellhnidqdffdglpcpGKNMTPAKDDSFPLEHSAFNTSIHA 432
Cdd:cd16151 295 DFLPTLAELAGAPLPEDYPLDGRSFAPQLL-------------------------GKTGSPRREWIYWYYRNPHKKFGSR 349
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 125656171 433 GIRYKNWKLltghpgcgYWfpppsqsnvseippvdpPTKtlwLFDINQDPEERHD 487
Cdd:cd16151 350 FVRTKRYKL--------YA-----------------DGR---FFDLREDPLEKNP 376
|
|
| ARSG |
cd16161 |
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ... |
45-395 |
1.44e-62 |
|
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.
Pssm-ID: 293780 [Multi-domain] Cd Length: 383 Bit Score: 209.63 E-value: 1.44e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 45 PPHVVFVLADDLGWNDLGFHG--SVIRTPHLDALAAGGVVLDNYYVQ-PLCTPSRSQLLTGRYQIHLGLQHYLIMTCQpS 121
Cdd:cd16161 1 KPNFLLLFADDLGWGDLGANWapNAILTPNLDKLAAEGTRFVDWYSAaSVCSPSRASLMTGRLGLRNGVGHNFLPTSV-G 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 122 CVPLDEKLLPQLLKEAGYATHMVGKWHLGmYRKECLPTRRGFDTYFGYLlgsedyYTHEAcapieslngtrcaldlrdge 201
Cdd:cd16161 80 GLPLNETTLAEVLRQAGYATGMIGKWHLG-QREAYLPNSRGFDYYFGIP------FSHDS-------------------- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 202 EPAKEYnniystnifTKRATTVIANHP-PEKPLFLYLAFQSVHDPLQVPEEYMEPygfiqDKHRRIYAGMVSLMDEAVGN 280
Cdd:cd16161 133 SLADRY---------AQFATDFIQRASaKDRPFFLYAALAHVHVPLANLPRFQSP-----TSGRGPYGDALQEMDDLVGQ 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 281 VTKALKSHGLWNNTVFIFSTDNGG---QTRSGGN--------NWPLRGRKGTLWEGGIRGTGFVASPLLKQKGVKSRELM 349
Cdd:cd16161 199 IMDAVKHAGLKDNTLTWFTSDNGPwevKCELAVGpgtgdwqgNLGGSVAKASTWEGGHREPAIVYWPGRIPANSTSAALV 278
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 125656171 350 HITDWLPTLVDLAGGSTNGTKPLDGFNMWKTISEGHPSPRVELLHN 395
Cdd:cd16161 279 STLDIFPTVVALAGASLPPGRIYDGKDLSPVLFGGSKTGHRCLFHP 324
|
|
| SGSH |
cd16027 |
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
46-364 |
6.73e-58 |
|
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 196.96 E-value: 6.73e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHGSVIRTPHLDALAAGGVVLDNYYV-QPLCTPSRSQLLTGRYQIHLGLQHyliMTCQPSCVP 124
Cdd:cd16027 1 PNILWIIADDLSPDLGGYGGNVVKTPNLDRLAAEGVRFTNAFTtAPVCSPSRSALLTGLYPHQNGAHG---LRSRGFPLP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 125 LDEKLLPQLLKEAGYATHMVGKWHLGmyrkeclptrRGFDTYFGYLLGSEDYYTHEAcapieslngtrcaldlRDGEEPA 204
Cdd:cd16027 78 DGVKTLPELLREAGYYTGLIGKTHYN----------PDAVFPFDDEMRGPDDGGRNA----------------WDYASNA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 205 KEYnniystniftkrattvIANHPPEKPLFLYLAFQSVH--------DPLQVPEEYMEPYGFIQD-----KHRRIYAGMV 271
Cdd:cd16027 132 ADF----------------LNRAKKGQPFFLWFGFHDPHrpyppgdgEEPGYDPEKVKVPPYLPDtpevrEDLADYYDEI 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 272 SLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGQtrsggnnWPlRGrKGTLWEGGIRgTGFVAS-PLLKQKGVKSRELMH 350
Cdd:cd16027 196 ERLDQQVGEILDELEEDGLLDNTIVIFTSDHGMP-------FP-RA-KGTLYDSGLR-VPLIVRwPGKIKPGSVSDALVS 265
|
330
....*....|....
gi 125656171 351 ITDWLPTLVDLAGG 364
Cdd:cd16027 266 FIDLAPTLLDLAGI 279
|
|
| ARSA |
cd16158 |
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ... |
45-527 |
2.44e-56 |
|
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.
Pssm-ID: 293777 [Multi-domain] Cd Length: 479 Bit Score: 195.74 E-value: 2.44e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 45 PPHVVFVLADDLGWNDLGFHG-SVIRTPHLDALAAGGVVLDNYYVQ-PLCTPSRSQLLTGRYQIHLGLQHYLIMTCQPSC 122
Cdd:cd16158 1 PPNIVLLFADDLGYGDLGCYGhPSSSTPNLDRLAANGLRFTDFYSSsPVCSPSRAALLTGRYQVRSGVYPGVFYPGSRGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 123 VPLDEKLLPQLLKEAGYATHMVGKWHLGM-YRKECLPTRRGFDTYFGYLlgsedyYTHEACaPIESLN----GTRCALDL 197
Cdd:cd16158 81 LPLNETTIAEVLKTVGYQTAMVGKWHLGVgLNGTYLPTHQGFDHYLGIP------YSHDQG-PCQNLTcfppNIPCFGGC 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 198 RDGEEPAKEYNN-------IYSTNI---FTKRATTVIANHPPE-KPLFLYLAFQSVHDPLQVPEEYMEPYGfiqdkhRRI 266
Cdd:cd16158 154 DQGEVPCPLFYNesivqqpVDLLTLeerYAKFAKDFIADNAKEgKPFFLYYASHHTHYPQFAGQKFAGRSS------RGP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 267 YAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGQTR---SGGNNWPLRGRKGTLWEGGIRGTGFVASPLLKQKGV 343
Cdd:cd16158 228 FGDALAELDGSVGELLQTLKENGIDNNTLVFFTSDNGPSTMrksRGGNAGLLKCGKGTTYEGGVREPAIAYWPGRIKPGV 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 344 kSRELMHITDWLPTLVDLAGGSTNGTKpLDGFNMWKTISEGHPSPRvellhnidQDFFDGLPCPGKNmtpakddsfpleH 423
Cdd:cd16158 308 -THELASTLDILPTIAKLAGAPLPNVT-LDGVDMSPILFEQGKSPR--------QTFFYYPTSPDPD------------K 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 424 SAFNTSIHagiRYKNWKLLTGHPGCGYwFPPPSQSNVSEIPPVDPPTktlwLFDINQDPEERHDVSREhPHIVQ--NLLS 501
Cdd:cd16158 366 GVFAVRWG---KYKAHFYTQGAAHSGT-TPDKDCHPSAELTSHDPPL----LFDLSQDPSENYNLLGL-PEYNQvlKQIQ 436
|
490 500 510
....*....|....*....|....*....|....
gi 125656171 502 RLQYYHEHSV---PSHF-----PPLDPRCDPKST 527
Cdd:cd16158 437 QVKERFEASMkfgESEInkgedPALEPCCKPGCT 470
|
|
| G6S_like |
cd16031 |
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ... |
44-504 |
9.02e-54 |
|
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
Pssm-ID: 293755 [Multi-domain] Cd Length: 429 Bit Score: 187.74 E-value: 9.02e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 44 QPPHVVFVLADDLGWNDLGFHGS-VIRTPHLDALAAGGVVLDNYYV-QPLCTPSRSQLLTGRYQIHLGlqhylIMTCQPS 121
Cdd:cd16031 1 KRPNIIFILTDDHRYDALGCYGNpIVKTPNIDRLAKEGVRFDNAFVtTSICAPSRASILTGQYSHRHG-----VTDNNGP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 122 CVPLDEKLLPQLLKEAGYATHMVGKWHLGMYRKEClptRRGFDtYFGYLLGSEDYYTheacAPIESLNGtrcaldlRDGE 201
Cdd:cd16031 76 LFDASQPTYPKLLRKAGYQTAFIGKWHLGSGGDLP---PPGFD-YWVSFPGQGSYYD----PEFIENGK-------RVGQ 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 202 EPakeynniYSTNIFTKRATTVIANHPPEKPLFLYLAFQSVHDPLQVPEEYMEPYG--------------------FIQD 261
Cdd:cd16031 141 KG-------YVTDIITDKALDFLKERDKDKPFCLSLSFKAPHRPFTPAPRHRGLYEdvtipepetfddddyagrpeWARE 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 262 KHRRI--------------------YAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNG---GQtrsggnnwplRGR 318
Cdd:cd16031 214 QRNRIrgvldgrfdtpekyqrymkdYLRTVTGVDDNVGRILDYLEEQGLADNTIIIYTSDNGfflGE----------HGL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 319 --KGTLWEGGIRGTGFVASPLLKQKGVKSRELMHITDWLPTLVDLAGGSTngTKPLDGFNMWKTISEGHPSP-RVELLHN 395
Cdd:cd16031 284 fdKRLMYEESIRVPLIIRDPRLIKAGTVVDALVLNIDFAPTILDLAGVPI--PEDMQGRSLLPLLEGEKPVDwRKEFYYE 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 396 idqdFFDGlpcPGKNMTPAkddsfplehsafntsiHAGIRYKNWKLLtghpgcgYWfpppsqsnvseipPVDPPTktlW- 474
Cdd:cd16031 362 ----YYEE---PNFHNVPT----------------HEGVRTERYKYI-------YY-------------YGVWDE---Ee 395
|
490 500 510
....*....|....*....|....*....|..
gi 125656171 475 LFDINQDPEERHDV--SREHPHIVQNLLSRLQ 504
Cdd:cd16031 396 LYDLKKDPLELNNLanDPEYAEVLKELRKRLE 427
|
|
| spARS_like |
cd16160 |
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ... |
46-393 |
6.31e-52 |
|
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293779 [Multi-domain] Cd Length: 445 Bit Score: 183.01 E-value: 6.31e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHGSVIRTP-HLDALAAGGVVLDNYYV-QPLCTPSRSQLLTGRYQIHLGL--QHYLIMTCQPS 121
Cdd:cd16160 2 PNIVLFFADDMGYGDLASYGHPTQERgPIDDMAAEGIRFTQAYSaDSVCTPSRAALLTGRLPIRSGMygGTRVFLPWDIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 122 CVPLDEKLLPQLLKEAGYATHMVGKWHLGM--YRKE---CLPTRRGFDtYFGYLLgseDYYTHEACAP----IESLNGTR 192
Cdd:cd16160 82 GLPKTEVTMAEALKEAGYTTGMVGKWHLGIneNNHSdgaHLPSHHGFD-FVGTNL---PFTNSWACDDtgrhVDFPDRSA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 193 CALDLRDgEEPAKEYNNIYSTNIFTKRATTVIANHpPEKPLFLYLAFQSVHDPLQVPEEymepygFIQDKHRRIYAGMVS 272
Cdd:cd16160 158 CFLYYND-TIVEQPIQHEHLTETLVGDAKSFIEDN-QENPFFLYFSFPQTHTPLFASKR------FKGKSKRGRYGDNIN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 273 LMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGQTR---SGGNNWPLRGRKGTLWEGGIRGTGFVASPLLKQKGVKSrELM 349
Cdd:cd16160 230 EMSWAVGEVLDTLVDTGLDQNTLVFFLSDHGPHVEyclEGGSTGGLKGGKGNSWEGGIRVPFIAYWPGTIKPRVSH-EVV 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 125656171 350 HITDWLPTLVDLAGGSTNGTKPLDGFNMWKTISEGHPSPRVELL 393
Cdd:cd16160 309 STMDIFPTFVDLAGGTLPTDRIYDGLSITDLLLGEADSPHDDIL 352
|
|
| sulfatase_like |
cd16155 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-504 |
1.55e-51 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293774 [Multi-domain] Cd Length: 372 Bit Score: 180.07 E-value: 1.55e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHG-SVIRTPHLDALAAGGVVLDNYYVQ-----PLCTPSRSQLLTGRYQIHLGLQHylimtcq 119
Cdd:cd16155 3 PNILFILADDQRADTIGALGnPEIQTPNLDRLARRGTSFTNAYNMggwsgAVCVPSRAMLMTGRTLFHAPEGG------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 120 PSCVPLDEKLLPQLLKEAGYATHMVGKWHlgmyrkeclptrrgfdtyfgyllgsedyytheacapieslngtrcaldlrd 199
Cdd:cd16155 76 KAAIPSDDKTWPETFKKAGYRTFATGKWH--------------------------------------------------- 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 200 geepakeynniystNIFTKRATTVIANHP-PEKPLFLYLAFQSVHDPLQVPEEYMEPY---------------------G 257
Cdd:cd16155 105 --------------NGFADAAIEFLEEYKdGDKPFFMYVAFTAPHDPRQAPPEYLDMYppetiplpenflpqhpfdngeG 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 258 FIQD--------------KHRRIYAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNG---GQtrSGgnnwpLRGrKG 320
Cdd:cd16155 171 TVRDeqlapfprtpeavrQHLAEYYAMITHLDAQIGRILDALEASGELDNTIIVFTSDHGlavGS--HG-----LMG-KQ 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 321 TLWEGGIRGTGFVASPLLKqKGVKSRELMHITDWLPTLVDLAGgsTNGTKPLDGFNMWKTISEGHPSPRVELLHnidqdf 400
Cdd:cd16155 243 NLYEHSMRVPLIISGPGIP-KGKRRDALVYLQDVFPTLCELAG--IEIPESVEGKSLLPVIRGEKKAVRDTLYG------ 313
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 401 fdglpcpgknmtpakddsfplehsAFNTSIHAGIRyKNWKLLtghpgcgywfpppsqsnvseipPVDPPTKTLWLFDINQ 480
Cdd:cd16155 314 ------------------------AYRDGQRAIRD-DRWKLI----------------------IYVPGVKRTQLFDLKK 346
|
490 500
....*....|....*....|....*.
gi 125656171 481 DPEERHDVS--REHPHIVQNLLSRLQ 504
Cdd:cd16155 347 DPDELNNLAdePEYQERLKKLLAELK 372
|
|
| sulfatase_like |
cd16034 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-377 |
5.61e-51 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 179.30 E-value: 5.61e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHG-SVIRTPHLDALAAGGVVLDNYY-VQPLCTPSRSQLLTGRYQIHLGLQHylimtcqpSCV 123
Cdd:cd16034 2 PNILFIFADQHRAQALGCAGdDPVKTPNLDRLAKEGVVFTNAVsNYPVCSPYRASLLTGQYPLTNGVFG--------NDV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 124 PL--DEKLLPQLLKEAGYATHMVGKWHL-GMYRKECL-------PTRR-GFDTYFGYllGSEDYYTHeacaPIESLNgtr 192
Cdd:cd16034 74 PLppDAPTIADVLKDAGYRTGYIGKWHLdGPERNDGRaddytppPERRhGFDYWKGY--ECNHDHNN----PHYYDD--- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 193 caldlrdgeEPAKEYNNIYSTNIFTKRATTVIANH-PPEKPLFLYLAFQSVHDP-LQVPEEYMEPYGFIQDKHR------ 264
Cdd:cd16034 145 ---------DGKRIYIKGYSPDAETDLAIEYLENQaDKDKPFALVLSWNPPHDPyTTAPEEYLDMYDPKKLLLRpnvped 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 265 -----------RIYAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGQTRSGGNNwplrgRKGTLWEGGIRGTGFV 333
Cdd:cd16034 216 kkeeaglredlRGYYAMITALDDNIGRLLDALKELGLLENTIVVFTSDHGDMLGSHGLM-----NKQVPYEESIRVPFII 290
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 125656171 334 ASPLLKQKGVKSRELMHITDWLPTLVDLAGGSTNGTkpLDGFNM 377
Cdd:cd16034 291 RYPGKIKAGRVVDLLINTVDIMPTLLGLCGLPIPDT--VEGRDL 332
|
|
| GALNS |
cd16157 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
45-385 |
9.77e-51 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293776 [Multi-domain] Cd Length: 466 Bit Score: 180.36 E-value: 9.77e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 45 PPHVVFVLADDLGWNDLGFHGSVIR-TPHLDALAAGGVVLDNYY-VQPLCTPSRSQLLTGRYQIHLGL----QH----YL 114
Cdd:cd16157 1 KPNIILMLMDDMGWGDLGVFGEPSReTPNLDRMAAEGMLFTDFYsANPLCSPSRAALLTGRLPIRNGFyttnAHarnaYT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 115 ---IMtcqpSCVPLDEKLLPQLLKEAGYATHMVGKWHLGmYRKECLPTRRGFDTYFGYLLGSEDYYTHEACAPIESLNGT 191
Cdd:cd16157 81 pqnIV----GGIPDSEILLPELLKKAGYRNKIVGKWHLG-HRPQYHPLKHGFDEWFGAPNCHFGPYDNKAYPNIPVYRDW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 192 RCA--------LDLRDGEepakeyNNIysTNIFTKRATTVIAN-HPPEKPLFLYLAFQSVHDPLqvpeeYMEPyGFIQDK 262
Cdd:cd16157 156 EMIgryyeefkIDKKTGE------SNL--TQIYLQEALEFIEKqHDAQKPFFLYWAPDATHAPV-----YASK-PFLGTS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 263 HRRIYAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGQT----RSGGNNWPLRGRKGTLWEGGIRGTGFVASPLL 338
Cdd:cd16157 222 QRGLYGDAVMELDSSVGKILESLKSLGIENNTFVFFSSDNGAALisapEQGGSNGPFLCGKQTTFEGGMREPAIAWWPGH 301
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 125656171 339 KQKGVKSRELMHITDWLPTLVDLAGGSTNGTKPLDGFNMWKTISEGH 385
Cdd:cd16157 302 IKPGQVSHQLGSLMDLFTTSLALAGLPIPSDRAIDGIDLLPVLLNGK 348
|
|
| ES |
cd16159 |
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ... |
45-485 |
3.20e-48 |
|
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.
Pssm-ID: 293778 [Multi-domain] Cd Length: 521 Bit Score: 174.78 E-value: 3.20e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 45 PPHVVFVLADDLGWNDLGFHG-SVIRTPHLDALAAGGVVLD-NYYVQPLCTPSRSQLLTGRYQIHLGLQH-----YLIMT 117
Cdd:cd16159 1 KPNIVLFMADDLGIGDVGCFGnDTIRTPNIDRLAKEGVKLThHLAAAPLCTPSRAAFLTGRYPIRSGMASshgmrVILFT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 118 CQPSCVPLDEKLLPQLLKEAGYATHMVGKWHLGMYRKECL-----PTRRGFDTYFGYLL--------GSEDYYTHEACAP 184
Cdd:cd16159 81 ASSGGLPPNETTFAEVLKQQGYSTALIGKWHLGLHCESRNdfchhPLNHGFDYFYGLPLtnlkdcgdGSNGEYDLSFDPL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 185 IESLNG----------------------------------------------TRCALdLRDG---EEPAkEYNNIysTNI 215
Cdd:cd16159 161 FPLLTAfvlitaltiflllylgavskrffvfllilsllfislfflllitnryFNCIL-MRNHevvEQPM-SLENL--TQR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 216 FTKRATTVIANHpPEKPLFLYLAFQSVHDPLqvpeeYMEPYGFIQDKHRRiYAGMVSLMDEAVGNVTKALKSHGLWNNTV 295
Cdd:cd16159 237 LTKEAISFLERN-KERPFLLVMSFLHVHTAL-----FTSKKFKGRSKHGR-YGDNVEEMDWSVGQILDALDELGLKDNTF 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 296 FIFSTDNGG--------QTRSGGNNWPLRGRKGTLWEGGIRGTGFVASPLLKQKGVKSRELMHITDWLPTLVDLAGGSTN 367
Cdd:cd16159 310 VYFTSDNGGhleeisvgGEYGGGNGGIYGGKKMGGWEGGIRVPTIVRWPGVIPPGSVIDEPTSLMDIFPTVAALAGAPLP 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 368 GTKPLDGFNMwktiseghpsprVELLhnidqdffdglpcpgKNMTPAKDDSFpLEHSAfNTSIHAgIRYKN------WKL 441
Cdd:cd16159 390 SDRIIDGRDL------------MPLL---------------TGQEKRSPHEF-LFHYC-GAELHA-VRYRPrdggavWKA 439
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 125656171 442 L--------TGHPGCGYWFPPPSQSNVSEIppvDPPTktlwLFDINQDPEER 485
Cdd:cd16159 440 HyftpnfypGTEGCCGTLLCRCFGDSVTHH---DPPL----LFDLSADPSES 484
|
|
| sulfatase_like |
cd16154 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-366 |
7.59e-41 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293773 [Multi-domain] Cd Length: 372 Bit Score: 151.35 E-value: 7.59e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDL---GFHGSVIRTPHLDALAAGGVVLDNYYVQPLCTPSRSQLLTGRYQIHLGLqhylimTCQPSC 122
Cdd:cd16154 1 PNILLIIADDQGLDSSaqySLSSDLPVTPTLDSLANSGIVFDNLWATPACSPTRATILTGKYGFRTGV------LAVPDE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 123 VPLDEKLLPQLLKE----AGYATHMVGKWHLGmyrkECLPTRR---GFDTYFGYLLGS-EDYYTHEacapiESLNGTrca 194
Cdd:cd16154 75 LLLSEETLLQLLIKdattAGYSSAVIGKWHLG----GNDNSPNnpgGIPYYAGILGGGvQDYYNWN-----LTNNGQ--- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 195 ldlrdgeepaKEYNNIYSTNIFTKRATTVIANHppEKPLFLYLAFQSVHDPLQVPEEYMEPYGF------IQDKHRRIYA 268
Cdd:cd16154 143 ----------TTNSTEYATTKLTNLAIDWIDQQ--TKPWFLWLAYNAPHTPFHLPPAELHSRSLlgdsadIEANPRPYYL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 269 GMVSLMDEAVGNVTKALKSHGLwNNTVFIFSTDNG--GQTRsggNNWPLRGR-KGTLWEGGIRGTGFVASPLLKQKGVKS 345
Cdd:cd16154 211 AAIEAMDTEIGRLLASIDEEER-ENTIIIFIGDNGtpGQVV---DLPYTRNHaKGSLYEGGINVPLIVSGAGVERANERE 286
|
330 340
....*....|....*....|.
gi 125656171 346 RELMHITDWLPTLVDLAGGST 366
Cdd:cd16154 287 SALVNATDLYATIAELAGVDA 307
|
|
| sulfatase_like |
cd16152 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
45-363 |
2.79e-37 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293771 [Multi-domain] Cd Length: 373 Bit Score: 141.21 E-value: 2.79e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 45 PPHVVFVLADDLGWNDLGFHGSVI-RTPHLDALAAGGVVLDN-YYVQPLCTPSRSQLLTGRYQIHLGLQHYLIMtcqpsc 122
Cdd:cd16152 1 KPNVIVFFTDQQRWDTLGCYGQPLdLTPNLDALAEEGVLFENaFTPQPVCGPARACLQTGLYPTETGCFRNGIP------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 123 VPLDEKLLPQLLKEAGYATHMVGKWHLGMYRKECLptrrgfdtyfgyllgsedyytheacapieslngtrcaldlrdgee 202
Cdd:cd16152 75 LPADEKTLAHYFRDAGYETGYVGKWHLAGYRVDAL--------------------------------------------- 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 203 pakeynniystnifTKRATTVIANHPPEKPLFLYLAF-----QSVHDPLQVPEEYMEPY----------GFIQDKHRRI- 266
Cdd:cd16152 110 --------------TDFAIDYLDNRQKDKPFFLFLSYlephhQNDRDRYVAPEGSAERFanfwvppdlaALPGDWAEELp 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 267 -YAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGG--QTRSggnnwplRGRKGTLWEGGIR------GTGFvaspl 337
Cdd:cd16152 176 dYLGCCERLDENVGRIRDALKELGLYDNTIIVFTSDHGChfRTRN-------AEYKRSCHESSIRvplviyGPGF----- 243
|
330 340
....*....|....*....|....*.
gi 125656171 338 lkQKGVKSRELMHITDWLPTLVDLAG 363
Cdd:cd16152 244 --NGGGRVEELVSLIDLPPTLLDAAG 267
|
|
| sulfatase_like |
cd16033 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-363 |
8.24e-36 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293757 [Multi-domain] Cd Length: 411 Bit Score: 138.12 E-value: 8.24e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHGSVI-RTPHLDALAAGGVVLDNYY-VQPLCTPSRSQLLTGRYQIHLGLQH-YLIMTCQPSC 122
Cdd:cd16033 1 PNILFIMTDQQRYDTLGCYGNPIvKTPNIDRLAAEGVRFTNAYtPSPVCCPARASLLTGLYPHEHGVLNnVENAGAYSRG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 123 VPLDEKLLPQLLKEAGYATHMVGKWHLGmyrKECLPTRRGFDTYFGYLLGSEDYYTHEACAPIESLNGTrcaldlrdgee 202
Cdd:cd16033 81 LPPGVETFSEDLREAGYRNGYVGKWHVG---PEETPLDYGFDEYLPVETTIEYFLADRAIEMLEELAAD----------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 203 pakeynniystniftkrattvianhppEKPLFLYLAFQSVHDPLQVPEEY--------MEPYGFIQD-------KHRRI- 266
Cdd:cd16033 147 ---------------------------DKPFFLRVNFWGPHDPYIPPEPYldmydpedIPLPESFADdfedkpyIYRREr 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 267 -------------------YAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGQTRSGGnnwplrgrkgtLWEGG- 326
Cdd:cd16033 200 krwgvdtedeedwkeiiahYWGYITLIDDAIGRILDALEELGLADDTLVIFTSDHGDALGAHR-----------LWDKGp 268
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 125656171 327 ------------IRGTGfvasplLKQKGVKSRELMHITDWLPTLVDLAG 363
Cdd:cd16033 269 fmyeetyripliIKWPG------VIAAGQVVDEFVSLLDLAPTILDLAG 311
|
|
| sulfatase_like |
cd16149 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-365 |
2.01e-35 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293768 [Multi-domain] Cd Length: 257 Bit Score: 133.13 E-value: 2.01e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHG-SVIRTPHLDALAAGGVVLDNYY-VQPLCTPSRSQLLTGRYQIHLGL-----QHYLIMTC 118
Cdd:cd16149 1 PNILFILTDDQGPWALGCYGnSEAVTPNLDRLAAEGVRFENFFcTSPVCSPARASLLTGRMPSQHGIhdwivEGSHGKTK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 119 QPSCVPLDEKLLPQLLKEAGYATHMVGKWHLGmyrkeclptrrgfdtyfgyllgsedyytheacapieslngtrcaldlr 198
Cdd:cd16149 81 KPEGYLEGQTTLPEVLQDAGYRCGLSGKWHLG------------------------------------------------ 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 199 dgeepakeynniystnifTKRATTVIANHPPEKPLFLYLAFQSVHDPLQvpeeymepygfiqdkhrriYAGMVSLMDEAV 278
Cdd:cd16149 113 ------------------DDAADFLRRRAEAEKPFFLSVNYTAPHSPWG-------------------YFAAVTGVDRNV 155
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 279 GNVTKALKSHGLWNNTVFIFSTDNG------GQTRSGGNNWPLrgrkgTLWEGGIRGTGFVASPLLKQKGVKSRELMHIT 352
Cdd:cd16149 156 GRLLDELEELGLTENTLVIFTSDNGfnmghhGIWGKGNGTFPL-----NMYDNSVKVPFIIRWPGVVPAGRVVDSLVSAY 230
|
330
....*....|...
gi 125656171 353 DWLPTLVDLAGGS 365
Cdd:cd16149 231 DFFPTLLELAGVD 243
|
|
| PRK13759 |
PRK13759 |
arylsulfatase; Provisional |
42-489 |
9.22e-35 |
|
arylsulfatase; Provisional
Pssm-ID: 237491 [Multi-domain] Cd Length: 485 Bit Score: 136.72 E-value: 9.22e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 42 ATQPPHVVFVLADDLGWNDLGFHGS-VIRTPHLDALAAGGVVLDN-YYVQPLCTPSRSQLLTGRYQIHLGLQHYlimtcq 119
Cdd:PRK13759 3 QTKKPNIILIMVDQMRGDCLGCNGNkAVETPNLDMLASEGYNFENaYSAVPSCTPARAALLTGLSQWHHGRVGY------ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 120 PSCVPLDEK-LLPQLLKEAGYATHMVGKWHLGMYRKEClptrrGFDtyfGYLLgsEDYYTHEAcapiesLNGTRCALDLR 198
Cdd:PRK13759 77 GDVVPWNYKnTLPQEFRDAGYYTQCIGKMHVFPQRNLL-----GFH---NVLL--HDGYLHSG------RNEDKSQFDFV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 199 D-----------GEEP-------------AKEYN---NIYSTNIFTKRATTVIANHPPEKPLFLYLAFQSVHDPLQVPEE 251
Cdd:PRK13759 141 SdylawlrekapGKDPdltdigwdcnswvARPWDleeRLHPTNWVGSESIEFLRRRDPTKPFFLKMSFARPHSPYDPPKR 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 252 YME------------------------------PYGFIQDKH----RRIYAGMVSLMDEAVGNVTKALKSHGLWNNTVFI 297
Cdd:PRK13759 221 YFDmykdadipdphigdweyaedqdpeggsidaLRGNLGEEYarraRAAYYGLITHIDHQIGRFLQALKEFGLLDNTIIL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 298 FSTDNGGQTrsGGNNWplrGRKGTLWEGGIRGTGFVASP---LLKQKGVKSRELMHITDWLPTLVDLAGGSTngTKPLDG 374
Cdd:PRK13759 301 FVSDHGDML--GDHYL---FRKGYPYEGSAHIPFIIYDPgglLAGNRGTVIDQVVELRDIMPTLLDLAGGTI--PDDVDG 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 375 FNMWKTISEGHPSPRvellhnidqDFFDGlpcpgknmtpakddsfplEHSAFNTSIHAgIRYKNWKLLtghpgcgyWFpp 454
Cdd:PRK13759 374 RSLKNLIFGQYEGWR---------PYLHG------------------EHALGYSSDNY-LTDGKWKYI--------WF-- 415
|
490 500 510
....*....|....*....|....*....|....*
gi 125656171 455 pSQSNVSEippvdpptktlwLFDINQDPEERHDVS 489
Cdd:PRK13759 416 -SQTGEEQ------------LFDLKKDPHELHNLS 437
|
|
| sulfatase_like |
cd16037 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-390 |
9.01e-33 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293760 [Multi-domain] Cd Length: 321 Bit Score: 127.66 E-value: 9.01e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHG-SVIRTPHLDALAAGGVVLDNYYVQ-PLCTPSRSQLLTGRYQIHLGlqhylimtCQPSCV 123
Cdd:cd16037 1 PNILIIMSDEHNPDAMGCYGhPVVRTPNLDRLAARGTRFENAYTPsPICVPSRASFLTGRYVHETG--------VWDNAD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 124 PLDEKL--LPQLLKEAGYATHMVGKWHlgmYRKECLPTrrGFDTyfgyllgsEDYYTHEACAPIESlngtrcaldlrdge 201
Cdd:cd16037 73 PYDGDVpsWGHALRAAGYETVLIGKLH---FRGEDQRH--GFRY--------DRDVTEAAVDWLRE-------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 202 epakeynniystniftkrattviaNHPPEKPLFLYLAFQSVHDPLQVPEEYMEPYgfiQDKHRRIYAGMVSLMDEAVGNV 281
Cdd:cd16037 126 ------------------------EAADDKPWFLFVGFVAPHFPLIAPQEFYDLY---VRRARAAYYGLVEFLDENIGRV 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 282 TKALKSHGLWNNTVFIFSTDNGGQTRSGGNNWplrgrKGTLWEGG------IRGTGFVAspllkqkGVKSRELMHITDWL 355
Cdd:cd16037 179 LDALEELGLLDNTLIIYTSDHGDMLGERGLWG-----KSTMYEESvrvpmiISGPGIPA-------GKRVKTPVSLVDLA 246
|
330 340 350
....*....|....*....|....*....|....*
gi 125656171 356 PTLVDLAGGSTNGTkpLDGFNMWKTISEGHPSPRV 390
Cdd:cd16037 247 PTILEAAGAPPPPD--LDGRSLLPLAEGPDDPDRV 279
|
|
| iduronate-2-sulfatase |
cd16030 |
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ... |
44-363 |
1.34e-32 |
|
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.
Pssm-ID: 293754 [Multi-domain] Cd Length: 435 Bit Score: 129.62 E-value: 1.34e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 44 QPPHVVFVLADDLgwND-LGFHGS-VIRTPHLDALAAGGVVLDNYYVQ-PLCTPSRSQLLTGRY--QIHL-GLQHYLIMT 117
Cdd:cd16030 1 KKPNVLFIAVDDL--RPwLGCYGGhPAKTPNIDRLAARGVLFTNAYCQqPVCGPSRASLLTGRRpdTTGVyDNNSYFRKV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 118 CQpscvplDEKLLPQLLKEAGYATHMVGK-WHlgMYRKECLPTRRGFDTYFgYLLGSEDYYTHEACAPIESLNGTRCALD 196
Cdd:cd16030 79 AP------DAVTLPQYFKENGYTTAGVGKiFH--PGIPDGDDDPASWDEPP-NPPGPEKYPPGKLCPGKKGGKGGGGGPA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 197 LRDGEEPAKEYNNIYSTNiftkRATTVIAN-HPPEKPLFLYLAFQSVHDPLQVPEEYMEPY------------------- 256
Cdd:cd16030 150 WEAADVPDEAYPDGKVAD----EAIEQLRKlKDSDKPFFLAVGFYKPHLPFVAPKKYFDLYplesiplpnpfdpidlpev 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 257 -----------------------GFI----QDKHRRIYAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNG---GQT 306
Cdd:cd16030 226 awndlddlpkygdipalnpgdpkGPLpdeqARELRQAYYASVSYVDAQVGRVLDALEELGLADNTIVVLWSDHGwhlGEH 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 125656171 307 rsggNNWplrgRKGTLWEGGIRGTGFVASPLLKQKGVKSRELMHITDWLPTLVDLAG 363
Cdd:cd16030 306 ----GHW----GKHTLFEEATRVPLIIRAPGVTKPGKVTDALVELVDIYPTLAELAG 354
|
|
| G6S |
cd16147 |
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ... |
45-374 |
1.77e-32 |
|
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).
Pssm-ID: 293766 [Multi-domain] Cd Length: 396 Bit Score: 128.44 E-value: 1.77e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 45 PPHVVFVLADDLGWNDlgfhGSVIRTPHLDA-LAAGGVVLDNYYV-QPLCTPSRSQLLTGRYqIHlglQHyLIMTCQPS- 121
Cdd:cd16147 1 RPNIVLILTDDQDVEL----GSMDPMPKTKKlLADQGTTFTNAFVtTPLCCPSRASILTGQY-AH---NH-GVTNNSPPg 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 122 -CVP------LDEKLLPQLLKEAGYATHMVGKwHLGMYRKECLPTR--RGFDTYFGYLLGSEDYYTHEAcapieslNGTR 192
Cdd:cd16147 72 gGYPkfwqngLERSTLPVWLQEAGYRTAYAGK-YLNGYGVPGGVSYvpPGWDEWDGLVGNSTYYNYTLS-------NGGN 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 193 caldlrdgEEPAKEYNNIYSTNIFTKRATTVIANHPPE-KPLFLYLAFQSVHDPLQVPEEYMEPYGFIQDKHRR------ 265
Cdd:cd16147 144 --------GKHGVSYPGDYLTDVIANKALDFLRRAAADdKPFFLVVAPPAPHGPFTPAPRYANLFPNVTAPPRPppnnpd 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 266 ------------------------IYAG-MVSLM--DEAVGNVTKALKSHGLWNNTVFIFSTDNG---GQTRsggnnwpL 315
Cdd:cd16147 216 vsdkphwlrrlpplnptqiayideLYRKrLRTLQsvDDLVERLVNTLEATGQLDNTYIIYTSDNGyhlGQHR-------L 288
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 125656171 316 RGRKGTLWEGGIRGTGFVASPLLKqKGVKSRELMHITDWLPTLVDLAGGSTNgtKPLDG 374
Cdd:cd16147 289 PPGKRTPYEEDIRVPLLVRGPGIP-AGVTVDQLVSNIDLAPTILDLAGAPPP--SDMDG 344
|
|
| choline-sulfatase |
cd16032 |
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ... |
46-374 |
7.36e-32 |
|
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.
Pssm-ID: 293756 [Multi-domain] Cd Length: 327 Bit Score: 125.00 E-value: 7.36e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHG-SVIRTPHLDALAAGGVVLDNYY-VQPLCTPSRSQLLTGRYQIHLGLqhYLIMTCQPSCV 123
Cdd:cd16032 1 PNILLIMADQLTAAALPAYGnTVVKTPNLDRLAARGVVFDNAYcNSPLCAPSRASMMTGRLPSRIGA--YDNAAEFPADI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 124 PLdeklLPQLLKEAGYATHMVGKWHLgmyrkeCLPTR-RGFDtyfgyllgsedyYTHEACApieslNGTRCALDLRDGEE 202
Cdd:cd16032 79 PT----FAHYLRAAGYRTALSGKMHF------VGPDQlHGFD------------YDEEVAF-----KAVQKLYDLARGED 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 203 pakeynniystniftkrattvianhppEKPLFLYLAFQSVHDPLQVPEEYMEPYgfIQdKHRRIYAGMVSLMDEAVGNVT 282
Cdd:cd16032 132 ---------------------------GRPFFLTVSFTHPHDPYVIPQEYWDLY--VR-RARRAYYGMVSYVDDKVGQLL 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 283 KALKSHGLWNNTVFIFSTDNG---GQtrsggnnwplRGR--KGTLWEGGIRGTGFVASPLLKQkGVKSRELMHITDWLPT 357
Cdd:cd16032 182 DTLERTGLADDTIVIFTSDHGdmlGE----------RGLwyKMSFFEGSARVPLIISAPGRFA-PRRVAEPVSLVDLLPT 250
|
330
....*....|....*...
gi 125656171 358 LVDLAGGST-NGTKPLDG 374
Cdd:cd16032 251 LVDLAGGGTaPHVPPLDG 268
|
|
| sulfatase_like |
cd16148 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-369 |
4.61e-31 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 121.50 E-value: 4.61e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHGS-VIRTPHLDALAAGGVVLDNYYVQ-PLCTPSRSQLLTGRYQIHLGLQHYLImtcqpscv 123
Cdd:cd16148 1 MNVILIVIDSLRADHLGCYGYdRVTTPNLDRLAAEGVVFDNHYSGsNPTLPSRFSLFTGLYPFYHGVWGGPL-------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 124 PLDEKLLPQLLKEAGYATHMVGKWHLgmyrkecLPTRRGFDTYFgyllgseDYYtheacapieslngtrcalDLRDGEEP 203
Cdd:cd16148 73 EPDDPTLAEILRKAGYYTAAVSSNPH-------LFGGPGFDRGF-------DTF------------------EDFRGQEG 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 204 AKEYNNIYSTNIFTKRATTVIANHPPEKPLFLYLAFQSVHdplqvpeeymEPYGfiqdkhrriYAGMVSLMDEAVGNVTK 283
Cdd:cd16148 121 DPGEEGDERAERVTDRALEWLDRNADDDPFFLFLHYFDPH----------EPYL---------YDAEVRYVDEQIGRLLD 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 284 ALKSHGLWNNTVFIFSTDNG------GQTrsGGNNWPlrgrkgtLWEGGIRgtgfVasPLL-----KQKGVKSRELMHIT 352
Cdd:cd16148 182 KLKELGLLEDTLVIVTSDHGeefgehGLY--WGHGSN-------LYDEQLH----V--PLIirwpgKEPGKRVDALVSHI 246
|
330
....*....|....*..
gi 125656171 353 DWLPTLVDLAGGSTNGT 369
Cdd:cd16148 247 DIAPTLLDLLGVEPPDY 263
|
|
| PMH |
cd16028 |
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ... |
48-503 |
3.08e-28 |
|
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.
Pssm-ID: 293752 [Multi-domain] Cd Length: 449 Bit Score: 117.36 E-value: 3.08e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 48 VVFVLADDLGWNDLGFHG-SVIRTPHLDALAAGGVVLDNYYVQ-PLCTPSRSQLLTGRYQIHLGlqhyliMTCQPSCVPL 125
Cdd:cd16028 3 VLFITADQWRADCLSCLGhPLVKTPNLDRLAAEGVRFRNHYTQaAPCGPSRASLYTGRYLMNHR------SVWNGTPLDA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 126 DEKLLPQLLKEAGYATHMVGKWHL-----GMYRKEclPTRR-------GFDTYF---GYllGSED----YYTHEACApie 186
Cdd:cd16028 77 RHLTLALELRKAGYDPALFGYTDTspdprGLAPLD--PRLLsyelampGFDPVDrldEY--PAEDsdtaFLTDRAIE--- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 187 slngtrcALDLRDGEE----------------PAkEYNNIYSTNIFTK--RATTV---IANHPPEKPLF----LYLAFQS 241
Cdd:cd16028 150 -------YLDERQDEPwflhlsyirphppfvaPA-PYHALYDPADVPPpiRAESLaaeAAQHPLLAAFLerieSLSFSPG 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 242 VHDPLQVPEEYMepygfiqDKHRRIYAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGQtrsGGNNWpLRGrKGT 321
Cdd:cd16028 222 AANAADLDDEEV-------AQMRATYLGLIAEVDDHLGRLFDYLKETGQWDDTLIVFTSDHGEQ---LGDHW-LWG-KDG 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 322 LWEGGIRGTGFVASPLLKQKGVKSRELMHIT---DWLPTLVDLAGGSTngTKPLDGFNMWKTISEGHPSPRVELLHnIDQ 398
Cdd:cd16028 290 FFDQAYRVPLIVRDPRREADATRGQVVDAFTesvDVMPTILDWLGGEI--PHQCDGRSLLPLLAGAQPSDWRDAVH-YEY 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 399 DFFDGlpcpgknmtpakddSFPLEHSAFNTSIH----AGIRYKNWKLLTghpgcgywFPppsqsnvsEIPPVdpptktlw 474
Cdd:cd16028 367 DFRDV--------------STRRPQEALGLSPDecslAVIRDERWKYVH--------FA--------ALPPL-------- 408
|
490 500 510
....*....|....*....|....*....|.
gi 125656171 475 LFDINQDPEERHDVSR--EHPHIVQNLLSRL 503
Cdd:cd16028 409 LFDLKNDPGELRDLAAdpAYAAVVLRYAQKL 439
|
|
| sulfatase_like |
cd16153 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-379 |
2.94e-26 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293772 [Multi-domain] Cd Length: 282 Bit Score: 108.23 E-value: 2.94e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLGFHGSV-----------IRTPHLDALAAGGVVLDNYYVQ-PLCTPSRSQLLTGRYQIHLGLQHY 113
Cdd:cd16153 2 PNILWIITDDQRVDSLSCYNNAhtgksesrlgyVESPNIDALAAEGVLFTNAYCNsPVCVPSRTSMLTGRYPHRTGVYGF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 114 LIMTCQPSCVPLdekLLPQLLKEAGYATHMVGKWHLGMYRKeclptrrgfdtyfgYLlgsedyytheacapieslngtrc 193
Cdd:cd16153 82 EAAHPALDHGLP---TFPEVLKKAGYQTASFGKSHLEAFQR--------------YL----------------------- 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 194 aldlrdgEEPAKEYNNIYSTNIFTKRattvianhpPEKPLFLYLAFQSVHDPLQVPEEYMEpygfiqdkhRRIYAGMVSL 273
Cdd:cd16153 122 -------KNANQSYKSFWGKIAKGAD---------SDKPFFVRLSFLQPHTPVLPPKEFRD---------RFDYYAFCAY 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 274 MDEAVGNVTKALKSHGLWN---NTVFIFSTDNGgqtrsggnnWPLrGRKG-----TLWEGGIRGTGFVASPLLKQKGVKS 345
Cdd:cd16153 177 GDAQVGRAVEAFKAYSLKQdrdYTIVYVTGDHG---------WHL-GEQGilakfTFWPQSHRVPLIVVSSDKLKAPAGK 246
|
330 340 350
....*....|....*....|....*....|....*.
gi 125656171 346 R--ELMHITDWLPTLVDLAGGSTNGTKPLDGFNMWK 379
Cdd:cd16153 247 VrhDFVEFVDLAPTLLAAAGVDVDAPDYLDGRDLFE 282
|
|
| sulfatase_like |
cd16150 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-363 |
2.51e-25 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293769 [Multi-domain] Cd Length: 423 Bit Score: 108.48 E-value: 2.51e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLG-FHGSVIRTPHLDALAAGGVVLDNYYVQ-PLCTPSRSQLLTGRY---QIHLGLQHYLimtcQP 120
Cdd:cd16150 1 PNIVIFVADQLRADSLGhLGNPAAVTPNLDALAAEGVRFSNAYCQnPVCSPSRCSFLTGWYphvNGHRTLHHLL----RP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 121 scvplDEKLLPQLLKEAGYATHMVGKWHlgmyrkeCLPTRRGFDTYfgyllgsedyytheacapieslngtrCALDlrdg 200
Cdd:cd16150 77 -----DEPNLLKTLKDAGYHVAWAGKND-------DLPGEFAAEAY--------------------------CDSD---- 114
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 201 eepakeYNNIYStniftkrATTVIANHPPEKPLFLYLAFQSVHDPLQVPEEY---------------------------- 252
Cdd:cd16150 115 ------EACVRT-------AIDWLRNRRPDKPFCLYLPLIFPHPPYGVEEPWfsmidreklpprrppglrakgkpsmleg 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 253 MEPYGF------IQDKHRRIYAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGQTRSGG--NNWPlrgrkgtlwe 324
Cdd:cd16150 182 IEKQGLdrwseeRWRELRATYLGMVSRLDHQFGRLLEALKETGLYDDTAVFFFSDHGDYTGDYGlvEKWP---------- 251
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 125656171 325 ggirgTGF----VASPLLKQ--KGVKSR---ELMHITDWLPTLVDLAG 363
Cdd:cd16150 252 -----NTFedclTRVPLIIKppGGPAGGvsdALVELVDIPPTLLDLAG 294
|
|
| sulfatase_like |
cd16156 |
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ... |
46-404 |
1.28e-23 |
|
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293775 [Multi-domain] Cd Length: 468 Bit Score: 103.62 E-value: 1.28e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLG-FHGSVIRTPHLDALAAGGVVLDN-YYVQPLCTPSRSQLLTGRYQiHlglqhylimTCQP--S 121
Cdd:cd16156 1 KQFIFIMTDTQRWDMVGcYGNKAMKTPNLDRLAAEGVRFDSaYTTQPVCGPARSGLFTGLYP-H---------TNGSwtN 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 122 CVPLDE--KLLPQLLKEAGYATHMVGKWHLGmyrkeclptrrGFDtYFGYllG------SEDYYTHEAC----APIESLN 189
Cdd:cd16156 71 CMALGDnvKTIGQRLSDNGIHTAYIGKWHLD-----------GGD-YFGN--GicpqgwDPDYWYDMRNyldeLTEEERR 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 190 GTRCALDLRDGEEPAKEYNniYSTNIfTKRATTVIANHpPEKPLFLYLAFQSVHDPLQVPEEYMEPY-GFIQDK------ 262
Cdd:cd16156 137 KSRRGLTSLEAEGIKEEFT--YGHRC-TNRALDFIEKH-KDEDFFLVVSYDEPHHPFLCPKPYASMYkDFEFPKgenayd 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 263 -------HRRIYA-------------------GMVSLMDEAVGNVTKALKSHGlwNNTVFIFSTDNGGQTRSGG------ 310
Cdd:cd16156 213 dlenkplHQRLWAgakphedgdkgtikhplyfGCNSFVDYEIGRVLDAADEIA--EDAWVIYTSDHGDMLGAHKlwakgp 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 311 ------NNWPLRGRkgtlWEGGIRGTGFVASPllkqkgvksreLMHItDWLPTLVDLAGgsTNGTKPLDGFNMWKTISEG 384
Cdd:cd16156 291 avydeiTNIPLIIR----GKGGEKAGTVTDTP-----------VSHI-DLAPTILDYAG--IPQPKVLEGESILATIEDP 352
|
410 420
....*....|....*....|....*
gi 125656171 385 HPSPRVELL-----HNIDQDFFDGL 404
Cdd:cd16156 353 EIPENRGVFvefgrYEVDHDGFGGF 377
|
|
| sulfatase_like |
cd16035 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
71-365 |
9.03e-19 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293759 [Multi-domain] Cd Length: 311 Bit Score: 87.26 E-value: 9.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 71 PHLDALAAGGVVLDNYYV-QPLCTPSRSQLLTGRYQIHlglqHYLIMTCQPSCVPLDEKLLPQL---LKEAGYATHMVGK 146
Cdd:cd16035 27 PARERLAANGLSFENHYTaACMCSPSRSTLYTGLHPQQ----TGVTDTLGSPMQPLLSPDVPTLghmLRAAGYYTAYKGK 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 147 WHLGmyrkeclptrrgfdtyfGYLLGSEDY---YTHEACAPieslngtrcaldLRDGEEPAKEynniystniftkrattv 223
Cdd:cd16035 103 WHLS-----------------GAAGGGYKRdpgIAAQAVEW------------LRERGAKNAD----------------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 224 ianhppEKPLFLYLAFQSVHDPLQVPEEYMEPYgfiqdKHRRIYAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNG 303
Cdd:cd16035 137 ------GKPWFLVVSLVNPHDIMFPPDDEERWR-----RFRNFYYNLIRDVDRQIGRVLDALDASGLADNTIVVFTSDHG 205
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 125656171 304 GQTRSGGnnwpLRGRKGTLWEGGIRGTGFVASPLLKQKGVKSRELM-HItDWLPTLVDLAGGS 365
Cdd:cd16035 206 EMGGAHG----LRGKGFNAYEEALHVPLIISHPDLFGTGQTTDALTsHI-DLLPTLLGLAGVD 263
|
|
| ALP_like |
cd00016 |
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
46-362 |
9.73e-15 |
|
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 73.61 E-value: 9.73e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGWNDLG-FHGSVIRTPHLDALAAGGVVLDNYYVQPLC--TPSRSQLLTGRYQIHLGlqhyliMTCQPSC 122
Cdd:cd00016 1 KHVVLIVLDGLGADDLGkAGNPAPTTPNLKRLASEGATFNFRSVSPPTssAPNHAALLTGAYPTLHG------YTGNGSA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 123 VPLDEK----------LLPQLLKEAGYATHMVGkwhlgmyrkeclptrrgFDTYFGYLLgsedyytheacapieslngtr 192
Cdd:cd00016 75 DPELPSraagkdedgpTIPELLKQAGYRTGVIG-----------------LLKAIDETS--------------------- 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 193 caldlrdgeepakeynniystniftkrattvianhpPEKPLFLYLAFQSVHDPLQVPEEYMEPYGfiqdkhrriyaGMVS 272
Cdd:cd00016 117 ------------------------------------KEKPFVLFLHFDGPDGPGHAYGPNTPEYY-----------DAVE 149
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 273 LMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGqTRSGGNNWPLRGRKGTLWEGGIRGTGFVASPLLKQKGVKSRELMHiT 352
Cdd:cd00016 150 EIDERIGKVLDALKKAGDADDTVIIVTADHGG-IDKGHGGDPKADGKADKSHTGMRVPFIAYGPGVKKGGVKHELISQ-Y 227
|
330
....*....|
gi 125656171 353 DWLPTLVDLA 362
Cdd:cd00016 228 DIAPTLADLL 237
|
|
| LTA_synthase |
cd16015 |
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
46-363 |
1.18e-14 |
|
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.
Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 74.26 E-value: 1.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLA---DDLGWNDLGFHGSVirTPHLDALAAGGVVLDNYYVQPLCTP-SRSQ--LLTGRYQIHLG--LQHYLIMT 117
Cdd:cd16015 1 PNVIVILLesfSDPYIDKDVGGEDL--TPNLNKLAKEGLYFGNFYSPGFGGGtANGEfeVLTGLPPLPLGsgSYTLYKLN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 118 CQPScvpldeklLPQLLKEAGYATHMVGKWHLGMYRkeclptRRGFDTYFGYllgsEDYYtheacapieslngtrcalDL 197
Cdd:cd16015 79 PLPS--------LPSILKEQGYETIFIHGGDASFYN------RDSVYPNLGF----DEFY------------------DL 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 198 RDGEEPAKEYNNIY-STNIFTKRATTVIANHPpEKPLFLYLafQSV--HDPLQVPEEYMEPYGFIQDKHRRI--YAGMVS 272
Cdd:cd16015 123 EDFPDDEKETNGWGvSDESLFDQALEELEELK-KKPFFIFL--VTMsnHGPYDLPEEKKDEPLKVEEDKTELenYLNAIH 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 273 LMDEAVGNVTKALKSHGLWNNTVFIFSTD---NGGQTRSGGNNWPLRGRKGTLweggirgtgFVASPLLKQKGVKSRELM 349
Cdd:cd16015 200 YTDKALGEFIEKLKKSGLYENTIIVIYGDhlpSLGSDYDETDEDPLDLYRTPL---------LIYSPGLKKPKKIDRVGS 270
|
330
....*....|....
gi 125656171 350 HItDWLPTLVDLAG 363
Cdd:cd16015 271 QI-DIAPTLLDLLG 283
|
|
| MdoB |
COG1368 |
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
35-367 |
3.85e-13 |
|
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 71.99 E-value: 3.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 35 SPARASGATQPPHVVFVLADDLGWNDLGFHG---SVirTPHLDALAAGGVVLDNYYVQplcTP--SRSQ--LLTGRYQIH 107
Cdd:COG1368 224 PTPNPFGPAKKPNVVVILLESFSDFFIGALGngkDV--TPFLDSLAKESLYFGNFYSQ---GGrtSRGEfaVLTGLPPLP 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 108 LG--LQHYLIMTcQPScvpldeklLPQLLKEAGYATHMV----GKWhlgMYRKECLPtRRGFDTYFGyllgsEDYYTHEA 181
Cdd:COG1368 299 GGspYKRPGQNN-FPS--------LPSILKKQGYETSFFhggdGSF---WNRDSFYK-NLGFDEFYD-----REDFDDPF 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 182 CAPieslngtrcaLDLRDGEepakeynniystniFTKRATTVIANHPpeKPLFLYLAFQSVHDPLQVPEEYMEPYGFIQD 261
Cdd:COG1368 361 DGG----------WGVSDED--------------LFDKALEELEKLK--KPFFAFLITLSNHGPYTLPEEDKKIPDYGKT 414
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 262 KHRRiYAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGqtRSGGNNWPLrgrkgtLWEGGIRGTGFVASPLLKQK 341
Cdd:COG1368 415 TLNN-YLNAVRYADQALGEFIEKLKKSGWYDNTIFVIYGDHGP--RSPGKTDYE------NPLERYRVPLLIYSPGLKKP 485
|
330 340
....*....|....*....|....*.
gi 125656171 342 GVKSReLMHITDWLPTLVDLAGGSTN 367
Cdd:COG1368 486 KVIDT-VGSQIDIAPTLLDLLGIDYP 510
|
|
| ARSK |
cd16171 |
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ... |
46-383 |
1.12e-08 |
|
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293781 [Multi-domain] Cd Length: 366 Bit Score: 57.17 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 46 PHVVFVLADDLGwNDLGFHG--SVIRTPHLDALAAGGVVLDNYYVQ-PLCTPSRSQLLTGRYqIHL--GLQHYlimtcqp 120
Cdd:cd16171 1 PNVVMVMSDSFD-GRLTFRPgnQVVDLPYINFMKQHGSVFLNAYTNsPICCPSRAAMWSGLF-THLteSWNNY------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 121 SCVPLDEKLLPQLLKEAGYATHMVGKW------HLGMYRKECLpTRrgfDTYFgyLLGSEDyytheacAPIESLNGTRCA 194
Cdd:cd16171 72 KGLDPNYPTWMDRLEKHGYHTQKYGKLdytsghHSVSNRVEAW-TR---DVPF--LLRQEG-------RPTVNLVGDRST 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 195 LDLRdgeepAKEYNNiystnifTKRATTVIANHPP--EKPLFLYLAFQSVHdplQVPEEYM-EPYGFIQDKhRRIYAGMV 271
Cdd:cd16171 139 VRVM-----LKDWQN-------TDKAVHWIRKEAPnlTQPFALYLGLNLPH---PYPSPSMgENFGSIRNI-RAFYYAMC 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 272 SLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGgqtrsggnNWPLRGR---KGTLWEGGIRGTGFVASPLLKqKGVKSREL 348
Cdd:cd16171 203 AETDAMLGEIISALKDTGLLDKTYVFFTSDHG--------ELAMEHRqfyKMSMYEGSSHVPLLIMGPGIK-AGQQVSDV 273
|
330 340 350
....*....|....*....|....*....|....*
gi 125656171 349 MHITDWLPTLVDLAGGSTngTKPLDGFNMWKTISE 383
Cdd:cd16171 274 VSLVDIYPTMLDIAGVPQ--PQNLSGYSLLPLLSE 306
|
|
| AtaC |
COG1524 |
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
37-303 |
2.65e-06 |
|
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms];
Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 49.75 E-value: 2.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 37 ARASGATQPPHVVFVLADDLGWNDLGFHgsviRTPHLDALAAGGVVLDNYY-VQPLCT-PSRSQLLTGRY-QIHlGLQHY 113
Cdd:COG1524 15 AAAAAAPPAKKVVLILVDGLRADLLERA----HAPNLAALAARGVYARPLTsVFPSTTaPAHTTLLTGLYpGEH-GIVGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 114 --------LIMTCQPSCVPLD--EKLLP-----QLLKEAGYATHMVGKWHLGMYrkeclptrRGFDTYFGYLLGSEDYYT 178
Cdd:COG1524 90 gwydpelgRVVNSLSWVEDGFgsNSLLPvptifERARAAGLTTAAVFWPSFEGS--------GLIDAARPYPYDGRKPLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 179 HEacaPIESLNGTRCALDLRDGEEPAkeynniystniftkrattvianhppekplFLYLAFQSV----HDplqvpeeyme 254
Cdd:COG1524 162 GN---PAADRWIAAAALELLREGRPD-----------------------------LLLVYLPDLdyagHR---------- 199
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 125656171 255 pYGFIQDKhrriYAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNG 303
Cdd:COG1524 200 -YGPDSPE----YRAALREVDAALGRLLDALKARGLYEGTLVIVTADHG 243
|
|
| Sulfatase_C |
pfam14707 |
C-terminal region of aryl-sulfatase; |
427-499 |
9.60e-03 |
|
C-terminal region of aryl-sulfatase;
Pssm-ID: 405407 [Multi-domain] Cd Length: 122 Bit Score: 36.52 E-value: 9.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125656171 427 NTSIHAgIRYKNWKL--LTGHpgcgyWFPPPSQSNVSEIPPV---DPPtktLwLFDINQDPEERHDV---SREHPHIVQN 498
Cdd:pfam14707 11 GAALHA-VRWGPYKAhfFTPS-----FDPPGAEGCYGSKVPVthhDPP---L-LFDLERDPSEKYPLspdSPEYPEVLAE 80
|
.
gi 125656171 499 L 499
Cdd:pfam14707 81 I 81
|
|
| |
