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Conserved domains on  [gi|1556756084|ref|NP_033316|]
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protein Wnt-8a precursor [Mus musculus]

Protein Classification

wnt family protein( domain architecture ID 1562737)

wnt family protein may function in development and differentiation

Gene Ontology:  GO:0016055|GO:0005102|GO:0005576
PubMed:  22952392|20477987|8167409
SCOP:  4005649|4007801

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Wnt super family cl38924
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 31-337 0e+00

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


The actual alignment was detected with superfamily member cd19351:

Pssm-ID: 393294  Cd Length: 307  Bit Score: 532.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  31 TRPKAYLTYTASVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLE 110
Cdd:cd19351     1 TGPKAYLTYSSSVAAGAQSGIEECKHQFAWERWNCPESALQLSTHNGLRSATRETSFVHAISSAGVMYTLTRNCSLGDFE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 111 NCGCDESQNGKTGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCS 190
Cdd:cd19351    81 NCGCDDSRNGRTGGRGWIWGGCSDNVEFGERISKQFVDALETGQDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 191 IQTCWLQLADFRQMGNYLKAKYDRALKIEMDKRQLRAGNRAEGRWALTEAFLPSTEAELIFLEGSPDYCNRNASLSIQGT 270
Cdd:cd19351   161 IQTCWLQLADFREIGNYLKVKHDQALKLEMDKRRMRAGNSADNRGAIAEAFGSVAETELIYLEDSPDYCTKNASLGLQGT 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1556756084 271 EGRECLQNARSASRREQRSCGRLCTECGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYCT 337
Cdd:cd19351   241 EGRECLQSGKNLSQWERRSCRRLCTECGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYCA 307
 
Name Accession Description Interval E-value
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 31-337 0e+00

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 532.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  31 TRPKAYLTYTASVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLE 110
Cdd:cd19351     1 TGPKAYLTYSSSVAAGAQSGIEECKHQFAWERWNCPESALQLSTHNGLRSATRETSFVHAISSAGVMYTLTRNCSLGDFE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 111 NCGCDESQNGKTGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCS 190
Cdd:cd19351    81 NCGCDDSRNGRTGGRGWIWGGCSDNVEFGERISKQFVDALETGQDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 191 IQTCWLQLADFRQMGNYLKAKYDRALKIEMDKRQLRAGNRAEGRWALTEAFLPSTEAELIFLEGSPDYCNRNASLSIQGT 270
Cdd:cd19351   161 IQTCWLQLADFREIGNYLKVKHDQALKLEMDKRRMRAGNSADNRGAIAEAFGSVAETELIYLEDSPDYCTKNASLGLQGT 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1556756084 271 EGRECLQNARSASRREQRSCGRLCTECGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYCT 337
Cdd:cd19351   241 EGRECLQSGKNLSQWERRSCRRLCTECGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYCA 307
WNT1 smart00097
found in Wnt-1;
21-336 4.32e-135

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 387.06  E-value: 4.32e-135
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084   21 SAWSVNNFLITRPKAYLTYTASVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNRLRAATRETSFIHAIRSAAIMYAV 100
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVFGKVLRQGTRETAFVYAISSAGVAHAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  101 TKNCSMGDLENCGCDESQNGKTGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTC 180
Cdd:smart00097  81 TRACSEGELDSCGCDYRKRGRAGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKREC 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  181 KCHGISGSCSIQTCWLQLADFRQMGNYLKAKYDRALKIEMDKRQLRAGNRAEGRwalteAFLPSTEAELIFLEGSPDYCN 260
Cdd:smart00097 161 KCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVPKNS-----TFKPPTETDLVYLESSPDFCE 235

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1556756084  261 RNASLSIQGTEGRECLQNARSASrreqrSCGRLCTECGLQVeeRRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:smart00097 236 KNPKTGSLGTQGRQCNKTSKGLD-----GCDLLCCGRGYNT--RTVEVVERCNCKFHWCCYVKCKQCRETVEKHTC 304
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 40-336 2.41e-117

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 341.84  E-value: 2.41e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  40 TASVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNR-LRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCDESQ 118
Cdd:pfam00110  20 MASVAEGAQLAIEECQHQFRNRRWNCSTLENKRPVFGKvLKRGTRETAFVYAISSAGVTHAVTRACSSGELTSCGCDRKK 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 119 NGK-TGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGK-DARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSIQTCWL 196
Cdd:pfam00110 100 RGKsSGEGGWEWGGCSDNIDYGYKFSRKFVDAREKKRrDARALMNLHNNEAGRKAVKSNMRTECKCHGVSGSCSVKTCWK 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 197 QLADFRQMGNYLKAKYDRALKIEM---DKRQLRAGNRaegrwalteAFLPSTEAELIFLEGSPDYCNRNASLSIQGTEGR 273
Cdd:pfam00110 180 ALPPFREVGDRLKEKYDGAVKVNRrrnKRGRLVPRNS---------RFKPPTKNDLVYLEKSPDYCERNPKTGSLGTRGR 250

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1556756084 274 ECLQNARSASrreqrSCGRLCteCG---LQVEERRAEavsSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:pfam00110 251 ECNKTSSGPD-----GCDLLC--CGrgyNTRTVTVTE---RCNCKFHWCCYVKCKTCTETVEVYTC 306
 
Name Accession Description Interval E-value
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 31-337 0e+00

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 532.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  31 TRPKAYLTYTASVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLE 110
Cdd:cd19351     1 TGPKAYLTYSSSVAAGAQSGIEECKHQFAWERWNCPESALQLSTHNGLRSATRETSFVHAISSAGVMYTLTRNCSLGDFE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 111 NCGCDESQNGKTGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCS 190
Cdd:cd19351    81 NCGCDDSRNGRTGGRGWIWGGCSDNVEFGERISKQFVDALETGQDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 191 IQTCWLQLADFRQMGNYLKAKYDRALKIEMDKRQLRAGNRAEGRWALTEAFLPSTEAELIFLEGSPDYCNRNASLSIQGT 270
Cdd:cd19351   161 IQTCWLQLADFREIGNYLKVKHDQALKLEMDKRRMRAGNSADNRGAIAEAFGSVAETELIYLEDSPDYCTKNASLGLQGT 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1556756084 271 EGRECLQNARSASRREQRSCGRLCTECGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYCT 337
Cdd:cd19351   241 EGRECLQSGKNLSQWERRSCRRLCTECGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYCA 307
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 30-337 9.88e-149

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 421.74  E-value: 9.88e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  30 ITRPKAYLTYTASVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDL 109
Cdd:cd19352     1 MTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHSGLRSANRETAFVHAISSAGVMYTLTRNCSLGDF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 110 ENCGCDESQNGKTGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSC 189
Cdd:cd19352    81 DNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 190 SIQTCWLQLADFRQMGNYLKAKYDRALKIEMDKrqlRAGNRAEGRWALTEAFLPSTEAELIFLEGSPDYCNRNASLSIQG 269
Cdd:cd19352   161 TTQTCWLQLPEFREVGNYLKEKYHRALKVDLLQ---GAGNSAASRGAIAETFRSISKKELVHLEDSPDYCLENKTLGLLG 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1556756084 270 TEGRECLQNARSASRREQRSCGRLCTECGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYCT 337
Cdd:cd19352   238 TEGRECLKRGKALSKWEKRSCRRLCGDCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFCV 305
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 31-336 2.47e-148

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 420.16  E-value: 2.47e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  31 TRPKAYLTYTASVALGAQIGIEECKFQFAWERWNCPEHAFqfSTHNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLE 110
Cdd:cd19340     1 SGPKAYLSLSDSVAAGAQLAMEECQYQFKWDRWNCPESAF--FSQKNNPSATRETAFVHAISSAGVMYTLTRNCSLGHFE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 111 NCGCDESQNGKTGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCS 190
Cdd:cd19340    79 GCGCDDSKKGSKGGEGWTWGGCSDNVKFGERVSKKFLDSLETGQDAQALMNLHNNRAGRKAVRKTMKKTCKCHGVSGSCS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 191 IQTCWLQLADFRQMGNYLKAKYDRALKIEMDKRQLRAGNRAEGRwalteAFLPSTEAELIFLEGSPDYCNRNASLSIQGT 270
Cdd:cd19340   159 TQTCWMQLAPFREIGTDLKRKYDRAVRVDYENGGLRETNGSRAI-----KLLNIKKNDLVYLEKSPNYCRANVTLGWPGT 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1556756084 271 EGRECLQN-ARSASRREQRSCGRLCTECGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19340   234 LGRQCSRDkKESVSRWERKSCRRLCRACGLKVRKKVVEVTSSCNCKFHWCCEVKCETCVELVIEYTC 300
WNT1 smart00097
found in Wnt-1;
21-336 4.32e-135

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 387.06  E-value: 4.32e-135
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084   21 SAWSVNNFLITRPKAYLTYTASVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNRLRAATRETSFIHAIRSAAIMYAV 100
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVFGKVLRQGTRETAFVYAISSAGVAHAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  101 TKNCSMGDLENCGCDESQNGKTGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTC 180
Cdd:smart00097  81 TRACSEGELDSCGCDYRKRGRAGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKREC 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  181 KCHGISGSCSIQTCWLQLADFRQMGNYLKAKYDRALKIEMDKRQLRAGNRAEGRwalteAFLPSTEAELIFLEGSPDYCN 260
Cdd:smart00097 161 KCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVPKNS-----TFKPPTETDLVYLESSPDFCE 235

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1556756084  261 RNASLSIQGTEGRECLQNARSASrreqrSCGRLCTECGLQVeeRRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:smart00097 236 KNPKTGSLGTQGRQCNKTSKGLD-----GCDLLCCGRGYNT--RTVEVVERCNCKFHWCCYVKCKQCRETVEKHTC 304
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 42-336 7.86e-123

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 355.06  E-value: 7.86e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  42 SVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCDESQNGK 121
Cdd:cd13113     4 SIAEGAQLALKECQRQFANRRWNCSTFNEPLLFGKILKRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCDRTRQGP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 122 TGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGK--DARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSIQTCWLQLA 199
Cdd:cd13113    84 EGQGDWTWGGCSDNIKFGIKFSRKFLDAREKKKgsDARSLMNLHNNEAGRKAVKKTMKKKCKCHGVSGSCTTKTCWRQLP 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 200 DFRQMGNYLKAKYDRALKIEMDKRQLRAGNRAEGRwalteAFLPSTEAELIFLEGSPDYCNRNASLSIQGTEGRECLQNA 279
Cdd:cd13113   164 SFREIGDYLKEKYDNAVKVKLNNNGSGLRLVPKRS-----RFRSPTETDLVYLEESPDYCEPNPTLGSLGTAGRECNPTS 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1556756084 280 RSASrreqrSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd13113   239 PGPD-----SCELLC--CGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 40-336 2.41e-117

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 341.84  E-value: 2.41e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  40 TASVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNR-LRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCDESQ 118
Cdd:pfam00110  20 MASVAEGAQLAIEECQHQFRNRRWNCSTLENKRPVFGKvLKRGTRETAFVYAISSAGVTHAVTRACSSGELTSCGCDRKK 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 119 NGK-TGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGK-DARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSIQTCWL 196
Cdd:pfam00110 100 RGKsSGEGGWEWGGCSDNIDYGYKFSRKFVDAREKKRrDARALMNLHNNEAGRKAVKSNMRTECKCHGVSGSCSVKTCWK 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 197 QLADFRQMGNYLKAKYDRALKIEM---DKRQLRAGNRaegrwalteAFLPSTEAELIFLEGSPDYCNRNASLSIQGTEGR 273
Cdd:pfam00110 180 ALPPFREVGDRLKEKYDGAVKVNRrrnKRGRLVPRNS---------RFKPPTKNDLVYLEKSPDYCERNPKTGSLGTRGR 250

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1556756084 274 ECLQNARSASrreqrSCGRLCteCG---LQVEERRAEavsSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:pfam00110 251 ECNKTSSGPD-----GCDLLC--CGrgyNTRTVTVTE---RCNCKFHWCCYVKCKTCTETVEVYTC 306
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 41-336 4.25e-104

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 308.38  E-value: 4.25e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  41 ASVALGAQIGIEECKFQFAWERWNCPEHAFQFstHNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCDESQNG 120
Cdd:cd19338    29 EEVAKGAKLGIRECQYQFRNRRWNCSTSRKSF--GKILKRDTRETAFVYAITSAGVTYSVTRACSMGELLQCGCDKSKRG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 121 KTGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGK-DARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSIQTCWLQLA 199
Cdd:cd19338   107 KSTEGEWEWGGCSDNVRYGYRKSREFMDAKEKNRsDIRTLMNLHNNEAGRLAVKNNMRKECKCHGLSGSCTLKTCWRKMP 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 200 DFRQMGNYLKAKYDRALKIEM--DKRQLR-AGNRAEgrwalteaflPSTEAELIFLEGSPDYCNRNASLSIQGTEGRECl 276
Cdd:cd19338   187 PFREVGDRLKERFDGAIKVKGsnDGKSLIpEGKTIK----------PPTKEDLVYLEESPDFCEPNKKTGSLGTRGREC- 255

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 277 qNARSASrreQRSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19338   256 -NRTSMG---VDGCDLLC--CGRGYQTEVRVVEENCNCRFHWCCEVKCETCKVRKEIHTC 309
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 42-336 8.36e-99

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 294.53  E-value: 8.36e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  42 SVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCDESQNGK 121
Cdd:cd19344    18 SVSEGARLGIYECQHQFRHERWNCSTTNDQNVFGKTLSRGTKETAFIYAITSAGVVHAVTRACSAGNLTDCSCDSRRQGQ 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 122 TGGHGWIWGGCSDNVEFGEKISRLFVDSLEK-----GKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSIQTCWL 196
Cdd:cd19344    98 SASEGWKWGGCSDNVDYGIWFARKFVDAPEKserkrSRDVRSLMNLHNNEVGRQAIARLMKVKCRCHGVSGSCEVKTCWK 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 197 QLADFRQMGNYLKAKYDRALKIEMD--KRQLRAGNRAEGRwalteafLPSTEAELIFLEGSPDYCNRNASLSIQGTEGRE 274
Cdd:cd19344   178 TMPSFEEVGDFLKQKYENSIQIATKksKRRLRRRERRKRK-------VPISKDELVYIHKSPNYCVRDPKKGILGTSGRE 250

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1556756084 275 CLQNARSASrreqrSCGRLCteCG----LQVEERraeaVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19344   251 CNRTSTGPD-----SCDLLC--CGrgynTQVVRH----VERCNCKFVWCCYVKCKTCETMTDVHTC 305
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 42-336 9.71e-98

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 292.32  E-value: 9.71e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  42 SVALGAQIGIEECKFQFAWERWNCpehafqfSTHNR--------LRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCG 113
Cdd:cd19334    29 SIGEGAKLGVKECQYQFRNQRWNC-------STVDRdatvfgkvLLKGSREAAFVYAISSAGVVHAITRACSKGELLNCA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 114 CDESQNGKTGGH--GWIWGGCSDNVEFGEKISRLFVDSLE-KGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCS 190
Cdd:cd19334   102 CDPTKRGKGRDSkgEFDWGGCSDNVKYGINFARKFVDARErRVRDARALMNLHNNRAGRKAVKKNLKLQCKCHGVSGSCT 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 191 IQTCWLQLADFRQMGNYLKAKYDRALKIEMDkrqlragNRAEGRWALTEAFLPSTEAELIFLEGSPDYCNRNASLSIQGT 270
Cdd:cd19334   182 IRTCWRALAEFREVGDYLREKYDGAVQVTMN-------QSGTNLLAANKGHKKPTRSDLVYFESSPDYCVPNPETGSLGT 254

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1556756084 271 EGRECLQNARSASrreqrSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19334   255 AGRVCNKTSTGTD-----GCDIMC--CGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCTETVDVHTC 313
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 42-336 7.07e-97

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 290.06  E-value: 7.07e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  42 SVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNR-LRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCDESQNG 120
Cdd:cd19335    27 SVAEGAKLGIQECQHQFRGRRWNCTTIEGDLSVFGPvLDKASRESAFVHAIASAGVAHAVTRACAEGDSTSCGCDSRHKG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 121 KTGGhGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSIQTCWLQLAD 200
Cdd:cd19335   107 PPGE-GWRWGGCSEDVEFGVRFSREFADARENRPDARSAMNRHNNEAGRQAILDNMELKCKCHGLSGSCELKTCWWAQPD 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 201 FRQMGNYLKAKYDRALKIEMDkRQLRAGNRAEGRWALTEAFLPSTEAELIFLEGSPDYCNRNASLSIQGTEGREClqNAR 280
Cdd:cd19335   186 FRKIGDYLKDKYDSASEMVVE-RHRESRGWVETLRPKYKLFKPPTERDLIYYEESPNFCEPNPETGSFGTRGREC--NVT 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1556756084 281 SASrreQRSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19335   263 SHG---IDGCDLLC--CGRGYNTRTEKRTEKCHCIFVWCCYVSCQECIRVYDVHTC 313
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 40-328 2.22e-95

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 286.47  E-value: 2.22e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  40 TASVALGAQIGIEECKFQFAWERWNCPEhafqFSTHNR-------LRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENC 112
Cdd:cd19342    25 TASAIQGIQLAVHECQRQFRDHRWNCSS----LETKNKnphtspiLSRGYRETAFAYAISAAGVAHQVARACSLGKLLSC 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 113 GCDESQNGKTG-GHGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSI 191
Cdd:cd19342   101 GCDRSRRGKRSsGNDWKWGGCSHNLDFGEKFSRKFLDSREKARDIHSRMNLHNNRAGRLAVSENMERKCKCHGMSGSCEL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 192 QTCWLQLADFRQMGNYLKAKYDRALKIEMDKRqlraGNRAEGRWALTEAFLPST-EAELIFLEGSPDYCNRNASLSIQGT 270
Cdd:cd19342   181 KTCWKAAPDFREVGDILKEKYDHATLVDQSNL----NNGARRRRLTRRKRRRRPpKTDLVYYERSPNFCEADPSLDSPGT 256

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1556756084 271 EGREClqnarSASRREQRSCGRLCteCGL---QVEERRAEavsSCDCNFQWCCTVKCGQCR 328
Cdd:cd19342   257 RGRVC-----NKTSTGPDSCDSLC--CGRgynTVRQTRTE---RCNCRFHWCCYVVCEKCT 307
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 42-336 5.01e-94

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 282.67  E-value: 5.01e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  42 SVALGAQIGIEECKFQFAWERWNC----PEHAFQfsthNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCDES 117
Cdd:cd19336    24 SVRRGAQLAIEECQFQFRNRRWNCstldKEPVFG----KVLNQGTREAAFVHAISSAGVAHAVTRACSSGELEKCGCDRS 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 118 QNGKTGgHGWIWGGCSDNVEFGEKISRLFVDSLEKGK----DARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSIQT 193
Cdd:cd19336   100 VRGRSP-EGFQWSGCSDNVAYGVAFSKSFVDARERRKgrasSSRALMNLHNNEAGRKAIEKNMRVECKCHGVSGSCELKT 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 194 CWLQLADFRQMGNYLKAKYDRALKIEMDK----RQLRAGNRaegrwalteAFLPSTEAELIFLEGSPDYCNRNASLSIQG 269
Cdd:cd19336   179 CWRAMPTFREVGNILKEKFDGATEVQQKRigsrPVLVPKNP---------QFKPHTDADLVYLDSSPDFCEPDPKTGSLG 249

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1556756084 270 TEGRECLQNARSASrreqrSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19336   250 THGRVCNKTSKAID-----GCDLLC--CGRGYVTRTEEVVERCSCKFHWCCYVKCKTCRREVEVHTC 309
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 42-336 5.04e-94

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 282.70  E-value: 5.04e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  42 SVALGAQIGIEECKFQFAWERWNCPEHAFQFSTH---NRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCDESQ 118
Cdd:cd19333    18 AIARGARMAIKECKWQFRNRRWNCPTTDSRGGPNvfgKILNRGCRETAFIYAITSAAVTHSVARACSEGSIESCSCDYRR 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 119 NGKtGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSIQTCWLQL 198
Cdd:cd19333    98 RGP-GGPDWEWGGCSDNIDFGRKFSREFVDAGEKGRDLRYLMNLHNNEAGRVHVSSEMRQECKCHGMSGSCTVKTCWMRL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 199 ADFRQMGNYLKAKYDRALKIEM-DKRQLRAGNRAEGRWALTE--AFLPSTEAELIFLEGSPDYCNRNASLSIQGTEGREC 275
Cdd:cd19333   177 PTFRTVGDRLKDRFDGASRVAYgNNGNNRGSRRAKKFLLEPEnpNHKPPTSKDLVYFEESPNFCEKNPKLGTLGTRGREC 256

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1556756084 276 lqnarSASRREQRSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19333   257 -----NATSIGLDGCDLMC--CGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTC 310
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 41-336 1.15e-93

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 281.82  E-value: 1.15e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  41 ASVALGAQIGIEECKFQFAWERWNC--PEHAFQFstHNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCDESQ 118
Cdd:cd19337    23 PSVGRGAKLAIEECQYQFRYRRWNCstPDSSSVF--GPVTNIGTREAAFTYAISAAGVVHAIARACREGNLSTCGCSRER 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 119 NGKTGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGKD--------ARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCS 190
Cdd:cd19337   101 RPKDLPRDWLWGGCGDNIEYGYKFAKEFIDARERETNyprhsrelARVLMNLHNNEAGRRAVYEKARVACKCHGVSGSCS 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 191 IQTCWLQLADFRQMGNYLKAKYDRALKIEMDKRqlraGNRAEGRwalTEAFLPSTEAELIFLEGSPDYCNRNASLSIQGT 270
Cdd:cd19337   181 LKTCWRQLAPFREVGDRLKDKYDGAVKVKLNRR----GTLLRRR---NSRFNKPTKDDLVYLDDSPDYCERNPKTGSLGT 253

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1556756084 271 EGRECLQNARSAsrreqRSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19337   254 KGRECNKTSSGT-----DGCELLC--CGRGYNTKKVEVVERCHCKFHWCCEVKCKTCEKIVDVHIC 312
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 31-336 1.33e-92

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 279.17  E-value: 1.33e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  31 TRPKAyltyTASVALGAQIGIEECKFQFAWERWNCP----EHAFQFsthnRLRAATRETSFIHAIRSAAIMYAVTKNCSM 106
Cdd:cd19339    18 SRPDA----IVAIGEGAQLGIEECQFQFRNHRWNCTllgeRTVFGQ----ELPVGSREAAFTYAITSAGVAYAITQACSQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 107 GDLENCGCDESQNG-KTGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGI 185
Cdd:cd19339    90 GNLSDCGCDKSKKGyGKSDEGWKWGGCSADVKYGLRFSRKFVDAREVKRNARSLMNLHNNEAGRKAVEENLKLECKCHGV 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 186 SGSCSIQTCWLQLADFRQMGNYLKAKYDRALKIEMDKRQLRAGNRAEGRWALTEAFLPStEAELIFLEGSPDYCNRNASL 265
Cdd:cd19339   170 SGSCTTKTCWTTLPSFREIGDYLKKKYERARRVEPVRGRRRRRPTFLKLKISRKYKKPR-PRDLVYLEKSPNYCEKDPLT 248

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1556756084 266 SIQGTEGRECLQNARSASrreqrSCGRLCTECGLQVEERRaeAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19339   249 GSLGTVGRRCNRTSTGTD-----GCDLMCCGRGYNTHQYT--KTWQCNCKFHWCCYVKCNTCSERTEEYTC 312
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 42-336 9.12e-83

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 253.72  E-value: 9.12e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  42 SVALGAQIGIEECKFQFAWERWNCP--EHAFQFSthNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGC----D 115
Cdd:cd19343    18 SVVEAARLTVDTCQEQFADRRWNCSsiELAPNFT--PDLTRGTREQAFVYALSSAALTHTIARACASGALPGCGCgrlpR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 116 ESQNGktgghGWIWGGCSDNVEFGEKISRLFVDSLEK-----GKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCS 190
Cdd:cd19343    96 EPPDG-----DFKWGGCGDNVRYGLRFAKRFTDAPEKkkkkkKRQARALMNLHNNRVGRKAVRDSLETQCKCHGVSGSCS 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 191 IQTCWLQLADFRQMGNYLKAKYDRALKIemdkRQLRAGNRAEgRWALTEAFLPSTEAELIFLEGSPDYCNRNASLSIQGT 270
Cdd:cd19343   171 VKTCWKALPDLSEVASRLKRKYARAVEV----VSRKVGSRRK-LVPKSLKVRPYTKDDLIYLTKSPDYCLPDEKLGSLGT 245

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1556756084 271 EGRECLQNARSASrreqrSCGRLCteCG-------LQVEERraeavssCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19343   246 RGRECNKTSVGSD-----SCDSMC--CGrgyrtytVEVVER-------CHCKYHWCCYVKCKTCRRTVEVHVC 304
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 46-336 8.36e-77

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 238.34  E-value: 8.36e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  46 GAQIGIEECKFQFAWERWNCpehAFQFSTHNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCDESQNGKTGGH 125
Cdd:cd19341    22 AIRLSVLECQEQFRYERWNC---SLGKYRINLLKKGYKETAFLYAISSAGLTHSVARACSSGRLDRCTCDESFSLEENRQ 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 126 GWIWGGCSDNVEFGEKISRLFVDSLEKG-KDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSIQTCWLQLADFRQM 204
Cdd:cd19341    99 TWLWGGCGDNIKYGKKFTRRFLQLKKKSgKDLRAEIDRHNSEVGIRVVREGVKKTCKCHGVSGSCTVKTCWKQLAPFNEI 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 205 GNYLKAKYDRALKIEMDKRQLRAGNRAEGRWALTEAFLPSTE-AELIFLEGSPDYCNRNASLSiqGTEGRECLQNarsas 283
Cdd:cd19341   179 GKILKRKYEKAVKVVSENNAATGGSQLRKGKSGSVKKKSRPRrKDLVYLEKSPSFCRSTRYSP--GTKGRRCLKG----- 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1556756084 284 rreqRSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19341   252 ----DNCDTLC--CGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTEREEIYTC 298
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 42-336 9.21e-76

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 235.98  E-value: 9.21e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  42 SVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNR-LRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCDESQNG 120
Cdd:cd19345    29 AIGSGVKEWIAECQHQFRNHRWNCNTLDRDHSLFGRlLLRSSRESAFVYAISSAGVVFAITRACSQGELKSCSCDPKKKG 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 121 --KTGGHGWIWGGCSDNVEFGEKISRLFVDSLE-KGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSIQTCWLQ 197
Cdd:cd19345   109 ssKDSKGSFDWGGCSDNIDYGIRFARAFVDAKErKGKDARALMNLHNNRAGRKAVKRFMTLECKCHGVSGSCTVRTCWLA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 198 LADFRQMGNYLKAKYDRALKIEMDKrqlragnRAEGRWALTEAFLPSTEAELIFLEGSPDYCNRNASLSIQGTEGRECLQ 277
Cdd:cd19345   189 MADFRKTGDYLRKKYNGAIQVVMNQ-------DGTGFTVANKHFKKPTKNDLVYFENSPDYCVRDRDAGSLGTAGRVCNR 261

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1556756084 278 NARSASrreqrSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19345   262 TSRGMD-----GCEVMC--CGRGYDTSRVGRMTKCECKFHWCCAVRCKDCHQQVDVHTC 313
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 42-336 1.53e-75

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 235.59  E-value: 1.53e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  42 SVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNR-LRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCDESQNG 120
Cdd:cd19346    29 SIGEGAKEWIRECQHQFRHHRWNCSTLDRDHTVFGRvMLRSSREAAFVYAISSAGVVYAITRACSQGELKSCSCDPHKRG 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 121 KTGGH--GWIWGGCSDNVEFGEKISRLFVDSLEKG-KDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSIQTCWLQ 197
Cdd:cd19346   109 RSHDErgEFDWGGCSDNINYGIKFAKAFVDAKEKKeKDARALMNLHNNRCGRMAVKRFMKLECKCHGVSGSCTLRTCWLA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 198 LADFRQMGNYLKAKYDRALKIEMDKrqlragnRAEGRWALTEAFLPSTEAELIFLEGSPDYCNRNASLSIQGTEGREClq 277
Cdd:cd19346   189 MSDFRKTGDYLRKRYNGAVQVTMNQ-------DGTGFTVANKNFRKATKTDLVYFENSPDYCVMDKSAGSLGTAGRVC-- 259

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1556756084 278 narSASRREQRSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19346   260 ---NKSSRGTDGCEVMC--CGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTC 313
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 36-336 4.81e-74

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 231.88  E-value: 4.81e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  36 YLTYTASVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCD 115
Cdd:cd19347    18 YQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAISAAGVVNAVSRACREGELSTCGCS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 116 ESQNGKTGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGK--------DARALVNLHNNRAGRLAVRASTKRTCKCHGISG 187
Cdd:cd19347    98 RAARPKDLPRDWLWGGCGDNLEYGYRFAKEFVDAREREKiyqkgsyeSARTLMNLHNNEAGRRTVYNLADVACKCHGVSG 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 188 SCSIQTCWLQLADFRQMGNYLKAKYDRALKIEMDKRqlraGNRAEgrwaLTEAFLPSTEAELIFLEGSPDYCNRNASLSI 267
Cdd:cd19347   178 SCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNSR----GKLVQ----VNSRFNPPTTLDLVYIDPSPDYCVRNESTGS 249

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1556756084 268 QGTEGRECLQNARSASRREQRSCGRLCTECGLQVEERraeavssCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19347   250 LGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTER-------CHCKFHWCCYVKCKKCTEIVDQFVC 311
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 36-336 7.50e-73

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 228.71  E-value: 7.50e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  36 YLTYTASVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCD 115
Cdd:cd19348    18 YQDHMVYIGEGAKTGIKECQYQFRQRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 116 ESQNGKTGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGKD--------ARALVNLHNNRAGRLAVRASTKRTCKCHGISG 187
Cdd:cd19348    98 RAARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREREKNypkgseehARTLMNLQNNEAGRRAVYNLADVACKCHGVSG 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 188 SCSIQTCWLQLADFRQMGNYLKAKYDRALKIEMDKRqlragnraeGRWALTEA-FLPSTEAELIFLEGSPDYCNRNASLS 266
Cdd:cd19348   178 SCSLKTCWLQLADFRKVGDLLKEKYDSAAAMRINRK---------GKLELVNSrFNPPTAEDLVYIDPSPDYCLRNETTG 248

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 267 IQGTEGRECLQNARSASrreqrSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19348   249 SLGTQGRLCNKTSEGMD-----GCELMC--CGRGYDQFKTVQVERCHCKFHWCCYVKCKKCTEIVDQFVC 311
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 31-336 6.39e-69

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 218.77  E-value: 6.39e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  31 TRPKAYLTytasVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLE 110
Cdd:cd19349    23 SRPDAIIV----IGEGAQMGINECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 111 NCGCDESQNGKTG-GHGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSC 189
Cdd:cd19349    99 DCGCDKEKQGQYNqEEGWKWGGCSADIRYGIGFSKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSC 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 190 SIQTCWLQLADFRQMGNYLKAKYDRALKIEmDKRQLRAGNRAEGRWALTEAFLPSTEAELIFLEGSPDYCNRNASLSIQG 269
Cdd:cd19349   179 TTKTCWTTLPKFRELGYILKDKYNEAVHVE-PVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVG 257

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1556756084 270 TEGRECLQNARSASrreqrSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19349   258 TQGRMCNKTAQQNN-----GCDLMC--CGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTC 317
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 31-336 2.38e-67

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 214.87  E-value: 2.38e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  31 TRPKAYLTytasVALGAQIGIEECKFQFAWERWNCPEHAFQFSTHNRLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLE 110
Cdd:cd19350    23 SRPDAIIV----IGEGAQMGINECQYQFRYGRWNCSALGERTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 111 NCGCD-ESQNGKTGGHGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSC 189
Cdd:cd19350    99 NCGCDrEKQGYYNQEEGWKWGGCSADIKYGIDFSRKFVDAREIKKNARRLMNLHNNEAGRKVLEERMKLECKCHGVSGSC 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 190 SIQTCWLQLADFRQMGNYLKAKYDRALKIEMdKRQLRAGNRAEGRWALTEAFLPSTEAELIFLEGSPDYCNRNASLSIQG 269
Cdd:cd19350   179 TTKTCWTTLPKFREIGYVLKEKYNAAVQVEV-VRASRLRQPTFLKIKKRRSYQKPMETDLVYIERSPNYCEEDAATGSVG 257

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1556756084 270 TEGRECLQNARSASrreqrSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19350   258 TQGRLCNRTSPHTD-----GCDLMC--CGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTC 317
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 40-328 3.33e-63

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 203.67  E-value: 3.33e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  40 TASVALGAQIGIEECKFQFAWERWNCPehafQFSTHNRLRAAT-------RETSFIHAIRSAAIMYAVTKNCSMGDLENC 112
Cdd:cd19355    25 TASAIQGIQIAIHECQHQFRDHRWNCS----SLETRNKIPYESvvfsrgfRESAFAYAIAAAGVVHAVSNACAMGKLKAC 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 113 GCDesqngktgghgWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSIQ 192
Cdd:cd19355   101 GCD-----------WEWGGCSPDVEYGERFSKDFLDSRETYRDIHARMRLHNNRVGRQVVMDNMRRKCKCHGTSGSCQLK 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 193 TCWLQLADFRQMGNYLKAKYDRALKIEMDKR---QLRAGNRAEGRWAlteaflpsTEAELIFLEGSPDYCNRNASLSIQG 269
Cdd:cd19355   170 TCWQVTPEFRTVGSLLKDRFYVATLIKPHNRntgQLEPGHAPHRRRA--------SINDLVYFEKSPDFCEREPRLDSAG 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1556756084 270 TEGRECLQNARSASrreqrSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCR 328
Cdd:cd19355   242 TQGRICNKTSPGMD-----NCESLC--CGRGHNILRQTRSERCNCKFHWCCYVVCEECR 293
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 47-336 6.58e-61

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 197.43  E-value: 6.58e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  47 AQIGIEECKFQFAWERWNCpehafqfSTHNR---LRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCDESQnGKTG 123
Cdd:cd19354    23 VRLGLLECQFQFRSERWNC-------SLEGRgslLKRGFKETAFLYAVSSAALTHSLAKACSSGRMERCTCDDSP-GLEN 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 124 GHGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSIQTCWLQLADFRQ 203
Cdd:cd19354    95 REAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSCAVRTCWKQLSPFHE 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 204 MGNYLKAKYDRALKIemdkrqLRAGNRAEGRWALTEAFLPST--------EAELIFLEGSPDYCnrNASLSIQGTEGREC 275
Cdd:cd19354   175 TGRLLKLKYENAVKV------HSVTNDATGETELWSPERHGHtlkghsprSTDLVYLEDSPSFC--RPSKYSPGTAGRTC 246

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1556756084 276 LQNArsasrreqrSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19354   247 SRET---------NCDSLC--CGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTC 296
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 40-328 4.89e-58

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 190.10  E-value: 4.89e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  40 TASVALGAQIGIEECKFQFAWERWNCP--EHAFQFSTHNR-LRAATRETSFIHAIRSAAIMYAVTKNCSMGDLENCGCde 116
Cdd:cd19356    25 TASALQGIQIAIHECQHQLRDQRWNCSslEGGGKLPHDSAiLKRGFRESAFSFSLLAAGVMHSVATACSLGKLRGCGC-- 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 117 sqngktgghGWIWGGCSDNVEFGEKISRLFVDSLEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSIQTCWL 196
Cdd:cd19356   103 ---------EWEWGGCSHDIEFGEKFSRDFLDSRESPRDIQARMRIHNNRVGRQVVTENMKRKCKCHGTSGSCQFKTCWH 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 197 QLADFRQMGNYLKAKYDRALKIEMDKRQLRAGNRAEGRWALTEaflpsteaELIFLEGSPDYCNRNASLSIQGTEGRECl 276
Cdd:cd19356   174 VTPEFRLVGALLREKFQRAIFINSHNKNSGVFLPRLRPRRLAR--------ELVYFEKSPDFCERDPAVDSPGTQGRIC- 244

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1556756084 277 qnarSASRREQRSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCR 328
Cdd:cd19356   245 ----NKTSPGMDGCGSLC--CGRGHNILKQTRSERCHCRFHWCCYVLCEECR 290
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 33-336 4.72e-56

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 184.85  E-value: 4.72e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084  33 PKAYLTYTASVALGAQigieECKFQFAWERWNCP-EHAFQFSThnrLRAATRETSFIHAIRSAAIMYAVTKNCSMGDLEN 111
Cdd:cd19353    13 PGVAETLMEAISMSAL----ECQYQFRFERWNCTlEGRYRASL---LKRGFKETAFLYAISSAGLTHAMAKACSAGRMER 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 112 CGCDESQNGKTGgHGWIWGGCSDNVEFGEKISRLFVDSlEKGKDARALVNLHNNRAGRLAVRASTKRTCKCHGISGSCSI 191
Cdd:cd19353    86 CTCDEAPDLENR-EAWQWGGCGDNLKYSNKFVKEFLGR-KSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSGSCTV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1556756084 192 QTCWLQLADFRQMGNYLKAKYDRALKIEMDKRQLRA-GNRAEGRWALT--EAFLPSTeAELIFLEGSPDYCnrNASLSIQ 268
Cdd:cd19353   164 RTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNEATGeGDISPPKKSGAghSDQIPRT-TDLVYIDDSPSFC--LMSRFSP 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1556756084 269 GTEGRECLQNarsasrreqRSCGRLCteCGLQVEERRAEAVSSCDCNFQWCCTVKCGQCRRVVSRYYC 336
Cdd:cd19353   241 GTSGRRCYKD---------KNCESIC--CGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTC 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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