|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
95-424 |
1.22e-25 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 109.25 E-value: 1.22e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 95 NDLVKLKTLRLTRNKISRLPRAILDKMVLLEQLFLDHNalrdldqNLFQQLRNLQELGLNQNQLSFLPANLfSSLRELKL 174
Cdd:COG4886 69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKE 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 175 LDLSRNNLTHLPKGLlGAQVKLEKLLLYSNQLTSVDSGLlSNLGALTELRLERNHLRSVaPGAFDRLGNLSSLTLSGNLL 254
Cdd:COG4886 141 LDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 255 ESLPPALFlHVSSVSRLTLFENPLEELPDvlFGEMAGLRELWLNGTHLSTLPAAAfrNLSGLQTLGLTRNPRLSALPRGV 334
Cdd:COG4886 218 TDLPEPLA-NLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKEL 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 335 FQGLRELRVLALHTNALAELRDDALRGLGHLRQVSLRHNRLRALPRTLFRNLSSLESVQLEHNQLETLPGDVFAALPQLT 414
Cdd:COG4886 293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372
|
330
....*....|
gi 31982322 415 QVLLGHNPWL 424
Cdd:COG4886 373 GLLEATLLTL 382
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
103-422 |
8.13e-21 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 96.69 E-value: 8.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 103 LRLTRNKISRLPRAILDKMVlleQLFLDHNALRDLDQNLFQqlrNLQELGLNQNQLSFLPANLFSSLRElklLDLSRNNL 182
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQIT---TLILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATLPDTIQE---MELSINRI 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 183 THLPKGLLGAqvkLEKLLLYSNQLTSVDSGLLSNLGALTelrLERNHLRSvapgafdrlgnlssltlsgnLLESLPpalf 262
Cdd:PRK15370 254 TELPERLPSA---LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRT--------------------LPAHLP---- 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 263 lhvSSVSRLTLFENPLEELPDVLfgeMAGLRELWLNGTHLSTLPAA---AFRNLSglqtlglTRNPRLSALPRGVFQGLR 339
Cdd:PRK15370 304 ---SGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASlppELQVLD-------VSKNQITVLPETLPPTIT 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 340 ELRVlalhtnalaelrddalrglghlrqvslRHNRLRALPRTLfrnLSSLESVQLEHNQLETLPGDVFAAL---PQLTQV 416
Cdd:PRK15370 371 TLDV---------------------------SRNALTNLPENL---PAALQIMQASRNNLVRLPESLPHFRgegPQPTRI 420
|
....*.
gi 31982322 417 LLGHNP 422
Cdd:PRK15370 421 IVEYNP 426
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
50-230 |
1.01e-14 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 73.28 E-value: 1.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 50 TNLTHilLFRMDQGILRNHSFSGMTVLQRLMLSDSHISAIDPgtFNDLVKLKTLRLTRNKISRLPRaiLDKMVLLEQLFL 129
Cdd:cd21340 2 KRITH--LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 130 DHNALRDLDqNLfQQLRNLQELGL-NQN-----QLSFLPANLFSSLRELKLLDLSRNNLTHLpkGLLGAQVKLEKLLLYS 203
Cdd:cd21340 76 GGNRISVVE-GL-ENLTNLEELHIeNQRlppgeKLTFDPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASN 151
|
170 180
....*....|....*....|....*....
gi 31982322 204 NQLTSVD--SGLLSNLGALTELRLERNHL 230
Cdd:cd21340 152 NQISDLEelLDLLSSWPSLRELDLTGNPV 180
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
124-182 |
3.19e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.91 E-value: 3.19e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 31982322 124 LEQLFLDHNALRDLDQNLFQQLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNL 182
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
394-454 |
1.31e-05 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 48.54 E-value: 1.31e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982322 394 LEHNQLETLPGDVFAALPQLTQVLLGHNPWLCDCGLWPFLQWLRHHPDILGRDEPPQCRGP 454
Cdd:TIGR00864 2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGP 62
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
65-110 |
7.60e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 7.60e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 31982322 65 LRNHSFSGMTVLQRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKI 110
Cdd:pfam13855 16 LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
421-454 |
3.69e-03 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 35.87 E-value: 3.69e-03
10 20 30
....*....|....*....|....*....|....*....
gi 31982322 421 NPWLCDCGLWPFLQWLRHHPDILGRDE-----PPQCRGP 454
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDlrcasPSSLRGP 39
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
95-424 |
1.22e-25 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 109.25 E-value: 1.22e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 95 NDLVKLKTLRLTRNKISRLPRAILDKMVLLEQLFLDHNalrdldqNLFQQLRNLQELGLNQNQLSFLPANLfSSLRELKL 174
Cdd:COG4886 69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKE 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 175 LDLSRNNLTHLPKGLlGAQVKLEKLLLYSNQLTSVDSGLlSNLGALTELRLERNHLRSVaPGAFDRLGNLSSLTLSGNLL 254
Cdd:COG4886 141 LDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 255 ESLPPALFlHVSSVSRLTLFENPLEELPDvlFGEMAGLRELWLNGTHLSTLPAAAfrNLSGLQTLGLTRNPRLSALPRGV 334
Cdd:COG4886 218 TDLPEPLA-NLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKEL 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 335 FQGLRELRVLALHTNALAELRDDALRGLGHLRQVSLRHNRLRALPRTLFRNLSSLESVQLEHNQLETLPGDVFAALPQLT 414
Cdd:COG4886 293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372
|
330
....*....|
gi 31982322 415 QVLLGHNPWL 424
Cdd:COG4886 373 GLLEATLLTL 382
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
67-285 |
2.43e-24 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 105.40 E-value: 2.43e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 67 NHSFSGMTVLQRLMLSDSHISAIdPGTFNDLVKLKTLRLTRNKISRLPRAiLDKMVLLEQLFLDHNALRDLDQNLfQQLR 146
Cdd:COG4886 106 NEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLT 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 147 NLQELGLNQNQLSFLPANLfSSLRELKLLDLSRNNLTHLPKGlLGAQVKLEKLLLYSNQLTSVDSglLSNLGALTELRLE 226
Cdd:COG4886 183 NLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLS 258
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 31982322 227 RNHLRSVAPGAfdRLGNLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPLEELPDVL 285
Cdd:COG4886 259 NNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
69-331 |
7.79e-23 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 101.16 E-value: 7.79e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 69 SFSGMTVLQRLMLSDSHISAIdPGTFNDLVKLKTLRLTRNKISRLPRAILdKMVLLEQLFLDHNALRDLDQNLfQQLRNL 148
Cdd:COG4886 131 ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLPEPL-GNLTNL 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 149 QELGLNQNQLSFLPANLfSSLRELKLLDLSRNNLTHLPKglLGAQVKLEKLLLYSNQLTSVDSglLSNLGALTELRLERN 228
Cdd:COG4886 208 EELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNN 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 229 HLRSVAPGAFDRLGNLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPLEELPDVLFGEMAGLRELWLNGTHLSTLPAA 308
Cdd:COG4886 283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
|
250 260
....*....|....*....|...
gi 31982322 309 AFRNLSGLQTLGLTRNPRLSALP 331
Cdd:COG4886 363 LTLLLTLGLLGLLEATLLTLALL 385
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
117-424 |
1.67e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 96.93 E-value: 1.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 117 ILDKMVLLEQLFLDHNALRDLDQNLFQQLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNLTHLPKGLLGAQVKL 196
Cdd:COG4886 9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 197 EKLLLYSNQLTSVD---SGLLSNLGALTELRLERNHLRSVaPGAFDRLGNLSSLTLSGNLLESLPPALFlHVSSVSRLTL 273
Cdd:COG4886 89 LTDLGDLTNLTELDlsgNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 274 FENPLEELPDVLfGEMAGLRELWLNGTHLSTLPaAAFRNLSGLQTLGLTRNpRLSALPRGvFQGLRELRVLALHTNALAE 353
Cdd:COG4886 167 SNNQLTDLPEEL-GNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGN-QLTDLPEP-LANLTNLETLDLSNNQLTD 242
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982322 354 LrdDALRGLGHLRQVSLRHNRLRALPRTLfrNLSSLESVQLEHNQLETLPGDVFAALPQLTQVLLGHNPWL 424
Cdd:COG4886 243 L--PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
103-422 |
8.13e-21 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 96.69 E-value: 8.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 103 LRLTRNKISRLPRAILDKMVlleQLFLDHNALRDLDQNLFQqlrNLQELGLNQNQLSFLPANLFSSLRElklLDLSRNNL 182
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQIT---TLILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATLPDTIQE---MELSINRI 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 183 THLPKGLLGAqvkLEKLLLYSNQLTSVDSGLLSNLGALTelrLERNHLRSvapgafdrlgnlssltlsgnLLESLPpalf 262
Cdd:PRK15370 254 TELPERLPSA---LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRT--------------------LPAHLP---- 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 263 lhvSSVSRLTLFENPLEELPDVLfgeMAGLRELWLNGTHLSTLPAA---AFRNLSglqtlglTRNPRLSALPRGVFQGLR 339
Cdd:PRK15370 304 ---SGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASlppELQVLD-------VSKNQITVLPETLPPTIT 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 340 ELRVlalhtnalaelrddalrglghlrqvslRHNRLRALPRTLfrnLSSLESVQLEHNQLETLPGDVFAAL---PQLTQV 416
Cdd:PRK15370 371 TLDV---------------------------SRNALTNLPENL---PAALQIMQASRNNLVRLPESLPHFRgegPQPTRI 420
|
....*.
gi 31982322 417 LLGHNP 422
Cdd:PRK15370 421 IVEYNP 426
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
72-421 |
3.34e-15 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 79.12 E-value: 3.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 72 GMTVLQRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKIS-RLPRAILDKMVLLeQLFLDHNALRDLDQNLFQQLRNLQE 150
Cdd:PLN00113 234 GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLI-SLDLSDNSLSGEIPELVIQLQNLEI 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 151 LGLNQNQLSFLPANLFSSLRELKLLDLSRNNLT-HLPKGLlGAQVKLEKLLLYSNQLTSVDSGLLSNLGALTELRLERNH 229
Cdd:PLN00113 313 LHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNL-GKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNS 391
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 230 LRSVAPGAFDRLGNLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPLEELPDVLFGEMAGLRELWLNGTHLSTLPAAA 309
Cdd:PLN00113 392 LEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDS 471
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 310 FRNlSGLQTLGLTRNPRLSALPRGvFQGLRELRVLALHTNALAELRDDALRGLGHLRQVSLRHNRLRALPRTLFRNLSSL 389
Cdd:PLN00113 472 FGS-KRLENLDLSRNQFSGAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVL 549
|
330 340 350
....*....|....*....|....*....|....*
gi 31982322 390 ESVQLEHNQLEtlpGDVFAAL---PQLTQVLLGHN 421
Cdd:PLN00113 550 SQLDLSQNQLS---GEIPKNLgnvESLVQVNISHN 581
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
50-230 |
1.01e-14 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 73.28 E-value: 1.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 50 TNLTHilLFRMDQGILRNHSFSGMTVLQRLMLSDSHISAIDPgtFNDLVKLKTLRLTRNKISRLPRaiLDKMVLLEQLFL 129
Cdd:cd21340 2 KRITH--LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 130 DHNALRDLDqNLfQQLRNLQELGL-NQN-----QLSFLPANLFSSLRELKLLDLSRNNLTHLpkGLLGAQVKLEKLLLYS 203
Cdd:cd21340 76 GGNRISVVE-GL-ENLTNLEELHIeNQRlppgeKLTFDPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASN 151
|
170 180
....*....|....*....|....*....
gi 31982322 204 NQLTSVD--SGLLSNLGALTELRLERNHL 230
Cdd:cd21340 152 NQISDLEelLDLLSSWPSLRELDLTGNPV 180
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
100-353 |
2.39e-12 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 69.73 E-value: 2.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 100 LKTLRLTRNKISRLPRAILDKMVLLEqlfLDHNALRDLDQNLFQQlrnLQELGLNQNQLSFLPANLfssLRELKLLDLSR 179
Cdd:PRK15370 222 IKTLYANSNQLTSIPATLPDTIQEME---LSINRITELPERLPSA---LQSLDLFHNKISCLPENL---PEELRYLSVYD 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 180 NNLTHLPKGLLGAQVkleKLLLYSNQLTSVDSGLLSNLGALTElrlERNHLRSvapgafdrlgnlssltlsgnLLESLPP 259
Cdd:PRK15370 293 NSIRTLPAHLPSGIT---HLNVQSNSLTALPETLPPGLKTLEA---GENALTS--------------------LPASLPP 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 260 AlfLHVSSVSRltlfeNPLEELPDVLfgeMAGLRELWLNGTHLSTLPaaafRNL-SGLQTLGLTRN--PRL-SALPRGVF 335
Cdd:PRK15370 347 E--LQVLDVSK-----NQITVLPETL---PPTITTLDVSRNALTNLP----ENLpAALQIMQASRNnlVRLpESLPHFRG 412
|
250
....*....|....*...
gi 31982322 336 QGLRELRVLALHtNALAE 353
Cdd:PRK15370 413 EGPQPTRIIVEY-NPFSE 429
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
62-411 |
5.69e-12 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 68.72 E-value: 5.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 62 QGILRNHSfSGMTVLQrlmLSDSHISA-IDPGTFNdLVKLKTLRLTRNKIS-RLPRAILDKMVLLEQLFLDHNALRDLDQ 139
Cdd:PLN00113 61 QGITCNNS-SRVVSID---LSGKNISGkISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIP 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 140 NLFqqLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNLT-HLPkGLLGAQVKLEKLLLYSNQLTS---VDSGLLS 215
Cdd:PLN00113 136 RGS--IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVgKIP-NSLTNLTSLEFLTLASNQLVGqipRELGQMK 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 216 NL------------------GALTELR---LERNHLRSVAPGAFDRLGNLSSLTLSGNLLE-SLPPALFLHVSSVSrLTL 273
Cdd:PLN00113 213 SLkwiylgynnlsgeipyeiGGLTSLNhldLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLIS-LDL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 274 FENPLE-ELPDvLFGEMAGLRELWLNGTHLSTLPAAAFRNLSGLQTLGLTRNPRLSALPRGVFQGlRELRVLALHTNALA 352
Cdd:PLN00113 292 SDNSLSgEIPE-LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKH-NNLTVLDLSTNNLT 369
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982322 353 ELRDDALRGLGHLRQVSLRHNRLRA-LPRTLfRNLSSLESVQLEHNQLE-TLPGDvFAALP 411
Cdd:PLN00113 370 GEIPEGLCSSGNLFKLILFSNSLEGeIPKSL-GACRSLRRVRLQDNSFSgELPSE-FTKLP 428
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
124-182 |
3.19e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.91 E-value: 3.19e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 31982322 124 LEQLFLDHNALRDLDQNLFQQLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNL 182
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
364-422 |
7.11e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.14 E-value: 7.11e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 31982322 364 HLRQVSLRHNRLRALPRTLFRNLSSLESVQLEHNQLETLPGDVFAALPQLTQVLLGHNP 422
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
76-134 |
7.84e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.14 E-value: 7.84e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 31982322 76 LQRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKISRLPRAILDKMVLLEQLFLDHNAL 134
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
195-254 |
2.09e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.60 E-value: 2.09e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 195 KLEKLLLYSNQLTSVDSGLLSNLGALTELRLERNHLRSVAPGAFDRLGNLSSLTLSGNLL 254
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
161-422 |
4.21e-08 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 56.32 E-value: 4.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 161 LPANLFSSLR----ELKLLDLSRNNLTH---LPKGLLgaqvkleKLLLYSNQLTSVDSgLLSNLGALTELRLERNHLRSV 233
Cdd:PRK15387 229 IPDNNLTSLPalppELRTLEVSGNQLTSlpvLPPGLL-------ELSIFSNPLTHLPA-LPSGLCKLWIFGNQLTSLPVL 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 234 APGafdrlgnLSSLTLSGNLLESLPPAlflhVSSVSRLTLFENPLEELPDVlfgeMAGLRELWLNGTHLSTLPAAAfrnl 313
Cdd:PRK15387 301 PPG-------LQELSVSDNQLASLPAL----PSELCKLWAYNNQLTSLPTL----PSGLQELSVSDNQLASLPTLP---- 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 314 SGLQTLgLTRNPRLSALPrGVFQGLRELRVLALHTNALAELRDDalrglghLRQVSLRHNRLRALPRTlfrnLSSLESVQ 393
Cdd:PRK15387 362 SELYKL-WAYNNRLTSLP-ALPSGLKELIVSGNRLTSLPVLPSE-------LKELMVSGNRLTSLPML----PSGLLSLS 428
|
250 260
....*....|....*....|....*....
gi 31982322 394 LEHNQLETLPgDVFAALPQLTQVLLGHNP 422
Cdd:PRK15387 429 VYRNQLTRLP-ESLIHLSSETTVNLEGNP 456
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
146-206 |
1.66e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.29 E-value: 1.66e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982322 146 RNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNLTHLPKGLLGAQVKLEKLLLYSNQL 206
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
170-230 |
2.42e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.90 E-value: 2.42e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982322 170 RELKLLDLSRNNLTHLPKGLLGAQVKLEKLLLYSNQLTSVDSGLLSNLGALTELRLERNHL 230
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
65-259 |
2.60e-07 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 53.70 E-value: 2.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 65 LRNHSFSG-----MTVLQR---LMLSDSHISAIDPGTFNDLVKLKTLRLTRNKIS-RLPRAILDKMvlLEQLFLDHNALR 135
Cdd:PLN00113 411 LQDNSFSGelpseFTKLPLvyfLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPDSFGSKR--LENLDLSRNQFS 488
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 136 DLDQNLFQQLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNLT-HLPKGLLGAQVkLEKLLLYSNQLTSVDSGLL 214
Cdd:PLN00113 489 GAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPV-LSQLDLSQNQLSGEIPKNL 567
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 31982322 215 SNLGALTELRLERNHLRSVAP--GAFDRLgNLSSLT-----LSGNLLESLPP 259
Cdd:PLN00113 568 GNVESLVQVNISHNHLHGSLPstGAFLAI-NASAVAgnidlCGGDTTSGLPP 618
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
220-278 |
2.61e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.52 E-value: 2.61e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 31982322 220 LTELRLERNHLRSVAPGAFDRLGNLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPL 278
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
339-399 |
3.54e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.13 E-value: 3.54e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982322 339 RELRVLALHTNALAELRDDALRGLGHLRQVSLRHNRLRALPRTLFRNLSSLESVQLEHNQL 399
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
99-158 |
5.56e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 46.75 E-value: 5.56e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 99 KLKTLRLTRNKISRLPRAILDKMVLLEQLFLDHNALRDLDQNLFQQLRNLQELGLNQNQL 158
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
314-375 |
6.19e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 46.75 E-value: 6.19e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31982322 314 SGLQTLGLTRNpRLSALPRGVFQGLRELRVLALHTNALAELRDDALRGLGHLRQVSLRHNRL 375
Cdd:pfam13855 1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
175-349 |
2.96e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 48.63 E-value: 2.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 175 LDLSRNNLTHLPKglLGAQVKLEKLLLYSNQLTSVDSglLSNLGALTELRLERNHLRSVAPgaFDRLGNLSSLTLSGNL- 253
Cdd:cd21340 7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRi 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 254 -----LESLPPALFLHVSSVsRLTLfENPLEELPDVLFGEMAGLRELWLNGTHLSTLpaAAFRNLSGLQTLGLTRNpRLS 328
Cdd:cd21340 81 svvegLENLTNLEELHIENQ-RLPP-GEKLTFDPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNN-QIS 155
|
170 180
....*....|....*....|...
gi 31982322 329 ALPR--GVFQGLRELRVLALHTN 349
Cdd:cd21340 156 DLEEllDLLSSWPSLRELDLTGN 178
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
76-278 |
3.08e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 50.23 E-value: 3.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 76 LQRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKIS-RLPRAILdKMVLLEQLFLDHNALRDLDQNLFQQLRNLQELGLN 154
Cdd:PLN00113 382 LFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFT-KLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLA 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 155 QNQLSFLPANLFSSLReLKLLDLSRNNLTHLPKGLLGAQVKLEKLLLYSNQLTSVDSGLLSNLGALTELRLERNHLRSVA 234
Cdd:PLN00113 461 RNKFFGGLPDSFGSKR-LENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQI 539
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 31982322 235 PGAFDRLGNLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPL 278
Cdd:PLN00113 540 PASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
223-340 |
6.03e-06 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 49.04 E-value: 6.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 223 LRLERNHLRSVAPGAFDRLGNLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPLE-ELPDVLfGEMAGLRELWLNGTH 301
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESL-GQLTSLRILNLNGNS 501
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 31982322 302 LS-TLPAAAFRNLSGLQTLGLTRNPRLSALPrgvfqGLRE 340
Cdd:PLN03150 502 LSgRVPAALGGRLLHRASFNFTDNAGLCGIP-----GLRA 536
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
126-402 |
1.19e-05 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 47.35 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 126 QLFLDHNALRDLD-QNLFQQLRNLQELGLNQNQLSFLPAN-LFSSLR---ELKLLDLSRNNLTHLPKGL------LGAQV 194
Cdd:cd00116 2 QLSLKGELLKTERaTELLPKLLCLQVLRLEGNTLGEEAAKaLASALRpqpSLKELCLSLNETGRIPRGLqsllqgLTKGC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 195 KLEKLLLYSNQLTSVDSGLLSNL---GALTELRLERN-----HLRSVAPGAFDRLGNLSSLTLSGNLLESLPPA----LF 262
Cdd:cd00116 82 GLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNglgdrGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEalakAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 263 LHVSSVSRLTLFENPL-EELPDVLFGEMA---GLRELWLNGTHL----STLPAAAFRNLSGLQTLGLTRNP----RLSAL 330
Cdd:cd00116 162 RANRDLKELNLANNGIgDAGIRALAEGLKancNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNltdaGAAAL 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31982322 331 PRGVFQGLRELRVLALHTNalaELRDDALRGLGH-------LRQVSLRHNRLRALPRTLfrnlsSLESVQLEHNQLETL 402
Cdd:cd00116 242 ASALLSPNISLLTLSLSCN---DITDDGAKDLAEvlaekesLLELDLRGNKFGEEGAQL-----LAESLLEPGNELESL 312
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
394-454 |
1.31e-05 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 48.54 E-value: 1.31e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982322 394 LEHNQLETLPGDVFAALPQLTQVLLGHNPWLCDCGLWPFLQWLRHHPDILGRDEPPQCRGP 454
Cdd:TIGR00864 2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGP 62
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
43-187 |
1.67e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 46.32 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 43 IAELGLPTNLTHILLFrmDQGILRNHSFSGMTVLQRLMLSDSHISAIDPgtFNDLVKLKTLRLTRNKISRLprAILDKMV 122
Cdd:cd21340 17 IDNLSLCKNLKVLYLY--DNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV--EGLENLT 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 123 LLEQLFLD------------------------------HNALRDLDQnlFQQLRNLQELGLNQNQLSFLP--ANLFSSLR 170
Cdd:cd21340 91 NLEELHIEnqrlppgekltfdprslaalsnslrvlnisGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWP 168
|
170
....*....|....*..
gi 31982322 171 ELKLLDLSRNNLTHLPK 187
Cdd:cd21340 169 SLRELDLTGNPVCKKPK 185
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
148-314 |
2.62e-05 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 47.08 E-value: 2.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 148 LQELGLNQNQLSFLPAnLFSSLRELKLLDLSRNNLTHLPKGLLGAQV-------------KLEKLLLYSNQLTSvdsgLL 214
Cdd:PRK15387 304 LQELSVSDNQLASLPA-LPSELCKLWAYNNQLTSLPTLPSGLQELSVsdnqlaslptlpsELYKLWAYNNRLTS----LP 378
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 215 SNLGALTELRLERNHLRS--VAPgafdrlGNLSSLTLSGNLLESLPpalfLHVSSVSRLTLFENPLEELPDVLFgEMAGL 292
Cdd:PRK15387 379 ALPSGLKELIVSGNRLTSlpVLP------SELKELMVSGNRLTSLP----MLPSGLLSLSVYRNQLTRLPESLI-HLSSE 447
|
170 180
....*....|....*....|..
gi 31982322 293 RELWLNGTHLSTLPAAAFRNLS 314
Cdd:PRK15387 448 TTVNLEGNPLSERTLQALREIT 469
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
65-110 |
7.60e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 7.60e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 31982322 65 LRNHSFSGMTVLQRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKI 110
Cdd:pfam13855 16 LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
76-255 |
1.05e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 44.65 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 76 LQRLMLSDSHISAIDPGTFNDLVK---LKTLRLTRNKISRLPRAILDKmvlleqlfldhnALRDLDQNL--FQQLRNLQE 150
Cdd:cd00116 83 LQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLGDRGLRLLAK------------GLKDLPPALekLVLGRNRLE 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 151 lglnqNQLSFLPANLFSSLRELKLLDLSRNNL-----THLPKGLLgAQVKLEKLLLYSNQLTSVD----SGLLSNLGALT 221
Cdd:cd00116 151 -----GASCEALAKALRANRDLKELNLANNGIgdagiRALAEGLK-ANCNLEVLDLNNNGLTDEGasalAETLASLKSLE 224
|
170 180 190
....*....|....*....|....*....|....*....
gi 31982322 222 ELRLERNHLRSV-----APGAFDRLGNLSSLTLSGNLLE 255
Cdd:cd00116 225 VLNLGDNNLTDAgaaalASALLSPNISLLTLSLSCNDIT 263
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
243-302 |
1.91e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.43 E-value: 1.91e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 243 NLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPLEELPDVLFGEMAGLRELWLNGTHL 302
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
421-454 |
3.69e-03 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 35.87 E-value: 3.69e-03
10 20 30
....*....|....*....|....*....|....*....
gi 31982322 421 NPWLCDCGLWPFLQWLRHHPDILGRDE-----PPQCRGP 454
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDlrcasPSSLRGP 39
|
|
|