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Conserved domains on  [gi|31982322|ref|NP_032174|]
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platelet glycoprotein V precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 13847510)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Anopheles gambiae APL1A

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-424 1.22e-25

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 1.22e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  95 NDLVKLKTLRLTRNKISRLPRAILDKMVLLEQLFLDHNalrdldqNLFQQLRNLQELGLNQNQLSFLPANLfSSLRELKL 174
Cdd:COG4886  69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKE 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 175 LDLSRNNLTHLPKGLlGAQVKLEKLLLYSNQLTSVDSGLlSNLGALTELRLERNHLRSVaPGAFDRLGNLSSLTLSGNLL 254
Cdd:COG4886 141 LDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 255 ESLPPALFlHVSSVSRLTLFENPLEELPDvlFGEMAGLRELWLNGTHLSTLPAAAfrNLSGLQTLGLTRNPRLSALPRGV 334
Cdd:COG4886 218 TDLPEPLA-NLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKEL 292

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 335 FQGLRELRVLALHTNALAELRDDALRGLGHLRQVSLRHNRLRALPRTLFRNLSSLESVQLEHNQLETLPGDVFAALPQLT 414
Cdd:COG4886 293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372

                       330
                ....*....|
gi 31982322 415 QVLLGHNPWL 424
Cdd:COG4886 373 GLLEATLLTL 382
LRR_8 pfam13855
Leucine rich repeat;
65-110 7.60e-05

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 7.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 31982322    65 LRNHSFSGMTVLQRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKI 110
Cdd:pfam13855  16 LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
421-454 3.69e-03

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.87  E-value: 3.69e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 31982322    421 NPWLCDCGLWPFLQWLRHHPDILGRDE-----PPQCRGP 454
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDlrcasPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-424 1.22e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 1.22e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  95 NDLVKLKTLRLTRNKISRLPRAILDKMVLLEQLFLDHNalrdldqNLFQQLRNLQELGLNQNQLSFLPANLfSSLRELKL 174
Cdd:COG4886  69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKE 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 175 LDLSRNNLTHLPKGLlGAQVKLEKLLLYSNQLTSVDSGLlSNLGALTELRLERNHLRSVaPGAFDRLGNLSSLTLSGNLL 254
Cdd:COG4886 141 LDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 255 ESLPPALFlHVSSVSRLTLFENPLEELPDvlFGEMAGLRELWLNGTHLSTLPAAAfrNLSGLQTLGLTRNPRLSALPRGV 334
Cdd:COG4886 218 TDLPEPLA-NLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKEL 292

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 335 FQGLRELRVLALHTNALAELRDDALRGLGHLRQVSLRHNRLRALPRTLFRNLSSLESVQLEHNQLETLPGDVFAALPQLT 414
Cdd:COG4886 293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372

                       330
                ....*....|
gi 31982322 415 QVLLGHNPWL 424
Cdd:COG4886 373 GLLEATLLTL 382
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
103-422 8.13e-21

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 96.69  E-value: 8.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  103 LRLTRNKISRLPRAILDKMVlleQLFLDHNALRDLDQNLFQqlrNLQELGLNQNQLSFLPANLFSSLRElklLDLSRNNL 182
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQIT---TLILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATLPDTIQE---MELSINRI 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  183 THLPKGLLGAqvkLEKLLLYSNQLTSVDSGLLSNLGALTelrLERNHLRSvapgafdrlgnlssltlsgnLLESLPpalf 262
Cdd:PRK15370 254 TELPERLPSA---LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRT--------------------LPAHLP---- 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  263 lhvSSVSRLTLFENPLEELPDVLfgeMAGLRELWLNGTHLSTLPAA---AFRNLSglqtlglTRNPRLSALPRGVFQGLR 339
Cdd:PRK15370 304 ---SGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASlppELQVLD-------VSKNQITVLPETLPPTIT 370

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  340 ELRVlalhtnalaelrddalrglghlrqvslRHNRLRALPRTLfrnLSSLESVQLEHNQLETLPGDVFAAL---PQLTQV 416
Cdd:PRK15370 371 TLDV---------------------------SRNALTNLPENL---PAALQIMQASRNNLVRLPESLPHFRgegPQPTRI 420


                 ....*.
gi 31982322  417 LLGHNP 422
Cdd:PRK15370 421 IVEYNP 426
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-230 1.01e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.28  E-value: 1.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  50 TNLTHilLFRMDQGILRNHSFSGMTVLQRLMLSDSHISAIDPgtFNDLVKLKTLRLTRNKISRLPRaiLDKMVLLEQLFL 129
Cdd:cd21340   2 KRITH--LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 130 DHNALRDLDqNLfQQLRNLQELGL-NQN-----QLSFLPANLFSSLRELKLLDLSRNNLTHLpkGLLGAQVKLEKLLLYS 203
Cdd:cd21340  76 GGNRISVVE-GL-ENLTNLEELHIeNQRlppgeKLTFDPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASN 151

                       170       180
                ....*....|....*....|....*....
gi 31982322 204 NQLTSVD--SGLLSNLGALTELRLERNHL 230
Cdd:cd21340 152 NQISDLEelLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
124-182 3.19e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 3.19e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31982322   124 LEQLFLDHNALRDLDQNLFQQLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNL 182
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 394-454 1.31e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.54  E-value: 1.31e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982322    394 LEHNQLETLPGDVFAALPQLTQVLLGHNPWLCDCGLWPFLQWLRHHPDILGRDEPPQCRGP 454
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGP 62
LRR_8 pfam13855
Leucine rich repeat;
65-110 7.60e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 7.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 31982322    65 LRNHSFSGMTVLQRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKI 110
Cdd:pfam13855  16 LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
421-454 3.69e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.87  E-value: 3.69e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 31982322    421 NPWLCDCGLWPFLQWLRHHPDILGRDE-----PPQCRGP 454
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDlrcasPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-424 1.22e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 1.22e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  95 NDLVKLKTLRLTRNKISRLPRAILDKMVLLEQLFLDHNalrdldqNLFQQLRNLQELGLNQNQLSFLPANLfSSLRELKL 174
Cdd:COG4886  69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKE 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 175 LDLSRNNLTHLPKGLlGAQVKLEKLLLYSNQLTSVDSGLlSNLGALTELRLERNHLRSVaPGAFDRLGNLSSLTLSGNLL 254
Cdd:COG4886 141 LDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 255 ESLPPALFlHVSSVSRLTLFENPLEELPDvlFGEMAGLRELWLNGTHLSTLPAAAfrNLSGLQTLGLTRNPRLSALPRGV 334
Cdd:COG4886 218 TDLPEPLA-NLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKEL 292

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 335 FQGLRELRVLALHTNALAELRDDALRGLGHLRQVSLRHNRLRALPRTLFRNLSSLESVQLEHNQLETLPGDVFAALPQLT 414
Cdd:COG4886 293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372

                       330
                ....*....|
gi 31982322 415 QVLLGHNPWL 424
Cdd:COG4886 373 GLLEATLLTL 382
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
67-285 2.43e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.40  E-value: 2.43e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  67 NHSFSGMTVLQRLMLSDSHISAIdPGTFNDLVKLKTLRLTRNKISRLPRAiLDKMVLLEQLFLDHNALRDLDQNLfQQLR 146
Cdd:COG4886 106 NEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLT 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 147 NLQELGLNQNQLSFLPANLfSSLRELKLLDLSRNNLTHLPKGlLGAQVKLEKLLLYSNQLTSVDSglLSNLGALTELRLE 226
Cdd:COG4886 183 NLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLS 258

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 31982322 227 RNHLRSVAPGAfdRLGNLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPLEELPDVL 285
Cdd:COG4886 259 NNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-331 7.79e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 7.79e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  69 SFSGMTVLQRLMLSDSHISAIdPGTFNDLVKLKTLRLTRNKISRLPRAILdKMVLLEQLFLDHNALRDLDQNLfQQLRNL 148
Cdd:COG4886 131 ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLPEPL-GNLTNL 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 149 QELGLNQNQLSFLPANLfSSLRELKLLDLSRNNLTHLPKglLGAQVKLEKLLLYSNQLTSVDSglLSNLGALTELRLERN 228
Cdd:COG4886 208 EELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNN 282

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 229 HLRSVAPGAFDRLGNLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPLEELPDVLFGEMAGLRELWLNGTHLSTLPAA 308
Cdd:COG4886 283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362

                       250       260
                ....*....|....*....|...
gi 31982322 309 AFRNLSGLQTLGLTRNPRLSALP 331
Cdd:COG4886 363 LTLLLTLGLLGLLEATLLTLALL 385
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
117-424 1.67e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.93  E-value: 1.67e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 117 ILDKMVLLEQLFLDHNALRDLDQNLFQQLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNLTHLPKGLLGAQVKL 196
Cdd:COG4886   9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 197 EKLLLYSNQLTSVD---SGLLSNLGALTELRLERNHLRSVaPGAFDRLGNLSSLTLSGNLLESLPPALFlHVSSVSRLTL 273
Cdd:COG4886  89 LTDLGDLTNLTELDlsgNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDL 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 274 FENPLEELPDVLfGEMAGLRELWLNGTHLSTLPaAAFRNLSGLQTLGLTRNpRLSALPRGvFQGLRELRVLALHTNALAE 353
Cdd:COG4886 167 SNNQLTDLPEEL-GNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGN-QLTDLPEP-LANLTNLETLDLSNNQLTD 242

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982322 354 LrdDALRGLGHLRQVSLRHNRLRALPRTLfrNLSSLESVQLEHNQLETLPGDVFAALPQLTQVLLGHNPWL 424
Cdd:COG4886 243 L--PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
103-422 8.13e-21

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 96.69  E-value: 8.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  103 LRLTRNKISRLPRAILDKMVlleQLFLDHNALRDLDQNLFQqlrNLQELGLNQNQLSFLPANLFSSLRElklLDLSRNNL 182
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQIT---TLILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATLPDTIQE---MELSINRI 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  183 THLPKGLLGAqvkLEKLLLYSNQLTSVDSGLLSNLGALTelrLERNHLRSvapgafdrlgnlssltlsgnLLESLPpalf 262
Cdd:PRK15370 254 TELPERLPSA---LQSLDLFHNKISCLPENLPEELRYLS---VYDNSIRT--------------------LPAHLP---- 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  263 lhvSSVSRLTLFENPLEELPDVLfgeMAGLRELWLNGTHLSTLPAA---AFRNLSglqtlglTRNPRLSALPRGVFQGLR 339
Cdd:PRK15370 304 ---SGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASlppELQVLD-------VSKNQITVLPETLPPTIT 370

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  340 ELRVlalhtnalaelrddalrglghlrqvslRHNRLRALPRTLfrnLSSLESVQLEHNQLETLPGDVFAAL---PQLTQV 416
Cdd:PRK15370 371 TLDV---------------------------SRNALTNLPENL---PAALQIMQASRNNLVRLPESLPHFRgegPQPTRI 420


                 ....*.
gi 31982322  417 LLGHNP 422
Cdd:PRK15370 421 IVEYNP 426
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-421 3.34e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.12  E-value: 3.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322   72 GMTVLQRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKIS-RLPRAILDKMVLLeQLFLDHNALRDLDQNLFQQLRNLQE 150
Cdd:PLN00113 234 GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLI-SLDLSDNSLSGEIPELVIQLQNLEI 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  151 LGLNQNQLSFLPANLFSSLRELKLLDLSRNNLT-HLPKGLlGAQVKLEKLLLYSNQLTSVDSGLLSNLGALTELRLERNH 229
Cdd:PLN00113 313 LHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNL-GKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNS 391

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  230 LRSVAPGAFDRLGNLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPLEELPDVLFGEMAGLRELWLNGTHLSTLPAAA 309
Cdd:PLN00113 392 LEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDS 471

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  310 FRNlSGLQTLGLTRNPRLSALPRGvFQGLRELRVLALHTNALAELRDDALRGLGHLRQVSLRHNRLRALPRTLFRNLSSL 389
Cdd:PLN00113 472 FGS-KRLENLDLSRNQFSGAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVL 549

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 31982322  390 ESVQLEHNQLEtlpGDVFAAL---PQLTQVLLGHN 421
Cdd:PLN00113 550 SQLDLSQNQLS---GEIPKNLgnvESLVQVNISHN 581
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-230 1.01e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 73.28  E-value: 1.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  50 TNLTHilLFRMDQGILRNHSFSGMTVLQRLMLSDSHISAIDPgtFNDLVKLKTLRLTRNKISRLPRaiLDKMVLLEQLFL 129
Cdd:cd21340   2 KRITH--LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 130 DHNALRDLDqNLfQQLRNLQELGL-NQN-----QLSFLPANLFSSLRELKLLDLSRNNLTHLpkGLLGAQVKLEKLLLYS 203
Cdd:cd21340  76 GGNRISVVE-GL-ENLTNLEELHIeNQRlppgeKLTFDPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASN 151

                       170       180
                ....*....|....*....|....*....
gi 31982322 204 NQLTSVD--SGLLSNLGALTELRLERNHL 230
Cdd:cd21340 152 NQISDLEelLDLLSSWPSLRELDLTGNPV 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
100-353 2.39e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.73  E-value: 2.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  100 LKTLRLTRNKISRLPRAILDKMVLLEqlfLDHNALRDLDQNLFQQlrnLQELGLNQNQLSFLPANLfssLRELKLLDLSR 179
Cdd:PRK15370 222 IKTLYANSNQLTSIPATLPDTIQEME---LSINRITELPERLPSA---LQSLDLFHNKISCLPENL---PEELRYLSVYD 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  180 NNLTHLPKGLLGAQVkleKLLLYSNQLTSVDSGLLSNLGALTElrlERNHLRSvapgafdrlgnlssltlsgnLLESLPP 259
Cdd:PRK15370 293 NSIRTLPAHLPSGIT---HLNVQSNSLTALPETLPPGLKTLEA---GENALTS--------------------LPASLPP 346

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  260 AlfLHVSSVSRltlfeNPLEELPDVLfgeMAGLRELWLNGTHLSTLPaaafRNL-SGLQTLGLTRN--PRL-SALPRGVF 335
Cdd:PRK15370 347 E--LQVLDVSK-----NQITVLPETL---PPTITTLDVSRNALTNLP----ENLpAALQIMQASRNnlVRLpESLPHFRG 412

                        250
                 ....*....|....*...
gi 31982322  336 QGLRELRVLALHtNALAE 353
Cdd:PRK15370 413 EGPQPTRIIVEY-NPFSE 429
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 62-411 5.69e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.72  E-value: 5.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322   62 QGILRNHSfSGMTVLQrlmLSDSHISA-IDPGTFNdLVKLKTLRLTRNKIS-RLPRAILDKMVLLEQLFLDHNALRDLDQ 139
Cdd:PLN00113  61 QGITCNNS-SRVVSID---LSGKNISGkISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIP 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  140 NLFqqLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNLT-HLPkGLLGAQVKLEKLLLYSNQLTS---VDSGLLS 215
Cdd:PLN00113 136 RGS--IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVgKIP-NSLTNLTSLEFLTLASNQLVGqipRELGQMK 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  216 NL------------------GALTELR---LERNHLRSVAPGAFDRLGNLSSLTLSGNLLE-SLPPALFLHVSSVSrLTL 273
Cdd:PLN00113 213 SLkwiylgynnlsgeipyeiGGLTSLNhldLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLIS-LDL 291

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  274 FENPLE-ELPDvLFGEMAGLRELWLNGTHLSTLPAAAFRNLSGLQTLGLTRNPRLSALPRGVFQGlRELRVLALHTNALA 352
Cdd:PLN00113 292 SDNSLSgEIPE-LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKH-NNLTVLDLSTNNLT 369

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982322  353 ELRDDALRGLGHLRQVSLRHNRLRA-LPRTLfRNLSSLESVQLEHNQLE-TLPGDvFAALP 411
Cdd:PLN00113 370 GEIPEGLCSSGNLFKLILFSNSLEGeIPKSL-GACRSLRRVRLQDNSFSgELPSE-FTKLP 428
LRR_8 pfam13855
Leucine rich repeat;
124-182 3.19e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 3.19e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31982322   124 LEQLFLDHNALRDLDQNLFQQLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNL 182
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
364-422 7.11e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 7.11e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31982322   364 HLRQVSLRHNRLRALPRTLFRNLSSLESVQLEHNQLETLPGDVFAALPQLTQVLLGHNP 422
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
76-134 7.84e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 7.84e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31982322    76 LQRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKISRLPRAILDKMVLLEQLFLDHNAL 134
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
195-254 2.09e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 2.09e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322   195 KLEKLLLYSNQLTSVDSGLLSNLGALTELRLERNHLRSVAPGAFDRLGNLSSLTLSGNLL 254
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
161-422 4.21e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 56.32  E-value: 4.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  161 LPANLFSSLR----ELKLLDLSRNNLTH---LPKGLLgaqvkleKLLLYSNQLTSVDSgLLSNLGALTELRLERNHLRSV 233
Cdd:PRK15387 229 IPDNNLTSLPalppELRTLEVSGNQLTSlpvLPPGLL-------ELSIFSNPLTHLPA-LPSGLCKLWIFGNQLTSLPVL 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  234 APGafdrlgnLSSLTLSGNLLESLPPAlflhVSSVSRLTLFENPLEELPDVlfgeMAGLRELWLNGTHLSTLPAAAfrnl 313
Cdd:PRK15387 301 PPG-------LQELSVSDNQLASLPAL----PSELCKLWAYNNQLTSLPTL----PSGLQELSVSDNQLASLPTLP---- 361

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  314 SGLQTLgLTRNPRLSALPrGVFQGLRELRVLALHTNALAELRDDalrglghLRQVSLRHNRLRALPRTlfrnLSSLESVQ 393
Cdd:PRK15387 362 SELYKL-WAYNNRLTSLP-ALPSGLKELIVSGNRLTSLPVLPSE-------LKELMVSGNRLTSLPML----PSGLLSLS 428

                        250       260
                 ....*....|....*....|....*....
gi 31982322  394 LEHNQLETLPgDVFAALPQLTQVLLGHNP 422
Cdd:PRK15387 429 VYRNQLTRLP-ESLIHLSSETTVNLEGNP 456
LRR_8 pfam13855
Leucine rich repeat;
146-206 1.66e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.66e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982322   146 RNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNLTHLPKGLLGAQVKLEKLLLYSNQL 206
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
170-230 2.42e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.42e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982322   170 RELKLLDLSRNNLTHLPKGLLGAQVKLEKLLLYSNQLTSVDSGLLSNLGALTELRLERNHL 230
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 65-259 2.60e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.70  E-value: 2.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322   65 LRNHSFSG-----MTVLQR---LMLSDSHISAIDPGTFNDLVKLKTLRLTRNKIS-RLPRAILDKMvlLEQLFLDHNALR 135
Cdd:PLN00113 411 LQDNSFSGelpseFTKLPLvyfLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPDSFGSKR--LENLDLSRNQFS 488

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  136 DLDQNLFQQLRNLQELGLNQNQLSFLPANLFSSLRELKLLDLSRNNLT-HLPKGLLGAQVkLEKLLLYSNQLTSVDSGLL 214
Cdd:PLN00113 489 GAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPV-LSQLDLSQNQLSGEIPKNL 567

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 31982322  215 SNLGALTELRLERNHLRSVAP--GAFDRLgNLSSLT-----LSGNLLESLPP 259
Cdd:PLN00113 568 GNVESLVQVNISHNHLHGSLPstGAFLAI-NASAVAgnidlCGGDTTSGLPP 618
LRR_8 pfam13855
Leucine rich repeat;
220-278 2.61e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.61e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31982322   220 LTELRLERNHLRSVAPGAFDRLGNLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPL 278
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
339-399 3.54e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 3.54e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982322   339 RELRVLALHTNALAELRDDALRGLGHLRQVSLRHNRLRALPRTLFRNLSSLESVQLEHNQL 399
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
99-158 5.56e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 5.56e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322    99 KLKTLRLTRNKISRLPRAILDKMVLLEQLFLDHNALRDLDQNLFQQLRNLQELGLNQNQL 158
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
314-375 6.19e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 6.19e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31982322   314 SGLQTLGLTRNpRLSALPRGVFQGLRELRVLALHTNALAELRDDALRGLGHLRQVSLRHNRL 375
Cdd:pfam13855   1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 175-349 2.96e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 2.96e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 175 LDLSRNNLTHLPKglLGAQVKLEKLLLYSNQLTSVDSglLSNLGALTELRLERNHLRSVAPgaFDRLGNLSSLTLSGNL- 253
Cdd:cd21340   7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRi 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 254 -----LESLPPALFLHVSSVsRLTLfENPLEELPDVLFGEMAGLRELWLNGTHLSTLpaAAFRNLSGLQTLGLTRNpRLS 328
Cdd:cd21340  81 svvegLENLTNLEELHIENQ-RLPP-GEKLTFDPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNN-QIS 155

                       170       180
                ....*....|....*....|...
gi 31982322 329 ALPR--GVFQGLRELRVLALHTN 349
Cdd:cd21340 156 DLEEllDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-278 3.08e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 3.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322   76 LQRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKIS-RLPRAILdKMVLLEQLFLDHNALRDLDQNLFQQLRNLQELGLN 154
Cdd:PLN00113 382 LFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFT-KLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLA 460

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  155 QNQLSFLPANLFSSLReLKLLDLSRNNLTHLPKGLLGAQVKLEKLLLYSNQLTSVDSGLLSNLGALTELRLERNHLRSVA 234
Cdd:PLN00113 461 RNKFFGGLPDSFGSKR-LENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQI 539

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 31982322  235 PGAFDRLGNLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPL 278
Cdd:PLN00113 540 PASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
PLN03150 PLN03150
hypothetical protein; Provisional
 223-340 6.03e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.04  E-value: 6.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  223 LRLERNHLRSVAPGAFDRLGNLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPLE-ELPDVLfGEMAGLRELWLNGTH 301
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESL-GQLTSLRILNLNGNS 501

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 31982322  302 LS-TLPAAAFRNLSGLQTLGLTRNPRLSALPrgvfqGLRE 340
Cdd:PLN03150 502 LSgRVPAALGGRLLHRASFNFTDNAGLCGIP-----GLRA 536
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 126-402 1.19e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.35  E-value: 1.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 126 QLFLDHNALRDLD-QNLFQQLRNLQELGLNQNQLSFLPAN-LFSSLR---ELKLLDLSRNNLTHLPKGL------LGAQV 194
Cdd:cd00116   2 QLSLKGELLKTERaTELLPKLLCLQVLRLEGNTLGEEAAKaLASALRpqpSLKELCLSLNETGRIPRGLqsllqgLTKGC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 195 KLEKLLLYSNQLTSVDSGLLSNL---GALTELRLERN-----HLRSVAPGAFDRLGNLSSLTLSGNLLESLPPA----LF 262
Cdd:cd00116  82 GLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNglgdrGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEalakAL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 263 LHVSSVSRLTLFENPL-EELPDVLFGEMA---GLRELWLNGTHL----STLPAAAFRNLSGLQTLGLTRNP----RLSAL 330
Cdd:cd00116 162 RANRDLKELNLANNGIgDAGIRALAEGLKancNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNltdaGAAAL 241

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31982322 331 PRGVFQGLRELRVLALHTNalaELRDDALRGLGH-------LRQVSLRHNRLRALPRTLfrnlsSLESVQLEHNQLETL 402
Cdd:cd00116 242 ASALLSPNISLLTLSLSCN---DITDDGAKDLAEvlaekesLLELDLRGNKFGEEGAQL-----LAESLLEPGNELESL 312
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 394-454 1.31e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.54  E-value: 1.31e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982322    394 LEHNQLETLPGDVFAALPQLTQVLLGHNPWLCDCGLWPFLQWLRHHPDILGRDEPPQCRGP 454
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGP 62
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-187 1.67e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 1.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  43 IAELGLPTNLTHILLFrmDQGILRNHSFSGMTVLQRLMLSDSHISAIDPgtFNDLVKLKTLRLTRNKISRLprAILDKMV 122
Cdd:cd21340  17 IDNLSLCKNLKVLYLY--DNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV--EGLENLT 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 123 LLEQLFLD------------------------------HNALRDLDQnlFQQLRNLQELGLNQNQLSFLP--ANLFSSLR 170
Cdd:cd21340  91 NLEELHIEnqrlppgekltfdprslaalsnslrvlnisGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWP 168

                       170
                ....*....|....*..
gi 31982322 171 ELKLLDLSRNNLTHLPK 187
Cdd:cd21340 169 SLRELDLTGNPVCKKPK 185
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
148-314 2.62e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.08  E-value: 2.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  148 LQELGLNQNQLSFLPAnLFSSLRELKLLDLSRNNLTHLPKGLLGAQV-------------KLEKLLLYSNQLTSvdsgLL 214
Cdd:PRK15387 304 LQELSVSDNQLASLPA-LPSELCKLWAYNNQLTSLPTLPSGLQELSVsdnqlaslptlpsELYKLWAYNNRLTS----LP 378

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  215 SNLGALTELRLERNHLRS--VAPgafdrlGNLSSLTLSGNLLESLPpalfLHVSSVSRLTLFENPLEELPDVLFgEMAGL 292
Cdd:PRK15387 379 ALPSGLKELIVSGNRLTSlpVLP------SELKELMVSGNRLTSLP----MLPSGLLSLSVYRNQLTRLPESLI-HLSSE 447

                        170       180
                 ....*....|....*....|..
gi 31982322  293 RELWLNGTHLSTLPAAAFRNLS 314
Cdd:PRK15387 448 TTVNLEGNPLSERTLQALREIT 469
LRR_8 pfam13855
Leucine rich repeat;
65-110 7.60e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 7.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 31982322    65 LRNHSFSGMTVLQRLMLSDSHISAIDPGTFNDLVKLKTLRLTRNKI 110
Cdd:pfam13855  16 LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 76-255 1.05e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322  76 LQRLMLSDSHISAIDPGTFNDLVK---LKTLRLTRNKISRLPRAILDKmvlleqlfldhnALRDLDQNL--FQQLRNLQE 150
Cdd:cd00116  83 LQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLGDRGLRLLAK------------GLKDLPPALekLVLGRNRLE 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322 151 lglnqNQLSFLPANLFSSLRELKLLDLSRNNL-----THLPKGLLgAQVKLEKLLLYSNQLTSVD----SGLLSNLGALT 221
Cdd:cd00116 151 -----GASCEALAKALRANRDLKELNLANNGIgdagiRALAEGLK-ANCNLEVLDLNNNGLTDEGasalAETLASLKSLE 224

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 31982322 222 ELRLERNHLRSV-----APGAFDRLGNLSSLTLSGNLLE 255
Cdd:cd00116 225 VLNLGDNNLTDAgaaalASALLSPNISLLTLSLSCNDIT 263
LRR_8 pfam13855
Leucine rich repeat;
243-302 1.91e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982322   243 NLSSLTLSGNLLESLPPALFLHVSSVSRLTLFENPLEELPDVLFGEMAGLRELWLNGTHL 302
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
421-454 3.69e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 35.87  E-value: 3.69e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 31982322    421 NPWLCDCGLWPFLQWLRHHPDILGRDE-----PPQCRGP 454
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDlrcasPSSLRGP 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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