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Conserved domains on  [gi|6680926|ref|NP_031715|]
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chondroadherin precursor [Mus musculus]

Protein Classification

LRR and LRRCT domain-containing protein( domain architecture ID 12020582)

protein containing domains LRRNT, LRR, and LRRCT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-300 3.27e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.10  E-value: 3.27e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   49 SETTKLLNLQRNNFPVLAANSFRTMPNLVSLHLQHCNIREVAAGAFRGLKQLIYLYLSHNDirvlragAFDDLTELTYLY 128
Cdd:COG4886  47 LLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLD 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  129 LDHNKVSELPRGLlSPLVNLFILQLNNNKIRELRAgAFQGAKDLRWLYLSENALSSLqPGSLDDVENLAKFHLDKNQLSS 208
Cdd:COG4886 120 LSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITD 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  209 YPsAALSKLRVVEELKLSHNPLKSIPDnAFQSFGRyLETLWLDNTNLEKFSDaaFSGVTTLKHVHLDNNRLNQLPSSFPF 288
Cdd:COG4886 197 LP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTN-LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANL 271

                       250
                ....*....|..
gi 6680926  289 DNLETLTLTNNP 300
Cdd:COG4886 272 TNLKTLDLSNNQ 283
LRRCT smart00082
Leucine rich repeat C-terminal domain;
299-346 3.57e-09

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 52.05  E-value: 3.57e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 6680926     299 NPWKCTCQLRGLRRWLEAK---ASRPDATCSSPAKFKGQRIRDTDALRSCK 346
Cdd:smart00082   1 NPFICDCELRWLLRWLQANehlQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 22-48 2.34e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 2.34e-05
                          10        20
                  ....*....|....*....|....*..
gi 6680926     22 CPQNCHCHGdlQHVICDKVGLQKIPKV 48
Cdd:pfam01462   2 CPVPCHCSA--TVVNCSDRGLTAVPRD 26
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-300 3.27e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.10  E-value: 3.27e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   49 SETTKLLNLQRNNFPVLAANSFRTMPNLVSLHLQHCNIREVAAGAFRGLKQLIYLYLSHNDirvlragAFDDLTELTYLY 128
Cdd:COG4886  47 LLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLD 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  129 LDHNKVSELPRGLlSPLVNLFILQLNNNKIRELRAgAFQGAKDLRWLYLSENALSSLqPGSLDDVENLAKFHLDKNQLSS 208
Cdd:COG4886 120 LSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITD 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  209 YPsAALSKLRVVEELKLSHNPLKSIPDnAFQSFGRyLETLWLDNTNLEKFSDaaFSGVTTLKHVHLDNNRLNQLPSSFPF 288
Cdd:COG4886 197 LP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTN-LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANL 271

                       250
                ....*....|..
gi 6680926  289 DNLETLTLTNNP 300
Cdd:COG4886 272 TNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
74-134 2.78e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 2.78e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6680926     74 PNLVSLHLQHCNIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKV 134
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 34-234 2.48e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.58  E-value: 2.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   34 HVICDKVGLQKIPKVSETTKL--LNLQRNNFPVLaaNSFRTMPNLVSLHLQHCNIREVaaGAFRGLKQLIYLYLSHNDIR 111
Cdd:cd21340   6 HLYLNDKNITKIDNLSLCKNLkvLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  112 VLraGAFDDLTELTYLYLDHNKVSE------LPRGLLSPLVNLFILQLNNNKIRELRagAFQGAKDLRWLYLSENALSsl 185
Cdd:cd21340  82 VV--EGLENLTNLEELHIENQRLPPgekltfDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQIS-- 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 6680926  186 qpgSLDDVENLakfhldknqlssypsaaLSKLRVVEELKLSHNPLKSIP 234
Cdd:cd21340 156 ---DLEELLDL-----------------LSSWPSLRELDLTGNPVCKKP 184
LRRCT smart00082
Leucine rich repeat C-terminal domain;
299-346 3.57e-09

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 52.05  E-value: 3.57e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 6680926     299 NPWKCTCQLRGLRRWLEAK---ASRPDATCSSPAKFKGQRIRDTDALRSCK 346
Cdd:smart00082   1 NPFICDCELRWLLRWLQANehlQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
35-236 9.41e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.01  E-value: 9.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926    35 VICDKVGLQKIPK-VSETTKLLNLQRNNFPVLAAnsfrTMPNLVS-LHLQHCNIREVAAGAFRGLKQLIylyLSHNDIRV 112
Cdd:PRK15370 204 LILDNNELKSLPEnLQGNIKTLYANSNQLTSIPA----TLPDTIQeMELSINRITELPERLPSALQSLD---LFHNKISC 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   113 LRagafDDLTE-LTYLYLDHNKVSELPRGLLSPLVNLFILqlnNNKIRELRAGAFQGakdLRWLYLSENALSSLqPGSL- 190
Cdd:PRK15370 277 LP----ENLPEeLRYLSVYDNSIRTLPAHLPSGITHLNVQ---SNSLTALPETLPPG---LKTLEAGENALTSL-PASLp 345

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 6680926   191 DDVENLAkfhLDKNQLSSYPSAALSKLrvvEELKLSHNPLKSIPDN 236
Cdd:PRK15370 346 PELQVLD---VSKNQITVLPETLPPTI---TTLDVSRNALTNLPEN 385
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 22-48 2.34e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 2.34e-05
                          10        20
                  ....*....|....*....|....*..
gi 6680926     22 CPQNCHCHGdlQHVICDKVGLQKIPKV 48
Cdd:pfam01462   2 CPVPCHCSA--TVVNCSDRGLTAVPRD 26
LRRNT smart00013
Leucine rich repeat N-terminal domain;
22-48 6.54e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.61  E-value: 6.54e-05
                           10        20
                   ....*....|....*....|....*..
gi 6680926      22 CPQNCHCHGdlQHVICDKVGLQKIPKV 48
Cdd:smart00013   2 CPAPCNCSG--TAVDCSGRGLTEVPLD 26
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 290-334 1.40e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 1.40e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 6680926     290 NLETLTLTNNPWKCTCQLRGLRRWLE---AKASRPDAT-CSSPAKFKGQ 334
Cdd:TIGR00864   20 NLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAAlCAGPGALAGQ 68
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-300 3.27e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.10  E-value: 3.27e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   49 SETTKLLNLQRNNFPVLAANSFRTMPNLVSLHLQHCNIREVAAGAFRGLKQLIYLYLSHNDirvlragAFDDLTELTYLY 128
Cdd:COG4886  47 LLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLD 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  129 LDHNKVSELPRGLlSPLVNLFILQLNNNKIRELRAgAFQGAKDLRWLYLSENALSSLqPGSLDDVENLAKFHLDKNQLSS 208
Cdd:COG4886 120 LSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITD 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  209 YPsAALSKLRVVEELKLSHNPLKSIPDnAFQSFGRyLETLWLDNTNLEKFSDaaFSGVTTLKHVHLDNNRLNQLPSSFPF 288
Cdd:COG4886 197 LP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTN-LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANL 271

                       250
                ....*....|..
gi 6680926  289 DNLETLTLTNNP 300
Cdd:COG4886 272 TNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-315 4.48e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 4.48e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   55 LNLQRNNFPVLAAnSFRTMPNLVSLHLQHCNIREVAAgAFRGLKQLIYLYLSHNDIRVLRAgAFDDLTELTYLYLDHNKV 134
Cdd:COG4886 118 LDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  135 SELPRGLlSPLVNLFILQLNNNKIRELrAGAFQGAKDLRWLYLSENALSSLqpGSLDDVENLAKFHLDKNQLSSYPSaaL 214
Cdd:COG4886 195 TDLPEPL-GNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP--L 268

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  215 SKLRVVEELKLSHNPLKSIpdnAFQSFGRYLETLWLDNTNLEKFSDAAFSGVTTLKHVHLDNNRLNQLPSSFPFDNLETL 294
Cdd:COG4886 269 ANLTNLKTLDLSNNQLTDL---KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                       250       260
                ....*....|....*....|.
gi 6680926  295 TLTNNPWKCTCQLRGLRRWLE 315
Cdd:COG4886 346 LLALLTLLLLLNLLSLLLTLL 366
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
31-299 1.58e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.92  E-value: 1.58e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   31 DLQHVICDKVGLQKIPK-VSETTKL--LNLQRNNFPVLAAnSFRTMPNLVSLHLQHCNIREVAAgAFRGLKQLIYLYLSH 107
Cdd:COG4886 114 NLESLDLSGNQLTDLPEeLANLTNLkeLDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSN 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  108 NDIRVLrAGAFDDLTELTYLYLDHNKVSELPRGLlSPLVNLFILQLNNNKIRELRAgaFQGAKDLRWLYLSENALSSLqp 187
Cdd:COG4886 192 NQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDL-- 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  188 GSLDDVENLAKFHLDKNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDN-AFQSFGRYLETLWLDNTNLEKFSDAAFSGV 266
Cdd:COG4886 266 PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLiLLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345

                       250       260       270
                ....*....|....*....|....*....|...
gi 6680926  267 TTLKHVHLDNNRLNQLPSSFPFDNLETLTLTNN 299
Cdd:COG4886 346 LLALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-295 4.11e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 4.11e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   32 LQHVICDKVGLQKIPKV-SETTKL--LNLQRNNFPVLAAnSFRTMPNLVSLHLQHCNIREVAAgAFRGLKQLIYLYLSHN 108
Cdd:COG4886 138 LKELDLSNNQLTDLPEPlGNLTNLksLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN 215

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  109 DIRVLrAGAFDDLTELTYLYLDHNKVSELPRglLSPLVNLFILQLNNNKIRELRAGAfqGAKDLRWLYLSENALSSLQPG 188
Cdd:COG4886 216 QLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLK 290

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  189 SLDDVENLAKFHLDKNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDAAFSGVTT 268
Cdd:COG4886 291 ELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370

                       250       260
                ....*....|....*....|....*..
gi 6680926  269 LKHVHLDNNRLNQLPSSFPFDNLETLT 295
Cdd:COG4886 371 LLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR_8 pfam13855
Leucine rich repeat;
74-134 2.78e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 2.78e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6680926     74 PNLVSLHLQHCNIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKV 134
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 34-234 2.48e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.58  E-value: 2.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   34 HVICDKVGLQKIPKVSETTKL--LNLQRNNFPVLaaNSFRTMPNLVSLHLQHCNIREVaaGAFRGLKQLIYLYLSHNDIR 111
Cdd:cd21340   6 HLYLNDKNITKIDNLSLCKNLkvLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  112 VLraGAFDDLTELTYLYLDHNKVSE------LPRGLLSPLVNLFILQLNNNKIRELRagAFQGAKDLRWLYLSENALSsl 185
Cdd:cd21340  82 VV--EGLENLTNLEELHIENQRLPPgekltfDPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQIS-- 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 6680926  186 qpgSLDDVENLakfhldknqlssypsaaLSKLRVVEELKLSHNPLKSIP 234
Cdd:cd21340 156 ---DLEELLDL-----------------LSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-248 9.11e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 9.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   79 LHLQHCNIREVaaGAFRGLKQLIYLYLSHNDIRVLRAgaFDDLTELTYLYLDHNKVSELPRglLSPLVNLFILQLNNNKI 158
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  159 RELraGAFQGAKDLRWLYLSENALSS-----LQPGSLDDV-ENLAKFHLDKNQLSSYpsAALSKLRVVEELKLSHNPLKS 232
Cdd:cd21340  81 SVV--EGLENLTNLEELHIENQRLPPgekltFDPRSLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISD 156

                       170
                ....*....|....*...
gi 6680926  233 IPD--NAFQSFgRYLETL 248
Cdd:cd21340 157 LEEllDLLSSW-PSLREL 173
LRRCT smart00082
Leucine rich repeat C-terminal domain;
299-346 3.57e-09

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 52.05  E-value: 3.57e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 6680926     299 NPWKCTCQLRGLRRWLEAK---ASRPDATCSSPAKFKGQRIRDTDALRSCK 346
Cdd:smart00082   1 NPFICDCELRWLLRWLQANehlQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
147-206 8.80e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 8.80e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926    147 NLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGSLDDVENLAKFHLDKNQL 206
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
35-236 9.41e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 57.01  E-value: 9.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926    35 VICDKVGLQKIPK-VSETTKLLNLQRNNFPVLAAnsfrTMPNLVS-LHLQHCNIREVAAGAFRGLKQLIylyLSHNDIRV 112
Cdd:PRK15370 204 LILDNNELKSLPEnLQGNIKTLYANSNQLTSIPA----TLPDTIQeMELSINRITELPERLPSALQSLD---LFHNKISC 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   113 LRagafDDLTE-LTYLYLDHNKVSELPRGLLSPLVNLFILqlnNNKIRELRAGAFQGakdLRWLYLSENALSSLqPGSL- 190
Cdd:PRK15370 277 LP----ENLPEeLRYLSVYDNSIRTLPAHLPSGITHLNVQ---SNSLTALPETLPPG---LKTLEAGENALTSL-PASLp 345

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 6680926   191 DDVENLAkfhLDKNQLSSYPSAALSKLrvvEELKLSHNPLKSIPDN 236
Cdd:PRK15370 346 PELQVLD---VSKNQITVLPETLPPTI---TTLDVSRNALTNLPEN 385
LRR_8 pfam13855
Leucine rich repeat;
122-182 1.00e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.00e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6680926    122 TELTYLYLDHNKVSELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENAL 182
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
99-158 1.11e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.11e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926     99 QLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVSELPRGLLSPLVNLFILQLNNNKI 158
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
141-300 1.99e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.32  E-value: 1.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  141 LLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGSLDDVENLAKFHldknQLSSYPSAALSKLRVV 220
Cdd:COG4886  40 LSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT----ELDLSGNEELSNLTNL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  221 EELKLSHNPLKSIPDNAFQSfgRYLETLWLDNTNLEKFsDAAFSGVTTLKHVHLDNNRLNQLPSSF-PFDNLETLTLTNN 299
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANL--TNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELgNLTNLKELDLSNN 192


                .
gi 6680926  300 P 300
Cdd:COG4886 193 Q 193
LRR_8 pfam13855
Leucine rich repeat;
55-110 3.65e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 3.65e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 6680926     55 LNLQRNNFPVLAANSFRTMPNLVSLHLQHCNIREVAAGAFRGLKQLIYLYLSHNDI 110
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 97-299 9.86e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 9.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   97 LKQLIYLYLSHNDIRVLraGAFDDLTELTYLYLDHNKVSELPRglLSPLVNLFILQLNNNKIRELragafqgakdlrwly 176
Cdd:cd21340   1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--------------- 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  177 lsENaLSSLQpgslddveNLAKFHLDKNQLSsypsaalsklrVVEELKLSHNplksipdnafqsfgryLETLWLDNTNL- 255
Cdd:cd21340  62 --EN-LENLV--------NLKKLYLGGNRIS-----------VVEGLENLTN----------------LEELHIENQRLp 103

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 6680926  256 --EKF-----SDAAFSGvtTLKHVHLDNNRLNQLPSSFPFDNLETLTLTNN 299
Cdd:cd21340 104 pgEKLtfdprSLAALSN--SLRVLNISGNNIDSLEPLAPLRNLEQLDASNN 152
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 120-236 5.80e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.39  E-value: 5.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   120 DLTELTYLYLDHNKVS-ELPRGLLSPlvNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGSLDDVENLAK 198
Cdd:PLN00113 450 DMPSLQMLSLARNKFFgGLPDSFGSK--RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVS 527

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 6680926   199 FHLDKNQLSSYPSAALSKLRVVEELKLSHNPLK-SIPDN 236
Cdd:PLN00113 528 LDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKN 566
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 89-281 5.07e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.74  E-value: 5.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   89 VAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLT---ELTYLYLDHNKVSELP-----RGLLSPLVNLFILQLNNNKI-- 158
Cdd:cd00116  72 SLLQGLTKGCGLQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGDRGlrllaKGLKDLPPALEKLVLGRNRLeg 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  159 ---RELrAGAFQGAKDLRWLYLSENALS-----SLQPGsLDDVENLAKFHLDKNQL----SSYPSAALSKLRVVEELKLS 226
Cdd:cd00116 152 ascEAL-AKALRANRDLKELNLANNGIGdagirALAEG-LKANCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLG 229

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6680926  227 HNPLKSIP----DNAFQSFGRYLETLWLDNTNLEKFSDAAFSGV----TTLKHVHLDNNRLNQ 281
Cdd:cd00116 230 DNNLTDAGaaalASALLSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGE 292
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-299 5.82e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 5.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926    97 LKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVS-ELPRGLlSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWL 175
Cdd:PLN00113 307 LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNL-GKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKL 385

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   176 YLSENALSSLQPGSLDDVENLAKFHLDKNQLSSYPSAALSKLRVVEELKLSHNPLKsipdnafqsfGRYLETLWlDNTNL 255
Cdd:PLN00113 386 ILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ----------GRINSRKW-DMPSL 454

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 6680926   256 EKFSDAAfsgvttlkhvhldNNRLNQLPSSFPFDNLETLTLTNN 299
Cdd:PLN00113 455 QMLSLAR-------------NKFFGGLPDSFGSKRLENLDLSRN 485
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-287 1.48e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.00  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926    38 DKVGLQKIPK-VSETTKLLNLQRNNFPVLAANsfrtmpnlvslhlQHCNIREvaagafrglkqliyLYLSHNDIRVLRAG 116
Cdd:PRK15370 186 KILGLTTIPAcIPEQITTLILDNNELKSLPEN-------------LQGNIKT--------------LYANSNQLTSIPAT 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   117 AFDDLTELTylyLDHNKVSELPRGLLSPLVNLfilQLNNNKIRELRAGAFQGakdLRWLYLSENALSSLqPGSLDdvENL 196
Cdd:PRK15370 239 LPDTIQEME---LSINRITELPERLPSALQSL---DLFHNKISCLPENLPEE---LRYLSVYDNSIRTL-PAHLP--SGI 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   197 AKFHLDKNQLSSYPSAALSKLRVVEElklSHNPLKSIPdnafQSFGRYLETLWLDNTNLEKFSDAAFSGVTTLkhvHLDN 276
Cdd:PRK15370 307 THLNVQSNSLTALPETLPPGLKTLEA---GENALTSLP----ASLPPELQVLDVSKNQITVLPETLPPTITTL---DVSR 376

                        250
                 ....*....|.
gi 6680926   277 NRLNQLPSSFP 287
Cdd:PRK15370 377 NALTNLPENLP 387
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
98-299 2.21e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926    98 KQLIYLYLSHNDIRVLRAGAFDDLTELtylYLDHNKVSELPRGLLSplvNLFILQLNNNKIRELRAgafQGAKDLRWLYL 177
Cdd:PRK15370 199 EQITTLILDNNELKSLPENLQGNIKTL---YANSNQLTSIPATLPD---TIQEMELSINRITELPE---RLPSALQSLDL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   178 SENALSSLqPGSLDDveNLAKFHLDKNQLSSYPSAALSKlrvVEELKLSHNPLKSIPdnafQSFGRYLETLWLDNTNLEK 257
Cdd:PRK15370 270 FHNKISCL-PENLPE--ELRYLSVYDNSIRTLPAHLPSG---ITHLNVQSNSLTALP----ETLPPGLKTLEAGENALTS 339

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 6680926   258 FSDaafSGVTTLKHVHLDNNRLNQLPSSFPfDNLETLTLTNN 299
Cdd:PRK15370 340 LPA---SLPPELQVLDVSKNQITVLPETLP-PTITTLDVSRN 377
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 22-48 2.34e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 2.34e-05
                          10        20
                  ....*....|....*....|....*..
gi 6680926     22 CPQNCHCHGdlQHVICDKVGLQKIPKV 48
Cdd:pfam01462   2 CPVPCHCSA--TVVNCSDRGLTAVPRD 26
LRRNT smart00013
Leucine rich repeat N-terminal domain;
22-48 6.54e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.61  E-value: 6.54e-05
                           10        20
                   ....*....|....*....|....*..
gi 6680926      22 CPQNCHCHGdlQHVICDKVGLQKIPKV 48
Cdd:smart00013   2 CPAPCNCSG--TAVDCSGRGLTEVPLD 26
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 44-234 9.69e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 9.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926    44 KIPK---VSETTKLLNLQRNNFPVLAANSFRTMPNLVSLHLQHCNIREVAAGAFRGLKQLIYLYLSHNDIrvlrAGAFDD 120
Cdd:PLN00113 395 EIPKslgACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF----FGGLPD 470

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   121 L---TELTYLYLDHNKVSE-LPRGLLSpLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGSLDDVENL 196
Cdd:PLN00113 471 SfgsKRLENLDLSRNQFSGaVPRKLGS-LSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVL 549

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 6680926   197 AKFHLDKNQLSSYPSAALSKLRVVEELKLSHNPLK-SIP 234
Cdd:PLN00113 550 SQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHgSLP 588
LRR_8 pfam13855
Leucine rich repeat;
220-279 9.85e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 9.85e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926    220 VEELKLSHNPLKSIPDNAFQSFgRYLETLWLDNTNLEKFSDAAFSGVTTLKHVHLDNNRL 279
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGL-SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 290-334 1.40e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 1.40e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 6680926     290 NLETLTLTNNPWKCTCQLRGLRRWLE---AKASRPDAT-CSSPAKFKGQ 334
Cdd:TIGR00864   20 NLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAAlCAGPGALAGQ 68
LRR_8 pfam13855
Leucine rich repeat;
243-300 3.05e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 3.05e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926    243 RYLETLWLDNTNLEKFSDAAFSGVTTLKHVHLDNNRLNQLP--SSFPFDNLETLTLTNNP 300
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
195-255 6.38e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 6.38e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6680926    195 NLAKFHLDKNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRyLETLWLDNTNL 255
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-LRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-286 2.28e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 2.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926    97 LKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVS-ELPRGL--LSPLVNLFILQlnnNKIRELRAGAFQGAKDLR 173
Cdd:PLN00113 211 MKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLgnLKNLQYLFLYQ---NKLSGPIPPSIFSLQKLI 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   174 WLYLSENALSSLQPGSLDDVENLAKFHLDKNQLSSYPSAALSKLRVVEELKLSHNPLK-SIPDNAFQS------------ 240
Cdd:PLN00113 288 SLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHnnltvldlstnn 367

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 6680926   241 -FGRYLETLwLDNTNLEK---FSDA-------AFSGVTTLKHVHLDNNRLN-QLPSSF 286
Cdd:PLN00113 368 lTGEIPEGL-CSSGNLFKlilFSNSlegeipkSLGACRSLRRVRLQDNSFSgELPSEF 424
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 195-299 3.28e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.14  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926    195 NLAKFHLDKNqLSSYPSAALSKLRVVEELKLSHNpLKSIPDNAFQSFGryLETLWLDNtNLEKFSDAAFSGVTTLKHVHL 274
Cdd:pfam13306  12 SLTSITIPSS-LTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCS--LTSITIPS-SLTSIGEYAFSNCSNLKSITL 86

                          90       100
                  ....*....|....*....|....*.
gi 6680926    275 DNNrLNQLPSS-FPFDNLETLTLTNN 299
Cdd:pfam13306  87 PSN-LTSIGSYaFSNCSLKSITIPSS 111
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 231-299 3.97e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.14  E-value: 3.97e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6680926    231 KSIPDNAFQSFgrYLETLWLDNtNLEKFSDAAFSGVTTLKHVHLDNNrLNQLpSSFPFDN--LETLTLTNN 299
Cdd:pfam13306   1 TSIGSYAFYNC--SLTSITIPS-SLTSIGEYAFSNCTSLKSITLPSS-LTSI-GSYAFYNcsLTSITIPSS 66
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 30-255 1.00e-02

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 37.85  E-value: 1.00e-02
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926   30 GDLQHVICDKVGLQKIPKVSETTKLLNLQRNNFPVLA----ANSFRTMPNLVSLHLQHCNIREVAAGAF----RGLKQLI 101
Cdd:COG5238 160 GLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGieelAEALTQNTTVTTLWLKRNPIGDEGAEILaealKGNKSLT 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  102 YLYLSHNDIR----VLRAGAFDDLTELTYLYLDHNKVSELPRGLLSPLV----NLFILQLNNNKIRELRAGAF----QGA 169
Cdd:COG5238 240 TLDLSNNQIGdegvIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgntTLTSLDLSVNRIGDEGAIALaeglQGN 319

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680926  170 KDLRWLYLSENALSSlqpgslDDVENLAKfhldknqlssypsaALSKLRVVEELKLSHNPLKsipDNAFQSFGRYLETlw 249
Cdd:COG5238 320 KTLHTLNLAYNGIGA------QGAIALAK--------------ALQENTTLHSLDLSDNQIG---DEGAIALAKYLEG-- 374


                ....*.
gi 6680926  250 ldNTNL 255
Cdd:COG5238 375 --NTTL 378
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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