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Conserved domains on  [gi|6323663|ref|NP_013734|]
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Mac1p [Saccharomyces cerevisiae S288C]

Protein Classification

copper fist DNA-binding domain-containing protein( domain architecture ID 10648026)

copper fist DNA-binding domain-containing protein similar to Yarrowia lipolytica copper resistance protein CRF1, a transcriptional regulator involved in resistance to high copper concentration

CATH:  3.90.430.10
Gene Ontology:  GO:0005507|GO:0000981
PubMed:  9665167
SCOP:  4003750

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cu_FIST smart00412
Copper-Fist; binds DNA only in present of copper or silver
 2-40 1.29e-19

Copper-Fist; binds DNA only in present of copper or silver


:

Pssm-ID: 128690  Cd Length: 39  Bit Score: 81.31  E-value: 1.29e-19
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 6323663       2 IIFNGNKYACASCIRGHRSSTCRHSHRMLIKVRTRGRPS 40
Cdd:smart00412   1 VVINGVKYACESCIRGHRSSTCNHNDRPLIPVRPRGRPS 39
 
Name Accession Description Interval E-value
Cu_FIST smart00412
Copper-Fist; binds DNA only in present of copper or silver
 2-40 1.29e-19

Copper-Fist; binds DNA only in present of copper or silver


Pssm-ID: 128690  Cd Length: 39  Bit Score: 81.31  E-value: 1.29e-19
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 6323663       2 IIFNGNKYACASCIRGHRSSTCRHSHRMLIKVRTRGRPS 40
Cdd:smart00412   1 VVINGVKYACESCIRGHRSSTCNHNDRPLIPVRPRGRPS 39
Copper-fist pfam00649
Copper fist DNA binding domain;
2-39 1.44e-18

Copper fist DNA binding domain;


Pssm-ID: 425799  Cd Length: 38  Bit Score: 78.37  E-value: 1.44e-18
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 6323663      2 IIFNGNKYACASCIRGHRSSTCRHSHRMLIKVRTRGRP 39
Cdd:pfam00649   1 ILINGEKYACESCIRGHRSSTCNHTDRPLFEIRKKGRP 38
 
Name Accession Description Interval E-value
Cu_FIST smart00412
Copper-Fist; binds DNA only in present of copper or silver
 2-40 1.29e-19

Copper-Fist; binds DNA only in present of copper or silver


Pssm-ID: 128690  Cd Length: 39  Bit Score: 81.31  E-value: 1.29e-19
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 6323663       2 IIFNGNKYACASCIRGHRSSTCRHSHRMLIKVRTRGRPS 40
Cdd:smart00412   1 VVINGVKYACESCIRGHRSSTCNHNDRPLIPVRPRGRPS 39
Copper-fist smart01090
Copper fist is an N-terminal domain involved in copper-dependent DNA binding; The domain is ...
 3-40 1.08e-18

Copper fist is an N-terminal domain involved in copper-dependent DNA binding; The domain is named for its resemblance to a fist. It can be found in some fungal transcription factors. These proteins activate the transcription of the metallothionein gene in response to copper. Metallothionein maintains copper levels in yeast. The copper fist domain is similar in structure to metallothionein itself, and on copper binding undergoes a large conformational change, which allows DNA binding.


Pssm-ID: 215019  Cd Length: 38  Bit Score: 78.92  E-value: 1.08e-18
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 6323663       3 IFNGNKYACASCIRGHRSSTCRHSHRMLIKVRTRGRPS 40
Cdd:smart01090   1 IINGVKYACEKCIRGHRSSTCTHNDRPLVKVRKRGRPS 38
Copper-fist pfam00649
Copper fist DNA binding domain;
2-39 1.44e-18

Copper fist DNA binding domain;


Pssm-ID: 425799  Cd Length: 38  Bit Score: 78.37  E-value: 1.44e-18
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 6323663      2 IIFNGNKYACASCIRGHRSSTCRHSHRMLIKVRTRGRP 39
Cdd:pfam00649   1 ILINGEKYACESCIRGHRSSTCNHTDRPLFEIRKKGRP 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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