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Conserved domains on  [gi|6322371|ref|NP_012445|]
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protein kinase activating protein DPB11 [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BRCT_Rad4_rpt3 cd18433
third BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar ...
 326-410 4.31e-21

third BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the third repeat.


:

Pssm-ID: 349386  Cd Length: 83  Bit Score: 88.14  E-value: 4.31e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371  326 IFKNCAFIIHHiFPGNHRSILTKIVVQNGGKIETSYLSGI---YDHSYYIIPSNKALDSfndlPEIIDDNDGIVTEFFIE 402
Cdd:cd18433   1 IFSGCTFYIHG-FDDKKIQILRKHLLSNGGQVVSSLSELEadeSKHRYVIVPHTNPPDE----LPPVSENAPLVTEWWIE 75


                ....*...
gi 6322371  403 RCLYYQKL 410
Cdd:cd18433  76 RCLHSKRL 83
BRCT super family cl00038
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 2-85 2.04e-12

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


The actual alignment was detected with superfamily member cd17740:

Pssm-ID: 469589  Cd Length: 82  Bit Score: 63.26  E-value: 2.04e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371    2 KPFQGITFCPTAINNEIlAKKISKKIIKLGGIFSKDLTRQVNVLVVGSTtNTNKFKFAVKHRFDIIFIDIQAIDDIYQLW 81
Cdd:cd17740   1 KPLSGIVLCCTSIPAEQ-RTEIATKASKMGAAYTADLTSDVTHLVAGQV-NTTKYKFAARSRPDIKVMTVEWVEHLYESW 78


                ....
gi 6322371   82 LSGE 85
Cdd:cd17740  79 QQGE 82
BRCT super family cl00038
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 446-489 4.18e-09

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


The actual alignment was detected with superfamily member cd17723:

Pssm-ID: 469589 [Multi-domain]  Cd Length: 74  Bit Score: 53.41  E-value: 4.18e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 6322371  446 LNVTITGFSGVELLHLTKVLNLLkpmGINYVEYLNKSTDILLIN 489
Cdd:cd17723   2 LSISLTGFSGVDLLHISKLIKLL---GAKYHESLTKDRSLLIVN 42
BRCT super family cl00038
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 154-221 1.91e-03

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


The actual alignment was detected with superfamily member cd17722:

Pssm-ID: 469589 [Multi-domain]  Cd Length: 90  Bit Score: 38.05  E-value: 1.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371  154 FVIKDTSSHNDDDD-------------QGQNGQISIFVTDTLLGARVNAAIEQN-IPIVHFKWILDCQKRSALLPYDPYY 219
Cdd:cd17722   8 CVMSDMSSPKSKAEleklikenggkvvQNPGAPDTICVIAGREVVKVKNLIKSGgHDVVKPSWLLDCIARKELLPLEPKY 87


                ..
gi 6322371  220 LL 221
Cdd:cd17722  88 MI 89
 
Name Accession Description Interval E-value
BRCT_Rad4_rpt3 cd18433
third BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar ...
 326-410 4.31e-21

third BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the third repeat.


Pssm-ID: 349386  Cd Length: 83  Bit Score: 88.14  E-value: 4.31e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371  326 IFKNCAFIIHHiFPGNHRSILTKIVVQNGGKIETSYLSGI---YDHSYYIIPSNKALDSfndlPEIIDDNDGIVTEFFIE 402
Cdd:cd18433   1 IFSGCTFYIHG-FDDKKIQILRKHLLSNGGQVVSSLSELEadeSKHRYVIVPHTNPPDE----LPPVSENAPLVTEWWIE 75


                ....*...
gi 6322371  403 RCLYYQKL 410
Cdd:cd18433  76 RCLHSKRL 83
BRCT_Rad4_rpt1 cd17740
first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar ...
 2-85 2.04e-12

first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples the S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the first one.


Pssm-ID: 349371  Cd Length: 82  Bit Score: 63.26  E-value: 2.04e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371    2 KPFQGITFCPTAINNEIlAKKISKKIIKLGGIFSKDLTRQVNVLVVGSTtNTNKFKFAVKHRFDIIFIDIQAIDDIYQLW 81
Cdd:cd17740   1 KPLSGIVLCCTSIPAEQ-RTEIATKASKMGAAYTADLTSDVTHLVAGQV-NTTKYKFAARSRPDIKVMTVEWVEHLYESW 78


                ....
gi 6322371   82 LSGE 85
Cdd:cd17740  79 QQGE 82
BRCT_Rad4_rpt4 cd17723
fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 446-489 4.18e-09

fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system, which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the fourth one.


Pssm-ID: 349355 [Multi-domain]  Cd Length: 74  Bit Score: 53.41  E-value: 4.18e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 6322371  446 LNVTITGFSGVELLHLTKVLNLLkpmGINYVEYLNKSTDILLIN 489
Cdd:cd17723   2 LSISLTGFSGVDLLHISKLIKLL---GAKYHESLTKDRSLLIVN 42
BRCT smart00292
breast cancer carboxy-terminal domain;
326-405 4.22e-08

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 50.84  E-value: 4.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371     326 IFKNCAFIIHHIFPGNHRSILTKIVVQNGGKIETSYLSGIYDHSYYIIPSNKALdsfnDLPEIIDDNDGIVTEFFIERCL 405
Cdd:smart00292   3 LFKGKTFYITGSFDKEERDELKELIEALGGKVTSSLSSKTTTHVIVGSPEGGKL----ELLKAIALGIPIVKEEWLLDCL 78
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 323-411 4.39e-04

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 39.66  E-value: 4.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371    323 STLIFKNCAFIIHhIFPGNHRSILTKIVVQNGGKIETSYLSGIYdhsYYIIPSNKaldsfnDLPEIIDDNDGIVTEFFIE 402
Cdd:pfam16589   1 LPNLFEPLRFYIN-AIPSPSRSKLKRLIEANGGTVVDNINPAVY---IVIAPYNK------TDKLAENTKLGVVSPQWIF 70


                  ....*....
gi 6322371    403 RCLYYQKLL 411
Cdd:pfam16589  71 DCVKKGKLL 79
BRCT_DNA_ligase_IV_rpt1 cd17722
first BRCT domain of DNA ligase 4 (LIG4) and similar proteins; LIG4 (EC 6.5.1.1), also termed ...
 154-221 1.91e-03

first BRCT domain of DNA ligase 4 (LIG4) and similar proteins; LIG4 (EC 6.5.1.1), also termed DNA ligase IV, or polydeoxyribonucleotide synthase [ATP] 4, is involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. It is a component of the LIG4-XRCC4 complex that is responsible for the NHEJ ligation step. LIG4 contains two BRCT domains. The family corresponds to the first one.


Pssm-ID: 349354 [Multi-domain]  Cd Length: 90  Bit Score: 38.05  E-value: 1.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371  154 FVIKDTSSHNDDDD-------------QGQNGQISIFVTDTLLGARVNAAIEQN-IPIVHFKWILDCQKRSALLPYDPYY 219
Cdd:cd17722   8 CVMSDMSSPKSKAEleklikenggkvvQNPGAPDTICVIAGREVVKVKNLIKSGgHDVVKPSWLLDCIARKELLPLEPKY 87


                ..
gi 6322371  220 LL 221
Cdd:cd17722  88 MI 89
BRCT smart00292
breast cancer carboxy-terminal domain;
114-206 2.06e-03

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 37.74  E-value: 2.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371     114 KYLHNFNIFIGRITDTNitSIDSLVRSIKKLGCssyNYQNFVIKDTSSHnddddqgqngqisiFVTDTLLGARV--NAAI 191
Cdd:smart00292   2 KLFKGKTFYITGSFDKE--ERDELKELIEALGG---KVTSSLSSKTTTH--------------VIVGSPEGGKLelLKAI 62

                           90
                   ....*....|....*
gi 6322371     192 EQNIPIVHFKWILDC 206
Cdd:smart00292  63 ALGIPIVKEEWLLDC 77
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 111-206 2.56e-03

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 37.27  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371    111 FSFKYLHNFNIFIGRITDTNITSIDSLvrsIKKLGCSSYNYQNfvikdtsshnddddqgqnGQISIFVTDTLLgARVNAA 190
Cdd:pfam00533   1 PKEKLFSGKTFVITGLDGLERDELKEL---IEKLGGKVTDSLS------------------KKTTHVIVEART-KKYLKA 58

                          90
                  ....*....|....*.
gi 6322371    191 IEQNIPIVHFKWILDC 206
Cdd:pfam00533  59 KELGIPIVTEEWLLDC 74
 
Name Accession Description Interval E-value
BRCT_Rad4_rpt3 cd18433
third BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar ...
 326-410 4.31e-21

third BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the third repeat.


Pssm-ID: 349386  Cd Length: 83  Bit Score: 88.14  E-value: 4.31e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371  326 IFKNCAFIIHHiFPGNHRSILTKIVVQNGGKIETSYLSGI---YDHSYYIIPSNKALDSfndlPEIIDDNDGIVTEFFIE 402
Cdd:cd18433   1 IFSGCTFYIHG-FDDKKIQILRKHLLSNGGQVVSSLSELEadeSKHRYVIVPHTNPPDE----LPPVSENAPLVTEWWIE 75


                ....*...
gi 6322371  403 RCLYYQKL 410
Cdd:cd18433  76 RCLHSKRL 83
BRCT_Rad4_rpt1 cd17740
first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar ...
 2-85 2.04e-12

first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples the S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the first one.


Pssm-ID: 349371  Cd Length: 82  Bit Score: 63.26  E-value: 2.04e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371    2 KPFQGITFCPTAINNEIlAKKISKKIIKLGGIFSKDLTRQVNVLVVGSTtNTNKFKFAVKHRFDIIFIDIQAIDDIYQLW 81
Cdd:cd17740   1 KPLSGIVLCCTSIPAEQ-RTEIATKASKMGAAYTADLTSDVTHLVAGQV-NTTKYKFAARSRPDIKVMTVEWVEHLYESW 78


                ....
gi 6322371   82 LSGE 85
Cdd:cd17740  79 QQGE 82
BRCT_Rad4_rpt4 cd17723
fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 446-489 4.18e-09

fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system, which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the fourth one.


Pssm-ID: 349355 [Multi-domain]  Cd Length: 74  Bit Score: 53.41  E-value: 4.18e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 6322371  446 LNVTITGFSGVELLHLTKVLNLLkpmGINYVEYLNKSTDILLIN 489
Cdd:cd17723   2 LSISLTGFSGVDLLHISKLIKLL---GAKYHESLTKDRSLLIVN 42
BRCT smart00292
breast cancer carboxy-terminal domain;
326-405 4.22e-08

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 50.84  E-value: 4.22e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371     326 IFKNCAFIIHHIFPGNHRSILTKIVVQNGGKIETSYLSGIYDHSYYIIPSNKALdsfnDLPEIIDDNDGIVTEFFIERCL 405
Cdd:smart00292   3 LFKGKTFYITGSFDKEERDELKELIEALGGKVTSSLSSKTTTHVIVGSPEGGKL----ELLKAIALGIPIVKEEWLLDCL 78
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 2-62 9.00e-05

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 41.37  E-value: 9.00e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6322371    2 KPFQGITFCPTAIN----NEIlakkiSKKIIKLGGIFSKDLTRQVNVLVVGSTTnTNKFKFAVKH 62
Cdd:cd17731   1 PPFKGLVICVTGFDseerKEI-----QQLVEQNGGSYSPDLSKNCTHLIAGSPS-GQKYEFARKW 59
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 323-411 4.39e-04

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 39.66  E-value: 4.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371    323 STLIFKNCAFIIHhIFPGNHRSILTKIVVQNGGKIETSYLSGIYdhsYYIIPSNKaldsfnDLPEIIDDNDGIVTEFFIE 402
Cdd:pfam16589   1 LPNLFEPLRFYIN-AIPSPSRSKLKRLIEANGGTVVDNINPAVY---IVIAPYNK------TDKLAENTKLGVVSPQWIF 70


                  ....*....
gi 6322371    403 RCLYYQKLL 411
Cdd:pfam16589  71 DCVKKGKLL 79
BRCT_DNA_ligase_IV_rpt1 cd17722
first BRCT domain of DNA ligase 4 (LIG4) and similar proteins; LIG4 (EC 6.5.1.1), also termed ...
 154-221 1.91e-03

first BRCT domain of DNA ligase 4 (LIG4) and similar proteins; LIG4 (EC 6.5.1.1), also termed DNA ligase IV, or polydeoxyribonucleotide synthase [ATP] 4, is involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. It is a component of the LIG4-XRCC4 complex that is responsible for the NHEJ ligation step. LIG4 contains two BRCT domains. The family corresponds to the first one.


Pssm-ID: 349354 [Multi-domain]  Cd Length: 90  Bit Score: 38.05  E-value: 1.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371  154 FVIKDTSSHNDDDD-------------QGQNGQISIFVTDTLLGARVNAAIEQN-IPIVHFKWILDCQKRSALLPYDPYY 219
Cdd:cd17722   8 CVMSDMSSPKSKAEleklikenggkvvQNPGAPDTICVIAGREVVKVKNLIKSGgHDVVKPSWLLDCIARKELLPLEPKY 87


                ..
gi 6322371  220 LL 221
Cdd:cd17722  88 MI 89
BRCT smart00292
breast cancer carboxy-terminal domain;
114-206 2.06e-03

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 37.74  E-value: 2.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371     114 KYLHNFNIFIGRITDTNitSIDSLVRSIKKLGCssyNYQNFVIKDTSSHnddddqgqngqisiFVTDTLLGARV--NAAI 191
Cdd:smart00292   2 KLFKGKTFYITGSFDKE--ERDELKELIEALGG---KVTSSLSSKTTTH--------------VIVGSPEGGKLelLKAI 62

                           90
                   ....*....|....*
gi 6322371     192 EQNIPIVHFKWILDC 206
Cdd:smart00292  63 ALGIPIVKEEWLLDC 77
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 111-206 2.56e-03

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 37.27  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322371    111 FSFKYLHNFNIFIGRITDTNITSIDSLvrsIKKLGCSSYNYQNfvikdtsshnddddqgqnGQISIFVTDTLLgARVNAA 190
Cdd:pfam00533   1 PKEKLFSGKTFVITGLDGLERDELKEL---IEKLGGKVTDSLS------------------KKTTHVIVEART-KKYLKA 58

                          90
                  ....*....|....*.
gi 6322371    191 IEQNIPIVHFKWILDC 206
Cdd:pfam00533  59 KELGIPIVTEEWLLDC 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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