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Conserved domains on  [gi|398366501|ref|NP_010624|]
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mitochondrial 37S ribosomal protein MRPS28 [Saccharomyces cerevisiae S288C]

Protein Classification

uS15 family ribosomal protein( domain architecture ID 11092050)

uS15 family ribosomal protein such as metazoan mitochondrial 28S ribosomal protein S15, fungal mitochondrial 37S ribosomal protein S28, and bacterial 30S ribosomal protein S15.

Gene Ontology:  GO:0003723|GO:0003735|GO:0006412
PubMed:  24524803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_S15 pfam00312
Ribosomal protein S15;
161-236 8.83e-32

Ribosomal protein S15;


:

Pssm-ID: 459756  Cd Length: 81  Bit Score: 112.91  E-value: 8.83e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398366501  161 RKEFERFPGDTGSSEVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYWTIQKLGL 236
Cdd:pfam00312   5 IKEFGRHPGDTGSPEVQIALLTERINNLTEHLKEHKKDKHSRRGLLKLVGKRRRLLKYLKRKDVERYRYLIEKLGL 80
 
Name Accession Description Interval E-value
Ribosomal_S15 pfam00312
Ribosomal protein S15;
161-236 8.83e-32

Ribosomal protein S15;


Pssm-ID: 459756  Cd Length: 81  Bit Score: 112.91  E-value: 8.83e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398366501  161 RKEFERFPGDTGSSEVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYWTIQKLGL 236
Cdd:pfam00312   5 IKEFGRHPGDTGSPEVQIALLTERINNLTEHLKEHKKDKHSRRGLLKLVGKRRRLLKYLKRKDVERYRYLIEKLGL 80
Ribosomal_S15p_S13e cd00353
Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and ...
 160-235 7.85e-27

Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome. S15 also plays an important autoregulatory role by binding and preventing its own mRNA from being translated. S15 has a predominantly alpha-helical fold that is highly structured except for the N-terminal alpha helix.


Pssm-ID: 238213  Cd Length: 80  Bit Score: 99.88  E-value: 7.85e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398366501 160 ARKEFERFPGDTGSSEVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYWTIQKLG 235
Cdd:cd00353    5 ILKEFGLAEGDTGSPEVQLALLTERIVNLTEHLEKNKKDKHSKRGLLLLVSKRRRLLKYLKRKDRLRYEWLIEKLG 80
rpsO PRK05626
30S ribosomal protein S15; Reviewed
 155-236 4.67e-20

30S ribosomal protein S15; Reviewed


Pssm-ID: 180170  Cd Length: 89  Bit Score: 82.47  E-value: 4.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366501 155 MAVELARK-----EFERFPGDTGSSEVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYW 229
Cdd:PRK05626   1 MSLTKEKKaeiikEYGRHEGDTGSPEVQVALLTERINHLTEHLKEHKKDHHSRRGLLKMVGQRRKLLDYLKKKDVERYRA 80


                 ....*..
gi 398366501 230 TIQKLGL 236
Cdd:PRK05626  81 LIERLGL 87
RpsO COG0184
Ribosomal protein S15P/S13E [Translation, ribosomal structure and biogenesis]; Ribosomal ...
 162-236 6.38e-19

Ribosomal protein S15P/S13E [Translation, ribosomal structure and biogenesis]; Ribosomal protein S15P/S13E is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 439954  Cd Length: 89  Bit Score: 79.33  E-value: 6.38e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366501 162 KEFERFPGDTGSSEVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYWTIQKLGL 236
Cdd:COG0184   13 KEYGRHEGDTGSPEVQIALLTERINNLTEHLKEHKKDHHSRRGLLKMVGKRRRLLDYLKKKDIERYRALIAKLGL 87
S15_bact TIGR00952
ribosomal protein S15, bacterial/organelle; This model is built to recognize specifically ...
 162-236 1.98e-18

ribosomal protein S15, bacterial/organelle; This model is built to recognize specifically bacterial, chloroplast, and mitochondrial ribosomal protein S15. The homologous proteins of Archaea and Eukarya are designated S13. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 130027 [Multi-domain]  Cd Length: 86  Bit Score: 78.13  E-value: 1.98e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366501  162 KEFERFPGDTGSSEVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYWTIQKLGL 236
Cdd:TIGR00952  10 KEFQLHEKDTGSPEVQIALLTERINQLTEHLKANKKDHHSRRGLLKLVGRRRRLLKYLKRTDVERYRSLIKRLGL 84
 
Name Accession Description Interval E-value
Ribosomal_S15 pfam00312
Ribosomal protein S15;
161-236 8.83e-32

Ribosomal protein S15;


Pssm-ID: 459756  Cd Length: 81  Bit Score: 112.91  E-value: 8.83e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398366501  161 RKEFERFPGDTGSSEVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYWTIQKLGL 236
Cdd:pfam00312   5 IKEFGRHPGDTGSPEVQIALLTERINNLTEHLKEHKKDKHSRRGLLKLVGKRRRLLKYLKRKDVERYRYLIEKLGL 80
Ribosomal_S15p_S13e cd00353
Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and ...
 160-235 7.85e-27

Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome. S15 also plays an important autoregulatory role by binding and preventing its own mRNA from being translated. S15 has a predominantly alpha-helical fold that is highly structured except for the N-terminal alpha helix.


Pssm-ID: 238213  Cd Length: 80  Bit Score: 99.88  E-value: 7.85e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398366501 160 ARKEFERFPGDTGSSEVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYWTIQKLG 235
Cdd:cd00353    5 ILKEFGLAEGDTGSPEVQLALLTERIVNLTEHLEKNKKDKHSKRGLLLLVSKRRRLLKYLKRKDRLRYEWLIEKLG 80
rpsO PRK05626
30S ribosomal protein S15; Reviewed
 155-236 4.67e-20

30S ribosomal protein S15; Reviewed


Pssm-ID: 180170  Cd Length: 89  Bit Score: 82.47  E-value: 4.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366501 155 MAVELARK-----EFERFPGDTGSSEVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYW 229
Cdd:PRK05626   1 MSLTKEKKaeiikEYGRHEGDTGSPEVQVALLTERINHLTEHLKEHKKDHHSRRGLLKMVGQRRKLLDYLKKKDVERYRA 80


                 ....*..
gi 398366501 230 TIQKLGL 236
Cdd:PRK05626  81 LIERLGL 87
RpsO COG0184
Ribosomal protein S15P/S13E [Translation, ribosomal structure and biogenesis]; Ribosomal ...
 162-236 6.38e-19

Ribosomal protein S15P/S13E [Translation, ribosomal structure and biogenesis]; Ribosomal protein S15P/S13E is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 439954  Cd Length: 89  Bit Score: 79.33  E-value: 6.38e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366501 162 KEFERFPGDTGSSEVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYWTIQKLGL 236
Cdd:COG0184   13 KEYGRHEGDTGSPEVQIALLTERINNLTEHLKEHKKDHHSRRGLLKMVGKRRRLLDYLKKKDIERYRALIAKLGL 87
S15_bact TIGR00952
ribosomal protein S15, bacterial/organelle; This model is built to recognize specifically ...
 162-236 1.98e-18

ribosomal protein S15, bacterial/organelle; This model is built to recognize specifically bacterial, chloroplast, and mitochondrial ribosomal protein S15. The homologous proteins of Archaea and Eukarya are designated S13. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 130027 [Multi-domain]  Cd Length: 86  Bit Score: 78.13  E-value: 1.98e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366501  162 KEFERFPGDTGSSEVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYWTIQKLGL 236
Cdd:TIGR00952  10 KEFQLHEKDTGSPEVQIALLTERINQLTEHLKANKKDHHSRRGLLKLVGRRRRLLKYLKRTDVERYRSLIKRLGL 84
PTZ00119 PTZ00119
40S ribosomal protein S15; Provisional
 113-234 7.16e-11

40S ribosomal protein S15; Provisional


Pssm-ID: 240278  Cd Length: 302  Bit Score: 61.50  E-value: 7.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366501 113 AELSGLNTEVVGIEDIEKLEDRREAILRILSMRNSENKNAIKMAVELARKEFERFPGDTGSSEVQAACMTVRIQNMANHI 192
Cdd:PTZ00119  66 SERNQIPNGYIGLWQYDDIKHLRKNIINMLHLNCANSKQIHKYKKLCIRRCLQRRPFDTGSAPVQIGCLTEKILNLRAHL 145

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 398366501 193 KEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYWTIQKL 234
Cdd:PTZ00119 146 ILRCKDHPKKRTMSILLARRQKLMKYLYKTDFELYKHTCNLL 187
rps15 CHL00027
ribosomal protein S15
 170-236 9.64e-10

ribosomal protein S15


Pssm-ID: 214339  Cd Length: 90  Bit Score: 54.58  E-value: 9.64e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 398366501 170 DTGSSEVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLKRDNPEKYYWTIQKLGL 236
Cdd:CHL00027  18 NRGSVEFQVFSFTNKIRRLTSHLELHKKDYSSQRGLRKILGKRQRLLAYLSKKNRVRYKKLISQLGI 84
S15_NS1_EPRS_RNA-bind cd00677
S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, ...
 175-220 2.01e-09

S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic aminoacyl tRNA synthetases (aaRSs), where it occurs as a single or a repeated unit. It is involved in both protein-RNA interactions by binding tRNA and protein-protein interactions in the formation of tRNA-synthetases into multienzyme complexes. While this domain lacks significant sequence similarity between the subgroups in which it is found, they share similar electrostatic surface potentials and thus are likely to bind to RNA via the same mechanism.


Pssm-ID: 238361  Cd Length: 46  Bit Score: 52.13  E-value: 2.01e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 398366501 175 EVQAACMTVRIQNMANHIKEHRKDFANTRNLRILVQQRQAILRYLK 220
Cdd:cd00677    1 EVQIALLTERIRNLKEHLAKNKKDKHSKRGLDLLVSKRLRLLKYLK 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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