NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|110347463|ref|NP_006725|]
View 

transcription factor HIVEP2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10604075)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|30718982
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
204-228 1.53e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.21  E-value: 1.53e-06
                           10        20
                   ....*....|....*....|....*
gi 110347463   204 LKKHIRSHTGERPYPCIPCGFSFKT 228
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 2029-2255 4.84e-05

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.92  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347463 2029 PSEP--SSSPRDFSPSSHHSSPGYDSSPCRDNSPKR---YLIPKGDLSPRRHLSPRRDLSPMRHLSPRkeaalRREMSQR 2103
Cdd:PTZ00449  579 PEFPkdPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLpelLDIPKSPKRPESPKSPKRPPPPQRPSSPE-----RPEGPKI 653

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347463 2104 DVSPRRHLSPRRPVSPG---KDITARRDLSPRRERRYMTTIRAPSPRRALYHNPPLSMGQYLQAEPIVlgPPNLRRglpq 2180
Cdd:PTZ00449  654 IKSPKPPKSPKPPFDPKfkeKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPL--PPKLPR---- 727

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110347463 2181 vpyfslygDQEGAYEHPGSSLFPEgPNDYVFSHLPLHSQQQVRAPIPMVPVGGIQMVHSMPPALSSLHPSPTLPL 2255
Cdd:PTZ00449  728 --------DEEFPFEPIGDPDAEQ-PDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAM 793
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1813-1838 1.30e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 1.30e-04
                           10        20
                   ....*....|....*....|....*.
gi 110347463  1813 MLKKHIRTHTDVRPYVCKLCNFAFKT 1838
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1799-1821 4.60e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 4.60e-04
                           10        20
                   ....*....|....*....|...
gi 110347463  1799 YICEECGIRCKKPSMLKKHIRTH 1821
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
204-228 1.53e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.21  E-value: 1.53e-06
                           10        20
                   ....*....|....*....|....*
gi 110347463   204 LKKHIRSHTGERPYPCIPCGFSFKT 228
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 2029-2255 4.84e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.92  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347463 2029 PSEP--SSSPRDFSPSSHHSSPGYDSSPCRDNSPKR---YLIPKGDLSPRRHLSPRRDLSPMRHLSPRkeaalRREMSQR 2103
Cdd:PTZ00449  579 PEFPkdPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLpelLDIPKSPKRPESPKSPKRPPPPQRPSSPE-----RPEGPKI 653

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347463 2104 DVSPRRHLSPRRPVSPG---KDITARRDLSPRRERRYMTTIRAPSPRRALYHNPPLSMGQYLQAEPIVlgPPNLRRglpq 2180
Cdd:PTZ00449  654 IKSPKPPKSPKPPFDPKfkeKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPL--PPKLPR---- 727

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110347463 2181 vpyfslygDQEGAYEHPGSSLFPEgPNDYVFSHLPLHSQQQVRAPIPMVPVGGIQMVHSMPPALSSLHPSPTLPL 2255
Cdd:PTZ00449  728 --------DEEFPFEPIGDPDAEQ-PDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAM 793
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1813-1838 1.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 1.30e-04
                           10        20
                   ....*....|....*....|....*.
gi 110347463  1813 MLKKHIRTHTDVRPYVCKLCNFAFKT 1838
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1799-1821 4.60e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 4.60e-04
                           10        20
                   ....*....|....*....|...
gi 110347463  1799 YICEECGIRCKKPSMLKKHIRTH 1821
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
204-228 1.53e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 46.21  E-value: 1.53e-06
                           10        20
                   ....*....|....*....|....*
gi 110347463   204 LKKHIRSHTGERPYPCIPCGFSFKT 228
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 2029-2255 4.84e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.92  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347463 2029 PSEP--SSSPRDFSPSSHHSSPGYDSSPCRDNSPKR---YLIPKGDLSPRRHLSPRRDLSPMRHLSPRkeaalRREMSQR 2103
Cdd:PTZ00449  579 PEFPkdPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLpelLDIPKSPKRPESPKSPKRPPPPQRPSSPE-----RPEGPKI 653

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110347463 2104 DVSPRRHLSPRRPVSPG---KDITARRDLSPRRERRYMTTIRAPSPRRALYHNPPLSMGQYLQAEPIVlgPPNLRRglpq 2180
Cdd:PTZ00449  654 IKSPKPPKSPKPPFDPKfkeKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPL--PPKLPR---- 727

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110347463 2181 vpyfslygDQEGAYEHPGSSLFPEgPNDYVFSHLPLHSQQQVRAPIPMVPVGGIQMVHSMPPALSSLHPSPTLPL 2255
Cdd:PTZ00449  728 --------DEEFPFEPIGDPDAEQ-PDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAETGEPDEAM 793
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1813-1838 1.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 1.30e-04
                           10        20
                   ....*....|....*....|....*.
gi 110347463  1813 MLKKHIRTHTDVRPYVCKLCNFAFKT 1838
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1799-1821 4.60e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 4.60e-04
                           10        20
                   ....*....|....*....|...
gi 110347463  1799 YICEECGIRCKKPSMLKKHIRTH 1821
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1827-1848 3.91e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 3.91e-03
                           10        20
                   ....*....|....*....|..
gi 110347463  1827 YVCKLCNFAFKTKGNLTKHMKS 1848
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRT 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH