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Conserved domains on  [gi|5729980|ref|NP_006547|]
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phosphomevalonate kinase isoform 1 [Homo sapiens]

Protein Classification

P-mevalo_kinase domain-containing protein( domain architecture ID 10515312)

P-mevalo_kinase domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-mevalo_kinase pfam04275
Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation ...
 14-123 5.16e-69

Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway. This family represents the animal type of the enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see pfam00288).


:

Pssm-ID: 461247  Cd Length: 112  Bit Score: 205.50  E-value: 5.16e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729980     14 FSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCR 93
Cdd:pfam04275   1 FSGKRKSGKDYVTELLQERLGGDRCAVLRISGPIKQQYAKEHGLDLDELLSDGPYKEQYRKDMIRWGEEKRNKDPGYFCR 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 5729980     94 KIVEGI--SQPIWLVSDTRRVSDIQWFREAYG 123
Cdd:pfam04275  81 AAIEMAdaQKPVWIVSDARRKTDLQWFRENYP 112
 
Name Accession Description Interval E-value
P-mevalo_kinase pfam04275
Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation ...
 14-123 5.16e-69

Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway. This family represents the animal type of the enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see pfam00288).


Pssm-ID: 461247  Cd Length: 112  Bit Score: 205.50  E-value: 5.16e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729980     14 FSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCR 93
Cdd:pfam04275   1 FSGKRKSGKDYVTELLQERLGGDRCAVLRISGPIKQQYAKEHGLDLDELLSDGPYKEQYRKDMIRWGEEKRNKDPGYFCR 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 5729980     94 KIVEGI--SQPIWLVSDTRRVSDIQWFREAYG 123
Cdd:pfam04275  81 AAIEMAdaQKPVWIVSDARRKTDLQWFRENYP 112
Pmev_kin_anim TIGR01223
phosphomevalonate kinase, animal type; This enzyme is part of the mevalonate pathway, one of ...
 11-186 1.93e-53

phosphomevalonate kinase, animal type; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found. One is this type, found in animals. The other is the ERG8 type, found in plants and fungi (TIGR01219) and in Gram-positive bacteria (TIGR01220). [Central intermediary metabolism, Other]


Pssm-ID: 130290  Cd Length: 182  Bit Score: 168.72  E-value: 1.93e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729980     11 VLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGF 90
Cdd:TIGR01223   1 VLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729980     91 FCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIEN 170
Cdd:TIGR01223  81 FCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIEN 160

                         170
                  ....*....|....*.
gi 5729980    171 HGVEQRLEEQLENLIE 186
Cdd:TIGR01223 161 HGVEQRLEEQLENLIE 176
 
Name Accession Description Interval E-value
P-mevalo_kinase pfam04275
Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation ...
 14-123 5.16e-69

Phosphomevalonate kinase; Phosphomevalonate kinase (EC:2.7.4.2) catalyzes the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway. This family represents the animal type of the enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see pfam00288).


Pssm-ID: 461247  Cd Length: 112  Bit Score: 205.50  E-value: 5.16e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729980     14 FSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCR 93
Cdd:pfam04275   1 FSGKRKSGKDYVTELLQERLGGDRCAVLRISGPIKQQYAKEHGLDLDELLSDGPYKEQYRKDMIRWGEEKRNKDPGYFCR 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 5729980     94 KIVEGI--SQPIWLVSDTRRVSDIQWFREAYG 123
Cdd:pfam04275  81 AAIEMAdaQKPVWIVSDARRKTDLQWFRENYP 112
Pmev_kin_anim TIGR01223
phosphomevalonate kinase, animal type; This enzyme is part of the mevalonate pathway, one of ...
 11-186 1.93e-53

phosphomevalonate kinase, animal type; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found. One is this type, found in animals. The other is the ERG8 type, found in plants and fungi (TIGR01219) and in Gram-positive bacteria (TIGR01220). [Central intermediary metabolism, Other]


Pssm-ID: 130290  Cd Length: 182  Bit Score: 168.72  E-value: 1.93e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729980     11 VLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGF 90
Cdd:TIGR01223   1 VLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729980     91 FCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIEN 170
Cdd:TIGR01223  81 FCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIEN 160

                         170
                  ....*....|....*.
gi 5729980    171 HGVEQRLEEQLENLIE 186
Cdd:TIGR01223 161 HGVEQRLEEQLENLIE 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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