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Conserved domains on  [gi|6041665|ref|NP_006403|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 62-253 2.91e-53

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 172.50  E-value: 2.91e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665   62 IIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFI 141
Cdd:COG0204  15 LVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665  142 NRQRSSTAMTVMADLGERMvRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSfSSFYNTKKKFFTSG 221
Cdd:COG0204  95 DRSKRRAALRALRQAVEAL-KAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDG-TERALPKGFLPRPG 172

                       170       180       190
                ....*....|....*....|....*....|..
gi 6041665  222 TVTVQVLEAIPTSGLTAADVPALVDTCHRAMR 253
Cdd:COG0204 173 KVTVRIGPPIDPSDLEGEDRRELAERLRAAIE 204
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 62-253 2.91e-53

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 172.50  E-value: 2.91e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665   62 IIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFI 141
Cdd:COG0204  15 LVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665  142 NRQRSSTAMTVMADLGERMvRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSfSSFYNTKKKFFTSG 221
Cdd:COG0204  95 DRSKRRAALRALRQAVEAL-KAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDG-TERALPKGFLPRPG 172

                       170       180       190
                ....*....|....*....|....*....|..
gi 6041665  222 TVTVQVLEAIPTSGLTAADVPALVDTCHRAMR 253
Cdd:COG0204 173 KVTVRIGPPIDPSDLEGEDRRELAERLRAAIE 204
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 67-249 3.02e-52

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 168.60  E-value: 3.02e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665   67 VRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRS 146
Cdd:cd07989   1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665  147 STAMTVMADLGERMvRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQ 226
Cdd:cd07989  81 RSAREALREAIEAL-KEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVR 159

                       170       180
                ....*....|....*....|....*
gi 6041665  227 VLEAIPTSGL--TAADVPALVDTCH 249
Cdd:cd07989 160 IGEPIPPEGLelAEEDRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 77-205 2.43e-44

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 146.65  E-value: 2.43e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665     77 RFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLP---ERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVM 153
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYkrgRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6041665    154 ADLGERMvRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYS 205
Cdd:pfam01553  81 EYLVELL-REGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 92-205 7.25e-36

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 124.39  E-value: 7.25e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665      92 CVIVSNHQSILDMMGLMEVLPE---RCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGeRMVRENLKVW 168
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklgRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAV-ELLKEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 6041665     169 IYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYS 205
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIR 116
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 75-205 2.66e-34

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 120.91  E-value: 2.66e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665     75 GLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELL---FLGPVGLIMylgGVFFINRqRSSTAMT 151
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKwipFFGIMLWLT---GAIFIDR-ENIRAIA 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 6041665    152 VMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYS 205
Cdd:TIGR00530  77 TALKAAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 37-270 1.74e-24

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 98.55  E-value: 1.74e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665    37 CFTVSAVASLVCLLrhGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCV 116
Cdd:PRK15018  14 SILVCVFGSIYCLF--SPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMVTASNIVQPPTV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665   117 QIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQ 196
Cdd:PRK15018  92 TVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHAAIAAG 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6041665   197 VPIVPVVYSSFSSFYNTKKkfFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATA 270
Cdd:PRK15018 172 VPIIPVCVSTTSNKINLNR--LHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAEREAAG 243
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 62-253 2.91e-53

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 172.50  E-value: 2.91e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665   62 IIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFI 141
Cdd:COG0204  15 LVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665  142 NRQRSSTAMTVMADLGERMvRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSfSSFYNTKKKFFTSG 221
Cdd:COG0204  95 DRSKRRAALRALRQAVEAL-KAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDG-TERALPKGFLPRPG 172

                       170       180       190
                ....*....|....*....|....*....|..
gi 6041665  222 TVTVQVLEAIPTSGLTAADVPALVDTCHRAMR 253
Cdd:COG0204 173 KVTVRIGPPIDPSDLEGEDRRELAERLRAAIE 204
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 67-249 3.02e-52

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 168.60  E-value: 3.02e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665   67 VRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRS 146
Cdd:cd07989   1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665  147 STAMTVMADLGERMvRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQ 226
Cdd:cd07989  81 RSAREALREAIEAL-KEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVR 159

                       170       180
                ....*....|....*....|....*
gi 6041665  227 VLEAIPTSGL--TAADVPALVDTCH 249
Cdd:cd07989 160 IGEPIPPEGLelAEEDRKELREKVR 184
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 77-205 2.43e-44

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 146.65  E-value: 2.43e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665     77 RFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLP---ERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVM 153
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYkrgRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6041665    154 ADLGERMvRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYS 205
Cdd:pfam01553  81 EYLVELL-REGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 92-205 7.25e-36

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 124.39  E-value: 7.25e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665      92 CVIVSNHQSILDMMGLMEVLPE---RCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGeRMVRENLKVW 168
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklgRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAV-ELLKEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 6041665     169 IYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYS 205
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIR 116
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 75-205 2.66e-34

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 120.91  E-value: 2.66e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665     75 GLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAKRELL---FLGPVGLIMylgGVFFINRqRSSTAMT 151
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKwipFFGIMLWLT---GAIFIDR-ENIRAIA 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 6041665    152 VMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVVYS 205
Cdd:TIGR00530  77 TALKAAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 37-270 1.74e-24

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 98.55  E-value: 1.74e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665    37 CFTVSAVASLVCLLrhGGRTVENMSIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCV 116
Cdd:PRK15018  14 SILVCVFGSIYCLF--SPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMVTASNIVQPPTV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665   117 QIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQ 196
Cdd:PRK15018  92 TVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHAAIAAG 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6041665   197 VPIVPVVYSSFSSFYNTKKkfFTSGTVTVQVLEAIPTSGLTAADVPALVDTCHRAMRTTFLHISKTPQENGATA 270
Cdd:PRK15018 172 VPIIPVCVSTTSNKINLNR--LHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAEREAAG 243
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 65-203 1.62e-17

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 79.00  E-value: 1.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665    65 WFVRSFKYFYGLRFEVRDPRRLQEArPCVIVSNHQSILDMMGLMEVlpERCVQIAKRELLFLGP-VGLIMYLGGVFFINR 143
Cdd:PLN02901  26 WATLSTSPFYKIEVEGLENLPSPDE-PAVYVSNHQSFLDIYTLFHL--GRPFKFISKTSIFLIPiIGWAMYMTGHIPLKR 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665   144 QRSSTAMTVMADLGErMVRENLKVWIYPEGTRNDNGDLLPFKKGAFYLAVQAQVPIVPVV 203
Cdd:PLN02901 103 MDRRSQLECLKRCME-LLKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPIT 161
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 70-203 3.73e-15

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 71.68  E-value: 3.73e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665   70 FKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLM----EVLPERCVQIAKRELLFLGPVgliMYLGGVFFINRQR 145
Cdd:cd06551   6 LNFFGFVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLILFllleRGLRRDVYGLMDEELLERYPF---FTRLGAFSVDRDS 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6041665  146 SSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGD-LLPFKKGAFYLAVQAQVPIVPVV 203
Cdd:cd06551  83 PRSAAKSLKYVARLLSKPGSVVWIFPEGTRTRRDKrPLQFKPGVAHLAEKAGVPIVPVA 141
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 63-212 4.57e-13

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 66.48  E-value: 4.57e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665   63 IGWFVRSFKYFY--GLRFEVRDPRrlqearpcVIVSNHQSILDMMGLMEVLPerCVQIAKRELLFLGPVGLIM-YLGGVF 139
Cdd:cd07991   3 VLLFAFGFYVIKvhGKPDPPEAPR--------IIVANHTSFIDPLILFSDLF--PSIVAKKELGKLPFIGTILrALGCIF 72

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6041665  140 FiNRQRSSTAMTVMADLGERmVRENLK--VWIYPEGTRNDNGDLLPFKKGAFYLavqaQVPIVPVV--YSSFSSFYN 212
Cdd:cd07991  73 V-DRSEPKDRKKVVEEIKER-ATDPNWppILIFPEGTTTNGKALIMFKKGAFEP----GVPVQPVAirYPNKFVDAF 143
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 93-244 1.85e-11

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 61.08  E-value: 1.85e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665   93 VIVSNHQSILD---MMGLMEVLpERCVQIAKRELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERmvRENLKVWI 169
Cdd:cd07988  24 VIGAPHTSNWDfvlGLLAAFAL-GLKISFLGKHSLFKPPLGPFMRWLGGIPVDRSRAGGLVEQVVEEFRR--REEFVLAI 100

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6041665  170 YPEGTRNDNGdllPFKKGAFYLAVQAQVPIVPVvyssfssfyntkkkFFTSGTVTVQVLEAIPTSGLTAADVPAL 244
Cdd:cd07988 101 APEGTRSKVD---KWKTGFYHIARGAGVPILLV--------------YLDYKRKTVGIGPLFEPSGDIEADLAAI 158
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 63-240 1.44e-09

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 56.50  E-value: 1.44e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665   63 IGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQ-SILDMMGLMEVLPERCVQIAKRELLFLGPVGLIMYLGGVFFI 141
Cdd:cd07992   1 VRLLSRVILRIYFRRITVVGRENVPKDGPVIFLGNHPnALIDPLLLAATLRRPVRFLAKADLFKNPLIGWLLESFGAIPV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665  142 NRQR----SSTAMTVMADLGERmVRENLK----VWIYPEGTRNDNGDLLPFKKGAFYLAVQA------QVPIVPVvyssf 207
Cdd:cd07992  81 YRPKdlarGGIGKISNAAVFDA-VGEALKaggaIGIFPEGGSHDRPRLLPLKAGAARMALEAleagqkDVKIVPV----- 154

                       170       180       190
                ....*....|....*....|....*....|...
gi 6041665  208 SSFYNTKKKFftSGTVTVQVLEAIPTSGLTAAD 240
Cdd:cd07992 155 GLNYEDKSRF--RSRVLVEFGKPISVSAFEEAE 185
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 70-175 2.32e-08

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 53.01  E-value: 2.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665   70 FKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVL-------PERCvqIAKRELLFLGPVGLIMYLGGVFFIN 142
Cdd:cd07990   4 FEWLSGVKVVVYGDEPKLPKERALIISNHRSEVDWLVLWMLAdrfgrlgRLKI--VLKDSLKYPPLGGWGWQLGEFIFLK 81

                        90       100       110
                ....*....|....*....|....*....|....*
gi 6041665  143 RqRSSTAMTVMADLGERMVRENLKVW--IYPEGTR 175
Cdd:cd07990  82 R-KWEKDEKTIKRQLKRLKDSPEPFWllIFPEGTR 115
PLN02833 PLN02833
glycerol acyltransferase family protein
 93-219 1.31e-04

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 42.84  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665    93 VIVSNHQSILDMMGLMEVLPERCVQIAKRellflGPVGL----IMYLGGVFFINRQRSSTAMTVMADLGERMVR-ENLKV 167
Cdd:PLN02833 166 VFVANHTSMIDFIVLEQMTPFAVIMQKHP-----GWVGFlqntILESVGCIWFNRTEAKDREVVAKKLRDHVQDpDRNPL 240

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 6041665   168 WIYPEGTRNDNGDLLPFKKGAFYLAVQAqVPIVPVVYSSF-SSFYNTKKKFFT 219
Cdd:PLN02833 241 LIFPEGTCVNNEYTVMFKKGAFELGCTV-CPIAIKYNKIFvDAFWNSRKQSFT 292
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 161-208 8.87e-04

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 40.68  E-value: 8.87e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 6041665    161 VRENLK----VWIYPEGTRNDNGDLLPFKKGaFYLAVQ-AQVPIVPvVY------SSFS 208
Cdd:PRK08633  504 IRKALDdgevVCIFPEGAITRNGQLNEFKRG-FELIVKgTDVPIIP-FYirglwgSIFS 560
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 101-202 6.76e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 36.88  E-value: 6.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6041665  101 ILDMMGLMEVLPERCVQIAKR-ELLFLGPvglimylGGVffinrqrsstamtvmadlgermvRENLKvwiypeGTRNDNG 179
Cdd:cd07987  68 LLRRLGAVPGSRENCVRLLREgELVLIFP-------GGA-----------------------REALK------SKREEYY 111

                        90       100
                ....*....|....*....|...
gi 6041665  180 DLLPFKKGAFYLAVQAQVPIVPV 202
Cdd:cd07987 112 LLWKKRKGFARLALRAGAPIVPV 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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