NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|50726968|ref|NP_005917|]
View 

microfibrillar-associated protein 1 [Homo sapiens]

Protein Classification

microfibrillar-associated 1 family protein( domain architecture ID 12073021)

microfibrillar-associated 1 family protein similar to human microfibrillar-associated protein 1, also called spliceosome B complex protein MFAP1, which is involved in pre-mRNA splicing as a component of the spliceosome

Gene Ontology:  GO:0000398|GO:0003723

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFAP1 pfam06991
Microfibril-associated/Pre-mRNA processing; MFAP1 was first named for proteins associated with ...
 190-399 1.22e-85

Microfibril-associated/Pre-mRNA processing; MFAP1 was first named for proteins associated with microfibrils which are an important component of the extracellular matrix (ECM) of many tissues. For example, MFAP1 has been shown to be associated with elastin-like fibres at the base of Schlemm's canal endothelium cells, in the juxtacanalicular tissue, and in the uveal region. Based on its role in the ECM and the proximity of the MFAP1 gene to FBN1 it was hypothesized that mutations in MFAP1 contributed to heritable diseases affecting microfibrils, Marfan syndrome but this has now been shown not to be the case. MFAP1 has also been shown to interact directly with certain pre-mRNA processing factor proteins, Prps, which are also spliceosome components and is thus required for pre-mRNA processing. MAFP1 bound to Pr38 of yeast is necessary for cells in vivo to progress from G2 to M phase.


:

Pssm-ID: 462060 [Multi-domain]  Cd Length: 215  Bit Score: 260.95  E-value: 1.22e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50726968   190 DSEDEME--PRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKkeleenkRSLAALDALNT 267
Cdd:pfam06991   1 SSEEEAPrrPLLKPVFVPKSKRGTIAEREKLEAEEEEEEEEAKKEAEERKKEADKLVEEEIR-------REAAAKEAGDE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50726968   268 DDENDE----------EEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKF 337
Cdd:pfam06991  74 DENEEDvddtdgldpeAEYEAWKLRELKRIKRDREEREAREKEREEIERRRNMTEEERLAEDRENPKKQREKKPKGKMKF 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50726968   338 LQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDT 399
Cdd:pfam06991 154 MQKYYHKGAFFQDEDEDIYKRDFSAPTGEDKVDKSLLPKVMQVRDFGKKGRTKYTHLKDEDT 215
 
Name Accession Description Interval E-value
MFAP1 pfam06991
Microfibril-associated/Pre-mRNA processing; MFAP1 was first named for proteins associated with ...
 190-399 1.22e-85

Microfibril-associated/Pre-mRNA processing; MFAP1 was first named for proteins associated with microfibrils which are an important component of the extracellular matrix (ECM) of many tissues. For example, MFAP1 has been shown to be associated with elastin-like fibres at the base of Schlemm's canal endothelium cells, in the juxtacanalicular tissue, and in the uveal region. Based on its role in the ECM and the proximity of the MFAP1 gene to FBN1 it was hypothesized that mutations in MFAP1 contributed to heritable diseases affecting microfibrils, Marfan syndrome but this has now been shown not to be the case. MFAP1 has also been shown to interact directly with certain pre-mRNA processing factor proteins, Prps, which are also spliceosome components and is thus required for pre-mRNA processing. MAFP1 bound to Pr38 of yeast is necessary for cells in vivo to progress from G2 to M phase.


Pssm-ID: 462060 [Multi-domain]  Cd Length: 215  Bit Score: 260.95  E-value: 1.22e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50726968   190 DSEDEME--PRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKkeleenkRSLAALDALNT 267
Cdd:pfam06991   1 SSEEEAPrrPLLKPVFVPKSKRGTIAEREKLEAEEEEEEEEAKKEAEERKKEADKLVEEEIR-------REAAAKEAGDE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50726968   268 DDENDE----------EEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKF 337
Cdd:pfam06991  74 DENEEDvddtdgldpeAEYEAWKLRELKRIKRDREEREAREKEREEIERRRNMTEEERLAEDRENPKKQREKKPKGKMKF 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50726968   338 LQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDT 399
Cdd:pfam06991 154 MQKYYHKGAFFQDEDEDIYKRDFSAPTGEDKVDKSLLPKVMQVRDFGKKGRTKYTHLKDEDT 215
 
Name Accession Description Interval E-value
MFAP1 pfam06991
Microfibril-associated/Pre-mRNA processing; MFAP1 was first named for proteins associated with ...
 190-399 1.22e-85

Microfibril-associated/Pre-mRNA processing; MFAP1 was first named for proteins associated with microfibrils which are an important component of the extracellular matrix (ECM) of many tissues. For example, MFAP1 has been shown to be associated with elastin-like fibres at the base of Schlemm's canal endothelium cells, in the juxtacanalicular tissue, and in the uveal region. Based on its role in the ECM and the proximity of the MFAP1 gene to FBN1 it was hypothesized that mutations in MFAP1 contributed to heritable diseases affecting microfibrils, Marfan syndrome but this has now been shown not to be the case. MFAP1 has also been shown to interact directly with certain pre-mRNA processing factor proteins, Prps, which are also spliceosome components and is thus required for pre-mRNA processing. MAFP1 bound to Pr38 of yeast is necessary for cells in vivo to progress from G2 to M phase.


Pssm-ID: 462060 [Multi-domain]  Cd Length: 215  Bit Score: 260.95  E-value: 1.22e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50726968   190 DSEDEME--PRLKPVFIRKKDRVTVQEREAEALKQKELEQEAKRMAEERRKYTLKIVEEETKkeleenkRSLAALDALNT 267
Cdd:pfam06991   1 SSEEEAPrrPLLKPVFVPKSKRGTIAEREKLEAEEEEEEEEAKKEAEERKKEADKLVEEEIR-------REAAAKEAGDE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50726968   268 DDENDE----------EEYEAWKVRELKRIKRDREDREALEKEKAEIERMRNLTEEERRAELRANGKVITNKAVKGKYKF 337
Cdd:pfam06991  74 DENEEDvddtdgldpeAEYEAWKLRELKRIKRDREEREAREKEREEIERRRNMTEEERLAEDRENPKKQREKKPKGKMKF 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50726968   338 LQKYYHRGAFFMDEDEEVYKRDFSAPTLEDHFNKTILPKVMQVKNFGRSGRTKYTHLVDQDT 399
Cdd:pfam06991 154 MQKYYHKGAFFQDEDEDIYKRDFSAPTGEDKVDKSLLPKVMQVRDFGKKGRTKYTHLKDEDT 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH