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Conserved domains on  [gi|5031695|ref|NP_005657|]
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complement factor H-related protein 2 isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 72-265 1.63e-13

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 68.53  E-value: 1.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031695    72 CAEEGWSPTPKCL-RLCFFPF-VENGHSESSGQTHleGDTVQIICNTGYRLQNNENniSCVERGWS-------TPPKCRS 142
Cdd:PHA02927  70 CTGTGWTLFNQCIkRRCPSPRdIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESK--SYCELGSTgsmvwnpEAPICES 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031695   143 TisaeKCGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPP-----KCLDPCVISQEIMEKY 217
Cdd:PHA02927 146 V----KCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGF 220

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 5031695   218 niklkwtnqQKLYSRTgDIVEFVCKSGYHPTKSHSfrAMCQNGKLVYP 265
Cdd:PHA02927 221 ---------KRSYSYN-DNVDFKCKYGYKLSGSSS--STCSPGNTWQP 256
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 72-265 1.63e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 68.53  E-value: 1.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031695    72 CAEEGWSPTPKCL-RLCFFPF-VENGHSESSGQTHleGDTVQIICNTGYRLQNNENniSCVERGWS-------TPPKCRS 142
Cdd:PHA02927  70 CTGTGWTLFNQCIkRRCPSPRdIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESK--SYCELGSTgsmvwnpEAPICES 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031695   143 TisaeKCGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPP-----KCLDPCVISQEIMEKY 217
Cdd:PHA02927 146 V----KCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGF 220

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 5031695   218 niklkwtnqQKLYSRTgDIVEFVCKSGYHPTKSHSfrAMCQNGKLVYP 265
Cdd:PHA02927 221 ---------KRSYSYN-DNVDFKCKYGYKLSGSSS--STCSPGNTWQP 256
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 149-203 5.48e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.70  E-value: 5.48e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031695  149 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 203
Cdd:cd00033   1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 149-203 2.28e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.14  E-value: 2.28e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031695     149 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 203
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
149-203 3.90e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 51.73  E-value: 3.90e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031695    149 CGPPPPIDNGDITSfLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 203
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 72-265 1.63e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 68.53  E-value: 1.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031695    72 CAEEGWSPTPKCL-RLCFFPF-VENGHSESSGQTHleGDTVQIICNTGYRLQNNENniSCVERGWS-------TPPKCRS 142
Cdd:PHA02927  70 CTGTGWTLFNQCIkRRCPSPRdIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESK--SYCELGSTgsmvwnpEAPICES 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031695   143 TisaeKCGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPP-----KCLDPCVISQEIMEKY 217
Cdd:PHA02927 146 V----KCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPtcqivKCPHPTISNGYLSSGF 220

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 5031695   218 niklkwtnqQKLYSRTgDIVEFVCKSGYHPTKSHSfrAMCQNGKLVYP 265
Cdd:PHA02927 221 ---------KRSYSYN-DNVDFKCKYGYKLSGSSS--STCSPGNTWQP 256
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 149-203 5.48e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 56.70  E-value: 5.48e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031695  149 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 203
Cdd:cd00033   1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNEGYTLVGSSTITCTeNGGWSpPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 149-203 2.28e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 52.14  E-value: 2.28e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031695     149 CGPPPPIDNGDITSFLlSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 203
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDPGYTLIGSSTITCLeNGTWSpPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
149-203 3.90e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 51.73  E-value: 3.90e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031695    149 CGPPPPIDNGDITSfLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 203
Cdd:pfam00084   1 CPPPPDIPNGKVSA-TKNEYNYGASVSYECDPGYRLVGSPTITCQeDGTWSpPFPEC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 102-245 3.11e-06

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 47.29  E-value: 3.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031695   102 QTHLEGDTVQIICNTGYrlqnNENNISCVERGWSTPPKCrstISAEKCGPPPPIDNGDITSfLLSVYAPGSSVEYQCQ-- 179
Cdd:PHA02831  38 KVYEENENLEYKCNNNF----DKVFVTCNNGSWSTKNMC---IGKRNCKDPVTILNGYIKN-KKDQYSFGDSVTYACKvn 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 5031695   180 --NLYQLEGNNQITCRNGQW-SEPPKC-LDPC---VISQEIMEKYniklkwtnQQKLYsrTGDIVEFVCKSGY 245
Cdd:PHA02831 110 klEKYSIVGNETVKCINKQWvPKYPVCkLIRCkypALQNGFLNVF--------EKKFY--YGDIVNFKCKKGF 172
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 90-141 1.38e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 41.68  E-value: 1.38e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 5031695   90 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNEnNISCVERG-WS-TPPKCR 141
Cdd:cd00033   5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSS-TITCTENGgWSpPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 90-140 1.30e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.05  E-value: 1.30e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 5031695      90 PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNEnNISCVERG-WS-TPPKC 140
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSS-TITCLENGtWSpPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 137-203 6.38e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 39.92  E-value: 6.38e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 5031695   137 PPKCRSTISAEKCGPPPPIDNGDITSfLLSVYAPGSSVEYQCQN-----LYQLEGNNQITC-RNGQWS-EPPKC 203
Cdd:PHA02817  12 CNKVYSLCDLNKCCYPPSIKNGYIYN-KKTEYNIGSNVTFFCGNntrgvRYTLVGEKNIICeKDGKWNkEFPVC 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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