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Conserved domains on  [gi|47419934|ref|NP_005525|]
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interferon gamma receptor 2 isoform 2 precursor [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 229438)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to Homo sapiens interleukin-5 receptor subunit alpha and interferon gamma receptor 2

PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tissue_fac super family cl47630
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 28-126 1.39e-17

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


The actual alignment was detected with superfamily member pfam01108:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 77.04  E-value: 1.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47419934    28 SQLPAPQHPKIRLYNAEQVLSWEPVAlsNSTRPVVYQVQFK-YTDSKWftadimsIGV-NCTQITATECDFTaaspSAGF 105
Cdd:pfam01108  20 PSLPAPQNVTFQSTNFKNILTWEPGP--NSPPDVVYTVQYKiYGSGDW-------KNVpNCTNITRTECDLT----DETS 86

                          90       100
                  ....*....|....*....|.
gi 47419934   106 PMDFNVTLRLRAELGALHSAW 126
Cdd:pfam01108  87 DLTETYYARVRAVSGGGTSSW 107
Interfer-bind super family cl46366
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 141-237 5.74e-08

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


The actual alignment was detected with superfamily member pfam09294:

Pssm-ID: 480706  Cd Length: 103  Bit Score: 50.03  E-value: 5.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47419934   141 GPPEnIEVTPGEGSLIIRFSSPFDIADTST------AFFCYYVHYWEKGGIQQVKG-PFRSNSISLDNLKPSRVYCLQVQ 213
Cdd:pfam09294   4 GPPE-VELEVEGGSLNVTVKDPETREGKNLslrdlyGSLQYRVSYWKNSSNGEKKNtTSTNSFVVLSDLEPGTTYCVSVQ 82

                          90       100
                  ....*....|....*....|....*
gi 47419934   214 AQL-LWNKSNIFrvghlSNISCYET 237
Cdd:pfam09294  83 AFSpLDNKSSQR-----SPPQCIRT 102
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 28-126 1.39e-17

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 77.04  E-value: 1.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47419934    28 SQLPAPQHPKIRLYNAEQVLSWEPVAlsNSTRPVVYQVQFK-YTDSKWftadimsIGV-NCTQITATECDFTaaspSAGF 105
Cdd:pfam01108  20 PSLPAPQNVTFQSTNFKNILTWEPGP--NSPPDVVYTVQYKiYGSGDW-------KNVpNCTNITRTECDLT----DETS 86

                          90       100
                  ....*....|....*....|.
gi 47419934   106 PMDFNVTLRLRAELGALHSAW 126
Cdd:pfam01108  87 DLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 141-237 5.74e-08

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 50.03  E-value: 5.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47419934   141 GPPEnIEVTPGEGSLIIRFSSPFDIADTST------AFFCYYVHYWEKGGIQQVKG-PFRSNSISLDNLKPSRVYCLQVQ 213
Cdd:pfam09294   4 GPPE-VELEVEGGSLNVTVKDPETREGKNLslrdlyGSLQYRVSYWKNSSNGEKKNtTSTNSFVVLSDLEPGTTYCVSVQ 82

                          90       100
                  ....*....|....*....|....*
gi 47419934   214 AQL-LWNKSNIFrvghlSNISCYET 237
Cdd:pfam09294  83 AFSpLDNKSSQR-----SPPQCIRT 102
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 141-214 7.41e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.76  E-value: 7.41e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47419934    141 GPPENIEVTP-GEGSLIIRFSSPFDiaDTSTAFFCYY-VHYWEKGGI-QQVKGPFRSNSISLDNLKPSRVYCLQVQA 214
Cdd:smart00060   2 SPPSNLRVTDvTSTSVTLSWEPPPD--DGITGYIVGYrVEYREEGSEwKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 141-214 1.73e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 1.73e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47419934 141 GPPENIEVTP-GEGSLIIRFSSPfdiADTSTAFFCYYVHYWEKGGIQQVK---GPFRSNSISLDNLKPSRVYCLQVQA 214
Cdd:cd00063   2 SPPTNLRVTDvTSTSVTLSWTPP---EDDGGPITGYVVEYREKGSGDWKEvevTPGSETSYTLTGLKPGTEYEFRVRA 76
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 28-126 1.39e-17

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 77.04  E-value: 1.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47419934    28 SQLPAPQHPKIRLYNAEQVLSWEPVAlsNSTRPVVYQVQFK-YTDSKWftadimsIGV-NCTQITATECDFTaaspSAGF 105
Cdd:pfam01108  20 PSLPAPQNVTFQSTNFKNILTWEPGP--NSPPDVVYTVQYKiYGSGDW-------KNVpNCTNITRTECDLT----DETS 86

                          90       100
                  ....*....|....*....|.
gi 47419934   106 PMDFNVTLRLRAELGALHSAW 126
Cdd:pfam01108  87 DLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 141-237 5.74e-08

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 50.03  E-value: 5.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47419934   141 GPPEnIEVTPGEGSLIIRFSSPFDIADTST------AFFCYYVHYWEKGGIQQVKG-PFRSNSISLDNLKPSRVYCLQVQ 213
Cdd:pfam09294   4 GPPE-VELEVEGGSLNVTVKDPETREGKNLslrdlyGSLQYRVSYWKNSSNGEKKNtTSTNSFVVLSDLEPGTTYCVSVQ 82

                          90       100
                  ....*....|....*....|....*
gi 47419934   214 AQL-LWNKSNIFrvghlSNISCYET 237
Cdd:pfam09294  83 AFSpLDNKSSQR-----SPPQCIRT 102
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 141-214 7.41e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.76  E-value: 7.41e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47419934    141 GPPENIEVTP-GEGSLIIRFSSPFDiaDTSTAFFCYY-VHYWEKGGI-QQVKGPFRSNSISLDNLKPSRVYCLQVQA 214
Cdd:smart00060   2 SPPSNLRVTDvTSTSVTLSWEPPPD--DGITGYIVGYrVEYREEGSEwKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 141-214 1.73e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 1.73e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47419934 141 GPPENIEVTP-GEGSLIIRFSSPfdiADTSTAFFCYYVHYWEKGGIQQVK---GPFRSNSISLDNLKPSRVYCLQVQA 214
Cdd:cd00063   2 SPPTNLRVTDvTSTSVTLSWTPP---EDDGGPITGYVVEYREKGSGDWKEvevTPGSETSYTLTGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
141-215 1.22e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47419934   141 GPPENIEVTP-GEGSLIIRFSSPFDIADTSTAffcYYVHYWEKGGI-----QQVKGPfrSNSISLDNLKPSRVYCLQVQA 214
Cdd:pfam00041   1 SAPSNLTVTDvTSTSLTVSWTPPPDGNGPITG---YEVEYRPKNSGepwneITVPGT--TTSVTLTGLKPGTEYEVRVQA 75


                  .
gi 47419934   215 Q 215
Cdd:pfam00041  76 V 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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