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Conserved domains on  [gi|1746322656|ref|NP_005513|]
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homeobox protein Hox-A1 isoform a [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 13432619)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003700|GO:0003677|GO:0030154|GO:0000978|GO:0006357
PubMed:  8768896|11470884|26464018|1357790|27768937|1980756
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
233-286 4.32e-28

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 103.73  E-value: 4.32e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1746322656 233 RTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKK 286
Cdd:pfam00046   4 RTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
COG5576 super family cl35021
Homeodomain-containing transcription factor [Transcription];
176-286 9.45e-08

Homeodomain-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5576:

Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 50.90  E-value: 9.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322656 176 YNNSLSPLHAShqEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYLGQPNAVRTnfTTKQLTELEKEFHFNKYLT 255
Cdd:COG5576     2 PVQPMQPLSAL--ESQRMPQIRTIKTTKNKREVEAADSEMKLERKQDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPS 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1746322656 256 RARRVEIAASLQLNETQVKIWFQNRRMKQKK 286
Cdd:COG5576    78 SITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
233-286 4.32e-28

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 103.73  E-value: 4.32e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1746322656 233 RTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKK 286
Cdd:pfam00046   4 RTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 233-285 3.28e-25

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 96.17  E-value: 3.28e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1746322656  233 RTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQK 285
Cdd:smart00389   5 RTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 233-288 4.84e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 95.77  E-value: 4.84e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1746322656 233 RTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKRE 288
Cdd:cd00086     4 RTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
176-286 9.45e-08

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 50.90  E-value: 9.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322656 176 YNNSLSPLHAShqEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYLGQPNAVRTnfTTKQLTELEKEFHFNKYLT 255
Cdd:COG5576     2 PVQPMQPLSAL--ESQRMPQIRTIKTTKNKREVEAADSEMKLERKQDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPS 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1746322656 256 RARRVEIAASLQLNETQVKIWFQNRRMKQKK 286
Cdd:COG5576    78 SITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
233-286 4.32e-28

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 103.73  E-value: 4.32e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1746322656 233 RTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKK 286
Cdd:pfam00046   4 RTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 233-285 3.28e-25

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 96.17  E-value: 3.28e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1746322656  233 RTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQK 285
Cdd:smart00389   5 RTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 233-288 4.84e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 95.77  E-value: 4.84e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1746322656 233 RTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKRE 288
Cdd:cd00086     4 RTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
176-286 9.45e-08

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 50.90  E-value: 9.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322656 176 YNNSLSPLHAShqEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYLGQPNAVRTnfTTKQLTELEKEFHFNKYLT 255
Cdd:COG5576     2 PVQPMQPLSAL--ESQRMPQIRTIKTTKNKREVEAADSEMKLERKQDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPS 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1746322656 256 RARRVEIAASLQLNETQVKIWFQNRRMKQKK 286
Cdd:COG5576    78 SITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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