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Conserved domains on  [gi|33695088|ref|NP_005267|]
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glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 1 [Homo sapiens]

Protein Classification

glycerol-3-phosphate dehydrogenase family protein( domain architecture ID 11496765)

glycerol-3-phosphate dehydrogenase family protein is similar to human L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1), which catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 5-342 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


:

Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 541.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088     5 KVCIVGSGNWGSAIAKIVGGNAAQLAQ-FDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAA 83
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPElFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088    84 EDADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCE 163
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   164 TTIGCKDPAQ----GQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFA 239
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   240 KLFC-SGPVSsaTFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLVDK 318
Cdd:TIGR03376 241 RMFFpTGEVT--FTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDE 318

                         330       340
                  ....*....|....*....|....
gi 33695088   319 FPLFMAVYKVCYEGQPVGEFIHCL 342
Cdd:TIGR03376 319 FPLFEAVYQILYEGLPPKKLPECL 342
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 5-342 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 541.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088     5 KVCIVGSGNWGSAIAKIVGGNAAQLAQ-FDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAA 83
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPElFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088    84 EDADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCE 163
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   164 TTIGCKDPAQ----GQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFA 239
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   240 KLFC-SGPVSsaTFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLVDK 318
Cdd:TIGR03376 241 RMFFpTGEVT--FTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDE 318

                         330       340
                  ....*....|....*....|....
gi 33695088   319 FPLFMAVYKVCYEGQPVGEFIHCL 342
Cdd:TIGR03376 319 FPLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 1-344 4.23e-159

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 449.86  E-value: 4.23e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088    1 MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNVVAVPDVV 80
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   81 QAAEDADILIFVVPHQFIGKICDQLK--GHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVAD 158
Cdd:PTZ00345  89 EAVEDADLLIFVIPHQFLESVLSQIKenNNLKKHARAISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVANDVAR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  159 EKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAF 238
Cdd:PTZ00345 169 EEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  239 AKLFCSGpVSSATFLESCGVADLITTCYGGRNRKVAEAFARTG--KSIEQLEKELLNGQKLQGPETARELYSILQHKGLV 316
Cdd:PTZ00345 249 GKIFFPN-VMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLK 327

                        330       340
                 ....*....|....*....|....*...
gi 33695088  317 DKFPLFMAVYKVCYEGQPVGEFIHCLQN 344
Cdd:PTZ00345 328 KEFPLFTVTYKIAFEGADPSSLIDVLST 355
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 4-337 7.52e-95

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 285.01  E-value: 7.52e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   4 KKVCIVGSGNWGSAIAKIVGGNAAQlaqfdprVTMWVFEEDIggkklTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAA 83
Cdd:COG0240   1 MKIAVLGAGSWGTALAKVLARNGHE-------VTLWGRDPEV-----AEEINETRENPRYLPGVKLPENLRATSDLEEAL 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  84 EDADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDegPNGLKLISEVIGERLG--IPMSVLMGANIASEVADEKF 161
Cdd:COG0240  69 AGADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIE--PGTGLLMSEVIAEELPgaLRIAVLSGPSFAEEVARGLP 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088 162 CETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKL 241
Cdd:COG0240 147 TAVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVA 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088 242 FCSGPvssATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQLEKELlnGQKLQGPETARELYSILQHKGlVDkF 319
Cdd:COG0240 227 LGARP---ETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLG-VE-M 298

                       330
                ....*....|....*...
gi 33695088 320 PLFMAVYKVCYEGQPVGE 337
Cdd:COG0240 299 PITEAVYAVLYEGKSPRE 316
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 5-172 1.90e-65

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 203.96  E-value: 1.90e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088     5 KVCIVGSGNWGSAIAKIVGGNAaqlaqfdPRVTMWVFEEDiggkkLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAAE 84
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNG-------HEVRLWGRDEE-----LIEEINTTHENVRYLPGIKLPENLKATTDLAEALK 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088    85 DADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDEGpnGLKLISEVIGERLGI--PMSVLMGANIASEVADEKFC 162
Cdd:pfam01210  69 GADIIVIVVPSQALREVLKQLKGLLKPDAILVSLSKGIEPG--TLKLLSEVIEEELGIqpPIAVLSGPSHAEEVAQGLPT 146

                         170
                  ....*....|
gi 33695088   163 ETTIGCKDPA 172
Cdd:pfam01210 147 ATVIASKDEE 156
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 5-342 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 541.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088     5 KVCIVGSGNWGSAIAKIVGGNAAQLAQ-FDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAA 83
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPElFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088    84 EDADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCE 163
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   164 TTIGCKDPAQ----GQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFA 239
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   240 KLFC-SGPVSsaTFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLVDK 318
Cdd:TIGR03376 241 RMFFpTGEVT--FTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDE 318

                         330       340
                  ....*....|....*....|....
gi 33695088   319 FPLFMAVYKVCYEGQPVGEFIHCL 342
Cdd:TIGR03376 319 FPLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 1-344 4.23e-159

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 449.86  E-value: 4.23e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088    1 MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNVVAVPDVV 80
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   81 QAAEDADILIFVVPHQFIGKICDQLK--GHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVAD 158
Cdd:PTZ00345  89 EAVEDADLLIFVIPHQFLESVLSQIKenNNLKKHARAISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVANDVAR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  159 EKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAF 238
Cdd:PTZ00345 169 EEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  239 AKLFCSGpVSSATFLESCGVADLITTCYGGRNRKVAEAFARTG--KSIEQLEKELLNGQKLQGPETARELYSILQHKGLV 316
Cdd:PTZ00345 249 GKIFFPN-VMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLK 327

                        330       340
                 ....*....|....*....|....*...
gi 33695088  317 DKFPLFMAVYKVCYEGQPVGEFIHCLQN 344
Cdd:PTZ00345 328 KEFPLFTVTYKIAFEGADPSSLIDVLST 355
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 4-337 7.52e-95

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 285.01  E-value: 7.52e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   4 KKVCIVGSGNWGSAIAKIVGGNAAQlaqfdprVTMWVFEEDIggkklTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAA 83
Cdd:COG0240   1 MKIAVLGAGSWGTALAKVLARNGHE-------VTLWGRDPEV-----AEEINETRENPRYLPGVKLPENLRATSDLEEAL 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  84 EDADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDegPNGLKLISEVIGERLG--IPMSVLMGANIASEVADEKF 161
Cdd:COG0240  69 AGADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIE--PGTGLLMSEVIAEELPgaLRIAVLSGPSFAEEVARGLP 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088 162 CETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKL 241
Cdd:COG0240 147 TAVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVA 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088 242 FCSGPvssATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQLEKELlnGQKLQGPETARELYSILQHKGlVDkF 319
Cdd:COG0240 227 LGARP---ETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLG-VE-M 298

                       330
                ....*....|....*...
gi 33695088 320 PLFMAVYKVCYEGQPVGE 337
Cdd:COG0240 299 PITEAVYAVLYEGKSPRE 316
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
4-342 2.72e-85

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 260.77  E-value: 2.72e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088    4 KKVCIVGSGNWGSAIAKIvggnaaqLAQFDPRVTMWVFEEDIggkklTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAA 83
Cdd:PRK00094   2 MKIAVLGAGSWGTALAIV-------LARNGHDVTLWARDPEQ-----AAEINADRENPRYLPGIKLPDNLRATTDLAEAL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   84 EDADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDEGPngLKLISEVIGERLG--IPMSVLMGANIASEVADEKF 161
Cdd:PRK00094  70 ADADLILVAVPSQALREVLKQLKPLLPPDAPIVWATKGIEPGT--GKLLSEVLEEELPdlAPIAVLSGPSFAKEVARGLP 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  162 CETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKL 241
Cdd:PRK00094 148 TAVVIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVA 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  242 FCSGPvssATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQLEKELlnGQKLQGPETARELYSILQHKGLvdKF 319
Cdd:PRK00094 228 LGANP---ETFLGLAGLGDLVLTCTSplSRNRRFGLALGQ-GKSLEEALAEI--GMVAEGVRTAKAVYELAKKLGV--EM 299

                        330       340
                 ....*....|....*....|...
gi 33695088  320 PLFMAVYKVCYEGQPVGEFIHCL 342
Cdd:PRK00094 300 PITEAVYAVLYEGKDPREAVEDL 322
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 5-172 1.90e-65

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 203.96  E-value: 1.90e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088     5 KVCIVGSGNWGSAIAKIVGGNAaqlaqfdPRVTMWVFEEDiggkkLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAAE 84
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNG-------HEVRLWGRDEE-----LIEEINTTHENVRYLPGIKLPENLKATTDLAEALK 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088    85 DADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDEGpnGLKLISEVIGERLGI--PMSVLMGANIASEVADEKFC 162
Cdd:pfam01210  69 GADIIVIVVPSQALREVLKQLKGLLKPDAILVSLSKGIEPG--TLKLLSEVIEEELGIqpPIAVLSGPSHAEEVAQGLPT 146

                         170
                  ....*....|
gi 33695088   163 ETTIGCKDPA 172
Cdd:pfam01210 147 ATVIASKDEE 156
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 194-339 1.34e-63

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 198.77  E-value: 1.34e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   194 VDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGPvssATFLESCGVADLITTCYGG--RNR 271
Cdd:pfam07479   2 VIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKP---ETFFGLAGLGDLIVTCTSGlsRNR 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 33695088   272 KVAEAFARtGKSIEQLEKELlnGQKLQGPETARELYSILQHKGLvdKFPLFMAVYKVCYEGQPVGEFI 339
Cdd:pfam07479  79 RFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEAL 141
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 5-287 2.65e-50

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 171.12  E-value: 2.65e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088    5 KVCIVGSGNWGSAIAKIVGGNAAQLaqfdprvtMWVFEEDIggkklTEIINTQHENVKYLP-GHKLPPNVVAVPDVVQAA 83
Cdd:PRK12439   9 KVVVLGGGSWGTTVASICARRGPTL--------QWVRSAET-----ADDINDNHRNSRYLGnDVVLSDTLRATTDFAEAA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   84 EDADILIFVVP-HQFIGkICDQLKGHLKANATGISLIKGVDEGPNglKLISEVIGERL-GIPMSVLMGANIASEVADEKF 161
Cdd:PRK12439  76 NCADVVVMGVPsHGFRG-VLTELAKELRPWVPVVSLVKGLEQGTN--MRMSQIIEEVLpGHPAGILAGPNIAREVAEGYA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  162 CETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMiafAKL 241
Cdd:PRK12439 153 AAAVLAMPDQHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIARALREM---TKL 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 33695088  242 FCSGPVSSATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQL 287
Cdd:PRK12439 230 GVAMGGNPETFAGLAGMGDLIVTCTSqrSRNRHVGEQLGA-GKPIDEI 276
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 2-347 1.36e-44

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 155.80  E-value: 1.36e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088    2 ASKKVCIVGSGNWGSAIAKivggNAAQLAQfdpRVTMWVFEEDiggkkLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQ 81
Cdd:PRK14618   3 HGMRVAVLGAGAWGTALAV----LAASKGV---PVRLWARRPE-----FAAALAAERENREYLPGVALPAELYPTADPEE 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   82 AAEDADILIFVVPHQFIGKICDQLKGHLKAnatgISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKF 161
Cdd:PRK14618  71 ALAGADFAVVAVPSKALRETLAGLPRALGY----VSCAKGLAPDGGRLSELARVLEFLTQARVAVLSGPNHAEEIARFLP 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  162 CETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKl 241
Cdd:PRK14618 147 AATVVASPEPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVRFGV- 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  242 fcSGPVSSATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQLEKEllnGQKLQGPETARELYSILQHKGlVDkF 319
Cdd:PRK14618 226 --ALGAEEATFYGLSGLGDLIATATSphSRNRAAGEAIVR-GVDREHLEAG---GKVVEGLYTVKALDAWAKAHG-HD-L 297

                        330       340
                 ....*....|....*....|....*....
gi 33695088  320 PLFMAVYKVCYEG-QPVGEFIHCLQNHPE 347
Cdd:PRK14618 298 PIVEAVARVARGGwDPLAGLRSLMGREAK 326
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 5-339 7.67e-39

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 140.35  E-value: 7.67e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088    5 KVCIVGSGNWGSAIAKIVGGNAAQlaqfdprVTMWVFEEDIggkklTEIINTQHENVKYLPGHKLPPNVV---AVPDVVq 81
Cdd:PRK14620   2 KISILGAGSFGTAIAIALSSKKIS-------VNLWGRNHTT-----FESINTKRKNLKYLPTCHLPDNISvksAIDEVL- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   82 aAEDADILIFVVPHQFIGKICDQLKG-HLKANATGISLIKGVDEgpNGLKLISEVIGERL-GIPMSVLMGANIASEVADE 159
Cdd:PRK14620  69 -SDNATCIILAVPTQQLRTICQQLQDcHLKKNTPILICSKGIEK--SSLKFPSEIVNEILpNNPIAILSGPSFAKEIAEK 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  160 KFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAF- 238
Cdd:PRK14620 146 LPCSIVLAGQNETLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKGMNEIKTLy 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  239 -AKlfcSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFA-RTGKSIEQLekeLLNGQKL-QGPETARELYSILqhKGL 315
Cdd:PRK14620 226 sAK---NGSIDLNTLIGPSCLGDLILTCTTLHSRNMSFGFKiGNGFNINQI---LSEGKSViEGFSTVKPLISLA--KKL 297

                        330       340
                 ....*....|....*....|....
gi 33695088  316 VDKFPLFMAVYKVCYEGQPVGEFI 339
Cdd:PRK14620 298 NIELPICESIYNLLYENISLEKTI 321
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-316 6.32e-27

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 108.15  E-value: 6.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088    1 MASKKVCIVGSGNWGSAIAKIVGGNaaqlaqfDPRVTMWVFEediGGKKLTEIIntqhenvkylpghklppnvvavpdvv 80
Cdd:PRK14619   2 TQPKTIAILGAGAWGSTLAGLASAN-------GHRVRVWSRR---SGLSLAAVL-------------------------- 45

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   81 qaaEDADILIFVVPHQFIGKICDQLKG-HLKANATGISLIKGVDegPNGLKLISEVIGERLGI-PMSVLMGANIASEVAD 158
Cdd:PRK14619  46 ---ADADVIVSAVSMKGVRPVAEQVQAlNLPPETIIVTATKGLD--PETTRTPSQIWQAAFPNhPVVVLSGPNLSKEIQQ 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  159 EKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAF 238
Cdd:PRK14619 121 GLPAATVVASRDLAAAETVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPEMIRV 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088  239 AKLFCSGPvssATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQLEKELlnGQKLQGPETARELYSILQHKGLV 316
Cdd:PRK14619 201 GTHLGAQT---ETFYGLSGLGDLLATCTSplSRNYQVGYGLAQ-GKSLEQILAEL--EGTAEGVNTANVLVQLAQQQNIA 274
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 256-325 9.72e-07

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 45.57  E-value: 9.72e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 33695088   256 CGVADLITTCYGG--RNRKVAEAFARtGKSIEqlekELLNGQKLQGPETARELYSILQHKGLVDkFPLFMAV 325
Cdd:pfam20618   1 AGLGDLVLTCTSDlsRNRTFGLLLGK-GMTLA----EAGNGQVAEGVRTAKAVAAILARAHNVE-MPILEAV 66
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 3-150 3.43e-06

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 47.75  E-value: 3.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33695088   3 SKKVCIVGSGNWGSAIAKivggnaAQLAQFDPRVTMWVFeeDIGGKKLTEIINTqhenvkylpghklpPNVVAVPDVVQA 82
Cdd:COG0345   2 SMKIGFIGAGNMGSAIIK------GLLKSGVPPEDIIVS--DRSPERLEALAER--------------YGVRVTTDNAEA 59

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 33695088  83 AEDADILIFVVPHQFIGKICDQLKGHLKANATGISLIKGVDegpngLKLISEVIGERLGI-------PMSVLMGA 150
Cdd:COG0345  60 AAQADVVVLAVKPQDLAEVLEELAPLLDPDKLVISIAAGVT-----LATLEEALGGGAPVvrampntPALVGEGV 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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