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Conserved domains on  [gi|4885165|ref|NP_005204|]
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cystatin-A [Homo sapiens]

Protein Classification

CY domain-containing protein( domain architecture ID 10440427)

CY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-92 1.70e-25

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 90.86  E-value: 1.70e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885165     4 GGLSEAKPATPEIQEIVDKVKPQLEEKT-NETYGKLEAVQYKTQVVAGTNYYIKVRAGDNKYM-HLKVFKSLPGQ-NEDL 80
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLdEKWL 80

                         90
                 ....*....|..
gi 4885165    81 VLTGYQVDKNKD 92
Cdd:pfam00031 81 GLCSAQVYKVPW 92
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-92 1.70e-25

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 90.86  E-value: 1.70e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885165     4 GGLSEAKPATPEIQEIVDKVKPQLEEKT-NETYGKLEAVQYKTQVVAGTNYYIKVRAGDNKYM-HLKVFKSLPGQ-NEDL 80
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLdEKWL 80

                         90
                 ....*....|..
gi 4885165    81 VLTGYQVDKNKD 92
Cdd:pfam00031 81 GLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 1-61 4.03e-17

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 70.15  E-value: 4.03e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4885165       1 MIPGGLSEAKPATPEIQEIVDKVKPQLEEKTNETY--GKLEAVQYKTQVVAGTNYYIKVRAGD 61
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYelRVIKVVSAKSQVVAGTNYYLKVEVGE 63
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 4-61 5.38e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 59.41  E-value: 5.38e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4885165    4 GGLSEAKPATPEIQEIVDKVKPQLEEKTNETY-GKLEAVQYKTQVVAGTNYYIKVRAGD 61
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYlEFFKVLSAKSQVVAGTNYYITVEAGD 59
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-92 1.70e-25

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 90.86  E-value: 1.70e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4885165     4 GGLSEAKPATPEIQEIVDKVKPQLEEKT-NETYGKLEAVQYKTQVVAGTNYYIKVRAGDNKYM-HLKVFKSLPGQ-NEDL 80
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLdEKWL 80

                         90
                 ....*....|..
gi 4885165    81 VLTGYQVDKNKD 92
Cdd:pfam00031 81 GLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 1-61 4.03e-17

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 70.15  E-value: 4.03e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4885165       1 MIPGGLSEAKPATPEIQEIVDKVKPQLEEKTNETY--GKLEAVQYKTQVVAGTNYYIKVRAGD 61
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYelRVIKVVSAKSQVVAGTNYYLKVEVGE 63
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 4-61 5.38e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 59.41  E-value: 5.38e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4885165    4 GGLSEAKPATPEIQEIVDKVKPQLEEKTNETY-GKLEAVQYKTQVVAGTNYYIKVRAGD 61
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYlEFFKVLSAKSQVVAGTNYYITVEAGD 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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