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Conserved domains on  [gi|27501450|ref|NP_003493|]
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axin-1 isoform a [Homo sapiens]

Protein Classification

regulator of G-protein signaling domain-containing protein( domain architecture ID 10184141)

regulator of G-protein signaling (RGS) domain-containing protein belongs to a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGS_Axin cd08707
Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of ...
 89-209 9.02e-69

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.


:

Pssm-ID: 188662  Cd Length: 117  Bit Score: 223.11  E-value: 9.02e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDsneEKRLKLARAIYRKYILdNNGIVSRQTKPATKSFI 168
Cdd:cd08707   1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMSDSE---EKRSKLAKAIYRRYIK-DNGIVSRQLKPATKSFI 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 27501450 169 KGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08707  77 KECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117
DIX pfam00778
DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in ...
 782-858 3.95e-33

DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in homo- and hetero-oligomerization. It is involved in the homo- oligomerization of mouse axin. The axin DIX domain also interacts with the dishevelled DIX domain. The DIX domain has also been called the DAX domain.


:

Pssm-ID: 459936  Cd Length: 77  Bit Score: 122.25  E-value: 3.95e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27501450   782 SIVVAYYFCGEPIPYRT--LVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCgvVFEEVREDEAVLPVFEEKIIGKV 858
Cdd:pfam00778   1 ETKVIYYLCDEPVPYRIkiHKPGGQITLGDFKELLPKKGNYRYFFKTLDPEFGT--VKEEITDDDDILPLWEGKIVAKV 77
Axin_TNKS_binding cd11582
Tankyrase binding N-terminal segment of axin; This N-terminal region of axin mediates ...
 11-80 1.20e-27

Tankyrase binding N-terminal segment of axin; This N-terminal region of axin mediates interactions with the ankyrin-repeat clusters 2 and 3 of tankyrase, which controls the turnover of axin via poly-ADP-ribosylation. Axin functions as a negative regulator of the WNT signaling pathway.


:

Pssm-ID: 211424  Cd Length: 69  Bit Score: 106.36  E-value: 1.20e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  11 DLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFcSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTP 80
Cdd:cd11582   1 DPGSSFREDAPRPPVPGEEGELTPSDPRSSSHSY-SNKSDSLKPEPSAATPRRIEAPLGFEPEGSASPTP 69
Axin_b-cat_bind pfam08833
Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is ...
 465-496 1.01e-09

Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex. It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin.


:

Pssm-ID: 462616  Cd Length: 35  Bit Score: 54.24  E-value: 1.01e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 27501450   465 ENPESILDEHVQRVLRTPGRQSPG---PGHRSPDS 496
Cdd:pfam08833   1 DNPQSILDEHVSRVWKTPGCQSPGrhsPRSRSPDS 35
 
Name Accession Description Interval E-value
RGS_Axin cd08707
Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of ...
 89-209 9.02e-69

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.


Pssm-ID: 188662  Cd Length: 117  Bit Score: 223.11  E-value: 9.02e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDsneEKRLKLARAIYRKYILdNNGIVSRQTKPATKSFI 168
Cdd:cd08707   1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMSDSE---EKRSKLAKAIYRRYIK-DNGIVSRQLKPATKSFI 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 27501450 169 KGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08707  77 KECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 88-210 6.15e-36

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 131.58  E-value: 6.15e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450    88 SLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPcdsnEEKRLKLARAIYRKYIlDNNGIVSRQTKPATKSF 167
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADP----DEERLKKAKEIYNEFL-APGSPKEINLDSDLREE 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 27501450   168 IKGCiMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 210
Cdd:pfam00615  76 IREN-LEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 88-210 4.10e-35

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 129.31  E-value: 4.10e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450     88 SLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdsNEEKRLKLARAIYRKYIlDNNGIVSRQTKPATKSF 167
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAE----DDEERIAKAREIYDKFL-SPNAPKEVNLDSDLREK 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 27501450    168 IKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 210
Cdd:smart00315  76 IEENLESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
DIX pfam00778
DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in ...
 782-858 3.95e-33

DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in homo- and hetero-oligomerization. It is involved in the homo- oligomerization of mouse axin. The axin DIX domain also interacts with the dishevelled DIX domain. The DIX domain has also been called the DAX domain.


Pssm-ID: 459936  Cd Length: 77  Bit Score: 122.25  E-value: 3.95e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27501450   782 SIVVAYYFCGEPIPYRT--LVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCgvVFEEVREDEAVLPVFEEKIIGKV 858
Cdd:pfam00778   1 ETKVIYYLCDEPVPYRIkiHKPGGQITLGDFKELLPKKGNYRYFFKTLDPEFGT--VKEEITDDDDILPLWEGKIVAKV 77
DAX smart00021
Domain present in Dishevelled and axin; Domain of unknown function.
 780-862 1.03e-32

Domain present in Dishevelled and axin; Domain of unknown function.


Pssm-ID: 197474  Cd Length: 83  Bit Score: 121.36  E-value: 1.03e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450    780 CDSIVVAYYFCGEPIPYRTLVRGRA--VTLGQFKELLTKKGsYRYYFKKVSDEFDcGVVFEEVREDEAVLPVFEEKIIGK 857
Cdd:smart00021   1 CSETKVIYHLDDEETPYLVKVPVPAerVTLGDFKEVLTKKN-YKYYFKSMDDDFG-GVVKEEIRDDSARLPCFNGRVVSW 78


                   ....*
gi 27501450    858 VEKVD 862
Cdd:smart00021  79 LVSVE 83
Axin_TNKS_binding cd11582
Tankyrase binding N-terminal segment of axin; This N-terminal region of axin mediates ...
 11-80 1.20e-27

Tankyrase binding N-terminal segment of axin; This N-terminal region of axin mediates interactions with the ankyrin-repeat clusters 2 and 3 of tankyrase, which controls the turnover of axin via poly-ADP-ribosylation. Axin functions as a negative regulator of the WNT signaling pathway.


Pssm-ID: 211424  Cd Length: 69  Bit Score: 106.36  E-value: 1.20e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  11 DLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFcSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTP 80
Cdd:cd11582   1 DPGSSFREDAPRPPVPGEEGELTPSDPRSSSHSY-SNKSDSLKPEPSAATPRRIEAPLGFEPEGSASPTP 69
AXIN1_TNKS_BD pfam16646
Axin-1 tankyrase binding domain; This is the N-terminal domain tankyrase binding domain of ...
 11-82 5.17e-27

Axin-1 tankyrase binding domain; This is the N-terminal domain tankyrase binding domain of Axin-1.


Pssm-ID: 465215  Cd Length: 75  Bit Score: 104.76  E-value: 5.17e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27501450    11 DLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPY 82
Cdd:pfam16646   4 DGGGSFREDAPRPPVPGEEGEVPGCGPQHGSFGPSSKKEALKKEASVASTPRRNEDGLGEEPEGSASPDPPL 75
Axin_b-cat_bind pfam08833
Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is ...
 465-496 1.01e-09

Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex. It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin.


Pssm-ID: 462616  Cd Length: 35  Bit Score: 54.24  E-value: 1.01e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 27501450   465 ENPESILDEHVQRVLRTPGRQSPG---PGHRSPDS 496
Cdd:pfam08833   1 DNPQSILDEHVSRVWKTPGCQSPGrhsPRSRSPDS 35
 
Name Accession Description Interval E-value
RGS_Axin cd08707
Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of ...
 89-209 9.02e-69

Regulator of G protein signaling (RGS) domain found in the Axin protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.


Pssm-ID: 188662  Cd Length: 117  Bit Score: 223.11  E-value: 9.02e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDsneEKRLKLARAIYRKYILdNNGIVSRQTKPATKSFI 168
Cdd:cd08707   1 LHSLLDDQDGIELFRTYLEQEGCADLLDFWFACNGFRKMSDSE---EKRSKLAKAIYRRYIK-DNGIVSRQLKPATKSFI 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 27501450 169 KGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08707  77 KECIKKQQLDPAMFDQAQTEIQTTMEENTYPSFLKSDIYLE 117
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 88-210 6.15e-36

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 131.58  E-value: 6.15e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450    88 SLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPcdsnEEKRLKLARAIYRKYIlDNNGIVSRQTKPATKSF 167
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADP----DEERLKKAKEIYNEFL-APGSPKEINLDSDLREE 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 27501450   168 IKGCiMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 210
Cdd:pfam00615  76 IREN-LEKEPTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 88-210 4.10e-35

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 129.31  E-value: 4.10e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450     88 SLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdsNEEKRLKLARAIYRKYIlDNNGIVSRQTKPATKSF 167
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAE----DDEERIAKAREIYDKFL-SPNAPKEVNLDSDLREK 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 27501450    168 IKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEY 210
Cdd:smart00315  76 IEENLESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
DIX pfam00778
DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in ...
 782-858 3.95e-33

DIX domain; The DIX domain is present in Dishevelled and axin. This domain is involved in homo- and hetero-oligomerization. It is involved in the homo- oligomerization of mouse axin. The axin DIX domain also interacts with the dishevelled DIX domain. The DIX domain has also been called the DAX domain.


Pssm-ID: 459936  Cd Length: 77  Bit Score: 122.25  E-value: 3.95e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27501450   782 SIVVAYYFCGEPIPYRT--LVRGRAVTLGQFKELLTKKGSYRYYFKKVSDEFDCgvVFEEVREDEAVLPVFEEKIIGKV 858
Cdd:pfam00778   1 ETKVIYYLCDEPVPYRIkiHKPGGQITLGDFKELLPKKGNYRYFFKTLDPEFGT--VKEEITDDDDILPLWEGKIVAKV 77
DAX smart00021
Domain present in Dishevelled and axin; Domain of unknown function.
 780-862 1.03e-32

Domain present in Dishevelled and axin; Domain of unknown function.


Pssm-ID: 197474  Cd Length: 83  Bit Score: 121.36  E-value: 1.03e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450    780 CDSIVVAYYFCGEPIPYRTLVRGRA--VTLGQFKELLTKKGsYRYYFKKVSDEFDcGVVFEEVREDEAVLPVFEEKIIGK 857
Cdd:smart00021   1 CSETKVIYHLDDEETPYLVKVPVPAerVTLGDFKEVLTKKN-YKYYFKSMDDDFG-GVVKEEIRDDSARLPCFNGRVVSW 78


                   ....*
gi 27501450    858 VEKVD 862
Cdd:smart00021  79 LVSVE 83
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 93-209 6.21e-30

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 114.41  E-value: 6.21e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  93 LDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDsneEKRLKLARAIYRKYILDNNgIVSRQTKPATKSFIKGCI 172
Cdd:cd07440   1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSD---EELKSKAKEIYDKYISKDA-PKEINIPESIREEIEENL 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 27501450 173 MKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd07440  77 EEPYPDPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113
Axin_TNKS_binding cd11582
Tankyrase binding N-terminal segment of axin; This N-terminal region of axin mediates ...
 11-80 1.20e-27

Tankyrase binding N-terminal segment of axin; This N-terminal region of axin mediates interactions with the ankyrin-repeat clusters 2 and 3 of tankyrase, which controls the turnover of axin via poly-ADP-ribosylation. Axin functions as a negative regulator of the WNT signaling pathway.


Pssm-ID: 211424  Cd Length: 69  Bit Score: 106.36  E-value: 1.20e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  11 DLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFcSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTP 80
Cdd:cd11582   1 DPGSSFREDAPRPPVPGEEGELTPSDPRSSSHSY-SNKSDSLKPEPSAATPRRIEAPLGFEPEGSASPTP 69
AXIN1_TNKS_BD pfam16646
Axin-1 tankyrase binding domain; This is the N-terminal domain tankyrase binding domain of ...
 11-82 5.17e-27

Axin-1 tankyrase binding domain; This is the N-terminal domain tankyrase binding domain of Axin-1.


Pssm-ID: 465215  Cd Length: 75  Bit Score: 104.76  E-value: 5.17e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27501450    11 DLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPY 82
Cdd:pfam16646   4 DGGGSFREDAPRPPVPGEEGEVPGCGPQHGSFGPSSKKEALKKEASVASTPRRNEDGLGEEPEGSASPDPPL 75
RGS_RGS3 cd08713
Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of ...
 89-209 6.16e-18

Regulator of G protein signaling (RGS) domain found in the RGS3 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS3 protein. RGS3 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS3 induces apoptosis when overexpressed and is involved in cell migration through interaction with the Ephrin receptor. RGS3 exits as several splice isoforms and interacts with neuroligin, estrogen receptor-alpha, and 14-3-3 outside of the GPCR pathways.


Pssm-ID: 188668  Cd Length: 114  Bit Score: 80.30  E-value: 6.16e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPcdsnEEKRLKLARAIYRKYI---------LDNngivsrQ 159
Cdd:cd08713   1 LEKLLLHKYGLAVFRAFLQTEFSEENLEFWLACEEYKKIKS----QSKMASRAKKIFAEYIaiqsckevnLDS------Y 70

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 27501450 160 TKPATKSFIkgcimkQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08713  71 TREHTKENL------QNPTRGCFDLAQKRIYGLMEKDSYPRFLRSDLYQD 114
RGS_RGS18 cd08712
Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator ...
 92-209 5.99e-17

Regulator of G protein signaling (RGS) domain found in the RGS18 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS18 protein. RGS18 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS18 is a member of the R4/RGS subfamily and is expressed predominantly in osteoclasts where it acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT signaling pathway. RANKL (receptor activator of nuclear factor B ligand) stimulates osteoclastogenesis by inhibiting expression of RGS18.


Pssm-ID: 188667  Cd Length: 114  Bit Score: 77.28  E-value: 5.99e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  92 LLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdSNEEKRLKlARAIYRKYI-LDNNGIVSRQTKpaTKSFIKG 170
Cdd:cd08712   4 LLSHKDGLEAFTRFLKTEFSEENIEFWIACEDYKKSK---TPQQIHLK-AKAIYEKFIqTDAPKEVNLDFH--TKEVTTN 77

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 27501450 171 CIMKQLIdpAMFDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08712  78 SIEQPTL--TSFDAAQSRVYQLMEQDSYPRFLKSDIYLD 114
RGS_RGS5 cd08717
Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of ...
 89-209 3.18e-16

Regulator of G protein signaling (RGS) domain found in the RGS5 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS5 protein. RGS5 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Two splice isoforms of RGS5 has been found: RGS5L (long) which is expressed in smooth muscle cells (pericytes) and heart and RGS5S (short) which is highly expressed in the ciliary body of the eye, kidney, brain, spleen, skeletal muscle, and small intestine. Outside of the GPCR pathway, RGS5 interacts with the 14-3-3 protein.


Pssm-ID: 188672  Cd Length: 114  Bit Score: 75.42  E-value: 3.18e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKrlklARAIYRKYIldnngivsrQTKPATK--- 165
Cdd:cd08717   1 LDKLLQNSYGLASFKSFLKSEFSEENIEFWEACEDYKKTKSPLKMATK----AKKIYEEFI---------QTEAPKEvni 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 27501450 166 -SFIKGCIMKQLIDPAM--FDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08717  68 dHFTKDVTMKNLVEPSSssFDLAQKRIFALMEKDSLPRFVRSEFYQE 114
RGS_RGS1 cd08715
Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of ...
 89-208 7.27e-16

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.


Pssm-ID: 188670  Cd Length: 114  Bit Score: 74.22  E-value: 7.27e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdsNEEKRLKlARAIYRKYILDNNGI---VSRQTKPATK 165
Cdd:cd08715   1 LEKLLASQTGQNVFRSFLKSEFSEENIEFWLACEDYKKTE----SDLLPCK-AEEIYKEFVQSDAAKqinIDFRTRESTA 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 27501450 166 sfikgcimKQLIDP--AMFDQAQTEIQATMEENTYPSFLKSDIYL 208
Cdd:cd08715  76 --------KKIKAPtpTCFDEAQKVIYILMERDSYPRFLKSDIYL 112
RGS_R12-like cd08706
Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS ...
 89-209 5.99e-15

Regulator of G protein signaling (RGS) domain found in the R12 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R12 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play a critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling, controlled by RGS domain, accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP that results in reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R12 RGS subfamily includes RGS10, RGS12 and RGS14 all of which are highly selective for G-alpha-i1 over G-alpha-q.


Pssm-ID: 188661  Cd Length: 113  Bit Score: 71.58  E-value: 5.99e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLepcdSNEEKRLKLARAIYRKYiLDNNGI----VSRQTKPAT 164
Cdd:cd08706   1 FERLLQDPVGVKYFTEFLKKEFSEENILFWQACEKFKKI----PDKKQLVQEAREIYDTF-LSSKASspvnIDSQAQLAE 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 27501450 165 KsfikgciMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08706  76 E-------MLEEPHPDMFQKQQLQIFNLMKFDSYSRFLKSPLYQQ 113
RGS_RGS20 cd08746
Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator ...
 62-207 1.25e-14

Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS20 protein (also known as RGSZ1), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP resulting in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins include RGS17, RGS19 (former GAIP), and the splice variant of RGS20, Ret-RGS. RGS20 is expressed exclusively in brain, with the highest concentrations in the temporal lobe and the caudate nucleus and may play a role in signaling regulation in these brain regions. RGS20 acts as a GAP of both G-alpha-z and G-alpha-I and controls signaling in the mu opioid receptor pathway.


Pssm-ID: 188700 [Multi-domain]  Cd Length: 167  Bit Score: 72.33  E-value: 1.25e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  62 RRSDLDLGYE--PEGSASPTPPYLK---WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEK 136
Cdd:cd08746  22 RRTSYEFRAEgiPNCEESPKPTLEEvcaWGQSFDKLMLTPAGRNAFREFLRTEFSEENMLFWMACEELKKEANKSVIEEK 101

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27501450 137 rlklARAIYRKYIldnnGIVSRQtKPATKSFIKGCIMKQLIDPA--MFDQAQTEIQATMEENTYPSFLKSDIY 207
Cdd:cd08746 102 ----ARIIYEDYI----SILSPK-EVSLDSRVREVINRNMLEPSqhTFDDAQLQIYTLMHRDSYPRFMNSAIY 165
RGS_RGS19 cd08745
Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator ...
 85-207 1.51e-14

Regulator of G protein signaling (RGS) domain found in the RGS19 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS19 protein (also known as GAIP), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, resulting in a reassociation of the alpha-subunit with the beta-gamma-dimer and an inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS20, and its splice variant Ret-RGS. RGS19 participates in regulation of dopamine receptor D2R and D3R, as well as beta-adrenergic receptors .


Pssm-ID: 188699  Cd Length: 118  Bit Score: 70.86  E-value: 1.51e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  85 WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKrlklARAIYRKYIldnnGIVSRQtKPAT 164
Cdd:cd08745   1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEELKAEANKHVIDEK----ARLIYEDYI----SILSPK-EVSL 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 27501450 165 KSFIKGCIMKQLIDPA--MFDQAQTEIQATMEENTYPSFLKSDIY 207
Cdd:cd08745  72 DSRVREGINRKMQEPSshTFDDAQLQIYTLMHRDSYPRFLNSPIY 116
RGS_RGS10 cd08741
Regulator of G protein signaling (RGS) domain found in the RGS10 protein; RGS (Regulator of ...
 89-209 2.30e-14

Regulator of G protein signaling (RGS) domain found in the RGS10 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS10 protein. RGS10 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS10 belong to the R12 RGS subfamily, which includes RGS12 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS10 exists in 2 splice isoforms. RGS10A is specifically expressed in osteoclasts and is a key component in the RANKL signaling mechanism for osteoclast differentiation, whereas RGS10B expressed in brain and in immune tissues and has been implicated in diverse processes including: promoting of dopaminergic neuron survival via regulation of the microglial inflammatory response, modulation of presynaptic and postsynaptic G-protein signalling, as well as a possible role in regulation of gene expression.


Pssm-ID: 188695  Cd Length: 113  Bit Score: 70.07  E-value: 2.30e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdsNEEKRLKLARAIYRKYILDNngiVSRQTKPATKSFI 168
Cdd:cd08741   1 LENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQ----DKTQMQEKAKEIYMTFLSSK---ASSQVNVEGQSRL 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 27501450 169 KGCIMKQlIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08741  74 NEKILEE-PHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLK 113
RGS_RZ-like cd08718
Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of ...
 85-207 3.03e-14

Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS.


Pssm-ID: 188673  Cd Length: 118  Bit Score: 69.80  E-value: 3.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  85 WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKrlklARAIYRKYIldnnGIVSRQtKPAT 164
Cdd:cd08718   1 WAQSFDKLMKSPAGRNVFREFLRTEYSEENMLFWLACEELKKEANKHVIEEK----ARLIYEDYI----SILSPK-EVSL 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 27501450 165 KSFIKGCIMKQLIDPA--MFDQAQTEIQATMEENTYPSFLKSDIY 207
Cdd:cd08718  72 DSRVREVINRNMLEPSphTFDDAQLQIYTLMHRDSYPRFLNSAIY 116
RGS_RGS21 cd08723
Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator ...
 92-209 5.13e-14

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part RGS21 protein, a member of RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, apoptosis, and cell proliferation, as well as modulation of cardiac development. RGS21 is a member of the R4/RGS subfamily and its mRNA was detected only in sensory taste cells that express sweet taste receptors and the taste G-alpha subunit, gustducin, suggesting a potential role in regulating taste transduction.


Pssm-ID: 188678  Cd Length: 111  Bit Score: 68.93  E-value: 5.13e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  92 LLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdSNEEKRLKlARAIYRKYildnngIVSRQTKPATKSF-IKG 170
Cdd:cd08723   1 LLANQAGLDAFRTFLKSEFSEENVEFWLACEDFKKTK---SSTEIALK-AQMIYSEF------IQADAPKEINIDFhTRD 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 27501450 171 CIMKQLIDPAM--FDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08723  71 LISQNISEPTLkcFDEAQSLIYCLMAKDSFPRFLKSEVYKK 111
RGS_RGS2 cd08709
Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of ...
 92-209 7.31e-14

Regulator of G protein signaling (RGS) domain found in the RGS2 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS2 protein. RGS2 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G- alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS2 plays important roles in the regulation of blood pressure and the pathogenesis of human hypertension, as well as in bone formation in osteoblasts. Outside of the GPCR pathway RGS2 interacts with calmodulin, beta- COP, tubulin, PKG1-alpha, and TRPV6.


Pssm-ID: 188664  Cd Length: 114  Bit Score: 68.54  E-value: 7.31e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  92 LLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdsNEEKRLKLARAIYRKYIldnngivsrqTKPATKSF---- 167
Cdd:cd08709   4 LLASKYGVAAFRAFLKSEFSEENIEFWLACEDFKKTK----SPQKLTSKAKKIYTDFI----------EKEAPKEInidf 69

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 27501450 168 -IKGCIMKQLIDPAM--FDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08709  70 qTKTLIAQNIQEATSgcFTAAQKRVYSLMENNSYPRFLESEFYQE 114
RGS_RGS8 cd08711
Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of ...
 84-209 9.40e-14

Regulator of G protein signaling (RGS) domain found in the RGS8 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS8 protein. RGS8 is a member of R4/RGS subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS8 is involved in G-protein-gated potassium channels regulation and predominantly expressed in the brain. RGS8 also is selectively expressed in the hematopoietic system (NK cells).


Pssm-ID: 188666  Cd Length: 125  Bit Score: 68.61  E-value: 9.40e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  84 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdsNEEKRLKLARAIYRKYI---LDNNGIVSRQT 160
Cdd:cd08711   7 RWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTR----STAKLVSKAHRIFEEFVdvqAPREVNIDFQT 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 27501450 161 KPATKsfikgcimKQLIDPAM--FDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08711  83 REATR--------KNLQEPSLtcFDQAQGKVHSLMEKDSYPRFLRSKMYLD 125
RGS_RGS16 cd08710
Regulator of G protein signaling (RGS) domain found in the RGS16 protein; The RGS (Regulator ...
 92-207 9.69e-13

Regulator of G protein signaling (RGS) domain found in the RGS16 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS16 protein. RGS16 is a member of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS16 is a member of the R4/RGS subfamily and interacts with neuronal G-alpha0. RGS16 expression is upregulated by IL-17 of the NF-kappaB signaling pathway in autoimmune B cells.


Pssm-ID: 188665  Cd Length: 114  Bit Score: 65.47  E-value: 9.69e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  92 LLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdsNEEKRLKLARAIYRKYILDNNGI---VSRQTKPATKSFI 168
Cdd:cd08710   4 LLNSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIR----SATKLASRAHHIFEEFIRSEAPKevnIDHETRELTRTNL 79

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 27501450 169 KGCImkqlidPAMFDQAQTEIQATMEENTYPSFLKSDIY 207
Cdd:cd08710  80 QAAT------TSCFDVAQGKTRTLMEKDSYPRFLKSPAY 112
RGS_RGS14 cd08743
Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of ...
 81-209 1.55e-12

Regulator of G protein signaling (RGS) domain found in the RGS14 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS14 protein. RGS14 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS14 belong to the R12 RGS subfamily, which includes RGS10 and RGS12, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS14 binds and regulates the subcellular localization and activities of H-Ras and Raf kinases in cells and thereby integrates G protein and Ras/Raf signaling pathways.


Pssm-ID: 188697  Cd Length: 129  Bit Score: 65.44  E-value: 1.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  81 PYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSneEKRLKLARAIYRKYildnngIVSRQT 160
Cdd:cd08743   3 SVASWAVSFERLLQDPLGVEYFTEFLKKEFSAENVNFWKACERFQQIPASDT--QQLAQEARKIYNEF------LSSSSQ 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 27501450 161 KPAT--KSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08743  75 SPVNidQQAWIGEDMLATPSPDMFRAQQLQIFNLMKFDSYARFVKSPLYQD 125
RGS_RGS4 cd08714
Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of ...
 89-209 1.69e-12

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS4 protein. RGS4 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. RGS4 is expressed widely in brain including prefrontal cortex, striatum, locus coeruleus (LC), and hippocampus and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia. RGS4 also is up-regulated in the failing human heart. RGS4 interacts with many binding partners outside of GPCR pathways, including calmodulin, COP, Kir3, PIP, calcium/CaM, PA, ErbB3, and 14-3-3.


Pssm-ID: 188669  Cd Length: 114  Bit Score: 64.90  E-value: 1.69e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  89 LHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKrlklARAIYRKYIldnngivsrqTKPATK--- 165
Cdd:cd08714   1 LENLINHECGLAAFKAFLKSEYSEENIDFWVSCEDYKKTKSPSKLSPK----ARKIYEEFI----------SVQATKevn 66

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 27501450 166 --SFIKGCIMKQLIDPAM--FDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08714  67 ldSCTREETSRNMLEPTIscFDEAQKKIFTLMEKDSYRRFLKSRFYLD 114
RGS_RGS17 cd08744
Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator ...
 85-207 2.45e-12

Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS17 protein, a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. The RZ subfamily of RGS proteins includes RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS. RGS17 is a relatively non-selective GAP for G-alpha-z and other G-alpha-i/o proteins. RGS17 blocks dopamine receptor-mediated inhibition of cAMP accumulation; it also blocks thyrotropin releasing hormone-stimulated Ca++ mobilization. RGS17, like other members of RZ subfamily, can act either as a GAP or as G-protein effector antogonist.


Pssm-ID: 188698  Cd Length: 118  Bit Score: 64.36  E-value: 2.45e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  85 WAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKrlklARAIYRKYIldnnGIVSRQtKPAT 164
Cdd:cd08744   1 WSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKVIEEK----ARLIYEDYI----SILSPK-EVSL 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 27501450 165 KSFIKGCIMKQLIDPA--MFDQAQTEIQATMEENTYPSFLKSDIY 207
Cdd:cd08744  72 DSRVREVINRNLLDPNphMYEDAQLQIYTLMHRDSFPRFLNSQIY 116
RGS_RGS13 cd08716
Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator ...
 98-207 2.90e-11

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.


Pssm-ID: 188671  Cd Length: 114  Bit Score: 61.10  E-value: 2.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  98 GISLFRTFLKQEGCADLLDFWFACTGFRKLepcdSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCimkQLI 177
Cdd:cd08716  10 GPIIYATYLKTEHSDENIEFWLACETYKKI----ASQRKRISMARKLFASYIQPQAPREINIDSPTRKAIIRNI---QEP 82

                        90       100       110
                ....*....|....*....|....*....|
gi 27501450 178 DPAMFDQAQTEIQATMEENTYPSFLKSDIY 207
Cdd:cd08716  83 TQSCFDEAQRIVYMHMERDSYPRFLESKFY 112
RGS_R7-like cd08705
Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS ...
 84-207 3.74e-10

Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R7 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R7 subfamily includes RGS6, RGS7, RGS9, and RGS11, all of which, in humans, are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes. In addition, R7 proteins were found to bind many other proteins outside of the G protein signaling pathways including: m-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, guanylyl cyclase, among others.


Pssm-ID: 188660  Cd Length: 121  Bit Score: 58.02  E-value: 3.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  84 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKlepCDSNEEKRlkLARAIYRKYILDNngiVSRQTKPA 163
Cdd:cd08705   4 RWGFSFSELLKDPVGREQFLKFLEKEFSGENLRFWEACQDLKY---GPQSQVPE--KVQEIYQEFLAPG---APSWINID 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 27501450 164 TKSFIKgcIMKQLIDPA--MFDQAQTEIQATMEENTYPSFLKSDIY 207
Cdd:cd08705  76 SKTMEI--TLKNLKDPHryTFDAAQEHIYMLMKKDSYPRFLRSDIY 119
Axin_b-cat_bind pfam08833
Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is ...
 465-496 1.01e-09

Axin beta-catenin binding motif; This motif is found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex. It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin.


Pssm-ID: 462616  Cd Length: 35  Bit Score: 54.24  E-value: 1.01e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 27501450   465 ENPESILDEHVQRVLRTPGRQSPG---PGHRSPDS 496
Cdd:pfam08833   1 DNPQSILDEHVSRVWKTPGCQSPGrhsPRSRSPDS 35
RGS_RGS9 cd08739
Regulator of G protein signaling (RGS) domain found in the RGS9 protein; The RGS (Regulator of ...
 84-209 4.13e-09

Regulator of G protein signaling (RGS) domain found in the RGS9 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS9 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS9 forms constitutive complexes with G-beta-5 subunit and controls such fundamental functions as vision and behavior. RGS9 exists in two splice isoforms: RGS9-1 which regulates phototransduction in rods and cones and RGS9-2 which regulates dopamine and opioid signaling in the basal ganglia. In addition, RGS9 was found to bind many other proteins outside of G protein signaling pathways including: mu-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, and guanylyl cyclase, among others.


Pssm-ID: 188693  Cd Length: 121  Bit Score: 55.42  E-value: 4.13e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  84 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKlepcdSNEEKRLKLARAIYRKYIldnngivsrqtKPA 163
Cdd:cd08739   4 RWAFNFSELIRDPKGRQSFQLFLKKEFSGENLGFWEACEDLKY-----GDQSKVKEKAEEIYKLFL-----------APG 67

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 27501450 164 TKSFIK------GCIMKQLIDPAMF--DQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08739  68 ARRWINidgktmDITVKGLKHPHRYvlDAAQTHIYMLMKKDSYARYLKSPIYKE 121
RGS_RGS11 cd08740
Regulator of G protein signaling (RGS) domain found in the RGS11 protein; The RGS (Regulator ...
 84-207 8.32e-09

Regulator of G protein signaling (RGS) domain found in the RGS11 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS11 protein, a member of R7 subfamily of the RGS protein family. RGS is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. Other members of the R7 subfamily (Neuronal RGS) include: RGS6, RGS7, and RGS9, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control. Additionally they have been implicated in many neurological conditions such as anxiety, schizophrenia, and drug dependence. RGS11 is expressed exclusively in retinal ON-bipolar neurons in which it forms complexes with G-beta-5 and R7AP (RGS7 anchor protein ) and plays crucial roles in processing the light responses of retinal neurons.


Pssm-ID: 188694  Cd Length: 126  Bit Score: 54.53  E-value: 8.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  84 KWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEpcdsnEEKRLKLARAIYRKYILDNngiVSRQTKPA 163
Cdd:cd08740   5 RWGFSFRELLNDPVGRKEFLDFLEKEFSAENLSFWEACEELRYGE-----QSKIPELVDSVYQQFLAPG---ATRWVNID 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 27501450 164 TKSFIKgcIMKQLIDPAMF--DQAQTEIQATMEENTYPSFLKSDIY 207
Cdd:cd08740  77 SKTMER--TLEGLKQPHRYvlDDAQMHIYMLMKKDSYPRFLKSDLY 120
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 92-207 3.72e-07

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


Pssm-ID: 188676  Cd Length: 121  Bit Score: 49.65  E-value: 3.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  92 LLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRK---LEPCDSNEEKRLKLARAIYRKYIldnngivSRQ-TKP----- 162
Cdd:cd08721   1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSqlaAKEGQYDGQQAQNDAMIIYDKYF-------SLQaTEPlgfdd 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 27501450 163 ATKSFIKGCIMKQL-IDPAMFDQAQTEIQATMEENTYPSFLKSDIY 207
Cdd:cd08721  74 KTRLEVESNICREGgPLPSCFEAPLLQALTTLEQHYLPGFLSSQLY 119
RGS_RGS12 cd08742
Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of ...
 92-209 6.83e-07

Regulator of G protein signaling (RGS) domain found in the RGS12 protein; RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS12 belong to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLoco domains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation.


Pssm-ID: 188696  Cd Length: 115  Bit Score: 48.90  E-value: 6.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  92 LLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKrlKLARAIYRKYildnngIVSRQTKPATKSfikgc 171
Cdd:cd08742   4 LLQDPVGVRYFSEFLRKEFSEENILFWQACEYFNHVPAHDKKELS--YRAREIFSKF------LCSKATTPVNID----- 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 27501450 172 IMKQLID-------PAMFDQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08742  71 SQAQLADdilnaphPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQE 115
RGS_SNX14 cd08722
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein; ...
 93-209 2.06e-06

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX14 (Sorting Nexin14) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX14 is believed to regulates membrane trafficking in motor neurons.


Pssm-ID: 188677  Cd Length: 127  Bit Score: 47.72  E-value: 2.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  93 LDDQDGISLFRTFLKQEGCADLLDFWFACTGF--RKLEPcDSNEEKRLKL---ARAIYRKYILDN------------NGI 155
Cdd:cd08722   2 LDDQRLLFPFMQFLKEEGAVHLLQFCLTVEDFnrRILNP-DLTDEEKQSLhkeAQEIYKTYFLPEapdrihfppdivEEI 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 27501450 156 VSRQTKPATKsFIKGCIMKQLIdpamfdQAQTEIQATMEENTYPSFLKSDIYLE 209
Cdd:cd08722  81 KQILEGGPEK-IVKLRTSRPLF------EAYEHVYSLLESVFCPLFCHSDEYFI 127
RGS-like_3 cd08730
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 3; These ...
 98-286 7.51e-05

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 3; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involved in many crucial cellular processes. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188685  Cd Length: 165  Bit Score: 44.26  E-value: 7.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  98 GISLFRTFLKQEGCADLLDFWFACTGFRKlEPCdSNEEKRLKLARAIYRKYILDNNGIVSRQtkpatksfikgciMKQLI 177
Cdd:cd08730   7 GMRRFRQFLAGTLGEDYLKFWLDVEMYRR-DYK-FGEIKRLDFFRSVVTKYLLKNSPYCLPV-------------FKRIE 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450 178 DPAMFDQAqteiqATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSsgsgtgkgisgYLPTLNEDEEWKCDQD----M 253
Cdd:cd08730  72 SNIGLDES-----AIMEVMSPMTEMPWQLLVYQMEVLSSTDTETTDGS-----------TLEDLKRSYCEYIQQEalfiL 135

                       170       180       190
                ....*....|....*....|....*....|....
gi 27501450 254 DEDDGRDaappgrLPQKLLLETA-APRVSSSRRY 286
Cdd:cd08730 136 DDANHEV------SRQTVLIPTQmSARLSNGLTS 163
RGS_PX cd08729
Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in ...
 93-208 8.22e-05

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188684  Cd Length: 136  Bit Score: 43.22  E-value: 8.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  93 LDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLA------------RAIYRKYILDNNGI--VSR 158
Cdd:cd08729   1 LRDPSSLSYFMEFMDRRNRSQLVQFWLVVEGFKNPLEDTENDYSLDSSQsrswidsdkediAMIYETYFSDPSPSlnVPK 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27501450 159 QTKPATKSFIKgCIMKQLIDP-------AMFdQAQTEIQATMEENTYPSFLKSDIYL 208
Cdd:cd08729  81 ASRDPIRLFLN-AGVNASPNEqyrkarrAVL-MAQRAVYEEMEEEDFPEFKKSELFY 135
RGS_GRK2_GRK3 cd08747
Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 ...
 98-212 3.83e-04

Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3); The RGS domain is an essential part of the GRK2 (G protein-coupled receptor kinases 2) and the GRK3 proteins, which are members of the beta-adrenergic receptor kinases subfamily. GRK2 and GRK3 are ubiquitously expressed and can phosphorylate many different GPCR. The C-terminus of GRK2 and 3 contains a plekstrin homology domain (PH) with binding sites for the membrane phospholipid PIP2 and free G#? subunits. These specific interactions could help to maintain a membrane-bound population of GRK2 prior to the agonist-dependent overt GRK2 translocation. GRK2 and GRK3 are members of the GRK kinase family which includes three major subfamilies: the GRK4 subfamily (GRK4, GRK5 and GRK6), the rhodopsin kinase or visual GRK subfamily (GRK1 and GRK7), and the beta-adrenergic receptor kinases subfamily (GRK2/GRK3). The RGS domain of the GRKs has very little sequence similarity with the canonical RGS domain of the RGS proteins and therefore is often refered to as the RH (RGS Homology) domain. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development.


Pssm-ID: 188701  Cd Length: 157  Bit Score: 41.96  E-value: 3.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  98 GISLFRTFLKQ--EGCADLLDFWFACTGFRKLEpcdsNEEKRLKLARAIYRKYILDNngIVSrQTKPATKS---FIKGCI 172
Cdd:cd08747  35 GYLLFKDFCENvsEEPVPQLKFYEEIKKYEKLD----TEEERIKKAREIYDNYIMKE--LLS-CSHPFSKSaveHVQKHL 107

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 27501450 173 MKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDiylEYTR 212
Cdd:cd08747 108 SKKEVPVDLFEPYIEEICDSLRGDVFQKFLESD---KFTR 144
RGS_SNX25 cd08720
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; ...
 92-207 5.50e-04

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 25 (SNX25) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX25 (Sorting Nexin 25) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX25 is a member of the Dopamine receptors (DAR) signalplex and regulates the trafficking of D1 and D2 DARs.


Pssm-ID: 188675  Cd Length: 110  Bit Score: 40.47  E-value: 5.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27501450  92 LLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRklepcDSNEEKRLKLARAIYRKYILDNNG--IVSRQTKPATKSFIK 169
Cdd:cd08720   1 ILANVFGRKYLSQFLERMDSQALIGFWEAVEELR-----SANKSEWHQLGAEIFYTFIVEPTAeiKVDKSLRKRIEQFLL 75

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 27501450 170 GCImkqliDPAMFDQAQTEIQATMEENTYPSFLKSDIY 207
Cdd:cd08720  76 GDK-----GPEVFYEVQENVVETLEEKYYPSFVVSDQY 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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