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Conserved domains on  [gi|117414150|ref|NP_003264|]
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delta(14)-sterol reductase TM7SF2 isoform 1 [Homo sapiens]

Protein Classification

phosphatidylethanolamine N-methyltransferase family domain-containing protein( domain architecture ID 229533)

phosphatidylethanolamine N-methyltransferase (PEMT) family domain-containing protein similar to Homo sapiens PEMT, which catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ICMT super family cl21511
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 73-418 5.82e-142

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


The actual alignment was detected with superfamily member pfam01222:

Pssm-ID: 473892  Cd Length: 429  Bit Score: 411.45  E-value: 5.82e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150   73 QAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAGLP-LGALPEMLLPLAFVATLTAFIFSLFLYMK 151
Cdd:pfam01222  81 QAVFYLTLPGKVVEGLPLSNGRKLPYKINAFWSFLLTLAAIGVLHYTQLFeLTYLYDNFVQIMSSAILFSFALAIYLYVR 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150  152 A-QVAPVSALAPGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQ 230
Cdd:pfam01222 161 SlKAPEEDKDAPGGNSGNLIYDFFIGRELNPRIGSLDIKMFFELRPGLLGWVFINLAALLKQYETYGYVTPSLLFVLLNQ 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150  231 LLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASV-ICLINATGYYIFRGANS 309
Cdd:pfam01222 241 LLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELGWSTYAVaIYALLLCGYYIFRSANS 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150  310 QKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREAR 389
Cdd:pfam01222 321 QKNNFRTNPADPKLIYLKYIQTKTGSGLLTDGWWGFARHINYLGDWLQSLSWSLPTGFNSVLPYFYPLYFAVLLVHREAR 400

                         330       340
                  ....*....|....*....|....*....
gi 117414150  390 DERQCLQKYGLAWQEYCRRVPYRIMPYIY 418
Cdd:pfam01222 401 DEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
 
Name Accession Description Interval E-value
ERG4_ERG24 pfam01222
Ergosterol biosynthesis ERG4/ERG24 family;
73-418 5.82e-142

Ergosterol biosynthesis ERG4/ERG24 family;


Pssm-ID: 250456  Cd Length: 429  Bit Score: 411.45  E-value: 5.82e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150   73 QAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAGLP-LGALPEMLLPLAFVATLTAFIFSLFLYMK 151
Cdd:pfam01222  81 QAVFYLTLPGKVVEGLPLSNGRKLPYKINAFWSFLLTLAAIGVLHYTQLFeLTYLYDNFVQIMSSAILFSFALAIYLYVR 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150  152 A-QVAPVSALAPGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQ 230
Cdd:pfam01222 161 SlKAPEEDKDAPGGNSGNLIYDFFIGRELNPRIGSLDIKMFFELRPGLLGWVFINLAALLKQYETYGYVTPSLLFVLLNQ 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150  231 LLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASV-ICLINATGYYIFRGANS 309
Cdd:pfam01222 241 LLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELGWSTYAVaIYALLLCGYYIFRSANS 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150  310 QKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREAR 389
Cdd:pfam01222 321 QKNNFRTNPADPKLIYLKYIQTKTGSGLLTDGWWGFARHINYLGDWLQSLSWSLPTGFNSVLPYFYPLYFAVLLVHREAR 400

                         330       340
                  ....*....|....*....|....*....
gi 117414150  390 DERQCLQKYGLAWQEYCRRVPYRIMPYIY 418
Cdd:pfam01222 401 DEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 334-417 2.43e-10

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 57.48  E-value: 2.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150 334 GRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCG-VSHLLPYFYLLYFTALLVHREardERQCLQKYGLAWQEYCRRVPyR 412
Cdd:COG2020   33 AHRLVTTGPYRYVRHPMYLGFLLLLLGLALLLGsLLALLLALLLLLLYVLRIRRE---ERRLRARFGEEYRAYAARVP-R 108


                 ....*
gi 117414150 413 IMPYI 417
Cdd:COG2020  109 LIPRL 113
 
Name Accession Description Interval E-value
ERG4_ERG24 pfam01222
Ergosterol biosynthesis ERG4/ERG24 family;
73-418 5.82e-142

Ergosterol biosynthesis ERG4/ERG24 family;


Pssm-ID: 250456  Cd Length: 429  Bit Score: 411.45  E-value: 5.82e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150   73 QAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAGLP-LGALPEMLLPLAFVATLTAFIFSLFLYMK 151
Cdd:pfam01222  81 QAVFYLTLPGKVVEGLPLSNGRKLPYKINAFWSFLLTLAAIGVLHYTQLFeLTYLYDNFVQIMSSAILFSFALAIYLYVR 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150  152 A-QVAPVSALAPGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQ 230
Cdd:pfam01222 161 SlKAPEEDKDAPGGNSGNLIYDFFIGRELNPRIGSLDIKMFFELRPGLLGWVFINLAALLKQYETYGYVTPSLLFVLLNQ 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150  231 LLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASV-ICLINATGYYIFRGANS 309
Cdd:pfam01222 241 LLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELGWSTYAVaIYALLLCGYYIFRSANS 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150  310 QKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREAR 389
Cdd:pfam01222 321 QKNNFRTNPADPKLIYLKYIQTKTGSGLLTDGWWGFARHINYLGDWLQSLSWSLPTGFNSVLPYFYPLYFAVLLVHREAR 400

                         330       340
                  ....*....|....*....|....*....
gi 117414150  390 DERQCLQKYGLAWQEYCRRVPYRIMPYIY 418
Cdd:pfam01222 401 DEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 334-417 2.43e-10

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 57.48  E-value: 2.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150 334 GRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCG-VSHLLPYFYLLYFTALLVHREardERQCLQKYGLAWQEYCRRVPyR 412
Cdd:COG2020   33 AHRLVTTGPYRYVRHPMYLGFLLLLLGLALLLGsLLALLLALLLLLLYVLRIRRE---ERRLRARFGEEYRAYAARVP-R 108


                 ....*
gi 117414150 413 IMPYI 417
Cdd:COG2020  109 LIPRL 113
COG3752 COG3752
Steroid 5-alpha reductase family enzyme [General function prediction only];
269-410 2.08e-03

Steroid 5-alpha reductase family enzyme [General function prediction only];


Pssm-ID: 442966  Cd Length: 264  Bit Score: 39.82  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117414150 269 FTYSLQAQFLLHHPQPLGLPMASVI-CLINATGYYIFRGANSQKNTFRKNPsdprvagletistATGRKLLVSGWWGMVR 347
Cdd:COG3752  121 WLVSLPVLAAAASPAPAPLGWLDVLgAALWLVGFAFEAVADAQLARFKADP-------------ANKGKVCDTGLWRYSR 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117414150 348 HPNYLGDL-----IMALAWSLPCG----VSHLLPYFYLLYFT--ALLvhreardERQCLQKYGlAWQEYCRRVP 410
Cdd:COG3752  188 HPNYFGEWlvwwgLALFALAAPPGwwtlIGPLLMTLLLLKVSgiPLL-------EKHMLESRP-AYREYQRRTS 253
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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