NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4506013|ref|NP_002703|]
View 

protein phosphatase 1 regulatory subunit 7 isoform 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 163-354 6.21e-40

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 140.69  E-value: 6.21e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  163 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRL 242
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  243 TKIEGLQNLVNLRELYLSHNGIEVIEGLENN--------NKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDL 314
Cdd:cd21340  81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDprslaalsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 4506013  315 DE-LKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 354
Cdd:cd21340 161 LDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 83-198 3.86e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 3.86e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   83 LNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLyDNQ--------IKKIENLEALTE-LEILDISFNL 153
Cdd:cd21340  53 LQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQrlppgeklTFDPRSLAALSNsLRVLNISGNN 131

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 4506013  154 LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQMLELGSNRI 198
Cdd:cd21340 132 IDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 163-354 6.21e-40

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 140.69  E-value: 6.21e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  163 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRL 242
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  243 TKIEGLQNLVNLRELYLSHNGIEVIEGLENN--------NKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDL 314
Cdd:cd21340  81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDprslaalsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 4506013  315 DE-LKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 354
Cdd:cd21340 161 LDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-312 5.11e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.88  E-value: 5.11e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   95 EVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNqikkiENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVN 173
Cdd:COG4886  71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  174 NKISKI-ENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQN-LDALTNLTVLSMQSNRLTKI-EGLQ 249
Cdd:COG4886 146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLA 225

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4506013  250 NLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWS 312
Cdd:COG4886 226 NLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 83-198 3.86e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 3.86e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   83 LNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLyDNQ--------IKKIENLEALTE-LEILDISFNL 153
Cdd:cd21340  53 LQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQrlppgeklTFDPRSLAALSNsLRVLNISGNN 131

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 4506013  154 LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQMLELGSNRI 198
Cdd:cd21340 132 IDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
LRR_9 pfam14580
Leucine-rich repeat;
123-244 8.06e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.38  E-value: 8.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013    123 RELDLYDNQIKKIENLEA-LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI-ENLSnlhqlqmlelgsnrira 200
Cdd:pfam14580  22 RELDLRGYKIPIIENLGAtLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLG----------------- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 4506013    201 ieniDTLTNLESLFLGKNKITKLQNLD---ALTNLTVLSMQSNRLTK 244
Cdd:pfam14580  85 ----EALPNLTELILTNNNLQELGDLDplaSLKKLTFLSLLRNPVTN 127
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 102-336 3.04e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 3.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   102 TLCLRQNLI--KCIENLEELQSLRELDLYDNQIK-KIEN-LEALTELEILDISFNLLrnIEGV----DKLTRLKKLFLVN 173
Cdd:PLN00113 144 TLDLSNNMLsgEIPNDIGSFSSLKVLDLGGNVLVgKIPNsLTNLTSLEFLTLASNQL--VGQIprelGQMKSLKWIYLGY 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   174 NKIS-----KIENLSNLHQLQMLElgSNRIRAI-ENIDTLTNLESLFLGKNKIT-----------KLQNLD--------- 227
Cdd:PLN00113 222 NNLSgeipyEIGGLTSLNHLDLVY--NNLTGPIpSSLGNLKNLQYLFLYQNKLSgpippsifslqKLISLDlsdnslsge 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   228 ------ALTNLTVLSMQSNRLT-KI-EGLQNLVNLRELYLSHNGI--EVIEGLENNNKLTMLDIASNRI-----KKIENI 292
Cdd:PLN00113 300 ipelviQLQNLEILHLFSNNFTgKIpVALTSLPRLQVLQLWSNKFsgEIPKNLGKHNNLTVLDLSTNNLtgeipEGLCSS 379

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 4506013   293 SHLTELQEFwmnDNLLESWSDLDeLKGARSLETVYLERNPLQKD 336
Cdd:PLN00113 380 GNLFKLILF---SNSLEGEIPKS-LGACRSLRRVRLQDNSFSGE 419
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 120-162 1.82e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 1.82e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 4506013    120 QSLRELDLYDNQIKKIENLEALTELEILDISFN-LLRNIEGVDK 162
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 336-354 3.86e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 34.20  E-value: 3.86e-03
                           10
                   ....*....|....*....
gi 4506013     336 DPQYRRKVMLALPSVRQID 354
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 163-354 6.21e-40

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 140.69  E-value: 6.21e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  163 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRL 242
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  243 TKIEGLQNLVNLRELYLSHNGIEVIEGLENN--------NKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDL 314
Cdd:cd21340  81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDprslaalsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 4506013  315 DE-LKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 354
Cdd:cd21340 161 LDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-312 5.11e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.88  E-value: 5.11e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   95 EVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNqikkiENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVN 173
Cdd:COG4886  71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  174 NKISKI-ENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQN-LDALTNLTVLSMQSNRLTKI-EGLQ 249
Cdd:COG4886 146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLA 225

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4506013  250 NLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWS 312
Cdd:COG4886 226 NLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-331 3.87e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.79  E-value: 3.87e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   68 DMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNlikciENLEELQSLRELDLYDNQIKKI-ENLEALTELEI 146
Cdd:COG4886  66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKE 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  147 LDISFNLLRNI-EGVDKLTRLKKLFLVNNKISKI-ENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKL 223
Cdd:COG4886 141 LDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDL 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  224 -QNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFW 302
Cdd:COG4886 221 pEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300

                       250       260
                ....*....|....*....|....*....
gi 4506013  303 MNDNLLESWSDLDELKGARSLETVYLERN 331
Cdd:COG4886 301 LLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-337 9.68e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 9.68e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  100 VKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNkiski 179
Cdd:COG4886  32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN----- 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  180 ENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKI-EGLQNLVNLRE 256
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKE 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  257 LYLSHNGIEVI-EGLENNNKLTMLDIASNRIKKI-ENISHLTELQEFWMNDNLLeswSDLDELKGARSLETVYLERNPLQ 334
Cdd:COG4886 187 LDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNNQLT 263


                ...
gi 4506013  335 KDP 337
Cdd:COG4886 264 DLP 266
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-325 2.94e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 2.94e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   82 DLNHYRIGKI-EGFEVLKKVKTLCLRQNLIKCI-ENLEELQSLRELDLYDNQIKKI-ENLEALTELEILDISFNLLRNI- 157
Cdd:COG4886 142 DLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLp 221

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  158 EGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKIT--KLQNLDALTNLTVL 235
Cdd:COG4886 222 EPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSL 301

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  236 SMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLD 315
Cdd:COG4886 302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381

                       250
                ....*....|
gi 4506013  316 ELKGARSLET 325
Cdd:COG4886 382 LALLLLTLLL 391
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
101-333 2.31e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 2.31e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  101 KTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE 180
Cdd:COG4886  11 KLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  181 NLSNLHQLQMLELGSNriraiENIDTLTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKI-EGLQNLVNLRELY 258
Cdd:COG4886  91 DLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLD 165

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4506013  259 LSHNGIEVI-EGLENNNKLTMLDIASNRIKKI-ENISHLTELQEFWMNDNLLESWSdlDELKGARSLETVYLERNPL 333
Cdd:COG4886 166 LSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-326 3.21e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 3.21e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   79 EDVDLNHYRIGKI-EGFEVLKKVKTLCLRQNLIKCI-ENLEELQSLRELDLYDNQIKKI-ENLEALTELEILDISFNLLR 155
Cdd:COG4886 162 KSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLT 241

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  156 NIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIR--AIENIDTLTNLESLFLGKNKITKLQNLDALTNLT 233
Cdd:COG4886 242 DLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  234 VLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSD 313
Cdd:COG4886 322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401

                       250
                ....*....|...
gi 4506013  314 LDELKGARSLETV 326
Cdd:COG4886 402 LLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 87-245 1.91e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 71.74  E-value: 1.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   87 RIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRL 166
Cdd:cd21340  35 KITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPGEKLTFDPRS 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  167 kklflvnnkiskIENLSNlhQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLD----ALTNLTVLSMQSNRL 242
Cdd:cd21340 115 ------------LAALSN--SLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdllsSWPSLRELDLTGNPV 180


                ...
gi 4506013  243 TKI 245
Cdd:cd21340 181 CKK 183
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 83-198 3.86e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.89  E-value: 3.86e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   83 LNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLyDNQ--------IKKIENLEALTE-LEILDISFNL 153
Cdd:cd21340  53 LQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQrlppgeklTFDPRSLAALSNsLRVLNISGNN 131

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 4506013  154 LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQMLELGSNRI 198
Cdd:cd21340 132 IDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
LRR_9 pfam14580
Leucine-rich repeat;
123-244 8.06e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.38  E-value: 8.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013    123 RELDLYDNQIKKIENLEA-LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI-ENLSnlhqlqmlelgsnrira 200
Cdd:pfam14580  22 RELDLRGYKIPIIENLGAtLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLG----------------- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 4506013    201 ieniDTLTNLESLFLGKNKITKLQNLD---ALTNLTVLSMQSNRLTK 244
Cdd:pfam14580  85 ----EALPNLTELILTNNNLQELGDLDplaSLKKLTFLSLLRNPVTN 127
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 69-340 1.00e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 56.34  E-value: 1.00e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   69 METINLDRDAEDVDLNHYRIGKiEGFEVLKKVktlcLRQNlikcienleelQSLRELDLYDNQIKKiENLEALteleild 148
Cdd:COG5238 173 MAKALQNNSVETVYLGCNQIGD-EGIEELAEA----LTQN-----------TTVTTLWLKRNPIGD-EGAEIL------- 228

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  149 isfnllrnIEGVDKLTRLKKLFLVNNKISK------IENLSNLHQLQMLELGSNRIRA------IENIDTLTNLESLFLG 216
Cdd:COG5238 229 --------AEALKGNKSLTTLDLSNNQIGDegvialAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLS 300

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  217 KNKITKlQNLDALtnltvlsmqsnrltkIEGLQNLVNLRELYLSHNGIEV------IEGLENNNKLTMLDIASNRI---- 286
Cdd:COG5238 301 VNRIGD-EGAIAL---------------AEGLQGNKTLHTLNLAYNGIGAqgaialAKALQENTTLHSLDLSDNQIgdeg 364

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4506013  287 -----KKIENISHLTELQEFWMNDNLLESWSDLDELKGARsLETVYLERNPLQKDPQYR 340
Cdd:COG5238 365 aialaKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQR 422
LRR_9 pfam14580
Leucine-rich repeat;
191-354 1.19e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 54.00  E-value: 1.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013    191 LELGSNRIRAIENID-TLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKI-EGL-QNLVNLRELYLSHNgievi 267
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNN----- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013    268 eglennnkltmldiasnrikkienisHLTELqefwmndnlleswSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLAL 347
Cdd:pfam14580  99 --------------------------NLQEL-------------GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKV 139


                  ....*..
gi 4506013    348 PSVRQID 354
Cdd:pfam14580 140 PQLRLLD 146
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
144-334 1.30e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 1.30e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  144 LEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKL 223
Cdd:COG4886  10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013  224 QNLDALTNLTVLSMQSNrltkiEGLQNLVNLRELYLSHNGIEVI-EGLENNNKLTMLDIASNRIKKI-ENISHLTELQEF 301
Cdd:COG4886  90 TDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSL 164

                       170       180       190
                ....*....|....*....|....*....|...
gi 4506013  302 WMNDNLLESWSdlDELKGARSLETVYLERNPLQ 334
Cdd:COG4886 165 DLSNNQLTDLP--EELGNLTNLKELDLSNNQIT 195
LRR_8 pfam13855
Leucine rich repeat;
230-286 1.01e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.01e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4506013    230 TNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRI 286
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
208-264 2.29e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.29e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4506013    208 TNLESLFLGKNKITKL--QNLDALTNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGI 264
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 102-336 3.04e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 3.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   102 TLCLRQNLI--KCIENLEELQSLRELDLYDNQIK-KIEN-LEALTELEILDISFNLLrnIEGV----DKLTRLKKLFLVN 173
Cdd:PLN00113 144 TLDLSNNMLsgEIPNDIGSFSSLKVLDLGGNVLVgKIPNsLTNLTSLEFLTLASNQL--VGQIprelGQMKSLKWIYLGY 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   174 NKIS-----KIENLSNLHQLQMLElgSNRIRAI-ENIDTLTNLESLFLGKNKIT-----------KLQNLD--------- 227
Cdd:PLN00113 222 NNLSgeipyEIGGLTSLNHLDLVY--NNLTGPIpSSLGNLKNLQYLFLYQNKLSgpippsifslqKLISLDlsdnslsge 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013   228 ------ALTNLTVLSMQSNRLT-KI-EGLQNLVNLRELYLSHNGI--EVIEGLENNNKLTMLDIASNRI-----KKIENI 292
Cdd:PLN00113 300 ipelviQLQNLEILHLFSNNFTgKIpVALTSLPRLQVLQLWSNKFsgEIPKNLGKHNNLTVLDLSTNNLtgeipEGLCSS 379

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 4506013   293 SHLTELQEFwmnDNLLESWSDLDeLKGARSLETVYLERNPLQKD 336
Cdd:PLN00113 380 GNLFKLILF---SNSLEGEIPKS-LGACRSLRRVRLQDNSFSGE 419
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 230-262 1.25e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 1.25e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 4506013    230 TNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN 262
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_8 pfam13855
Leucine rich repeat;
142-198 1.32e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.32e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4506013    142 TELEILDISFNLLRNIEGV--DKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRI 198
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 120-162 1.82e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 1.82e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 4506013    120 QSLRELDLYDNQIKKIENLEALTELEILDISFN-LLRNIEGVDK 162
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 208-250 1.95e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 1.95e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 4506013    208 TNLESLFLGKNKITKLQNLDALTNLTVLSMQSN-RLTKIEGLQN 250
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
164-220 4.42e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 4.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4506013    164 TRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKI 220
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 164-209 6.18e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 6.18e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 4506013    164 TRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIraIENIDTLTN 209
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
253-308 7.37e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 7.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506013    253 NLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDNLL 308
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 253-294 8.89e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 8.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 4506013    253 NLRELYLSHNGIEVIEGLENNNKLTMLDIASN-RIKKIENISH 294
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_9 pfam14580
Leucine-rich repeat;
81-156 1.14e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.36  E-value: 1.14e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4506013     81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCI-ENLEE-LQSLRELDLYDNQIKKIENLEALTELEILDiSFNLLRN 156
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGEaLPNLTELILTNNNLQELGDLDPLASLKKLT-FLSLLRN 123
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 142-184 1.26e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 4506013    142 TELEILDISFNLLRNIEGVDKLTRLKKLFLV-NNKISKIENLSN 184
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
120-176 2.70e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 2.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4506013    120 QSLRELDLYDNQIKKI--ENLEALTELEILDISFNLLRNIEGV--DKLTRLKKLFLVNNKI 176
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 98-139 3.17e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 3.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 4506013     98 KKVKTLCLRQNLIKCIENLEELQSLRELDLYDN-QIKKIENLE 139
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 336-354 3.86e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 34.20  E-value: 3.86e-03
                           10
                   ....*....|....*....
gi 4506013     336 DPQYRRKVMLALPSVRQID 354
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 187-227 5.78e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 5.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 4506013    187 QLQMLELGSNRIRAIENIDTLTNLESLFL-GKNKITKLQNLD 227
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITDLSDLA 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH