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Conserved domains on  [gi|66346695|ref|NP_001990|]
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fibrillin-2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 76-112 2.32e-15

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


:

Pssm-ID: 436338  Cd Length: 37  Bit Score: 71.85  E-value: 2.32e-15
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 66346695     76 RRGQQDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIV 112
Cdd:pfam18193    1 RRGGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1748-1791 1.56e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 61.14  E-value: 1.56e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 66346695   1748 TCENELPFNVTKRMCCCTYnVGKAWNKPCEPCPTPGTADFKTIC 1791
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 713-756 6.86e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.52  E-value: 6.86e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 66346695    713 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 756
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2111-2155 2.13e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.13e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 66346695   2111 GKCSVPKAFNTTKAKCCCSKMpGEGWGDPCELCPKDDEVAFQDLC 2155
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSV-GRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 373-417 6.38e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.82  E-value: 6.38e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 66346695    373 GRCAQELPGRMTKMQCCCE-PGRCWGIGtiPEACPVRGSEEYRRLC 417
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSP--CELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1010-1052 1.06e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.05  E-value: 1.06e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 66346695   1010 DECIHPVPGKFRMDACCCA-VGAAWGTECEECPKPGTKEYETLC 1052
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1412-1447 1.72e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.22  E-value: 1.72e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 66346695   1412 CSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC 1447
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2405-2437 7.03e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.74  E-value: 7.03e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 66346695   2405 VTKSECCCD-GGRGWGHQCELCPLPGTAQYKKIC 2437
Cdd:pfam00683   11 VTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1593-1633 8.22e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.74  E-value: 8.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 66346695   1593 CNTEIGVGVSRSSCCC-SLGKAWGNPCETCPPVNSTEYYTLC 1633
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1371-1406 6.15e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.90  E-value: 6.15e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 66346695   1371 CEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKC 1406
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1246-1281 1.50e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 1.50e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 66346695   1246 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC 1281
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2495-2530 4.64e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 4.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 66346695   2495 CSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTC 2530
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
658-698 7.39e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 7.39e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695     658 DVDECQTPGICMNG-HCINSEGSFRCDCPPGLavgMDGRVCV 698
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2213-2252 8.48e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 8.48e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 66346695    2213 DTDECSIGNPCGNG-TCTNVIGSFECNCNEGFEPGpmMNCE 2252
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1850-1882 1.51e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.51e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 66346695    1850 DIDECSNGdNLCQRNADCINSPGSYRCECAAGF 1882
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1934-1968 2.14e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.14e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 66346695    1934 DVDECE-RHPCGNG-TCKNTVGSYNCLCYPGFELTHN 1968
Cdd:smart00179    1 DIDECAsGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
2171-2212 3.07e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.07e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 66346695    2171 DVNEClESPGICSNG-QCINTDGSFRCECPMGYnldYTGVRCV 2212
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 906-935 3.92e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 40.34  E-value: 3.92e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 66346695    906 RCEVNINGATLKSECC-ATLGAAWGSPCERC 935
Cdd:pfam00683    2 RCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
575-616 4.05e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.05e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695     575 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFeltTDGKNCV 616
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1650-1691 5.54e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.54e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695    1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYylsEDTRICE 1691
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-845 6.98e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 6.98e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 66346695  810 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT 845
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1158-1190 8.46e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 8.46e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 66346695    1158 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1190
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
535-565 9.61e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 9.61e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 66346695     535 DVDECTS-NPCTNG-DCVNTPGSYYCKCHAGFQ 565
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2056-2096 1.27e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.27e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695    2056 DINECdEDPNICLFGS-CTNTPGGFQCLCPPGFVlsdNGRRC 2096
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1115-1149 1.41e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.41e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 66346695    1115 DIDECRiSPDLCGSG-ICVNTPGSFECECFEGYESG 1149
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1973-2015 1.51e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.51e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 66346695    1973 DIDECSSffGQVCRNG-RCFNEIGSFKCLCNEGYEltpDGKNCI 2015
Cdd:smart00179    1 DIDECAS--GNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 1887-1929 1.66e-03

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member cd01475:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 224  Bit Score: 42.76  E-value: 1.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 66346695 1887 NGACVDRNECLEIPNVCSHGlCVDLQGSYQCICHNGFKASQDQ 1929
Cdd:cd01475  181 GKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
EGF_CA smart00179
Calcium-binding EGF-like domain;
2614-2643 1.70e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.70e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 66346695    2614 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 2643
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1532-1563 1.79e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.79e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 66346695    1532 DIDECADPINCVNG-LCVNTPGRYECNCPPDFQ 1563
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
2532-2561 1.80e-03

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.80e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695   2532 DLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG 2561
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
617-657 1.88e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.88e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695     617 DHDECTTTNMCLNG-MCINEDGSFKCICKPGFVlapNGRYCT 657
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1200-1232 1.97e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.97e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 66346695    1200 DINECSlSDNLCRNG-KCVNMIGTYQCSCNPGYQ 1232
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1808-1840 2.33e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.33e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 66346695    1808 DIDECKEiPGICANG-VCINQIGSFRCECPTGFS 1840
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2449-2490 2.57e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.57e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 66346695    2449 DIDECKvMPNLCTNG-QCINTMGSFRCFCKVGYTtdiSGTSCI 2490
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
768-809 5.49e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.49e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 66346695     768 DINECAlDPDICANG-ICENLRGSYRCNCNSGYEpdaSGRNCI 809
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
955-985 5.63e-03

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 5.63e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695    955 DVNECEVFPGVCP-NGRCVNSKGSFHCECPEG 985
Cdd:pfam07645    1 DVDECATGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
276-306 5.68e-03

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 5.68e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695    276 DVDECQAIPGIC-QGGNCINTVGSFECRCPAG 306
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1491-1526 6.43e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 6.43e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 66346695    1491 DIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRT 1526
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 224-257 7.30e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.49  E-value: 7.30e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 66346695    224 MCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ 257
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2294-2326 8.26e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam07645:

Pssm-ID: 473889  Cd Length: 32  Bit Score: 36.06  E-value: 8.26e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 66346695   2294 DLDECAEGLHDCeSRGMMCKNLIGTFMCICPPG 2326
Cdd:pfam07645    1 DVDECATGTHNC-PANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2016-2048 8.90e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 8.90e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 66346695    2016 DTNECvALPGSCSPG-TCQNLEGSFRCICPPGYE 2048
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT 33
 
Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 76-112 2.32e-15

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


Pssm-ID: 436338  Cd Length: 37  Bit Score: 71.85  E-value: 2.32e-15
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 66346695     76 RRGQQDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIV 112
Cdd:pfam18193    1 RRGGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1748-1791 1.56e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 61.14  E-value: 1.56e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 66346695   1748 TCENELPFNVTKRMCCCTYnVGKAWNKPCEPCPTPGTADFKTIC 1791
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 713-756 6.86e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.52  E-value: 6.86e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 66346695    713 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 756
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2111-2155 2.13e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.13e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 66346695   2111 GKCSVPKAFNTTKAKCCCSKMpGEGWGDPCELCPKDDEVAFQDLC 2155
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSV-GRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 373-417 6.38e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.82  E-value: 6.38e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 66346695    373 GRCAQELPGRMTKMQCCCE-PGRCWGIGtiPEACPVRGSEEYRRLC 417
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSP--CELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1010-1052 1.06e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.05  E-value: 1.06e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 66346695   1010 DECIHPVPGKFRMDACCCA-VGAAWGTECEECPKPGTKEYETLC 1052
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1412-1447 1.72e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.22  E-value: 1.72e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 66346695   1412 CSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC 1447
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2405-2437 7.03e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.74  E-value: 7.03e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 66346695   2405 VTKSECCCD-GGRGWGHQCELCPLPGTAQYKKIC 2437
Cdd:pfam00683   11 VTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1593-1633 8.22e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.74  E-value: 8.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 66346695   1593 CNTEIGVGVSRSSCCC-SLGKAWGNPCETCPPVNSTEYYTLC 1633
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1371-1406 6.15e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.90  E-value: 6.15e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 66346695   1371 CEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKC 1406
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1246-1281 1.50e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 1.50e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 66346695   1246 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC 1281
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2495-2530 4.64e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 4.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 66346695   2495 CSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTC 2530
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
658-698 7.39e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 7.39e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695     658 DVDECQTPGICMNG-HCINSEGSFRCDCPPGLavgMDGRVCV 698
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2213-2252 8.48e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 8.48e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 66346695    2213 DTDECSIGNPCGNG-TCTNVIGSFECNCNEGFEPGpmMNCE 2252
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1850-1882 1.51e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.51e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 66346695    1850 DIDECSNGdNLCQRNADCINSPGSYRCECAAGF 1882
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2489-2529 2.09e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 45.45  E-value: 2.09e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 66346695 2489 CIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKT 2529
Cdd:cd01475  184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
1934-1968 2.14e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.14e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 66346695    1934 DVDECE-RHPCGNG-TCKNTVGSYNCLCYPGFELTHN 1968
Cdd:smart00179    1 DIDECAsGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 658-687 2.21e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.21e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 66346695  658 DVDECQTPGICMNGH-CINSEGSFRCDCPPG 687
Cdd:cd00054    1 DIDECASGNPCQNGGtCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1850-1884 2.51e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.51e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 66346695 1850 DIDECSNGdNLCQRNADCINSPGSYRCECAAGFKL 1884
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1408-1443 2.91e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 2.91e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 66346695 1408 DLDECSNGtHQCSINAQCVNTPGSYRCACSEGFTGD 1443
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
2171-2212 3.07e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.07e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 66346695    2171 DVNEClESPGICSNG-QCINTDGSFRCECPMGYnldYTGVRCV 2212
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1934-1967 3.21e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 3.21e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 66346695 1934 DVDECE-RHPCGN-GTCKNTVGSYNCLCYPGFELTH 1967
Cdd:cd00054    1 DIDECAsGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 906-935 3.92e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 40.34  E-value: 3.92e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 66346695    906 RCEVNINGATLKSECC-ATLGAAWGSPCERC 935
Cdd:pfam00683    2 RCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
575-616 4.05e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.05e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695     575 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFeltTDGKNCV 616
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1240-1280 4.99e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 44.30  E-value: 4.99e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 66346695 1240 CTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRS 1280
Cdd:cd01475  184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
1650-1691 5.54e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.54e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695    1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYylsEDTRICE 1691
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1408-1447 6.62e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 6.62e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 66346695    1408 DLDECSNGtHQCSINAQCVNTPGSYRCACSEGFTgDGFTC 1447
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-845 6.98e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 6.98e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 66346695  810 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT 845
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2213-2244 7.77e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 7.77e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 66346695 2213 DTDECSIGNPCGN-GTCTNVIGSFECNCNEGFE 2244
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1158-1190 8.46e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 8.46e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 66346695    1158 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1190
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
535-565 9.61e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 9.61e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 66346695     535 DVDECTS-NPCTNG-DCVNTPGSYYCKCHAGFQ 565
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1158-1191 1.01e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.01e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 66346695 1158 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHEL 1191
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
1850-1881 1.10e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 1.10e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695   1850 DIDECSNGDNLCQRNADCINSPGSYRCECAAG 1881
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2056-2096 1.27e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.27e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695    2056 DINECdEDPNICLFGS-CTNTPGGFQCLCPPGFVlsdNGRRC 2096
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1115-1149 1.41e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.41e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 66346695    1115 DIDECRiSPDLCGSG-ICVNTPGSFECECFEGYESG 1149
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1973-2015 1.51e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.51e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 66346695    1973 DIDECSSffGQVCRNG-RCFNEIGSFKCLCNEGYEltpDGKNCI 2015
Cdd:smart00179    1 DIDECAS--GNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
810-841 1.59e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.59e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 66346695     810 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGY 841
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1887-1929 1.66e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.76  E-value: 1.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 66346695 1887 NGACVDRNECLEIPNVCSHGlCVDLQGSYQCICHNGFKASQDQ 1929
Cdd:cd01475  181 GKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
EGF_CA smart00179
Calcium-binding EGF-like domain;
2614-2643 1.70e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.70e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 66346695    2614 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 2643
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2171-2212 1.71e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.71e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 66346695 2171 DVNEClESPGICSN-GQCINTDGSFRCECPMGynldYTGVRCV 2212
Cdd:cd00054    1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPG----YTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1532-1563 1.79e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.79e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 66346695    1532 DIDECADPINCVNG-LCVNTPGRYECNCPPDFQ 1563
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
2532-2561 1.80e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.80e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695   2532 DLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG 2561
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
617-657 1.88e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.88e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695     617 DHDECTTTNMCLNG-MCINEDGSFKCICKPGFVlapNGRYCT 657
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2527-2563 1.90e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.37  E-value: 1.90e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 66346695 2527 GKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFT 2563
Cdd:cd01475  181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYA 217
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1367-1401 1.90e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.90e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 66346695 1367 DVDECEIGaHNCDMHASCLNIPGSFKCSCREGWIG 1401
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 575-610 1.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.92e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 66346695  575 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTT 610
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1200-1232 1.97e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.97e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 66346695    1200 DINECSlSDNLCRNG-KCVNMIGTYQCSCNPGYQ 1232
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1650-1683 2.29e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.29e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 66346695 1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYL 1683
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1808-1840 2.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.33e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 66346695    1808 DIDECKEiPGICANG-VCINQIGSFRCECPTGFS 1840
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2449-2490 2.57e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.57e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 66346695    2449 DIDECKvMPNLCTNG-QCINTMGSFRCFCKVGYTtdiSGTSCI 2490
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 617-649 2.85e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.85e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 66346695  617 DHDECTTTNMCLN-GMCINEDGSFKCICKPGFVL 649
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 535-565 3.11e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 3.11e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 66346695  535 DVDECTS-NPCTN-GDCVNTPGSYYCKCHAGFQ 565
Cdd:cd00054    1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2056-2089 5.35e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.35e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 66346695 2056 DINECdEDPNICLF-GSCTNTPGGFQCLCPPGFVL 2089
Cdd:cd00054    1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
768-809 5.49e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.49e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 66346695     768 DINECAlDPDICANG-ICENLRGSYRCNCNSGYEpdaSGRNCI 809
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1532-1564 5.62e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.62e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 66346695 1532 DIDECADPINCVN-GLCVNTPGRYECNCPPDFQL 1564
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
955-985 5.63e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 5.63e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695    955 DVNECEVFPGVCP-NGRCVNSKGSFHCECPEG 985
Cdd:pfam07645    1 DVDECATGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
276-306 5.68e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 5.68e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695    276 DVDECQAIPGIC-QGGNCINTVGSFECRCPAG 306
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
276-306 5.77e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.77e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 66346695     276 DVDECqAIPGICQ-GGNCINTVGSFECRCPAG 306
Cdd:smart00179    1 DIDEC-ASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1200-1232 6.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 6.20e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 66346695 1200 DINECSlSDNLCRN-GKCVNMIGTYQCSCNPGYQ 1232
Cdd:cd00054    1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1491-1526 6.43e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 6.43e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 66346695    1491 DIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRT 1526
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA pfam07645
Calcium-binding EGF domain;
2171-2201 6.59e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 6.59e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695   2171 DVNECLESPGIC-SNGQCINTDGSFRCECPMG 2201
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1115-1145 6.99e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 6.99e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695   1115 DIDECRISPDLC-GSGICVNTPGSFECECFEG 1145
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2614-2644 7.26e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 7.26e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 66346695 2614 DVDECDGNHRCQHG--CQNILGGYRCGCPQGYI 2644
Cdd:cd00054    1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYT 33
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 224-257 7.30e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.49  E-value: 7.30e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 66346695    224 MCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ 257
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1491-1525 7.33e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 7.33e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 66346695 1491 DIDECSFQNICVF-GTCNNLPGMFHCICDDGYELDR 1525
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1367-1399 7.45e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.45e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 66346695    1367 DVDECEIGaHNCDMHASCLNIPGSFKCSCREGW 1399
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
2294-2326 8.26e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 8.26e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 66346695   2294 DLDECAEGLHDCeSRGMMCKNLIGTFMCICPPG 2326
Cdd:pfam07645    1 DVDECATGTHNC-PANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1808-1840 8.67e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 8.67e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 66346695 1808 DIDECKEIPGICANGVCINQIGSFRCECPTGFS 1840
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2016-2048 8.90e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 8.90e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 66346695    2016 DTNECvALPGSCSPG-TCQNLEGSFRCICPPGYE 2048
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1808-1838 9.02e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 9.02e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695   1808 DIDECKEIPGIC-ANGVCINQIGSFRCECPTG 1838
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 76-112 2.32e-15

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


Pssm-ID: 436338  Cd Length: 37  Bit Score: 71.85  E-value: 2.32e-15
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 66346695     76 RRGQQDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIV 112
Cdd:pfam18193    1 RRGGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1748-1791 1.56e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 61.14  E-value: 1.56e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 66346695   1748 TCENELPFNVTKRMCCCTYnVGKAWNKPCEPCPTPGTADFKTIC 1791
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 713-756 6.86e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.52  E-value: 6.86e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 66346695    713 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 756
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2111-2155 2.13e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 54.98  E-value: 2.13e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 66346695   2111 GKCSVPKAFNTTKAKCCCSKMpGEGWGDPCELCPKDDEVAFQDLC 2155
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSV-GRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 373-417 6.38e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.82  E-value: 6.38e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 66346695    373 GRCAQELPGRMTKMQCCCE-PGRCWGIGtiPEACPVRGSEEYRRLC 417
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSP--CELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1010-1052 1.06e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.05  E-value: 1.06e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 66346695   1010 DECIHPVPGKFRMDACCCA-VGAAWGTECEECPKPGTKEYETLC 1052
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1412-1447 1.72e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.22  E-value: 1.72e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 66346695   1412 CSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC 1447
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2405-2437 7.03e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.74  E-value: 7.03e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 66346695   2405 VTKSECCCD-GGRGWGHQCELCPLPGTAQYKKIC 2437
Cdd:pfam00683   11 VTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1593-1633 8.22e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.74  E-value: 8.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 66346695   1593 CNTEIGVGVSRSSCCC-SLGKAWGNPCETCPPVNSTEYYTLC 1633
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1371-1406 6.15e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.90  E-value: 6.15e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 66346695   1371 CEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKC 1406
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1246-1281 1.50e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 1.50e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 66346695   1246 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC 1281
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1367-1398 2.10e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.38  E-value: 2.10e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695   1367 DVDECEIGAHNCDMHASCLNIPGSFKCSCREG 1398
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2495-2530 4.64e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 4.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 66346695   2495 CSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTC 2530
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
658-698 7.39e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 7.39e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695     658 DVDECQTPGICMNG-HCINSEGSFRCDCPPGLavgMDGRVCV 698
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2213-2252 8.48e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 8.48e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 66346695    2213 DTDECSIGNPCGNG-TCTNVIGSFECNCNEGFEPGpmMNCE 2252
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1850-1882 1.51e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.51e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 66346695    1850 DIDECSNGdNLCQRNADCINSPGSYRCECAAGF 1882
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2489-2529 2.09e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 45.45  E-value: 2.09e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 66346695 2489 CIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKT 2529
Cdd:cd01475  184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
1934-1968 2.14e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.14e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 66346695    1934 DVDECE-RHPCGNG-TCKNTVGSYNCLCYPGFELTHN 1968
Cdd:smart00179    1 DIDECAsGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 658-687 2.21e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.21e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 66346695  658 DVDECQTPGICMNGH-CINSEGSFRCDCPPG 687
Cdd:cd00054    1 DIDECASGNPCQNGGtCVNTVGSYRCSCPPG 31
EGF_CA pfam07645
Calcium-binding EGF domain;
1408-1439 2.40e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 2.40e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695   1408 DLDECSNGTHQCSINAQCVNTPGSYRCACSEG 1439
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1850-1884 2.51e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.51e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 66346695 1850 DIDECSNGdNLCQRNADCINSPGSYRCECAAGFKL 1884
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1408-1443 2.91e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 2.91e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 66346695 1408 DLDECSNGtHQCSINAQCVNTPGSYRCACSEGFTGD 1443
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
2171-2212 3.07e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.07e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 66346695    2171 DVNEClESPGICSNG-QCINTDGSFRCECPMGYnldYTGVRCV 2212
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1934-1967 3.21e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 3.21e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 66346695 1934 DVDECE-RHPCGN-GTCKNTVGSYNCLCYPGFELTH 1967
Cdd:cd00054    1 DIDECAsGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 906-935 3.92e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 40.34  E-value: 3.92e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 66346695    906 RCEVNINGATLKSECC-ATLGAAWGSPCERC 935
Cdd:pfam00683    2 RCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
575-616 4.05e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 4.05e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695     575 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFeltTDGKNCV 616
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1240-1280 4.99e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 44.30  E-value: 4.99e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 66346695 1240 CTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRS 1280
Cdd:cd01475  184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
1650-1691 5.54e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.54e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695    1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYylsEDTRICE 1691
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1408-1447 6.62e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 6.62e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 66346695    1408 DLDECSNGtHQCSINAQCVNTPGSYRCACSEGFTgDGFTC 1447
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNC 38
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1847-1888 6.93e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.91  E-value: 6.93e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 66346695 1847 VCEDIDECSNGDNLCQRNadCINSPGSYRCECAAGFKLSPNG 1888
Cdd:cd01475  183 ICVVPDLCATLSHVCQQV--CISTPGSYLCACTEGYALLEDN 222
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-845 6.98e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 6.98e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 66346695  810 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT 845
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2213-2244 7.77e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 7.77e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 66346695 2213 DTDECSIGNPCGN-GTCTNVIGSFECNCNEGFE 2244
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1158-1190 8.46e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 8.46e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 66346695    1158 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1190
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1406-1441 9.36e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.53  E-value: 9.36e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 66346695 1406 CIDLDECSNGTHQCsinAQ-CVNTPGSYRCACSEGFT 1441
Cdd:cd01475  184 CVVPDLCATLSHVC---QQvCISTPGSYLCACTEGYA 217
EGF_CA smart00179
Calcium-binding EGF-like domain;
535-565 9.61e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 9.61e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 66346695     535 DVDECTS-NPCTNG-DCVNTPGSYYCKCHAGFQ 565
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1158-1191 1.01e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.01e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 66346695 1158 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHEL 1191
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
1850-1881 1.10e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 1.10e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695   1850 DIDECSNGDNLCQRNADCINSPGSYRCECAAG 1881
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2056-2096 1.27e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.27e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695    2056 DINECdEDPNICLFGS-CTNTPGGFQCLCPPGFVlsdNGRRC 2096
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1115-1149 1.41e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.41e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 66346695    1115 DIDECRiSPDLCGSG-ICVNTPGSFECECFEGYESG 1149
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1973-2015 1.51e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.51e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 66346695    1973 DIDECSSffGQVCRNG-RCFNEIGSFKCLCNEGYEltpDGKNCI 2015
Cdd:smart00179    1 DIDECAS--GNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
810-841 1.59e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.59e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 66346695     810 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGY 841
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1887-1929 1.66e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.76  E-value: 1.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 66346695 1887 NGACVDRNECLEIPNVCSHGlCVDLQGSYQCICHNGFKASQDQ 1929
Cdd:cd01475  181 GKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
EGF_CA smart00179
Calcium-binding EGF-like domain;
2614-2643 1.70e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.70e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 66346695    2614 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 2643
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2171-2212 1.71e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.71e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 66346695 2171 DVNEClESPGICSN-GQCINTDGSFRCECPMGynldYTGVRCV 2212
Cdd:cd00054    1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPG----YTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1532-1563 1.79e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.79e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 66346695    1532 DIDECADPINCVNG-LCVNTPGRYECNCPPDFQ 1563
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
2532-2561 1.80e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.80e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695   2532 DLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG 2561
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
617-657 1.88e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.88e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 66346695     617 DHDECTTTNMCLNG-MCINEDGSFKCICKPGFVlapNGRYCT 657
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2527-2563 1.90e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.37  E-value: 1.90e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 66346695 2527 GKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFT 2563
Cdd:cd01475  181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYA 217
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1367-1401 1.90e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.90e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 66346695 1367 DVDECEIGaHNCDMHASCLNIPGSFKCSCREGWIG 1401
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 575-610 1.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.92e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 66346695  575 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTT 610
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1200-1232 1.97e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.97e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 66346695    1200 DINECSlSDNLCRNG-KCVNMIGTYQCSCNPGYQ 1232
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1650-1683 2.29e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.29e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 66346695 1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYL 1683
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
1808-1840 2.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.33e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 66346695    1808 DIDECKEiPGICANG-VCINQIGSFRCECPTGFS 1840
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2449-2490 2.57e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.57e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 66346695    2449 DIDECKvMPNLCTNG-QCINTMGSFRCFCKVGYTtdiSGTSCI 2490
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 617-649 2.85e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.85e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 66346695  617 DHDECTTTNMCLN-GMCINEDGSFKCICKPGFVL 649
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 535-565 3.11e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 3.11e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 66346695  535 DVDECTS-NPCTN-GDCVNTPGSYYCKCHAGFQ 565
Cdd:cd00054    1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2056-2089 5.35e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.35e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 66346695 2056 DINECdEDPNICLF-GSCTNTPGGFQCLCPPGFVL 2089
Cdd:cd00054    1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
768-809 5.49e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.49e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 66346695     768 DINECAlDPDICANG-ICENLRGSYRCNCNSGYEpdaSGRNCI 809
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1532-1564 5.62e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.62e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 66346695 1532 DIDECADPINCVN-GLCVNTPGRYECNCPPDFQL 1564
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
955-985 5.63e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 5.63e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695    955 DVNECEVFPGVCP-NGRCVNSKGSFHCECPEG 985
Cdd:pfam07645    1 DVDECATGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
276-306 5.68e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 5.68e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695    276 DVDECQAIPGIC-QGGNCINTVGSFECRCPAG 306
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
276-306 5.77e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.77e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 66346695     276 DVDECqAIPGICQ-GGNCINTVGSFECRCPAG 306
Cdd:smart00179    1 DIDEC-ASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1200-1232 6.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 6.20e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 66346695 1200 DINECSlSDNLCRN-GKCVNMIGTYQCSCNPGYQ 1232
Cdd:cd00054    1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1491-1526 6.43e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 6.43e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 66346695    1491 DIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRT 1526
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA pfam07645
Calcium-binding EGF domain;
2171-2201 6.59e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 6.59e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695   2171 DVNECLESPGIC-SNGQCINTDGSFRCECPMG 2201
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1115-1145 6.99e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 6.99e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695   1115 DIDECRISPDLC-GSGICVNTPGSFECECFEG 1145
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2614-2644 7.26e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 7.26e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 66346695 2614 DVDECDGNHRCQHG--CQNILGGYRCGCPQGYI 2644
Cdd:cd00054    1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYT 33
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 224-257 7.30e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.49  E-value: 7.30e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 66346695    224 MCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ 257
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1491-1525 7.33e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 7.33e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 66346695 1491 DIDECSFQNICVF-GTCNNLPGMFHCICDDGYELDR 1525
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1367-1399 7.45e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.45e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 66346695    1367 DVDECEIGaHNCDMHASCLNIPGSFKCSCREGW 1399
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA pfam07645
Calcium-binding EGF domain;
2294-2326 8.26e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 8.26e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 66346695   2294 DLDECAEGLHDCeSRGMMCKNLIGTFMCICPPG 2326
Cdd:pfam07645    1 DVDECATGTHNC-PANTVCVNTIGSFECRCPDG 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1365-1400 8.58e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.45  E-value: 8.58e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 66346695 1365 CTDVDECEIGAHNCDmHAsCLNIPGSFKCSCREGWI 1400
Cdd:cd01475  184 CVVPDLCATLSHVCQ-QV-CISTPGSYLCACTEGYA 217
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1808-1840 8.67e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 8.67e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 66346695 1808 DIDECKEIPGICANGVCINQIGSFRCECPTGFS 1840
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 2514-2535 8.76e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.85  E-value: 8.76e-03
                           10        20
                   ....*....|....*....|..
gi 66346695   2514 QCSCPRGYVLQEDGKTCKDLDE 2535
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA smart00179
Calcium-binding EGF-like domain;
2016-2048 8.90e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 8.90e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 66346695    2016 DTNECvALPGSCSPG-TCQNLEGSFRCICPPGYE 2048
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1808-1838 9.02e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 9.02e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 66346695   1808 DIDECKEIPGIC-ANGVCINQIGSFRCECPTG 1838
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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