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Conserved domains on  [gi|2329567114|ref|NP_001401180|]
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low-density lipoprotein receptor-related protein 6 isoform h [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 592-627 1.88e-13

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 65.73  E-value: 1.88e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2329567114  592 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 627
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1205-1239 2.13e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 65.31  E-value: 2.13e-13
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567114 1205 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1239
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 150-191 2.01e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 62.95  E-value: 2.01e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  150 GFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDY 191
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 286-323 2.55e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 62.26  E-value: 2.55e-12
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2329567114  286 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLENGKTC 323
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 893-929 3.13e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 62.26  E-value: 3.13e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2329567114  893 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 929
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 483-524 4.36e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 4.36e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567114   483 VLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGR 524
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 397-437 1.04e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 1.04e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567114   397 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 437
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 458-499 1.88e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 59.87  E-value: 1.88e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  458 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 499
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 697-739 5.65e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 5.65e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567114   697 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 739
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
654-813 1.98e-10

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 62.79  E-value: 1.98e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  654 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 733
Cdd:COG3391     60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  734 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 806
Cdd:COG3391    137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                   ....*..
gi 2329567114  807 WTDLDTN 813
Cdd:COG3391    214 VANRGSN 220
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 175-216 1.49e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 1.49e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567114   175 IIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNR 216
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 89-127 1.64e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.83  E-value: 1.64e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2329567114    89 VVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGS 127
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 353-393 4.13e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 4.13e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567114   353 VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG 393
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1094-1136 7.81e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 7.81e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567114  1094 EVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR 1136
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1-204 1.52e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 1.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114    1 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGL----IYWSDVSEEAIK 76
Cdd:COG3391     14 AVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRVS 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114   77 RTEFNKTESVQNVVVSGllSPDGLACDWLGEKLYWTDSETNRIEVsnLDGSLRKVL-FWQELDQPRAIALDPSSGFMYWT 155
Cdd:COG3391     94 VIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVA 169

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2329567114  156 DWG--EVPKIERAgMDGSSRFII--INSEIYwPNGLTLDYEEQKLYWADAKLN 204
Cdd:COG3391    170 NSGsnTVSVIVSV-IDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANRGSN 220
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 827-866 1.09e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 1.09e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567114   827 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 866
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 958-998 3.25e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.51  E-value: 3.25e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567114   958 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 998
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 525-558 3.69e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.51  E-value: 3.69e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2329567114   525 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 558
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 217-251 1.18e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.97  E-value: 1.18e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2329567114   217 QAVVKGSLPHP--FALTLFEDILYWTDWSTHSILACN 251
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1069-1110 1.31e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 1.31e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114 1069 GYMYFTNLQERsPKIERAALDGTEREVLFFSGLSKPIALALD 1110
Cdd:pfam00058    1 GRLYWTDSSLR-ASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
968-1075 1.37e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.99  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  968 RAIDYDPLDKQLYWIDSRQNMIRKAqeDGSQGftVVVSSVPsqnLEIQPYDLSIDIYSRYIYWTCEATN---VInVTRLD 1044
Cdd:COG3391    113 RGLAVDPDGGRLYVADSGNGRVSVI--DTATG--KVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsVI-VSVID 184

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2329567114 1045 GRSvGVVLK--GEQDRPRAVVVNPEKGYMYFTN 1075
Cdd:COG3391    185 TAT-GKVVAtiPVGGGPVGVAVSPDGRRLYVAN 216
 
Name Accession Description Interval E-value
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 592-627 1.88e-13

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 65.73  E-value: 1.88e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2329567114  592 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 627
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1205-1239 2.13e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 65.31  E-value: 2.13e-13
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567114 1205 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1239
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 150-191 2.01e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 62.95  E-value: 2.01e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  150 GFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDY 191
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 286-323 2.55e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 62.26  E-value: 2.55e-12
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2329567114  286 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLENGKTC 323
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 893-929 3.13e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 62.26  E-value: 3.13e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2329567114  893 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 929
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 483-524 4.36e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 4.36e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567114   483 VLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGR 524
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 397-437 1.04e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 1.04e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567114   397 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 437
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 458-499 1.88e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 59.87  E-value: 1.88e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  458 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 499
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 697-739 5.65e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 5.65e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567114   697 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 739
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1205-1236 6.92e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 6.92e-11
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2329567114  1205 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1236
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 438-481 1.94e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 1.94e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2329567114   438 KILISEDLEEPRAIVLDPMVGYMYWTDWGEiPKIERAALDGSDR 481
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
654-813 1.98e-10

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 62.79  E-value: 1.98e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  654 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 733
Cdd:COG3391     60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  734 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 806
Cdd:COG3391    137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                   ....*..
gi 2329567114  807 WTDLDTN 813
Cdd:COG3391    214 VANRGSN 220
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 175-216 1.49e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 1.49e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567114   175 IIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNR 216
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1205-1239 1.64e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.56  E-value: 1.64e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567114 1205 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1239
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 130-173 3.14e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.76  E-value: 3.14e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2329567114   130 KVLFWQELDQPRAIALDPSSGFMYWTDWGEvPKIERAGMDGSSR 173
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 361-523 1.09e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 58.10  E-value: 1.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  361 HAIAIDYDpveGYIYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 435
Cdd:cd05819     58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  436 MRKIL-----ISEDLEEPRAIVLDPmVGYMYWTDWgeipkieraaldGSDRVVLVNT----------------SLGWPNG 494
Cdd:cd05819    134 FLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADT------------GNHRIQVFDPdgnflttfgstgtgpgQFNYPTG 200

                          170       180
                   ....*....|....*....|....*....
gi 2329567114  495 LALDyDEGKIYWGDAKTDKIEVMNTDGTG 523
Cdd:cd05819    201 IAVD-SDGNIYVADSGNNRVQVFDPDGAG 228
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 89-127 1.64e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.83  E-value: 1.64e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2329567114    89 VVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGS 127
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 740-783 3.60e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 3.60e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2329567114   740 QVLVWKDLDSPRALALDPAEGFMYWTEWgGKPKIDRAAMDGSER 783
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
361-528 5.40e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.47  E-value: 5.40e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  361 HAIAIDYDPVEGYIYWTDDEVRAIrrSFIDGSGSQFVVT-AQIAHPDGIAVDWVARNLYWTDTGTDRieVTRLNGTMRKI 439
Cdd:COG3391     69 DADGADAGADGRRLYVANSGSGRV--SVIDLATGKVVATiPVGGGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKV 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  440 LISEDL-EEPRAIVLDPMVGYMYWTDWG--EIPKIErAALDGSDRVVLVNTSLG-WPNGLALDYDEGKIYWGDAKTDKie 515
Cdd:COG3391    145 VATIPVgAGPHGIAVDPDGKRLYVANSGsnTVSVIV-SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT-- 221

                          170
                   ....*....|...
gi 2329567114  516 vmnTDGTGRRVLV 528
Cdd:COG3391    222 ---SNGGSNTVSV 231
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 415-455 1.43e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 1.43e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  415 RNLYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPRAIVLDP 455
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 107-147 1.81e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 1.81e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  107 EKLYWTDSET-NRIEVSNLDGSLRKVLFWQELDQPRAIALDP 147
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 353-393 4.13e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 4.13e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567114   353 VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG 393
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1094-1136 7.81e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 7.81e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567114  1094 EVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR 1136
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 760-800 2.22e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.61  E-value: 2.22e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  760 GFMYWTEWGGKPKIDRAAMDGSER-TTLVPNVGRANGLTIDY 800
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 699-813 1.25e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 48.36  E-value: 1.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  699 VVEF-GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLD-GQHRQ-VLVWKDLDSPRALALDPAeGFMYWTEWGGKPKIDR 775
Cdd:cd14952      3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVYVTDFGNNRVLKL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2329567114  776 AAmdGSERTTLVP--NVGRANGLTIDyAKRRLYWTDLDTN 813
Cdd:cd14952     79 AA--GSTTQTVLPftGLNDPTGVAVD-AAGNVYVADTGNN 115
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1-204 1.52e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 1.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114    1 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGL----IYWSDVSEEAIK 76
Cdd:COG3391     14 AVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRVS 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114   77 RTEFNKTESVQNVVVSGllSPDGLACDWLGEKLYWTDSETNRIEVsnLDGSLRKVL-FWQELDQPRAIALDPSSGFMYWT 155
Cdd:COG3391     94 VIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVA 169

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2329567114  156 DWG--EVPKIERAgMDGSSRFII--INSEIYwPNGLTLDYEEQKLYWADAKLN 204
Cdd:COG3391    170 NSGsnTVSVIVSV-IDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANRGSN 220
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 718-757 6.32e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.38  E-value: 6.32e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2329567114  718 NLYWADTGT-NRIEVSKLDGQHRQVLVWKDLDSPRALALDP 757
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 827-866 1.09e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 1.09e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567114   827 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 866
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 55-272 3.15e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.23  E-value: 3.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114   55 AVDfvfSHGLIYWSDVSEEAIKRteFNK-TESVQNVVVSG-----LLSPDGLACDWLGEkLYWTDSETNRIEVSNLDGSL 128
Cdd:cd05819     14 AVD---SSGNIYVADTGNNRIQV--FDPdGNFITSFGSFGsgdgqFNEPAGVAVDSDGN-LYVADTGNHRIQKFDPDGNF 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  129 RKV-----LFWQELDQPRAIALDpSSGFMYWTDWGEVpKIERAGMDGSSRFII-----INSEIYWPNGLTLDyEEQKLYW 198
Cdd:cd05819     88 LASfggsgDGDGEFNGPRGIAVD-SSGNIYVADTGNH-RIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVD-SDGNIYV 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  199 ADAKLNFIHKSNLDGT-----NRQAVVKGSLPHPFALTLFED-ILYWTDWSTHSILacnKYTGEGLREI--------HSD 264
Cdd:cd05819    165 ADTGNHRIQVFDPDGNflttfGSTGTGPGQFNYPTGIAVDSDgNIYVADSGNNRVQ---VFDPDGAGFGgngnflgsDGQ 241


                   ....*...
gi 2329567114  265 IFSPMDIH 272
Cdd:cd05819    242 FNRPSGLA 249
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 958-998 3.25e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.51  E-value: 3.25e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567114   958 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 998
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 525-558 3.69e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.51  E-value: 3.69e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2329567114   525 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 558
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 372-412 5.39e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.07  E-value: 5.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  372 GYIYWTDDEVRA-IRRSFIDGSGSQFVVTAQIAHPDGIAVDW 412
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 217-251 1.18e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.97  E-value: 1.18e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2329567114   217 QAVVKGSLPHP--FALTLFEDILYWTDWSTHSILACN 251
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1069-1110 1.31e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 1.31e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114 1069 GYMYFTNLQERsPKIERAALDGTEREVLFFSGLSKPIALALD 1110
Cdd:pfam00058    1 GRLYWTDSSLR-ASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
968-1075 1.37e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.99  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  968 RAIDYDPLDKQLYWIDSRQNMIRKAqeDGSQGftVVVSSVPsqnLEIQPYDLSIDIYSRYIYWTCEATN---VInVTRLD 1044
Cdd:COG3391    113 RGLAVDPDGGRLYVADSGNGRVSVI--DTATG--KVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsVI-VSVID 184

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2329567114 1045 GRSvGVVLK--GEQDRPRAVVVNPEKGYMYFTN 1075
Cdd:COG3391    185 TAT-GKVVAtiPVGGGPVGVAVSPDGRRLYVAN 216
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1114-1154 1.61e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 1.61e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114 1114 GKLFWADSDLR-RIESSDLSGANRIVLEDSNILQPVGLTVFE 1154
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 704-758 5.83e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 40.38  E-value: 5.83e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2329567114  704 LDYPEGMAVDWLGkNLYWADTGTNRIevSKLDGQHRQVLVW-------KDLDSPRALALDPA 758
Cdd:cd05819     54 FNEPAGVAVDSDG-NLYVADTGNHRI--QKFDPDGNFLASFggsgdgdGEFNGPRGIAVDSS 112
 
Name Accession Description Interval E-value
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 592-627 1.88e-13

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 65.73  E-value: 1.88e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2329567114  592 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC 627
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1205-1239 2.13e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 65.31  E-value: 2.13e-13
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567114 1205 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1239
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 150-191 2.01e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 62.95  E-value: 2.01e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  150 GFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDY 191
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 286-323 2.55e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 62.26  E-value: 2.55e-12
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2329567114  286 CGIDNGGCSHLCLMSPVKpfYQCACPTGVKLLENGKTC 323
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGG--YTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 893-929 3.13e-12

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 62.26  E-value: 3.13e-12
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2329567114  893 CASSNGHCSHLCLAVPvGGFVCGCPAHYSLNADNRTC 929
Cdd:pfam14670    1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 483-524 4.36e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 4.36e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567114   483 VLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGR 524
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 397-437 1.04e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 60.69  E-value: 1.04e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567114   397 VVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMR 437
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 458-499 1.88e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 59.87  E-value: 1.88e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  458 GYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDY 499
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 697-739 5.65e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 5.65e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567114   697 EHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHR 739
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 1205-1236 6.92e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 6.92e-11
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2329567114  1205 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1236
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 438-481 1.94e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 1.94e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2329567114   438 KILISEDLEEPRAIVLDPMVGYMYWTDWGEiPKIERAALDGSDR 481
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
654-813 1.98e-10

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 62.79  E-value: 1.98e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  654 VAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGKNLYWADTGTNRieVSK 733
Cdd:COG3391     60 LGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGR--VSV 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  734 LDGQHRQVL-VWKDLDSPRALALDPAEGFMYWTEWGGKP------KIDRAAMdgsERTTLVPNVGRANGLTIDYAKRRLY 806
Cdd:COG3391    137 IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNTvsvivsVIDTATG---KVVATIPVGGGPVGVAVSPDGRRLY 213


                   ....*..
gi 2329567114  807 WTDLDTN 813
Cdd:COG3391    214 VANRGSN 220
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 175-216 1.49e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 1.49e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567114   175 IIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNR 216
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1205-1239 1.64e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.56  E-value: 1.64e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2329567114 1205 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1239
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 130-173 3.14e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.76  E-value: 3.14e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2329567114   130 KVLFWQELDQPRAIALDPSSGFMYWTDWGEvPKIERAGMDGSSR 173
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 361-523 1.09e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 58.10  E-value: 1.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  361 HAIAIDYDpveGYIYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 435
Cdd:cd05819     58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  436 MRKIL-----ISEDLEEPRAIVLDPmVGYMYWTDWgeipkieraaldGSDRVVLVNT----------------SLGWPNG 494
Cdd:cd05819    134 FLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADT------------GNHRIQVFDPdgnflttfgstgtgpgQFNYPTG 200

                          170       180
                   ....*....|....*....|....*....
gi 2329567114  495 LALDyDEGKIYWGDAKTDKIEVMNTDGTG 523
Cdd:cd05819    201 IAVD-SDGNIYVADSGNNRVQVFDPDGAG 228
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 89-127 1.64e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.83  E-value: 1.64e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2329567114    89 VVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGS 127
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 740-783 3.60e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.68  E-value: 3.60e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2329567114   740 QVLVWKDLDSPRALALDPAEGFMYWTEWgGKPKIDRAAMDGSER 783
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
361-528 5.40e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.47  E-value: 5.40e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  361 HAIAIDYDPVEGYIYWTDDEVRAIrrSFIDGSGSQFVVT-AQIAHPDGIAVDWVARNLYWTDTGTDRieVTRLNGTMRKI 439
Cdd:COG3391     69 DADGADAGADGRRLYVANSGSGRV--SVIDLATGKVVATiPVGGGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKV 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  440 LISEDL-EEPRAIVLDPMVGYMYWTDWG--EIPKIErAALDGSDRVVLVNTSLG-WPNGLALDYDEGKIYWGDAKTDKie 515
Cdd:COG3391    145 VATIPVgAGPHGIAVDPDGKRLYVANSGsnTVSVIV-SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT-- 221

                          170
                   ....*....|...
gi 2329567114  516 vmnTDGTGRRVLV 528
Cdd:COG3391    222 ---SNGGSNTVSV 231
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 783-825 1.26e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.14  E-value: 1.26e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567114   783 RTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNR 825
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 415-455 1.43e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.08  E-value: 1.43e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  415 RNLYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPRAIVLDP 455
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 107-147 1.81e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 1.81e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  107 EKLYWTDSET-NRIEVSNLDGSLRKVLFWQELDQPRAIALDP 147
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 353-393 4.13e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 4.13e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567114   353 VLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG 393
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1094-1136 7.81e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 7.81e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2329567114  1094 EVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR 1136
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 55-208 1.38e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 51.55  E-value: 1.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114   55 AVDfvfSHGLIYWSDVSEEAIKRteFNKTESVQNVVVSG------LLSPDGLACDWLGeKLYWTDSETNRIEVSNLDGSL 128
Cdd:cd05819    108 AVD---SSGNIYVADTGNHRIQK--FDPDGEFLTTFGSGgsgpgqFNGPTGVAVDSDG-NIYVADTGNHRIQVFDPDGNF 181

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  129 rkVLFW-------QELDQPRAIALDpSSGFMYWTDWG--EVPKIERAGM--DGSSRFIIINSEIYWPNGLTLDyEEQKLY 197
Cdd:cd05819    182 --LTTFgstgtgpGQFNYPTGIAVD-SDGNIYVADSGnnRVQVFDPDGAgfGGNGNFLGSDGQFNRPSGLAVD-SDGNLY 257

                          170
                   ....*....|.
gi 2329567114  198 WADAKLNFIHK 208
Cdd:cd05819    258 VADTGNNRIQV 268
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
361-549 1.94e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.85  E-value: 1.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  361 HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEV--TRLNGTMRK 438
Cdd:COG3391     26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVidLATGKVVAT 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  439 ILISEDleePRAIVLDPMVGYMYWTDWGEiPKIerAALDGSDRVVLVNTSLG-WPNGLALDYDEGKIYWGDAKTDKI--- 514
Cdd:COG3391    106 IPVGGG---PRGLAVDPDGGRLYVADSGN-GRV--SVIDTATGKVVATIPVGaGPHGIAVDPDGKRLYVANSGSNTVsvi 179

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 2329567114  515 -EVMNT-DGTGRRVLVEDKIPHIFGFTLLGDYVYWTD 549
Cdd:COG3391    180 vSVIDTaTGKVVATIPVGGGPVGVAVSPDGRRLYVAN 216
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 760-800 2.22e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 45.61  E-value: 2.22e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  760 GFMYWTEWGGKPKIDRAAMDGSER-TTLVPNVGRANGLTIDY 800
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRkTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 656-694 4.10e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.90  E-value: 4.10e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2329567114   656 IPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGS 694
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 367-558 9.07e-06

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 49.12  E-value: 9.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  367 YDPvEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQiAHPDGIAVD-----WVARN---LYWTDTGTDRIEVtrlngtmrk 438
Cdd:COG3386     15 WDP-DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADHgrgLVRFDPADGEVTV--------- 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  439 ilISEDLEEPRA----IVLDPMvGYMYWTDwgeiPKIERAA-----LDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDA 509
Cdd:COG3386     84 --LADEYGKPLNrpndGVVDPD-GRLYFTD----MGEYLPTgalyrVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADT 156

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2329567114  510 KTDKIEVMNTDGTG----RRVLVEDKIPHIF--GFTLLGD-YVYWTDWQRRSIERV 558
Cdd:COG3386    157 GAGRIYRFDLDADGtlgnRRVFADLPDGPGGpdGLAVDADgNLWVALWGGGGVVRF 212
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 699-813 1.25e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 48.36  E-value: 1.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  699 VVEF-GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLD-GQHRQ-VLVWKDLDSPRALALDPAeGFMYWTEWGGKPKIDR 775
Cdd:cd14952      3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVYVTDFGNNRVLKL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 2329567114  776 AAmdGSERTTLVP--NVGRANGLTIDyAKRRLYWTDLDTN 813
Cdd:cd14952     79 AA--GSTTQTVLPftGLNDPTGVAVD-AAGNVYVADTGNN 115
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1-204 1.52e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 1.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114    1 MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGL----IYWSDVSEEAIK 76
Cdd:COG3391     14 AVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRVS 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114   77 RTEFNKTESVQNVVVSGllSPDGLACDWLGEKLYWTDSETNRIEVsnLDGSLRKVL-FWQELDQPRAIALDPSSGFMYWT 155
Cdd:COG3391     94 VIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVA 169

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2329567114  156 DWG--EVPKIERAgMDGSSRFII--INSEIYwPNGLTLDYEEQKLYWADAKLN 204
Cdd:COG3391    170 NSGsnTVSVIVSV-IDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANRGSN 220
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
106-246 1.70e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.77  E-value: 1.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  106 GEKLYWTDSETNRIEVSNLDgSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGE--VPKIeragmDGSSRFIIinSEI-- 181
Cdd:COG3391     79 GRRLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNgrVSVI-----DTATGKVV--ATIpv 150

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2329567114  182 -YWPNGLTLDYEEQKLYWADAKLNFIHK--SNLDGTNRQaVVK----GSLPHPFALTLFEDILYWTDWSTHS 246
Cdd:COG3391    151 gAGPHGIAVDPDGKRLYVANSGSNTVSVivSVIDTATGK-VVAtipvGGGPVGVAVSPDGRRLYVANRGSNT 221
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 362-514 1.72e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 48.08  E-value: 1.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  362 AIAIDYDpveGYIYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTm 436
Cdd:cd05819    153 GVAVDSD---GNIYVADTGNHRIQVfdpdgNFLTTFGSTGTGPGQFNYPTGIAVD-SDGNIYVADSGNNRVQVFDPDGA- 227

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2329567114  437 rkilisedleepraivldpmvgymYWTDWGEipkieraaldgsdrVVLVNTSLGWPNGLALDyDEGKIYWGDAKTDKI 514
Cdd:cd05819    228 ------------------------GFGGNGN--------------FLGSDGQFNRPSGLAVD-SDGNLYVADTGNNRI 266
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 703-813 1.78e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.97  E-value: 1.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  703 GLDYPEGMAVDWLGkNLYWADTGTNRieVSKLDGQH--RQVLVWKDLDSPRALALDPAeGFMYWTEWGGKpKIDRAAMDG 780
Cdd:cd14952     92 GLNDPTGVAVDAAG-NVYVADTGNNR--VLKLAAGSntQTVLPFTGLSNPDGVAVDGA-GNVYVTDTGNN-RVLKLAAGS 166

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2329567114  781 SERTTLvPNVGRA--NGLTIDyAKRRLYWTDLDTN 813
Cdd:cd14952    167 TTQTVL-PFTGLNspSGVAVD-TAGNVYVTDHGNN 199
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 361-522 5.22e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 46.89  E-value: 5.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  361 HAIAIDYDpveGYIYWTDD----------EVRAIRRSFIDGSGSQfvvtaQIAHPDGIAVDwVARNLYWTDTGTDRIEVT 430
Cdd:cd14956     16 RGIAVDAD---DNVYVADArngriqvfdkDGTFLRRFGTTGDGPG-----QFGRPRGLAVD-KDGWLYVADYWGDRIQVF 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  431 RLNGTMRKILISE-----DLEEPRAIVLDPMvGYMYWTDWGEiPKIERAALDGSdrvvLVNT---------SLGWPNGLA 496
Cdd:cd14956     87 TLTGELQTIGGSSgsgpgQFNAPRGVAVDAD-GNLYVADFGN-QRIQKFDPDGS----FLRQwggtgiepgSFNYPRGVA 160

                          170       180
                   ....*....|....*....|....*.
gi 2329567114  497 LDyDEGKIYWGDAKTDKIEVMNTDGT 522
Cdd:cd14956    161 VD-PDGTLYVADTYNDRIQVFDNDGA 185
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 718-757 6.32e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.38  E-value: 6.32e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2329567114  718 NLYWADTGT-NRIEVSKLDGQHRQVLVWKDLDSPRALALDP 757
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 827-866 1.09e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 1.09e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2329567114   827 VIADDLPHPFGLT--QYQDYIYWTDWSRRSIERANKTsGQNR 866
Cdd:smart00135    3 LLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 402-527 1.86e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 44.89  E-value: 1.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  402 IAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPmVGYMYWTDWGEIPKIERAAlDGSDR 481
Cdd:cd14952      9 LDGPGGVAVD-AAGNVYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDA-AGTVYVTDFGNNRVLKLAA-GSTTQ 85

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2329567114  482 VVLVNTSLGWPNGLALDyDEGKIYwgdaktdkieVmnTDGTGRRVL 527
Cdd:cd14952     86 TVLPFTGLNDPTGVAVD-AAGNVY----------V--ADTGNNRVL 118
DUF5050 pfam16472
Domain of unknown function (DUF5050);
373-549 1.98e-04

Domain of unknown function (DUF5050);


Pssm-ID: 465128 [Multi-domain]  Cd Length: 282  Bit Score: 44.92  E-value: 1.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  373 YIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDgIAVDWVarnlYWTDTGTD-RIEVTRLNGTMRKILISEDLEEPraI 451
Cdd:pfam16472  111 YQHYDNSDGGTLYKIKIDGKEKTKLSDEPISPAS-VSDGWI----YYSGTSDDhYIYKLNTDGDSISKLYDGNSYMP--N 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  452 VLDpmvGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNglaldYDEGKIYWGDAKTD-KIEVMNTDGTGRRVLVED 530
Cdd:pfam16472  184 VNG---DYIYYIDLSNNYALYRMNLSGGEKEVLTDDRVDNYN-----VYGNWIYYQNNGDDnKLYRINTDGSNKEKLAEG 255

                          170
                   ....*....|....*....
gi 2329567114  531 KIPHIfgfTLLGDYVYWTD 549
Cdd:pfam16472  256 NYTNI---NITSDYIYFTD 271
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 673-857 2.17e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 44.88  E-value: 2.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  673 DNRIYWTDISLKTISRAFMNGSALEHVVEFGlDYPEGMAVDWLGkNLYWADTGtNRIEVSKLDGQHRQVLV---WKDLDS 749
Cdd:COG3386     18 DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDPDG-RLLVADHG-RGLVRFDPADGEVTVLAdeyGKPLNR 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  750 PRALALDPAeGFMYWT---EWGGKPKIDRAAMDGsERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLI-----ESSNML 821
Cdd:COG3386     95 PNDGVVDPD-GRLYFTdmgEYLPTGALYRVDPDG-SLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIyrfdlDADGTL 172

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2329567114  822 GlNREVIADDLPHPF---GLTQYQD-YIYWTDWSRRSIER 857
Cdd:COG3386    173 G-NRRVFADLPDGPGgpdGLAVDADgNLWVALWGGGGVVR 211
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 136-427 2.88e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.62  E-value: 2.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  136 ELDQPRAIALDpSSGFMYWTDWGEVpKIERagMDGSSRFIII-------NSEIYWPNGLTLDYEEQkLYWADAKLNFIHK 208
Cdd:cd05819      6 ELNNPQGIAVD-SSGNIYVADTGNN-RIQV--FDPDGNFITSfgsfgsgDGQFNEPAGVAVDSDGN-LYVADTGNHRIQK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  209 SNLDGTNRQAVVK-----GSLPHPFALTL-FEDILYWTDWSTHSILACNKyTGEGLREIHS------DIFSPMDIhafsq 276
Cdd:cd05819     81 FDPDGNFLASFGGsgdgdGEFNGPRGIAVdSSGNIYVADTGNHRIQKFDP-DGEFLTTFGSggsgpgQFNGPTGV----- 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  277 qrqpnATNPCGI----DNGGCShlclmspVKPFYqcacPTGVKLLENGKTCKDGAtellllarrtdlrriSLDTPdftdi 352
Cdd:cd05819    155 -----AVDSDGNiyvaDTGNHR-------IQVFD----PDGNFLTTFGSTGTGPG---------------QFNYP----- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  353 vlqledirHAIAIDYDpveGYIYWTDDEVRAIRR-----SFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRI 427
Cdd:cd05819    199 --------TGIAVDSD---GNIYVADSGNNRVQVfdpdgAGFGGNGNFLGSDGQFNRPSGLAVD-SDGNLYVADTGNNRI 266
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 55-272 3.15e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 44.23  E-value: 3.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114   55 AVDfvfSHGLIYWSDVSEEAIKRteFNK-TESVQNVVVSG-----LLSPDGLACDWLGEkLYWTDSETNRIEVSNLDGSL 128
Cdd:cd05819     14 AVD---SSGNIYVADTGNNRIQV--FDPdGNFITSFGSFGsgdgqFNEPAGVAVDSDGN-LYVADTGNHRIQKFDPDGNF 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  129 RKV-----LFWQELDQPRAIALDpSSGFMYWTDWGEVpKIERAGMDGSSRFII-----INSEIYWPNGLTLDyEEQKLYW 198
Cdd:cd05819     88 LASfggsgDGDGEFNGPRGIAVD-SSGNIYVADTGNH-RIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVD-SDGNIYV 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  199 ADAKLNFIHKSNLDGT-----NRQAVVKGSLPHPFALTLFED-ILYWTDWSTHSILacnKYTGEGLREI--------HSD 264
Cdd:cd05819    165 ADTGNHRIQVFDPDGNflttfGSTGTGPGQFNYPTGIAVDSDgNIYVADSGNNRVQ---VFDPDGAGFGgngnflgsDGQ 241


                   ....*...
gi 2329567114  265 IFSPMDIH 272
Cdd:cd05819    242 FNRPSGLA 249
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 674-714 3.23e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.45  E-value: 3.23e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  674 NRIYWTDISLK-TISRAFMNGSALEHVVEFGLDYPEGMAVDW 714
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 958-998 3.25e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.51  E-value: 3.25e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2329567114   958 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQ 998
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 525-558 3.69e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.51  E-value: 3.69e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2329567114   525 RVLVEDKIPHIFGFTL--LGDYVYWTDWQRRSIERV 558
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 361-522 4.22e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 44.18  E-value: 4.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  361 HAIAIDYDpveGYIYWTDDEVRAIR-----RSFIDGSGSQFVVTAQIAHPDGIAVDwVARNLYWTDTGTDRIEV-TRLNG 434
Cdd:cd14957     21 RGIAVDSA---GNIYVADTGNNRIQvftssGVYSYSIGSGGTGSGQFNSPYGIAVD-SNGNIYVADTDNNRIQVfNSSGV 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  435 TMRKI----LISEDLEEPRAIVLDPMvGYMYWTDwgeipkieraalDGSDRVVLVNTS----------------LGWPNG 494
Cdd:cd14957     97 YQYSIgtggSGDGQFNGPYGIAVDSN-GNIYVAD------------TGNHRIQVFTSSgtfsysigsggtgpgqFNGPQG 163

                          170       180
                   ....*....|....*....|....*...
gi 2329567114  495 LALDYDeGKIYWGDAKTDKIEVMNTDGT 522
Cdd:cd14957    164 IAVDSD-GNIYVADTGNHRIQVFTSSGT 190
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 705-785 4.91e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.81  E-value: 4.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  705 DYPEGMAVDwLGKNLYWADTGTNRIEVSKLDGQH-RQvlVWK------DLDSPRALALDPAEGFMYWTEWGGkpKIDRAA 777
Cdd:cd14956     13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFlRR--FGTtgdgpgQFGRPRGLAVDKDGWLYVADYWGD--RIQVFT 87


                   ....*...
gi 2329567114  778 MDGSERTT 785
Cdd:cd14956     88 LTGELQTI 95
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 372-412 5.39e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.07  E-value: 5.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114  372 GYIYWTDDEVRA-IRRSFIDGSGSQFVVTAQIAHPDGIAVDW 412
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 703-816 9.41e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 43.04  E-value: 9.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  703 GLDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGqhRQVLVW-------KDLDSPRALALDPAeGFMYWTEWGGKpKIDR 775
Cdd:cd14956    152 SFNYPRGVAVDPDG-TLYVADTYNDRIQVFDNDG--AFLRKWggrgtgpGQFNYPYGIAIDPD-GNVFVADFGNN-RIQK 226

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2329567114  776 AAMDGSERTTlVPNVGRANG-------LTIDyAKRRLYWTDLDTNLIE 816
Cdd:cd14956    227 FTADGTFLTS-WGSPGTGPGqfknpwgVVVD-ADGTVYVADSNNNRVQ 272
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 401-527 9.60e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 42.69  E-value: 9.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  401 QIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTmRKILISED------LEEPRAIVLDPMvGYMYWTDWG--EIPKIe 472
Cdd:cd05819      6 ELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGN-FITSFGSFgsgdgqFNEPAGVAVDSD-GNLYVADTGnhRIQKF- 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2329567114  473 raalDGSDRVVLVNTSLGW-------PNGLALDyDEGKIYWGDAKTDKIEVMNTDGTGRRVL 527
Cdd:cd05819     82 ----DPDGNFLASFGGSGDgdgefngPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTF 138
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 671-815 1.17e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 42.69  E-value: 1.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  671 VTD---NRIYWTDISLKTISRAfmnGSALEHVVEFglDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQhrQVLVWKD- 746
Cdd:cd05819    117 VADtgnHRIQKFDPDGEFLTTF---GSGGSGPGQF--NGPTGVAVDSDG-NIYVADTGNHRIQVFDPDGN--FLTTFGSt 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  747 ------LDSPRALALDPaEGFMYWTEWGGKpKIDRAAMDGSERTTLVPNVGRAN------GLTIDyAKRRLYWTDLDTNL 814
Cdd:cd05819    189 gtgpgqFNYPTGIAVDS-DGNIYVADSGNN-RVQVFDPDGAGFGGNGNFLGSDGqfnrpsGLAVD-SDGNLYVADTGNNR 265


                   .
gi 2329567114  815 I 815
Cdd:cd05819    266 I 266
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 217-251 1.18e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.97  E-value: 1.18e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2329567114   217 QAVVKGSLPHP--FALTLFEDILYWTDWSTHSILACN 251
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1069-1110 1.31e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.91  E-value: 1.31e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114 1069 GYMYFTNLQERsPKIERAALDGTEREVLFFSGLSKPIALALD 1110
Cdd:pfam00058    1 GRLYWTDSSLR-ASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
968-1075 1.37e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.99  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  968 RAIDYDPLDKQLYWIDSRQNMIRKAqeDGSQGftVVVSSVPsqnLEIQPYDLSIDIYSRYIYWTCEATN---VInVTRLD 1044
Cdd:COG3391    113 RGLAVDPDGGRLYVADSGNGRVSVI--DTATG--KVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNtvsVI-VSVID 184

                           90       100       110
                   ....*....|....*....|....*....|...
gi 2329567114 1045 GRSvGVVLK--GEQDRPRAVVVNPEKGYMYFTN 1075
Cdd:COG3391    185 TAT-GKVVAtiPVGGGPVGVAVSPDGRRLYVAN 216
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1114-1154 1.61e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 1.61e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2329567114 1114 GKLFWADSDLR-RIESSDLSGANRIVLEDSNILQPVGLTVFE 1154
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 367-529 1.64e-03

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 41.86  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  367 YDPVEGYIYWTDDEVRAIRR-SFIDGSGSQFVVTAQIA----HPDGIAVDWVARNLYWTDTGTdrievtrlnGTMRKILI 441
Cdd:pfam08450    7 WDEEEGALYWVDILGGRIHRlDPATGKETVWDTPGPVGaiapRDDGGLIVALKDGVALLDLAT---------GELTPLAD 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  442 SEDLEEPRAI----VLDP----MVGYMywtDWGEIPKIERAAL---DGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAK 510
Cdd:pfam08450   78 PEDDDWPLNRfndgKVDPdgrfWFGTM---GDDEAPGGDPGALyrlDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSP 154

                          170       180
                   ....*....|....*....|....
gi 2329567114  511 TDKIEVMNTDGTG-----RRVLVE 529
Cdd:pfam08450  155 ARKIWAYDYDLDGglisnRRVFAD 178
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 667-756 1.75e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.89  E-value: 1.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  667 LDFDVTDNRIYWTDISLKTIsRAFMNGSalEHVVEFG--------LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQH 738
Cdd:cd14963     13 MGVAVSDGRIYVADTNNHRV-QVFDYEG--KFKKSFGgpgtgpgeFKYPYGIAVDSDG-NIYVADLYNGRIQVFDPDGKF 88

                           90       100
                   ....*....|....*....|..
gi 2329567114  739 RQVLVWKD----LDSPRALALD 756
Cdd:cd14963     89 LKYFPEKKdrvkLISPAGLAID 110
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 391-514 2.48e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.42  E-value: 2.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  391 GSGSQFVVT-AQIAHPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPmVGYMYWTDWGEiP 469
Cdd:cd14952    123 GSNTQTVLPfTGLSNPDGVAVD-GAGNVYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDT-AGNVYVTDHGN-N 199

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2329567114  470 KIERAALDGSDRVVLVNTSLGWPNGLALDyDEGKIYWGDAKTDKI 514
Cdd:cd14952    200 RVLKLAAGSTTPTVLPFTGLNGPLGVAVD-AAGNVYVADRGNDRV 243
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 405-527 2.77e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.04  E-value: 2.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  405 PDGIAVDwVARNLYWTDTGTDRieVTRLNG--TMRKILISEDLEEPRAIVLDPmVGYMYWTDWGEiPKIERAALDGSDRV 482
Cdd:cd14952     96 PTGVAVD-AAGNVYVADTGNNR--VLKLAAgsNTQTVLPFTGLSNPDGVAVDG-AGNVYVTDTGN-NRVLKLAAGSTTQT 170

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2329567114  483 VLVNTSLGWPNGLALDyDEGKIYwgdaktdkieVmnTDGTGRRVL 527
Cdd:cd14952    171 VLPFTGLNSPSGVAVD-TAGNVY----------V--TDHGNNRVL 202
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 665-757 2.87e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.15  E-value: 2.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  665 SALDFDvTDNRIYWTDISLKTISRAFMNGSALEHVVEFG-----LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQHr 739
Cdd:cd05819     58 AGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGGSGdgdgeFNGPRGIAVDSSG-NIYVADTGNHRIQKFDPDGEF- 134

                           90       100
                   ....*....|....*....|....*
gi 2329567114  740 qVLVWK-------DLDSPRALALDP 757
Cdd:cd05819    135 -LTTFGsggsgpgQFNGPTGVAVDS 158
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 670-757 3.73e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 3.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  670 DVTDNRIYWTDISLKTISRAFMNGsalEHVVEFG--------LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQHRQV 741
Cdd:cd14963    108 AIDDGKLYVSDVKKHKVIVFDLEG---KLLLEFGkpgsepgeLSYPNGIAVDEDG-NIYVADSGNGRIQVFDKNGKFIKE 183

                           90       100
                   ....*....|....*....|.
gi 2329567114  742 LVWKDLDS-----PRALALDP 757
Cdd:cd14963    184 LNGSPDGKsgfvnPRGIAVDP 204
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
339-427 5.28e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.39  E-value: 5.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  339 LRRISLDTPDFTDIVLQLEDIR-HAIAIDYDpveGYIYWTDDEVRAIRRsfID---GSGSQFVVTAQIAHPDGIAVDwVA 414
Cdd:COG4257    168 IGRIDPDTGTLTEYALPTPGAGpRGLAVDPD---GNLWVADTGSGRIGR--FDpktGTVTEYPLPGGGARPYGVAVD-GD 241

                           90
                   ....*....|...
gi 2329567114  415 RNLYWTDTGTDRI 427
Cdd:COG4257    242 GRVWFAESGANRI 254
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 704-758 5.83e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 40.38  E-value: 5.83e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2329567114  704 LDYPEGMAVDWLGkNLYWADTGTNRIevSKLDGQHRQVLVW-------KDLDSPRALALDPA 758
Cdd:cd05819     54 FNEPAGVAVDSDG-NLYVADTGNHRI--QKFDPDGNFLASFggsgdgdGEFNGPRGIAVDSS 112
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 704-757 5.93e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 40.61  E-value: 5.93e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2329567114  704 LDYPEGMAVDWLGkNLYWADTGTNRIEVSKLDGQH-----RQVLVWKDLDSPRALALDP 757
Cdd:cd14954    117 FNYPWGVAVDSEG-RIYVSDTRNHRVQVFDSDGQFirkfgFEGAGPGQLDSPRGVAVNP 174
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
642-815 8.60e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.00  E-value: 8.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  642 IRRISLETNN-NNVAIPlTGVKEASALDFDVtDNRIYWTDISLKTISR---AfmNGSALEHVVEFGLDYPEGMAVDWLGk 717
Cdd:COG4257     82 IGRIDPKTGEiTTFALP-GGGSNPHGIAFDP-DGNLWFTDQGGNRIGRldpA--TGEVTEFPLPTGGAGPYGIAVDPDG- 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329567114  718 NLYWADTGTNRI-EVSKLDGQHRQVLVWKDLDSPRALALDPaEGFMYWTEWGGKP--KIDRAamDGSERT-TLVPNVGRA 793
Cdd:COG4257    157 NLWVTDFGANAIgRIDPDTGTLTEYALPTPGAGPRGLAVDP-DGNLWVADTGSGRigRFDPK--TGTVTEyPLPGGGARP 233

                          170       180
                   ....*....|....*....|..
gi 2329567114  794 NGLTIDyAKRRLYWTDLDTNLI 815
Cdd:COG4257    234 YGVAVD-GDGRVWFAESGANRI 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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