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Conserved domains on  [gi|2328705329|ref|NP_001400959|]
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integrin alpha-7 isoform 9 precursor [Homo sapiens]

Protein Classification

integrin alpha( domain architecture ID 12192626)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 447-937 1.99e-148

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 451.77  E-value: 1.99e-148
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  447 RPILHVSHEVSIAPRSIDLEQPNCA--GGHSVCVDLRVCFSYIAVPSsYSPTVALDYVLDADTDRRlRGQVPRVTFLSRN 524
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTltGTPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKK-KGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  525 LeepkHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQtprlRRQAPGQGLPPVAPILNAHQPSTQRAE 604
Cdd:pfam08441   79 Q----PSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR----VDPRAPSDLPGLKPILDQNQPSTVQEQ 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  605 IHFLKQgCGEDKICQSNLQLvRARFCTRVSDTEFqplpmdvdgttalfALSGQPVIGLELMVTNlpsdpaqpqaDGDDAH 684
Cdd:pfam08441  151 ANFLKD-CGEDNVCVPDLQL-SAKFDSRESDEPL--------------LLGDDNDLALEITVTN----------LGEDAY 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  685 EAQLLVMLPDSLHYSGVRALDPAEKPLCLSNENAS--HVECELGNPMKRGAQVTFYLILSTSGISIETTELEVELLLATI 762
Cdd:pfam08441  205 EAELYVTLPPGLDYSGVRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRST 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  763 SEQELH--PVSARARVFIELPLSIAGMAIPQQLFFsGVVRGERAMQ--SERDVGSKVKYEVTVSNQGQSlrTLGSAFLNI 838
Cdd:pfam08441  285 NEQNSNsnPVSLKVPVVAEAQLSLSGVSKPDQVVG-GSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEI 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  839 MWPHEIANGKWLLYPMQVElegGQGPGQkglCSPRPNILHLDVDSRDRRRRELEPPEQQEPGERQEPSMSWWPVSSAEKk 918
Cdd:pfam08441  362 SWPYELSNGKWLLYLLDVQ---GQGKGE---CSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASV- 434

                          490
                   ....*....|....*....
gi 2328705329  919 kniTLDCARGtANCVVFSC 937
Cdd:pfam08441  435 ---LLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 357-404 1.08e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 60.85  E-value: 1.08e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2328705329   357 GAVLAVLGDLNQDGFPDIAVGAPFDGD----GKVFIYHGSSLGVVAKPSQVL 404
Cdd:smart00191    6 GYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 324-359 2.32e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 50.59  E-value: 2.32e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2328705329  324 FGYSLAVADLNSDGWPDLIVGAPYFFERQeelGGAV 359
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAV 33
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-109 1.90e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.91  E-value: 1.90e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2328705329    48 PGSLFGFSVALHRQLQPRPQSWLLVGAPQAlalpgQQANRTGGLFACPLSLEETDCYRVDID 109
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRA-----NDAGETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 263-305 1.84e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 40.44  E-value: 1.84e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2328705329   263 ANSYFGFSIDSGKGLVRAEELSFVAGAPRANHK---GAVVILRKDS 305
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSS 46
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 414-453 9.98e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.13  E-value: 9.98e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2328705329   414 FGYSLSGSLDMDGNQYPDLLVGS-LADTAVLFRARPILHVS 453
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGS 45
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 447-937 1.99e-148

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 451.77  E-value: 1.99e-148
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  447 RPILHVSHEVSIAPRSIDLEQPNCA--GGHSVCVDLRVCFSYIAVPSsYSPTVALDYVLDADTDRRlRGQVPRVTFLSRN 524
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTltGTPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKK-KGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  525 LeepkHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQtprlRRQAPGQGLPPVAPILNAHQPSTQRAE 604
Cdd:pfam08441   79 Q----PSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR----VDPRAPSDLPGLKPILDQNQPSTVQEQ 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  605 IHFLKQgCGEDKICQSNLQLvRARFCTRVSDTEFqplpmdvdgttalfALSGQPVIGLELMVTNlpsdpaqpqaDGDDAH 684
Cdd:pfam08441  151 ANFLKD-CGEDNVCVPDLQL-SAKFDSRESDEPL--------------LLGDDNDLALEITVTN----------LGEDAY 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  685 EAQLLVMLPDSLHYSGVRALDPAEKPLCLSNENAS--HVECELGNPMKRGAQVTFYLILSTSGISIETTELEVELLLATI 762
Cdd:pfam08441  205 EAELYVTLPPGLDYSGVRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRST 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  763 SEQELH--PVSARARVFIELPLSIAGMAIPQQLFFsGVVRGERAMQ--SERDVGSKVKYEVTVSNQGQSlrTLGSAFLNI 838
Cdd:pfam08441  285 NEQNSNsnPVSLKVPVVAEAQLSLSGVSKPDQVVG-GSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEI 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  839 MWPHEIANGKWLLYPMQVElegGQGPGQkglCSPRPNILHLDVDSRDRRRRELEPPEQQEPGERQEPSMSWWPVSSAEKk 918
Cdd:pfam08441  362 SWPYELSNGKWLLYLLDVQ---GQGKGE---CSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASV- 434

                          490
                   ....*....|....*....
gi 2328705329  919 kniTLDCARGtANCVVFSC 937
Cdd:pfam08441  435 ---LLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 357-404 1.08e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 60.85  E-value: 1.08e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2328705329   357 GAVLAVLGDLNQDGFPDIAVGAPFDGD----GKVFIYHGSSLGVVAKPSQVL 404
Cdd:smart00191    6 GYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 324-359 2.32e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 50.59  E-value: 2.32e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2328705329  324 FGYSLAVADLNSDGWPDLIVGAPYFFERQeelGGAV 359
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAV 33
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-109 1.90e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.91  E-value: 1.90e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2328705329    48 PGSLFGFSVALHRQLQPRPQSWLLVGAPQAlalpgQQANRTGGLFACPLSLEETDCYRVDID 109
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRA-----NDAGETGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 357-389 2.14e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 45.19  E-value: 2.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2328705329  357 GAVLAVlGDLNQDGFPDIAVGAPF---DGDGKVFIY 389
Cdd:pfam01839    2 GYSVAV-GDLNGDGYADLAVGAPGeggAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 263-305 1.84e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 40.44  E-value: 1.84e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2328705329   263 ANSYFGFSIDSGKGLVRAEELSFVAGAPRANHK---GAVVILRKDS 305
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSS 46
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 414-453 9.98e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.13  E-value: 9.98e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2328705329   414 FGYSLSGSLDMDGNQYPDLLVGS-LADTAVLFRARPILHVS 453
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGS 45
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 447-937 1.99e-148

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 451.77  E-value: 1.99e-148
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  447 RPILHVSHEVSIAPRSIDLEQPNCA--GGHSVCVDLRVCFSYIAVPSsYSPTVALDYVLDADTDRRlRGQVPRVTFLSRN 524
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTltGTPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKK-KGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  525 LeepkHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQtprlRRQAPGQGLPPVAPILNAHQPSTQRAE 604
Cdd:pfam08441   79 Q----PSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR----VDPRAPSDLPGLKPILDQNQPSTVQEQ 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  605 IHFLKQgCGEDKICQSNLQLvRARFCTRVSDTEFqplpmdvdgttalfALSGQPVIGLELMVTNlpsdpaqpqaDGDDAH 684
Cdd:pfam08441  151 ANFLKD-CGEDNVCVPDLQL-SAKFDSRESDEPL--------------LLGDDNDLALEITVTN----------LGEDAY 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  685 EAQLLVMLPDSLHYSGVRALDPAEKPLCLSNENAS--HVECELGNPMKRGAQVTFYLILSTSGISIETTELEVELLLATI 762
Cdd:pfam08441  205 EAELYVTLPPGLDYSGVRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRST 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  763 SEQELH--PVSARARVFIELPLSIAGMAIPQQLFFsGVVRGERAMQ--SERDVGSKVKYEVTVSNQGQSlrTLGSAFLNI 838
Cdd:pfam08441  285 NEQNSNsnPVSLKVPVVAEAQLSLSGVSKPDQVVG-GSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEI 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  839 MWPHEIANGKWLLYPMQVElegGQGPGQkglCSPRPNILHLDVDSRDRRRRELEPPEQQEPGERQEPSMSWWPVSSAEKk 918
Cdd:pfam08441  362 SWPYELSNGKWLLYLLDVQ---GQGKGE---CSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASV- 434

                          490
                   ....*....|....*....
gi 2328705329  919 kniTLDCARGtANCVVFSC 937
Cdd:pfam08441  435 ---LLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 357-404 1.08e-11

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 60.85  E-value: 1.08e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2328705329   357 GAVLAVLGDLNQDGFPDIAVGAPFDGD----GKVFIYHGSSLGVVAKPSQVL 404
Cdd:smart00191    6 GYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 324-359 2.32e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 50.59  E-value: 2.32e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2328705329  324 FGYSLAVADLNSDGWPDLIVGAPYFFERQeelGGAV 359
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAV 33
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-109 1.90e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.91  E-value: 1.90e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2328705329    48 PGSLFGFSVALHRQLQPRPQSWLLVGAPQAlalpgQQANRTGGLFACPLSLEETDCYRVDID 109
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRA-----NDAGETGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 357-389 2.14e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 45.19  E-value: 2.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2328705329  357 GAVLAVlGDLNQDGFPDIAVGAPF---DGDGKVFIY 389
Cdd:pfam01839    2 GYSVAV-GDLNGDGYADLAVGAPGeggAGAGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 365-434 5.65e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 41.83  E-value: 5.65e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2328705329  365 DLNQDGFPDIAVGapfdGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFgyslsGSLDMDGNQYPDLLV 434
Cdd:pfam13517    1 DLDGDGKLDLVVA----NDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSV-----AVGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 332-376 1.63e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 40.67  E-value: 1.63e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2328705329  332 DLNSDGWPDLIVGAP-----YFFERQEEL-----------GGAVLAVLGDLNQDGFPDIAV 376
Cdd:pfam13517    1 DLDGDGKLDLVVANDgglrlYLNNGDGTFtfitsvslgggGGGLSVAVGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 263-305 1.84e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 40.44  E-value: 1.84e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2328705329   263 ANSYFGFSIDSGKGLVRAEELSFVAGAPRANHK---GAVVILRKDS 305
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSS 46
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 414-453 9.98e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.13  E-value: 9.98e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2328705329   414 FGYSLSGSLDMDGNQYPDLLVGS-LADTAVLFRARPILHVS 453
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGS 45
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 293-343 2.33e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 37.20  E-value: 2.33e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2328705329  293 NHKGAVVILRKDSASRLVPEVMLSgerlTSGFGYSLAVADLNSDGWPDLIV 343
Cdd:pfam13517   15 DGGLRLYLNNGDGTFTFITSVSLG----GGGGGLSVAVGDLDGDGRLDLLV 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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