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Conserved domains on  [gi|2321695105|ref|NP_001400122|]
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brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform 9 [Homo sapiens]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 219-1560 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 884.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  219 LQKDAFLVFRSLCKLSMK-PLSDGPPDPKSheLRSKILSLQLLLSILQNAGPIFRTNEMFINAIKQYLCVALSKNGVSSV 297
Cdd:PLN03076   344 LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSL 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  298 PEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILET-STSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAA 376
Cdd:PLN03076   422 MIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSS 501

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  377 NIFERLVNDLSKIAQG-RGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTlgqEKPSEQEMS-EIK 454
Cdd:PLN03076   502 NIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLPDPASL---KKLDAVENNlEPG 578

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  455 HPETINRYGSLNSLESTSssgigsYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIA 534
Cdd:PLN03076   579 SLPVANGNGDENGEGSDS------HSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIA 652

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  535 QFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNqg 614
Cdd:PLN03076   653 AFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN-- 730

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  615 QTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKEtkELTIPT 694
Cdd:PLN03076   731 PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKE--DDLVPQ 808

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  695 KssKQNVASEKQRRLLYNLEMEQMAKTAKALMEA----VSHVQAPFT-----------SATHLEHVRPMFKLAWTPFLAA 759
Cdd:PLN03076   809 Q--KQSANSNRILGLDSILNIVIRKRGEDSYMETsddlIKHMQEQFKekarksesvyyAATDVVILRFMVEVCWAPMLAA 886

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  760 FSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGItemKQKNIDTIKTLITVAHTDGNY 839
Cdd:PLN03076   887 FSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNY 963

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  840 LGNSWHEILKCISQLELAQLIGTGVKP---------------RYISGTV--------RGR-----EGSLTGTKDQAPdef 891
Cdd:PLN03076   964 LQEAWEHILTCVSRFEHLHLLGEGAPPdatffaapqnesdksKQAKSPIlpvlkrkgPGKlqyaaAAVRRGSYDSAG--- 1040

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  892 VGlGLVGGNVDWKQIASIQESIGETsSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELLSTTHPRMFSLQKIVE 971
Cdd:PLN03076  1041 VG-GKASGVVTSEQMNNLVSNLNML-EQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVE 1118

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  972 ISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPT 1051
Cdd:PLN03076  1119 IAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVE 1198

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1052 IRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVtlvfEKHFPATID----SFQDAVKCL 1127
Cdd:PLN03076  1199 IRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKII----REYFPYITEtettTFTDCVNCL 1274

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1128 SEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVRG----------------WFPILFELSC 1191
Cdd:PLN03076  1275 IAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSE 1354

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1192 IINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIV-FRIFDNMK---------LPEQQTEKAE--------WMTT 1253
Cdd:PLN03076  1355 LSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYE 1434

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1254 TCNHALYAICDVFTQYLEVLsDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDIFKT 1333
Cdd:PLN03076  1435 TCTLALQLVVDLFVKFYPTV-NPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANA 1513

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1334 TIPHAlltwrpnsgetappppspDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEevskikstakfPEQKLFAALL- 1412
Cdd:PLN03076  1514 TLPDF------------------SYVVSGEYMPAENIQDSENAEAASSSTADNDAEAE-----------RSRRLYAAISd 1564

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1413 IKC--VVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdqGMYR-FLTSQQLFKLLDCLLESHRFAKA 1489
Cdd:PLN03076  1565 AKCraAVQLLLIQAVMEIY---------------------------------NMYRpRLSAKNTLVLFDALHTVASHAHK 1611

                         1370      1380      1390      1400      1410      1420      1430
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2321695105 1490 FNSNNEQRTALWKAGFKGKSK-PNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRLLNVCSEALSYFL 1560
Cdd:PLN03076  1612 INSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI 1683
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 219-1560 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 884.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  219 LQKDAFLVFRSLCKLSMK-PLSDGPPDPKSheLRSKILSLQLLLSILQNAGPIFRTNEMFINAIKQYLCVALSKNGVSSV 297
Cdd:PLN03076   344 LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSL 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  298 PEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILET-STSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAA 376
Cdd:PLN03076   422 MIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSS 501

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  377 NIFERLVNDLSKIAQG-RGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTlgqEKPSEQEMS-EIK 454
Cdd:PLN03076   502 NIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLPDPASL---KKLDAVENNlEPG 578

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  455 HPETINRYGSLNSLESTSssgigsYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIA 534
Cdd:PLN03076   579 SLPVANGNGDENGEGSDS------HSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIA 652

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  535 QFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNqg 614
Cdd:PLN03076   653 AFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN-- 730

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  615 QTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKEtkELTIPT 694
Cdd:PLN03076   731 PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKE--DDLVPQ 808

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  695 KssKQNVASEKQRRLLYNLEMEQMAKTAKALMEA----VSHVQAPFT-----------SATHLEHVRPMFKLAWTPFLAA 759
Cdd:PLN03076   809 Q--KQSANSNRILGLDSILNIVIRKRGEDSYMETsddlIKHMQEQFKekarksesvyyAATDVVILRFMVEVCWAPMLAA 886

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  760 FSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGItemKQKNIDTIKTLITVAHTDGNY 839
Cdd:PLN03076   887 FSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNY 963

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  840 LGNSWHEILKCISQLELAQLIGTGVKP---------------RYISGTV--------RGR-----EGSLTGTKDQAPdef 891
Cdd:PLN03076   964 LQEAWEHILTCVSRFEHLHLLGEGAPPdatffaapqnesdksKQAKSPIlpvlkrkgPGKlqyaaAAVRRGSYDSAG--- 1040

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  892 VGlGLVGGNVDWKQIASIQESIGETsSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELLSTTHPRMFSLQKIVE 971
Cdd:PLN03076  1041 VG-GKASGVVTSEQMNNLVSNLNML-EQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVE 1118

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  972 ISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPT 1051
Cdd:PLN03076  1119 IAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVE 1198

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1052 IRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVtlvfEKHFPATID----SFQDAVKCL 1127
Cdd:PLN03076  1199 IRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKII----REYFPYITEtettTFTDCVNCL 1274

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1128 SEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVRG----------------WFPILFELSC 1191
Cdd:PLN03076  1275 IAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSE 1354

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1192 IINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIV-FRIFDNMK---------LPEQQTEKAE--------WMTT 1253
Cdd:PLN03076  1355 LSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYE 1434

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1254 TCNHALYAICDVFTQYLEVLsDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDIFKT 1333
Cdd:PLN03076  1435 TCTLALQLVVDLFVKFYPTV-NPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANA 1513

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1334 TIPHAlltwrpnsgetappppspDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEevskikstakfPEQKLFAALL- 1412
Cdd:PLN03076  1514 TLPDF------------------SYVVSGEYMPAENIQDSENAEAASSSTADNDAEAE-----------RSRRLYAAISd 1564

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1413 IKC--VVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdqGMYR-FLTSQQLFKLLDCLLESHRFAKA 1489
Cdd:PLN03076  1565 AKCraAVQLLLIQAVMEIY---------------------------------NMYRpRLSAKNTLVLFDALHTVASHAHK 1611

                         1370      1380      1390      1400      1410      1420      1430
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2321695105 1490 FNSNNEQRTALWKAGFKGKSK-PNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRLLNVCSEALSYFL 1560
Cdd:PLN03076  1612 INSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI 1683
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 498-682 1.05e-101

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 323.26  E-value: 1.05e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  498 QKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDF 577
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  578 VSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 657
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 2321695105  658 GINDSKDLPEEYLSAIYNEIAGKKI 682
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 498-682 2.39e-91

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 293.75  E-value: 2.39e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  498 QKEIIEQGIDLFNKKPKRGIQYLQEQGML-GTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKD 576
Cdd:cd00171      1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  577 FVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 656
Cdd:cd00171     81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                          170       180
                   ....*....|....*....|....*.
gi 2321695105  657 RGINDSKDLPEEYLSAIYNEIAGKKI 682
Cdd:cd00171    160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 495-682 3.24e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 276.48  E-value: 3.24e-85
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105   495 LKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGT-TPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFS 573
Cdd:smart00222    1 SKGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFS 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105   574 GKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYI 653
Cdd:smart00222   81 AKDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFI 160

                           170       180
                    ....*....|....*....|....*....
gi 2321695105   654 KMNRGINDSKDLPEEYLSAIYNEIAGKKI 682
Cdd:smart00222  161 KNVRGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 219-1560 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 884.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  219 LQKDAFLVFRSLCKLSMK-PLSDGPPDPKSheLRSKILSLQLLLSILQNAGPIFRTNEMFINAIKQYLCVALSKNGVSSV 297
Cdd:PLN03076   344 LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSL 421

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  298 PEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILET-STSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAA 376
Cdd:PLN03076   422 MIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSS 501

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  377 NIFERLVNDLSKIAQG-RGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNPNSQTTlgqEKPSEQEMS-EIK 454
Cdd:PLN03076   502 NIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLPDPASL---KKLDAVENNlEPG 578

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  455 HPETINRYGSLNSLESTSssgigsYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIA 534
Cdd:PLN03076   579 SLPVANGNGDENGEGSDS------HSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIA 652

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  535 QFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNqg 614
Cdd:PLN03076   653 AFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN-- 730

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  615 QTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKEtkELTIPT 694
Cdd:PLN03076   731 PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKE--DDLVPQ 808

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  695 KssKQNVASEKQRRLLYNLEMEQMAKTAKALMEA----VSHVQAPFT-----------SATHLEHVRPMFKLAWTPFLAA 759
Cdd:PLN03076   809 Q--KQSANSNRILGLDSILNIVIRKRGEDSYMETsddlIKHMQEQFKekarksesvyyAATDVVILRFMVEVCWAPMLAA 886

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  760 FSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGItemKQKNIDTIKTLITVAHTDGNY 839
Cdd:PLN03076   887 FSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNY 963

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  840 LGNSWHEILKCISQLELAQLIGTGVKP---------------RYISGTV--------RGR-----EGSLTGTKDQAPdef 891
Cdd:PLN03076   964 LQEAWEHILTCVSRFEHLHLLGEGAPPdatffaapqnesdksKQAKSPIlpvlkrkgPGKlqyaaAAVRRGSYDSAG--- 1040

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  892 VGlGLVGGNVDWKQIASIQESIGETsSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELLSTTHPRMFSLQKIVE 971
Cdd:PLN03076  1041 VG-GKASGVVTSEQMNNLVSNLNML-EQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVE 1118

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  972 ISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKRNRSPT 1051
Cdd:PLN03076  1119 IAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVE 1198

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1052 IRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVtlvfEKHFPATID----SFQDAVKCL 1127
Cdd:PLN03076  1199 IRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKII----REYFPYITEtettTFTDCVNCL 1274

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1128 SEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVRG----------------WFPILFELSC 1191
Cdd:PLN03076  1275 IAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSE 1354

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1192 IINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIV-FRIFDNMK---------LPEQQTEKAE--------WMTT 1253
Cdd:PLN03076  1355 LSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYE 1434

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1254 TCNHALYAICDVFTQYLEVLsDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDIFKT 1333
Cdd:PLN03076  1435 TCTLALQLVVDLFVKFYPTV-NPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANA 1513

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1334 TIPHAlltwrpnsgetappppspDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEevskikstakfPEQKLFAALL- 1412
Cdd:PLN03076  1514 TLPDF------------------SYVVSGEYMPAENIQDSENAEAASSSTADNDAEAE-----------RSRRLYAAISd 1564

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1413 IKC--VVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdqGMYR-FLTSQQLFKLLDCLLESHRFAKA 1489
Cdd:PLN03076  1565 AKCraAVQLLLIQAVMEIY---------------------------------NMYRpRLSAKNTLVLFDALHTVASHAHK 1611

                         1370      1380      1390      1400      1410      1420      1430
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2321695105 1490 FNSNNEQRTALWKAGFKGKSK-PNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRLLNVCSEALSYFL 1560
Cdd:PLN03076  1612 INSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI 1683
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 498-682 1.05e-101

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 323.26  E-value: 1.05e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  498 QKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDF 577
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  578 VSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 657
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 2321695105  658 GINDSKDLPEEYLSAIYNEIAGKKI 682
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 498-682 2.39e-91

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 293.75  E-value: 2.39e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  498 QKEIIEQGIDLFNKKPKRGIQYLQEQGML-GTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKD 576
Cdd:cd00171      1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  577 FVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 656
Cdd:cd00171     81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                          170       180
                   ....*....|....*....|....*.
gi 2321695105  657 RGINDSKDLPEEYLSAIYNEIAGKKI 682
Cdd:cd00171    160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 495-682 3.24e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 276.48  E-value: 3.24e-85
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105   495 LKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGT-TPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFS 573
Cdd:smart00222    1 SKGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFS 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105   574 GKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYI 653
Cdd:smart00222   81 AKDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFI 160

                           170       180
                    ....*....|....*....|....*....
gi 2321695105   654 KMNRGINDSKDLPEEYLSAIYNEIAGKKI 682
Cdd:smart00222  161 KNVRGSNDGEDLPREFLEELYDSIKNNEI 189
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 219-374 1.15e-51

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 178.84  E-value: 1.15e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105  219 LQKDAFLVFRSLCKLS-MKPLSDgpPDPKSHELRSKILSLQLLLSILQNAGPIFRTNEMFINAIKQYLCVALSKNGVSSV 297
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSnGKPLSK--SDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSS 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2321695105  298 PEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILEtSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLN 374
Cdd:pfam12783   79 FPVFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLE-SDSSLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1416-1572 4.24e-44

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 158.17  E-value: 4.24e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1416 VVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdQGMYRFLTSQQLFKLLDCLLESHRFAKAFNSNNE 1495
Cdd:pfam20252    1 VVQLLLIQTVNEIL--------------------------------DEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLE 48

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1496 QRTALWKAGFkGKSKPNLLKQETSSLACGLRILFRMYMDES-RVSAWEEVQQRLLNVCSEALSYFLTL-TSESHRE--AW 1571
Cdd:pfam20252   49 LRTALWRAGF-MKQLPNLLKQETSSLSTYLRILFRLYADDEpRTSQREEVEERLIPLCEDILEYYLSLdEEEKQRElaAW 127


                   .
gi 2321695105 1572 T 1572
Cdd:pfam20252  128 T 128
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1020-1101 1.19e-39

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 141.86  E-value: 1.19e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695105 1020 KFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQ 1099
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ..
gi 2321695105 1100 TT 1101
Cdd:pfam09324   81 IL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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