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Conserved domains on  [gi|2321695091|ref|NP_001400115|]
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brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform 3 [Homo sapiens]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 15-1760 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1012.05  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091   15 ALEKILADKEVKKahHSQLRKACEVALEEIKAETEKQSPP--HGEAKAGSSTLP-PVKSKT----NFIEADKYFLPFELA 87
Cdd:PLN03076    17 ALEKIIKNASWRK--HSKLAHECKAVIERLNSPEKNPPSTssAAADSASASSLPgPLHDGGsieySLAESELILSPLINA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091   88 CQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQgpQTDEGVQLQIIKALLTAVTSQHIEIH 167
Cdd:PLN03076    95 CGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSLRIH 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  168 EGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMEN-------QALQEAKQMEkerhrqhhhllqspvshhe 240
Cdd:PLN03076   173 GDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEAdsstvpiQPIVVAELME------------------- 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  241 pespqlrylPPQTVD---HISQEHEGDLDLHTNDVDKSLQddtePENGSDISSAENEQTEADQATAAETLSknevlydge 317
Cdd:PLN03076   234 ---------PAEKSDsdtSMTQFVQGFITKIMQDIDGVLN----PATAGKSSGSGAHDGAFETTATVETTN--------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  318 nhdceekPQDIVQNIVEEMVNivvGDMGEGTTINASADGNIGTIEDGSDSEniqangipgtpisvaytpslpDDRLSVSS 397
Cdd:PLN03076   292 -------PADLLDSTDKDMLD---AKYWEISMYKSALEGRKGELADGEVEK---------------------DDDLEVQI 340

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  398 NDTqesgnssgpspgakfshiLQKDAFLVFRSLCKLSMK-PLSDGPPDPKSheLRSKILSLQLLLSILQNAGPIFRTNEM 476
Cdd:PLN03076   341 GNK------------------LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDR 400

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  477 FINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILET-STSSFDHKWMVIQTLTRI 555
Cdd:PLN03076   401 FLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKL 480

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  556 CADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-RGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNP 634
Cdd:PLN03076   481 CVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLP 560

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  635 NSQTTlgqEKPSEQEMS-EIKHPETINRYGSLNSLESTSssgigsYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKP 713
Cdd:PLN03076   561 DPASL---KKLDAVENNlEPGSLPVANGNGDENGEGSDS------HSELSSETSDAATIEQRRAYKLELQEGISLFNRKP 631

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  714 KRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGE 793
Cdd:PLN03076   632 KKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGE 711

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  794 AQKIDRLMEKFAARYLECNqgQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAI 873
Cdd:PLN03076   712 AQKIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSL 789

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  874 YNEIAGKKISMKEtkELTIPTKssKQNVASEKQRRLLYNLEMEQMAKTAKALMEA----VSHVQAPFT-----------S 938
Cdd:PLN03076   790 YERISKNEIKMKE--DDLVPQQ--KQSANSNRILGLDSILNIVIRKRGEDSYMETsddlIKHMQEQFKekarksesvyyA 865

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  939 ATHLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGItem 1018
Cdd:PLN03076   866 ATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI--- 942

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1019 KQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKP---------------RYISGTV--------RG 1075
Cdd:PLN03076   943 KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPdatffaapqnesdksKQAKSPIlpvlkrkgPG 1022

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1076 R-----EGSLTGTKDQAPdefVGlGLVGGNVDWKQIASIQESIGETsSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAV 1150
Cdd:PLN03076  1023 KlqyaaAAVRRGSYDSAG---VG-GKASGVVTSEQMNNLVSNLNML-EQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKV 1097

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1151 SMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANF 1230
Cdd:PLN03076  1098 SMEELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANY 1177

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1231 RFQKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVtlvfE 1310
Cdd:PLN03076  1178 NFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKII----R 1253

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1311 KHFPATID----SFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVRG----- 1381
Cdd:PLN03076  1254 EYFPYITEtettTFTDCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesg 1333

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1382 -----------WFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIV-FRIFDNMK---------L 1440
Cdd:PLN03076  1334 eftdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdE 1413

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1441 PEQQTEKAE--------WMTTTCNHALYAICDVFTQYLEVLsDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNG 1512
Cdd:PLN03076  1414 PEGQGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTV-NPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAG 1492

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1513 EKFTLEIWDKTCNCTLDIFKTTIPHAlltwrpnsgetappppspDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEe 1592
Cdd:PLN03076  1493 HLFSDEKWLEVVLSLKEAANATLPDF------------------SYVVSGEYMPAENIQDSENAEAASSSTADNDAEAE- 1553

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1593 vskikstakfPEQKLFAALL-IKC--VVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdqGMYR-FL 1668
Cdd:PLN03076  1554 ----------RSRRLYAAISdAKCraAVQLLLIQAVMEIY---------------------------------NMYRpRL 1590

                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1669 TSQQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSK-PNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQR 1747
Cdd:PLN03076  1591 SAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESR 1670

                         1850
                   ....*....|...
gi 2321695091 1748 LLNVCSEALSYFL 1760
Cdd:PLN03076  1671 LVELCEEVLQFYI 1683
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 15-1760 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1012.05  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091   15 ALEKILADKEVKKahHSQLRKACEVALEEIKAETEKQSPP--HGEAKAGSSTLP-PVKSKT----NFIEADKYFLPFELA 87
Cdd:PLN03076    17 ALEKIIKNASWRK--HSKLAHECKAVIERLNSPEKNPPSTssAAADSASASSLPgPLHDGGsieySLAESELILSPLINA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091   88 CQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQgpQTDEGVQLQIIKALLTAVTSQHIEIH 167
Cdd:PLN03076    95 CGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSLRIH 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  168 EGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMEN-------QALQEAKQMEkerhrqhhhllqspvshhe 240
Cdd:PLN03076   173 GDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEAdsstvpiQPIVVAELME------------------- 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  241 pespqlrylPPQTVD---HISQEHEGDLDLHTNDVDKSLQddtePENGSDISSAENEQTEADQATAAETLSknevlydge 317
Cdd:PLN03076   234 ---------PAEKSDsdtSMTQFVQGFITKIMQDIDGVLN----PATAGKSSGSGAHDGAFETTATVETTN--------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  318 nhdceekPQDIVQNIVEEMVNivvGDMGEGTTINASADGNIGTIEDGSDSEniqangipgtpisvaytpslpDDRLSVSS 397
Cdd:PLN03076   292 -------PADLLDSTDKDMLD---AKYWEISMYKSALEGRKGELADGEVEK---------------------DDDLEVQI 340

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  398 NDTqesgnssgpspgakfshiLQKDAFLVFRSLCKLSMK-PLSDGPPDPKSheLRSKILSLQLLLSILQNAGPIFRTNEM 476
Cdd:PLN03076   341 GNK------------------LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDR 400

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  477 FINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILET-STSSFDHKWMVIQTLTRI 555
Cdd:PLN03076   401 FLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKL 480

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  556 CADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-RGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNP 634
Cdd:PLN03076   481 CVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLP 560

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  635 NSQTTlgqEKPSEQEMS-EIKHPETINRYGSLNSLESTSssgigsYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKP 713
Cdd:PLN03076   561 DPASL---KKLDAVENNlEPGSLPVANGNGDENGEGSDS------HSELSSETSDAATIEQRRAYKLELQEGISLFNRKP 631

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  714 KRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGE 793
Cdd:PLN03076   632 KKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGE 711

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  794 AQKIDRLMEKFAARYLECNqgQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAI 873
Cdd:PLN03076   712 AQKIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSL 789

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  874 YNEIAGKKISMKEtkELTIPTKssKQNVASEKQRRLLYNLEMEQMAKTAKALMEA----VSHVQAPFT-----------S 938
Cdd:PLN03076   790 YERISKNEIKMKE--DDLVPQQ--KQSANSNRILGLDSILNIVIRKRGEDSYMETsddlIKHMQEQFKekarksesvyyA 865

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  939 ATHLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGItem 1018
Cdd:PLN03076   866 ATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI--- 942

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1019 KQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKP---------------RYISGTV--------RG 1075
Cdd:PLN03076   943 KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPdatffaapqnesdksKQAKSPIlpvlkrkgPG 1022

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1076 R-----EGSLTGTKDQAPdefVGlGLVGGNVDWKQIASIQESIGETsSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAV 1150
Cdd:PLN03076  1023 KlqyaaAAVRRGSYDSAG---VG-GKASGVVTSEQMNNLVSNLNML-EQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKV 1097

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1151 SMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANF 1230
Cdd:PLN03076  1098 SMEELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANY 1177

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1231 RFQKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVtlvfE 1310
Cdd:PLN03076  1178 NFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKII----R 1253

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1311 KHFPATID----SFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVRG----- 1381
Cdd:PLN03076  1254 EYFPYITEtettTFTDCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesg 1333

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1382 -----------WFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIV-FRIFDNMK---------L 1440
Cdd:PLN03076  1334 eftdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdE 1413

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1441 PEQQTEKAE--------WMTTTCNHALYAICDVFTQYLEVLsDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNG 1512
Cdd:PLN03076  1414 PEGQGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTV-NPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAG 1492

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1513 EKFTLEIWDKTCNCTLDIFKTTIPHAlltwrpnsgetappppspDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEe 1592
Cdd:PLN03076  1493 HLFSDEKWLEVVLSLKEAANATLPDF------------------SYVVSGEYMPAENIQDSENAEAASSSTADNDAEAE- 1553

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1593 vskikstakfPEQKLFAALL-IKC--VVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdqGMYR-FL 1668
Cdd:PLN03076  1554 ----------RSRRLYAAISdAKCraAVQLLLIQAVMEIY---------------------------------NMYRpRL 1590

                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1669 TSQQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSK-PNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQR 1747
Cdd:PLN03076  1591 SAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESR 1670

                         1850
                   ....*....|...
gi 2321695091 1748 LLNVCSEALSYFL 1760
Cdd:PLN03076  1671 LVELCEEVLQFYI 1683
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 698-882 1.54e-101

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 322.87  E-value: 1.54e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  698 QKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDF 777
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  778 VSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 857
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 2321695091  858 GINDSKDLPEEYLSAIYNEIAGKKI 882
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 698-882 2.85e-91

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 293.75  E-value: 2.85e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  698 QKEIIEQGIDLFNKKPKRGIQYLQEQGML-GTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKD 776
Cdd:cd00171      1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  777 FVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 856
Cdd:cd00171     81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                          170       180
                   ....*....|....*....|....*.
gi 2321695091  857 RGINDSKDLPEEYLSAIYNEIAGKKI 882
Cdd:cd00171    160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 695-882 3.16e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 276.86  E-value: 3.16e-85
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091   695 LKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGT-TPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFS 773
Cdd:smart00222    1 SKGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFS 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091   774 GKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYI 853
Cdd:smart00222   81 AKDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFI 160

                           170       180
                    ....*....|....*....|....*....
gi 2321695091   854 KMNRGINDSKDLPEEYLSAIYNEIAGKKI 882
Cdd:smart00222  161 KNVRGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 15-1760 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1012.05  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091   15 ALEKILADKEVKKahHSQLRKACEVALEEIKAETEKQSPP--HGEAKAGSSTLP-PVKSKT----NFIEADKYFLPFELA 87
Cdd:PLN03076    17 ALEKIIKNASWRK--HSKLAHECKAVIERLNSPEKNPPSTssAAADSASASSLPgPLHDGGsieySLAESELILSPLINA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091   88 CQSKCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQgpQTDEGVQLQIIKALLTAVTSQHIEIH 167
Cdd:PLN03076    95 CGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSLRIH 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  168 EGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMEN-------QALQEAKQMEkerhrqhhhllqspvshhe 240
Cdd:PLN03076   173 GDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRMEAdsstvpiQPIVVAELME------------------- 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  241 pespqlrylPPQTVD---HISQEHEGDLDLHTNDVDKSLQddtePENGSDISSAENEQTEADQATAAETLSknevlydge 317
Cdd:PLN03076   234 ---------PAEKSDsdtSMTQFVQGFITKIMQDIDGVLN----PATAGKSSGSGAHDGAFETTATVETTN--------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  318 nhdceekPQDIVQNIVEEMVNivvGDMGEGTTINASADGNIGTIEDGSDSEniqangipgtpisvaytpslpDDRLSVSS 397
Cdd:PLN03076   292 -------PADLLDSTDKDMLD---AKYWEISMYKSALEGRKGELADGEVEK---------------------DDDLEVQI 340

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  398 NDTqesgnssgpspgakfshiLQKDAFLVFRSLCKLSMK-PLSDGPPDPKSheLRSKILSLQLLLSILQNAGPIFRTNEM 476
Cdd:PLN03076   341 GNK------------------LRRDAFLVFRALCKLSMKtPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDR 400

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  477 FINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILET-STSSFDHKWMVIQTLTRI 555
Cdd:PLN03076   401 FLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRFRAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKL 480

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  556 CADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-RGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQYVNP 634
Cdd:PLN03076   481 CVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvPPGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWMNKQLRLP 560

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  635 NSQTTlgqEKPSEQEMS-EIKHPETINRYGSLNSLESTSssgigsYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKP 713
Cdd:PLN03076   561 DPASL---KKLDAVENNlEPGSLPVANGNGDENGEGSDS------HSELSSETSDAATIEQRRAYKLELQEGISLFNRKP 631

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  714 KRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGE 793
Cdd:PLN03076   632 KKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGEREDLSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGE 711

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  794 AQKIDRLMEKFAARYLECNqgQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAI 873
Cdd:PLN03076   712 AQKIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSL 789

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  874 YNEIAGKKISMKEtkELTIPTKssKQNVASEKQRRLLYNLEMEQMAKTAKALMEA----VSHVQAPFT-----------S 938
Cdd:PLN03076   790 YERISKNEIKMKE--DDLVPQQ--KQSANSNRILGLDSILNIVIRKRGEDSYMETsddlIKHMQEQFKekarksesvyyA 865

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  939 ATHLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGItem 1018
Cdd:PLN03076   866 ATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLEGFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI--- 942

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1019 KQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKP---------------RYISGTV--------RG 1075
Cdd:PLN03076   943 KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLHLLGEGAPPdatffaapqnesdksKQAKSPIlpvlkrkgPG 1022

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1076 R-----EGSLTGTKDQAPdefVGlGLVGGNVDWKQIASIQESIGETsSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAV 1150
Cdd:PLN03076  1023 KlqyaaAAVRRGSYDSAG---VG-GKASGVVTSEQMNNLVSNLNML-EQVGSFEMNRIFTRSQKLNSEAIIDFVKALCKV 1097

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1151 SMDELLSTTHPRMFSLQKIVEISYYNMGRIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANF 1230
Cdd:PLN03076  1098 SMEELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIWHVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANY 1177

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1231 RFQKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQTTGHIVtlvfE 1310
Cdd:PLN03076  1178 NFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKII----R 1253

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1311 KHFPATID----SFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRPQAFKEYTSDDMNVAPEDRVWVRG----- 1381
Cdd:PLN03076  1254 EYFPYITEtettTFTDCVNCLIAFTNSRFNKDISLNAIAFLRFCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesg 1333

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1382 -----------WFPILFELSCIINRCKLDVRTRGLTVMFEIMKTYGHTYEKHWWQDLFRIV-FRIFDNMK---------L 1440
Cdd:PLN03076  1334 eftdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTLRNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdE 1413

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1441 PEQQTEKAE--------WMTTTCNHALYAICDVFTQYLEVLsDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNG 1512
Cdd:PLN03076  1414 PEGQGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTV-NPLLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAG 1492

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1513 EKFTLEIWDKTCNCTLDIFKTTIPHAlltwrpnsgetappppspDTISQKSVDIHDSIQPRSVDNRPQAPLVSASAVNEe 1592
Cdd:PLN03076  1493 HLFSDEKWLEVVLSLKEAANATLPDF------------------SYVVSGEYMPAENIQDSENAEAASSSTADNDAEAE- 1553

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1593 vskikstakfPEQKLFAALL-IKC--VVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdqGMYR-FL 1668
Cdd:PLN03076  1554 ----------RSRRLYAAISdAKCraAVQLLLIQAVMEIY---------------------------------NMYRpRL 1590

                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1669 TSQQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSK-PNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQR 1747
Cdd:PLN03076  1591 SAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLENESYQICLTFLQNLILDKPPLAKEAEVESR 1670

                         1850
                   ....*....|...
gi 2321695091 1748 LLNVCSEALSYFL 1760
Cdd:PLN03076  1671 LVELCEEVLQFYI 1683
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 698-882 1.54e-101

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 322.87  E-value: 1.54e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  698 QKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDF 777
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  778 VSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 857
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 2321695091  858 GINDSKDLPEEYLSAIYNEIAGKKI 882
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 698-882 2.85e-91

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 293.75  E-value: 2.85e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  698 QKEIIEQGIDLFNKKPKRGIQYLQEQGML-GTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKD 776
Cdd:cd00171      1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  777 FVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 856
Cdd:cd00171     81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                          170       180
                   ....*....|....*....|....*.
gi 2321695091  857 RGINDSKDLPEEYLSAIYNEIAGKKI 882
Cdd:cd00171    160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 695-882 3.16e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 276.86  E-value: 3.16e-85
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091   695 LKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGT-TPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFS 773
Cdd:smart00222    1 SKGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFS 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091   774 GKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYI 853
Cdd:smart00222   81 AKDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFI 160

                           170       180
                    ....*....|....*....|....*....
gi 2321695091   854 KMNRGINDSKDLPEEYLSAIYNEIAGKKI 882
Cdd:smart00222  161 KNVRGSNDGEDLPREFLEELYDSIKNNEI 189
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 29-209 5.53e-52

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 180.91  E-value: 5.53e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091   29 HHSQLRKACEVALEEIKAETEKQSPP-HGEAKAGSSTLPPVKSK----TNFIEA-DKYFLPFELACQSKCPRIVSTSLDC 102
Cdd:pfam16213    1 QGSKLLEALQSDLRTLSSEAKRKYPPvKEASEKGILRLRTVHSSsplmQNLLSAsEDILKPFVLACETKNPKLVQIALGC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  103 LQKLIAYGHLTGNApdsttpgkklIDRIIETICGCFQGPQTdegVQLQIIKALLTAVTSQHIeIHEGTVLQAVRTCYNIY 182
Cdd:pfam16213   81 LQKLISHDAISQSA----------APYILDTLWMLMELGSE---IELKVLQTVLLLITTNSV-IHGDTLAKALVLCFRLH 146

                          170       180
                   ....*....|....*....|....*..
gi 2321695091  183 LaSKNLINQTTAKATLTQMLNVIFARM 209
Cdd:pfam16213  147 F-SKDPTVQNTASATLRQLVSVVFERV 172
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 419-574 6.71e-52

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 179.61  E-value: 6.71e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091  419 LQKDAFLVFRSLCKLS-MKPLSDgpPDPKSHELRSKILSLQLLLSILQNAGPIFRTNEMFINAIKQYLCVALSKNGVSSV 497
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSnGKPLSK--SDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSS 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2321695091  498 PEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILEtSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLN 574
Cdd:pfam12783   79 FPVFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLE-SDSSLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1616-1792 1.64e-44

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 159.71  E-value: 1.64e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1616 VVQLELIQTIDNIVffpatskkedaenlaaaqrdavdfdvrvdtqdQGMYRFLTSQQLFKLLDCLLESHRFAKAFNSNNE 1695
Cdd:pfam20252    1 VVQLLLIQTVNEIL--------------------------------DEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLE 48

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1696 QRTALWKAGFkGKSKPNLLKQETSSLACGLRILFRMYMDES-RVSAWEEVQQRLLNVCSEALSYFLTL-TSESHRE--AW 1771
Cdd:pfam20252   49 LRTALWRAGF-MKQLPNLLKQETSSLSTYLRILFRLYADDEpRTSQREEVEERLIPLCEDILEYYLSLdEEEKQRElaAW 127

                          170       180
                   ....*....|....*....|.
gi 2321695091 1772 TNLLLLFLTKVLKISDNRTKR 1792
Cdd:pfam20252  128 TPVVVLILQGLLALPDDDFRR 148
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1220-1301 1.61e-39

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 141.47  E-value: 1.61e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2321695091 1220 KFLEKGELANFRFQKDFLRPFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAFQ 1299
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ..
gi 2321695091 1300 TT 1301
Cdd:pfam09324   81 IL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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