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Conserved domains on  [gi|2311270509|ref|NP_001399261|]
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eukaryotic elongation factor 2 kinase isoform c [Mus musculus]

Protein Classification

alpha-protein kinase family protein; alpha kinase family protein( domain architecture ID 13015116)

alpha-protein kinase family protein is a member of a family that has been implicated in a large variety of cellular processes such as protein translation, Mg2+/Ca2+ homeostasis, intracellular transport, cell migration, adhesion, and proliferation; alpha kinase family protein has been implicated in a large variety of cellular processes such as protein translation, Mg2+/Ca2+ homeostasis, intracellular transport, cell migration, adhesion, and proliferation; similar to Dictyostelium discoideum myosin-II heavy chain kinase A (MHCK A)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Alpha_kinase_eEF2K cd16967
Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 ...
 102-317 3.01e-164

Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 kinase (eEF2K) is also called calcium/calmodulin (CaM)-dependent eEF2K. It phosphorylates eukaryotic elongation factor-2 (EEF2) at a single site, leading to its inactivation and inability to bind ribosomes, and slowing down the elongation stage of protein synthesis. It has been linked to many human diseases including cardiovascular conditions (atherosclerosis) and pulmonary arterial hypertension, as well as solid tumors and neurological disorders. eEF2K is an atypical protein kinase containing a CaM binding region, an alpha-kinase catalytic domain, and TPR-like Sel1 repeats at the C-terminus. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


:

Pssm-ID: 341217  Cd Length: 216  Bit Score: 467.58  E-value: 3.01e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 102 HLEDIATEHATRHRYNAVTGEWLKDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRSVYF 181
Cdd:cd16967     1 HLEDLPTERAVRHRYNAATKKWTKDEVLVKMESKPFARGAMRECYRAKKLSNFSHNQDWKHASNYVAKRYIEPVDREVYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 182 EDVQLQMEAKLWGEDYNRHKPPKQVDIMQMCIIELKDRPGQPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFT 261
Cdd:cd16967    81 EDVRLQMDAKLWGEEYNRHNPPKKVDIMQMCVLEFVDRPGSPLYHLEHFIEGDYIKYNSNSGFVRDDDIRLTPQAFSHFT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2311270509 262 FERSGHQLIVVDIQGVGDLYTDPQIHTEKGTDFGDGNLGVRGMALFFYSHACNRIC 317
Cdd:cd16967   161 FERSGHQLIVVDIQGVGDLYTDPQIHTADGEGYGDGNLGLRGMALFFHSHRCNPIC 216
TPR super family cl34042
TPR repeat [General function prediction only];
478-586 8.14e-07

TPR repeat [General function prediction only];


The actual alignment was detected with superfamily member COG0790:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 50.70  E-value: 8.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 478 GRETEENKTKGFDYLLKAAEAGDRHSMILVARAFDTGLNLSpdrcQDWSEALHWYNTALettdcdEGGEYDGiqdepQYA 557
Cdd:COG0790   148 GEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVP----KDPAKALEWYRKAA------EQGDADA-----QYN 212

                          90       100
                  ....*....|....*....|....*....
gi 2311270509 558 LlareAEMLLTgGFGLDKNPQRSGDLYTQ 586
Cdd:COG0790   213 L----GRLYLN-GEGVEKDLEKALRWLRK 236
 
Name Accession Description Interval E-value
Alpha_kinase_eEF2K cd16967
Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 ...
 102-317 3.01e-164

Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 kinase (eEF2K) is also called calcium/calmodulin (CaM)-dependent eEF2K. It phosphorylates eukaryotic elongation factor-2 (EEF2) at a single site, leading to its inactivation and inability to bind ribosomes, and slowing down the elongation stage of protein synthesis. It has been linked to many human diseases including cardiovascular conditions (atherosclerosis) and pulmonary arterial hypertension, as well as solid tumors and neurological disorders. eEF2K is an atypical protein kinase containing a CaM binding region, an alpha-kinase catalytic domain, and TPR-like Sel1 repeats at the C-terminus. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341217  Cd Length: 216  Bit Score: 467.58  E-value: 3.01e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 102 HLEDIATEHATRHRYNAVTGEWLKDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRSVYF 181
Cdd:cd16967     1 HLEDLPTERAVRHRYNAATKKWTKDEVLVKMESKPFARGAMRECYRAKKLSNFSHNQDWKHASNYVAKRYIEPVDREVYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 182 EDVQLQMEAKLWGEDYNRHKPPKQVDIMQMCIIELKDRPGQPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFT 261
Cdd:cd16967    81 EDVRLQMDAKLWGEEYNRHNPPKKVDIMQMCVLEFVDRPGSPLYHLEHFIEGDYIKYNSNSGFVRDDDIRLTPQAFSHFT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2311270509 262 FERSGHQLIVVDIQGVGDLYTDPQIHTEKGTDFGDGNLGVRGMALFFYSHACNRIC 317
Cdd:cd16967   161 FERSGHQLIVVDIQGVGDLYTDPQIHTADGEGYGDGNLGLRGMALFFHSHRCNPIC 216
Alpha_kinase smart00811
Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic ...
 120-317 7.46e-98

Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.


Pssm-ID: 214828  Cd Length: 198  Bit Score: 296.96  E-value: 7.46e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509  120 TGEWLKDEVLIKMASQPFGRGAMRECFRTKKLSNFLHaqQWKGASNYVAKRYIEPVdRSVYFEDVQLQMEAKLWGEDYNR 199
Cdd:smart00811   2 SGKWTVSETGVKIELKPFAKGAMRVAFRVKDLSEDGS--GTECVAKYFKKEYKNTV-EDRYFEDVEMQMVAKKFAEEFNQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509  200 HKP-PKQVDIMQMCIIELKDRPGQPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLT-PQAFSHFTFERSGHQLIVVDIQGV 277
Cdd:smart00811  79 LKPsPKKIEFLPSYVLELPDRSIPYLFTVEPFLEGEFVKYNSNNGWVNDEARSTEaPQAFSHFTYERSGGSLLVVDLQGV 158

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2311270509  278 GDLYTDPQIHTEKGTDFGDGNLGVRGMALFFYSHACNRIC 317
Cdd:smart00811 159 GDLLTDPQIHTEDGFGFGPGNLGEEGIEKFFATHKCNSIC 198
Alpha_kinase pfam02816
Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic ...
 138-317 6.81e-73

Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.


Pssm-ID: 460709  Cd Length: 185  Bit Score: 231.84  E-value: 6.81e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 138 GRGAMRECFRTKKLSnflhaqQWKGASNYVAKRYIEPV---DRSVYFEDVQLQMEAKLWGEDYN------RHKPPKQVDI 208
Cdd:pfam02816   1 AEGAMRKAFKAKVDP------GDESGQNYVAKEFKKIVygvELEYYFEDAQSQALAKELAEEFNaearalENFPPKKIEF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 209 MQMCIIELKDRPGQPLFHLEHYIEGKYIKYNSNSGFVRDDN--IRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQI 286
Cdd:pfam02816  75 IPPYVVELDPANGKPYYLVEPFLEGNFVKYNSNTGFVSEEDdeLEQTMQAFSHFTYERSGGQLLVCDLQGVGNLLTDPAI 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2311270509 287 HTEKGTDFGDGNLGVRGMALFFYSHACNRIC 317
Cdd:pfam02816 155 HTKDGKRFGDTNLGEEGIASFFSTHKCNKIC 185
TPR COG0790
TPR repeat [General function prediction only];
478-586 8.14e-07

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 50.70  E-value: 8.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 478 GRETEENKTKGFDYLLKAAEAGDRHSMILVARAFDTGLNLSpdrcQDWSEALHWYNTALettdcdEGGEYDGiqdepQYA 557
Cdd:COG0790   148 GEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVP----KDPAKALEWYRKAA------EQGDADA-----QYN 212

                          90       100
                  ....*....|....*....|....*....
gi 2311270509 558 LlareAEMLLTgGFGLDKNPQRSGDLYTQ 586
Cdd:COG0790   213 L----GRLYLN-GEGVEKDLEKALRWLRK 236
 
Name Accession Description Interval E-value
Alpha_kinase_eEF2K cd16967
Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 ...
 102-317 3.01e-164

Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 kinase (eEF2K) is also called calcium/calmodulin (CaM)-dependent eEF2K. It phosphorylates eukaryotic elongation factor-2 (EEF2) at a single site, leading to its inactivation and inability to bind ribosomes, and slowing down the elongation stage of protein synthesis. It has been linked to many human diseases including cardiovascular conditions (atherosclerosis) and pulmonary arterial hypertension, as well as solid tumors and neurological disorders. eEF2K is an atypical protein kinase containing a CaM binding region, an alpha-kinase catalytic domain, and TPR-like Sel1 repeats at the C-terminus. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341217  Cd Length: 216  Bit Score: 467.58  E-value: 3.01e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 102 HLEDIATEHATRHRYNAVTGEWLKDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRSVYF 181
Cdd:cd16967     1 HLEDLPTERAVRHRYNAATKKWTKDEVLVKMESKPFARGAMRECYRAKKLSNFSHNQDWKHASNYVAKRYIEPVDREVYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 182 EDVQLQMEAKLWGEDYNRHKPPKQVDIMQMCIIELKDRPGQPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFT 261
Cdd:cd16967    81 EDVRLQMDAKLWGEEYNRHNPPKKVDIMQMCVLEFVDRPGSPLYHLEHFIEGDYIKYNSNSGFVRDDDIRLTPQAFSHFT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2311270509 262 FERSGHQLIVVDIQGVGDLYTDPQIHTEKGTDFGDGNLGVRGMALFFYSHACNRIC 317
Cdd:cd16967   161 FERSGHQLIVVDIQGVGDLYTDPQIHTADGEGYGDGNLGLRGMALFFHSHRCNPIC 216
Alpha_kinase smart00811
Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic ...
 120-317 7.46e-98

Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.


Pssm-ID: 214828  Cd Length: 198  Bit Score: 296.96  E-value: 7.46e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509  120 TGEWLKDEVLIKMASQPFGRGAMRECFRTKKLSNFLHaqQWKGASNYVAKRYIEPVdRSVYFEDVQLQMEAKLWGEDYNR 199
Cdd:smart00811   2 SGKWTVSETGVKIELKPFAKGAMRVAFRVKDLSEDGS--GTECVAKYFKKEYKNTV-EDRYFEDVEMQMVAKKFAEEFNQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509  200 HKP-PKQVDIMQMCIIELKDRPGQPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLT-PQAFSHFTFERSGHQLIVVDIQGV 277
Cdd:smart00811  79 LKPsPKKIEFLPSYVLELPDRSIPYLFTVEPFLEGEFVKYNSNNGWVNDEARSTEaPQAFSHFTYERSGGSLLVVDLQGV 158

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2311270509  278 GDLYTDPQIHTEKGTDFGDGNLGVRGMALFFYSHACNRIC 317
Cdd:smart00811 159 GDLLTDPQIHTEDGFGFGPGNLGEEGIEKFFATHKCNSIC 198
Alpha_kinase_MHCK_like cd16968
Alpha-kinase domain of myosin heavy chain kinase and similar domains; This group is composed ...
 111-317 5.21e-96

Alpha-kinase domain of myosin heavy chain kinase and similar domains; This group is composed of alpha-kinase domains of Dictyostelium discoideum myosin heavy chain kinases A-D (MHCKA, MHCKB, MHCKC, MHCKD), alpha-protein kinase 1 (AK1), and similar proteins. The myosin heavy chain kinases are involved in regulating myosin II filament assembly in Dictyostelium discoideum. They phosphorylate target threonine residues located in the carboxyl-terminal portion of the myosin II heavy chain (MHC) tail, resulting in filament disassembly. The different MHCK isoforms display different spatial regulation, indicating specific roles for each isoform in fine tuning the Dictyostelium actomyosin cytoskeleton. They all contain an alpha-kinase domain as well as WD40 repeats at the C-terminus. AK1 contains an N-terminal Arf-GAP domain and a central alpha-kinase domain. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341218  Cd Length: 202  Bit Score: 292.60  E-value: 5.21e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 111 ATRHRYNAVTGEWLKDEVLIKMASQPFGRGAMRECFRTKKLSNFlhaqqwKGASNYVAKRYIEP-VDRSVYFEDVQLQME 189
Cdd:cd16968     2 AIKHEFDPETGKWTSTATKVKIDPKPFAEGALREAYHLKDLSAP------GPSTLFVAKLSKDPnESRETYFEDVEMQMV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 190 AKLWGEDYNRHKPPKQVDIMQMCIIELKDRPGQPLFHLEHYIEGKYIKYNSNSGFVRDDNiRLTPQAFSHFTFERSGHQL 269
Cdd:cd16968    76 CKKWAEKFNAKNPPKKVEFLPAWVLELVDRPPPPLCGVEPFIEGEYVKHNNNFGYVDEDE-RNTPQAFSHFTYEASGHQL 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2311270509 270 IVVDIQGVGDLYTDPQIHTEKGTDFGDGNLGVRGMALFFYSHACNRIC 317
Cdd:cd16968   155 LVVDIQGVGDLYTDPQIHTIDGKGFGKGNLGQKGIEKFLETHKCNAIC 202
Alpha_kinase pfam02816
Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic ...
 138-317 6.81e-73

Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.


Pssm-ID: 460709  Cd Length: 185  Bit Score: 231.84  E-value: 6.81e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 138 GRGAMRECFRTKKLSnflhaqQWKGASNYVAKRYIEPV---DRSVYFEDVQLQMEAKLWGEDYN------RHKPPKQVDI 208
Cdd:pfam02816   1 AEGAMRKAFKAKVDP------GDESGQNYVAKEFKKIVygvELEYYFEDAQSQALAKELAEEFNaearalENFPPKKIEF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 209 MQMCIIELKDRPGQPLFHLEHYIEGKYIKYNSNSGFVRDDN--IRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQI 286
Cdd:pfam02816  75 IPPYVVELDPANGKPYYLVEPFLEGNFVKYNSNTGFVSEEDdeLEQTMQAFSHFTYERSGGQLLVCDLQGVGNLLTDPAI 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 2311270509 287 HTEKGTDFGDGNLGVRGMALFFYSHACNRIC 317
Cdd:pfam02816 155 HTKDGKRFGDTNLGEEGIASFFSTHKCNKIC 185
Alpha_kinase cd04515
Alpha kinase family; The alpha kinase family is a novel family of eukaryotic protein kinase ...
 109-317 1.30e-68

Alpha kinase family; The alpha kinase family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional serine/threonine protein kinases. The family contains myosin heavy chain kinases, elongation factor-2 kinases, and bifunctional ion channel kinases. These kinases are implicated in a large variety of cellular processes such as protein translation, Mg2+/Ca2+ homeostasis, intracellular transport, cell migration, adhesion, and proliferation. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341214  Cd Length: 213  Bit Score: 221.89  E-value: 1.30e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 109 EHATRHRYNAVTGEWLKDEVLIKMASQ-PFGRGAMRECFRTKKLSNFlhaqqwkgASNYVAKRYIEPVDRSV----YFED 183
Cdd:cd04515     1 EIEVLRLISVTDLKWTTEETTVRVAKKkPFAQGAMREAFKAKDLDSK--------GKKYVAKRFKRIGDPEEnledLFDE 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 184 VQLQMEAKLWGEDYNRHK-----PPKQVDIMQMCIIELKDR--PGQPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQA 256
Cdd:cd04515    73 LRMQALAQYLAKEFNARAksknlIAPKINFVDPFVVKLGDRddPGKVVFLVEPFLEGKFVKYNNNNGMVNDEDLGETAQA 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2311270509 257 FSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTEKGTDFGDGNLGVRGMALFFYSHACNRIC 317
Cdd:cd04515   153 FSHFTYERSGGQLLVTDLQGVGLVLTDPQIHTVDGGGFGLGNLGEEGIKRFFKTHKCNEIC 213
Alpha_kinase_VwkA_like cd16970
Alpha-kinase domain of Dictyostelium discoideum VwkA and similar domains; Dictyostelium ...
 122-317 2.58e-38

Alpha-kinase domain of Dictyostelium discoideum VwkA and similar domains; Dictyostelium discoideum alpha-protein kinase VwkA is also called von Willebrand factor A alpha-kinase or vWF kinase. It influences myosin II abundance and assembly behavior as vWKA gene disruption leads to significant myosin II overassembly. VwkA also serves a critical conserved role in the periodic contractions of the contractile vacuole through its regulation of the myosin II cortical cytoskeleton. It contains a vWFa domain (named after its homology to von Willebrand factor A, a plasma glycoprotein essential for proper blood clotting) and a C-terminal alpha-kinase domain. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341220  Cd Length: 227  Bit Score: 141.32  E-value: 2.58e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 122 EWLKDEVLIKMASQPFGRGAMRECFRTKKLSNFLHaqqwkgaSNYVAKRYIEPVDRSV-----YFEDVQLQ-MEAKLwGE 195
Cdd:cd16970    26 EMSIREITVKIAPPPFAKGAERWAYYALDTTSDST-------KKVVLKEFKTPGSAQRnsrerYLESMEVQtVAAKL-AF 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 196 DYN----RHKPPKQVDIMQMCIIELKDRPGQPLFHLEHYIEGKYIKYNSNSGFVRDDNiRLTPQAFSHFTFERSGHQLIV 271
Cdd:cd16970    98 EFNkllaRAGINKKITFLEAKVLRVANGDSPQYYTMESFLEGEYKKFNNNVGVVNEDE-VEILQAFSHWTYEASKGYLMV 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2311270509 272 VDIQGV-----GDLYTDPQIHTEKGTDFGDGNLGVRGMALFFYSHACNRIC 317
Cdd:cd16970   177 VDLQGVrtdddGFLLTDPAIHCTDVLRFGRTNLGKEGIDKFFATHKCNQHC 227
Alpha_kinase cd17508
Alpha kinase family; uncharacterized subgroup; The alpha kinase family is a novel family of ...
 127-317 5.08e-31

Alpha kinase family; uncharacterized subgroup; The alpha kinase family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional serine/threonine protein kinases. The family contains myosin heavy chain kinases, elongation factor-2 kinases, and bifunctional ion channel kinases. These kinases are implicated in a large variety of cellular processes such as protein translation, Mg2+/Ca2+ homeostasis, intracellular transport, cell migration, adhesion, and proliferation. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341225  Cd Length: 243  Bit Score: 121.33  E-value: 5.08e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 127 EVLIKMASQPFGRGAMRECFRTKKLSN--FLHAQQWKGASnYVAK--RYIEPVDRSVYFEDVQL--QMEAKLWGEDYNR- 199
Cdd:cd17508    16 AFGIAVRKLPFGEGAERNVFRCTEISKegGTKTATKIGPR-LVAKesRHAEDESFDIKFHKKFCktQSTAQELAERFNKr 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 200 -----HKPPKQVDIMQMCIIELKD--RPGQPLFHLEHYIEGKYIKYNSNSGFVR------------DDNIRLT----PQA 256
Cdd:cd17508    95 lralpGGPAPRVKFLPCHVYKTKDvsYRGRAWVLVEKELEGKFTKWNTNAGGVKksiesvgegrgeSNSSRLRvddvPQA 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2311270509 257 FSHFTFERSGHQLIVVDIQGV------GDLYTDPQIHTEKGT--DFGDGNLGVRGMALFFYSHACNRIC 317
Cdd:cd17508   175 FSHFTYEHSGGRFLVCDLQGVwnatpdGFLLTDPVIHHVSGKrhRFGATDKGLEGIRNFLRTHKCSPLC 243
Alpha_kinase_ALPK1 cd16969
Alpha-kinase domain of alpha-protein kinase 1; Alpha-protein kinase 1 is also called ...
 115-317 2.01e-24

Alpha-kinase domain of alpha-protein kinase 1; Alpha-protein kinase 1 is also called chromosome 4 kinase or lymphocyte alpha-protein kinase (LAK). ALPK1 is implicated in epithelial cell polarity and exocytic vesicular transport towards the apical plasma membrane. It resides on Golgi-derived vesicles where it phosphorylates myosin IA, a motor protein that regulates the delivery of vesicles to the plasma-membrane. It may be associated with inflammation-related diseases such as gout and type 2 diabetes mellitus. ALPK1 contains a C-terminal alpha-kinase domain, an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341219  Cd Length: 227  Bit Score: 101.78  E-value: 2.01e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 115 RYNAVTGEWLKDEVLI------KMASQpfgrGAMRECFRTKklsnFLHaqQWKGASNYVAKRYIEPVDRSVYFEDVQLQM 188
Cdd:cd16969    14 KYSKKSGLWTAQETMVyigdnlQVGKQ----GKQRNAFWVH----FLH--QEETLGRYVGKEYKKPKELQYHFNDVERQM 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 189 EAKLWGEDYNR----HKPPKQVDIMQMCIIE-LKDRPGQPLFHLEHYIEGKYIKYNSNSGFVRDDNiRLTPQ--AFSHFT 261
Cdd:cd16969    84 TAQHYVTEFNKrlyeQNIPTQIFFIPSVILLiLEDKGIKGCVSVEPYMLGEFVKLTNNTTVKKEEY-KATDYglAYGHFT 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2311270509 262 FERSGHQLIVVDIQG------VGDLY-TDPQIHTEKGTdFGDGNLGVRGMALFFYSH--ACNRIC 317
Cdd:cd16969   163 YEFSNHQDVVVDLQGwvtangKGLTYlTDPQIHSVVKK-SGTTNFGKKGIEYFFNNQhtECNEIC 226
Alpha_kinase cd17509
Alpha kinase family; uncharacterized subgroup; The alpha kinase family is a novel family of ...
 228-317 6.59e-16

Alpha kinase family; uncharacterized subgroup; The alpha kinase family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional serine/threonine protein kinases. The family contains myosin heavy chain kinases, elongation factor-2 kinases, and bifunctional ion channel kinases. These kinases are implicated in a large variety of cellular processes such as protein translation, Mg2+/Ca2+ homeostasis, intracellular transport, cell migration, adhesion, and proliferation. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341226  Cd Length: 221  Bit Score: 77.00  E-value: 6.59e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 228 EHYIEGkYIKYNSNSG-FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGD----LYTDPQIHTEKGTDFGDGNLGVR 302
Cdd:cd17509   128 EPFIEN-YEKFNSNSGwNDDSKGWGEVMQALSHFSYHISGGKYLLCDLQGGVYkneyVLTDPVILSRTGREYGVTDLGPE 206

                          90
                  ....*....|....*
gi 2311270509 303 GMALFFYSHACNRIC 317
Cdd:cd17509   207 GIWNFFANHKCNKYC 221
Alpha_kinase_ChaK2_TRPM6 cd16972
Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation ...
 227-318 6.46e-15

Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6; Channel kinase 2 (ChaK2), also called transient receptor potential cation channel subfamily M member 6 (TRMP6) or melastatin-related TRP cation channel 6, is a fusion protein containing a transmembrane ion pore or channel and a C-terminal alpha-kinase domain, both of which are functional. It is highly expressed in the kidney and instestine. It is a cation-selective channel that preferentially permeates Zn2+, Mg2+, and Ca2+ ions. It is a central regulator of Mg2+ and Ca2+ homeostasis. TRPM6 is considered to be the Mg2+ entry pathway in the distal convoluted tubule of the kidney, where it functions as a gatekeeper for controlling the body's Mg2+ balance. Mutations in the TRPM6 gene cause the autosomal recessive disorder hypomagnesemia with secondary hypocalcemia, which often results in severe muscular and neurologic complications from early infancy that can lead to neurologic damage or cardiac arrest if left untreated. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341222  Cd Length: 239  Bit Score: 74.65  E-value: 6.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 227 LEHYIEGKYIKYNSNSGfvrdDNIrlTPQ--------AFSHFTFERSGHQLIVVDIQGVGDLYTDPQI-----HTEKGTD 293
Cdd:cd16972   140 IEKYLTGEFRKYNNNNG----DEI--TPTslleetllAFSHWTYEYTRGELLVLDLQGVGENLTDPSVikpedKQSRGMV 213

                          90       100
                  ....*....|....*....|....*
gi 2311270509 294 FGDGNLGVRGMALFFYSHACNRICQ 318
Cdd:cd16972   214 FGPANLGEDAIRNFIAKHHCNSCCR 238
Alpha_kinase_ChaK cd16965
Alpha-kinase domain of channel kinases; This group is composed of channel kinases 1 (ChaK1) ...
 135-318 4.84e-14

Alpha-kinase domain of channel kinases; This group is composed of channel kinases 1 (ChaK1) and 2 (ChaK2), and similar proteins. ChaK1 and ChaK2 are also called transient receptor potential cation channel subfamily M members 7 (TRMP7) and 6 (TRMP6), respectively. They are fusion proteins containing a transmembrane ion pore or channel and a C-terminal alpha-kinase domain, both of which are functional. They are both cation-selective channels that preferentially permeate Zn2+, Mg2+, and Ca2+ ions. They are central regulators of Mg2+ and Ca2+ homeostasis. TRMP7 is ubiquitously expressed while TRMP6 is highly expressed in specific tissues such as the kidney and intestine. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341215  Cd Length: 239  Bit Score: 71.91  E-value: 4.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 135 QPFGRGAMRECFR--TKKLSNFLHAQQWKGASNYVAKRYIEPVDR---SVYFED---------VQLQMEAKLWGEDYNRH 200
Cdd:cd16965    33 QPLSQEEMDGGLRraTKVVCTWSEGDILKLGSVYIVKSFLPEVVRtwqKIFPEStvlhlclreIQQQRAAQKLMQRFNQV 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 201 KP---PKQVDIMQMCIIELKDrPGQpLFHLEHYIEGKYIKYNSNSG--FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQ 275
Cdd:cd16965   113 KPssiPYSPRFLEVFLLYCHS-AGQ-WLTVENNMTGEFRKYNNNNGdeILPTNTLEETMLAFSHWTYEYTRGELLVLDLQ 190

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2311270509 276 GVGDLYTDPQI-----HTEKGTDFGDGNLGVRGMALFFYSHACNRICQ 318
Cdd:cd16965   191 GVGENLTDPSVikvedKSSGEMVFGPANLGEDAIQNFVAKHHCNSCCR 238
Alpha_kinase_ChaK1_TRMP7 cd16971
Alpha-kinase domain of channel kinase 1, also called transient receptor potential cation ...
 225-318 1.52e-13

Alpha-kinase domain of channel kinase 1, also called transient receptor potential cation channel subfamily M member 7; Channel kinase 1 (ChaK1), also called transient receptor potential cation channel subfamily M member 7 (TRMP7) or long transient receptor potential channel 7 (LTrpC7), is a fusion protein containing a transmembrane ion pore or channel and a C-terminal alpha-kinase domain, both of which are functional. It is ubiquitously expressed and is a cation-selective channel that preferentially permeates Zn2+, Mg2+, and Ca2+ ions. It is a central regulator of Mg2+ and Ca2+ homeostasis. TRPM7 plays a role in cancer proliferation, stroke, hydrogen peroxide dependent neurodegeneration, and heavy metal toxicity. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341221  Cd Length: 239  Bit Score: 70.80  E-value: 1.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 225 FHLEHYIEGKYIKYNSNSG--FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQI--HTEKGTD---FGDG 297
Cdd:cd16971   138 FAVEECMTGEFRKYNNNNGdeIIPTNMLEETMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVikAGEKRSYdmvFGPA 217

                          90       100
                  ....*....|....*....|.
gi 2311270509 298 NLGVRGMALFFYSHACNRICQ 318
Cdd:cd16971   218 NLGEDAIKNFRAKHHCNSCCR 238
TPR COG0790
TPR repeat [General function prediction only];
478-586 8.14e-07

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 50.70  E-value: 8.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 478 GRETEENKTKGFDYLLKAAEAGDRHSMILVARAFDTGLNLSpdrcQDWSEALHWYNTALettdcdEGGEYDGiqdepQYA 557
Cdd:COG0790   148 GEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVP----KDPAKALEWYRKAA------EQGDADA-----QYN 212

                          90       100
                  ....*....|....*....|....*....
gi 2311270509 558 LlareAEMLLTgGFGLDKNPQRSGDLYTQ 586
Cdd:COG0790   213 L----GRLYLN-GEGVEKDLEKALRWLRK 236
Alpha_kinase_ALPK2 cd16974
Alpha-kinase domain of alpha-protein kinase 2; Alpha-protein kinase 2 (ALPK2) is also called ...
 137-317 9.35e-07

Alpha-kinase domain of alpha-protein kinase 2; Alpha-protein kinase 2 (ALPK2) is also called heart alpha-protein kinase (HAK). Little functional information is known about ALPK2. In a three-dimensional colonic-crypt model, it has been identified as crucial for luminal apoptosis and expression of DNA repair-related genes, possibly in the transition of normal colonic crypt to adenoma. The ALPK2 gene may also be a novel candidate gene for inherited hypertension in Dahl rats. ALPK2 contains a C-terminal alpha-kinase domain and two immunoglobulin (Ig)-like domains. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341224  Cd Length: 239  Bit Score: 50.20  E-value: 9.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 137 FGRGAMRECFRTKKLSNFL------HAQQWK--GASNYVAKRYIEPVDRS--VYFEDVQLQMEAKLWGEDYNRHKPPKQV 206
Cdd:cd16974    39 FGEGMHRKAFRSKVMCGLLpvflpgHACVLKvhNAIAYGTKNNDELIQKNykLAVQECYVQNTAREYAKIYAAEAQPLEG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 207 --DIMQMCIIELKDRPGQ--PLFHLEHYIEGKYIKYNSNSG-----FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGV 277
Cdd:cd16974   119 fgEVPEIIPIFLIHRPANniPYATVEEELIGDFVKYSVRDGkeinvLRRDSEAGQKCCTFQHWVYQKTDGNLLVTDMQGV 198

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2311270509 278 GDLYTDPQIHT-EKGTDFGDGNLGVRGMALFFYSHACNRIC 317
Cdd:cd16974   199 GMKLTDVGIATcSKGYKGFKGNCSVSFIDQFKALHQCNKYC 239
TPR COG0790
TPR repeat [General function prediction only];
478-605 1.42e-06

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 49.93  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 478 GRETEENKTKGFDYLLKAAEAGDRHSMILVARAFDTGLNLSpdrcQDWSEALHWYNTALEttdcdeGGEYDGiqdepQYA 557
Cdd:COG0790   112 GLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVP----KDPAKAAEWYRKAAE------QGDADA-----QYN 176

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2311270509 558 LlareAEMLLTGgFGLDKNPQRSGDLYTQAAEAAMEAMKGRLANQYYE 605
Cdd:COG0790   177 L----GVLYENG-RGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLN 219
TPR COG0790
TPR repeat [General function prediction only];
477-586 2.54e-06

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 49.16  E-value: 2.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 477 SGRETEENKTKGFDYLLKAAEAGDRHSMILVARAFDTGLNLSpdrcQDWSEALHWYNTALEttdcdeggeydgiQDEP-- 554
Cdd:COG0790    75 EGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVP----QDYAKALEWYEKAAE-------------QGDAda 137

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2311270509 555 QYALlareAEMLLTgGFGLDKNPQRSGDLYTQ 586
Cdd:COG0790   138 QYNL----GLLYLN-GEGVPKDPAKAAEWYRK 164
TPR COG0790
TPR repeat [General function prediction only];
478-537 1.13e-05

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 47.23  E-value: 1.13e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 478 GRETEENKTKGFDYLLKAAEAGDRHSMILVARAFDTGLNLSPDRcqdwSEALHWYNTALE 537
Cdd:COG0790   184 GRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDL----EKALRWLRKAAE 239
Alpha_kinase_ALPK2_3 cd16966
Alpha-kinase domain of alpha-protein kinases 2 and 3; Alpha-protein kinases 2 (ALPK2) and 3 ...
 214-317 1.52e-04

Alpha-kinase domain of alpha-protein kinases 2 and 3; Alpha-protein kinases 2 (ALPK2) and 3 (ALPK3) are also called heart alpha-protein kinase (HAK) and muscle alpha-protein kinase (MAK), respectively. They both contain a C-terminal alpha-kinase domain and two immunoglobulin (Ig)-like domains. Loss of function mutations in ALPK3 can cause early-onset and familial cardiomyopathy in humans. The ALPK2 gene may also be a novel candidate gene for inherited hypertension in Dahl rats. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341216  Cd Length: 239  Bit Score: 43.72  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270509 214 IELKDRPGQ--PLFHLEHYIEGKYIKYNSNSG-----FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQI 286
Cdd:cd16966   128 LFLIYRPANniPYATVEEELIGPFVKYSIRDGkeinfLRSESEAGQKCCTFQHWVYQWTNGCLLVTDLQGVGMKLTDVGI 207

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2311270509 287 HTE-KGTDFGDGNLGVRGMALFFYSHACNRIC 317
Cdd:cd16966   208 ATLaKGYQGLKGNCSMTFIDQFAALHQCNKYC 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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