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Conserved domains on  [gi|2246031107|ref|NP_001394204|]
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transmembrane protein 43 isoform 3 [Homo sapiens]

Protein Classification

TMEM43 family protein( domain architecture ID 10544559)

TMEM43 (transmembrane 43) family protein similar to human transmembrane protein 43, also called LUMA, that may have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM43 pfam07787
Transmembrane protein 43; This entry represents the transmembrane protein 43 family of ...
 121-372 2.59e-112

Transmembrane protein 43; This entry represents the transmembrane protein 43 family of proteins, which may function as tetraspanin-like membrane organizers.


:

Pssm-ID: 462267  Cd Length: 249  Bit Score: 328.49  E-value: 2.59e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2246031107 121 MYQWVETEESREYTEDGQVKKETRYSYNTEWRSEIINSKNFDREIGHKNPSAMAVESFMATAPFVQIGRFFLSSGLIDKV 200
Cdd:pfam07787   1 MYQWVEESESETYKKNGGETTETTYTYTKEWRSELVDSSSFHIPEGHHNPSAMPVESETQVADDVKVGAFSLSPELKEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2246031107 201 DNFKSLSLSKLEDPHV------DIIRRGDFFYHSENPKYPEVGDLRVSFSYAGlsgddpdlgPAHVTVIARQRGDQLVPF 274
Cdd:pfam07787  81 NGFTELPLDDRNAQEIagperkNVKLHGGYIYHGQNPGEPEVGDLRISFSYAP---------PGDVTVVAKQKGNTLVPY 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2246031107 275 STKSGDTLLLLHHGDFSAEEVFHRELRSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCV 354
Cdd:pfam07787 152 RTKNGDKILLLYEGEFSAEEMFAKEHSENATLTWLLRLVGWLLMFIGFTLLFSPLSTLVSWIPLLGGIVGAGLFLVALIL 231

                         250
                  ....*....|....*...
gi 2246031107 355 ATSLTLLTVAAGWLFYRP 372
Cdd:pfam07787 232 SISLSLLVIALAWLFYRP 249
 
Name Accession Description Interval E-value
TMEM43 pfam07787
Transmembrane protein 43; This entry represents the transmembrane protein 43 family of ...
 121-372 2.59e-112

Transmembrane protein 43; This entry represents the transmembrane protein 43 family of proteins, which may function as tetraspanin-like membrane organizers.


Pssm-ID: 462267  Cd Length: 249  Bit Score: 328.49  E-value: 2.59e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2246031107 121 MYQWVETEESREYTEDGQVKKETRYSYNTEWRSEIINSKNFDREIGHKNPSAMAVESFMATAPFVQIGRFFLSSGLIDKV 200
Cdd:pfam07787   1 MYQWVEESESETYKKNGGETTETTYTYTKEWRSELVDSSSFHIPEGHHNPSAMPVESETQVADDVKVGAFSLSPELKEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2246031107 201 DNFKSLSLSKLEDPHV------DIIRRGDFFYHSENPKYPEVGDLRVSFSYAGlsgddpdlgPAHVTVIARQRGDQLVPF 274
Cdd:pfam07787  81 NGFTELPLDDRNAQEIagperkNVKLHGGYIYHGQNPGEPEVGDLRISFSYAP---------PGDVTVVAKQKGNTLVPY 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2246031107 275 STKSGDTLLLLHHGDFSAEEVFHRELRSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCV 354
Cdd:pfam07787 152 RTKNGDKILLLYEGEFSAEEMFAKEHSENATLTWLLRLVGWLLMFIGFTLLFSPLSTLVSWIPLLGGIVGAGLFLVALIL 231

                         250
                  ....*....|....*...
gi 2246031107 355 ATSLTLLTVAAGWLFYRP 372
Cdd:pfam07787 232 SISLSLLVIALAWLFYRP 249
 
Name Accession Description Interval E-value
TMEM43 pfam07787
Transmembrane protein 43; This entry represents the transmembrane protein 43 family of ...
 121-372 2.59e-112

Transmembrane protein 43; This entry represents the transmembrane protein 43 family of proteins, which may function as tetraspanin-like membrane organizers.


Pssm-ID: 462267  Cd Length: 249  Bit Score: 328.49  E-value: 2.59e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2246031107 121 MYQWVETEESREYTEDGQVKKETRYSYNTEWRSEIINSKNFDREIGHKNPSAMAVESFMATAPFVQIGRFFLSSGLIDKV 200
Cdd:pfam07787   1 MYQWVEESESETYKKNGGETTETTYTYTKEWRSELVDSSSFHIPEGHHNPSAMPVESETQVADDVKVGAFSLSPELKEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2246031107 201 DNFKSLSLSKLEDPHV------DIIRRGDFFYHSENPKYPEVGDLRVSFSYAGlsgddpdlgPAHVTVIARQRGDQLVPF 274
Cdd:pfam07787  81 NGFTELPLDDRNAQEIagperkNVKLHGGYIYHGQNPGEPEVGDLRISFSYAP---------PGDVTVVAKQKGNTLVPY 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2246031107 275 STKSGDTLLLLHHGDFSAEEVFHRELRSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCV 354
Cdd:pfam07787 152 RTKNGDKILLLYEGEFSAEEMFAKEHSENATLTWLLRLVGWLLMFIGFTLLFSPLSTLVSWIPLLGGIVGAGLFLVALIL 231

                         250
                  ....*....|....*...
gi 2246031107 355 ATSLTLLTVAAGWLFYRP 372
Cdd:pfam07787 232 SISLSLLVIALAWLFYRP 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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