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Conserved domains on  [gi|1845976620|ref|NP_001369795|]
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WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Protein Classification

WD40 and Utp21 domain-containing protein( domain architecture ID 13235296)

WD40 and Utp21 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 714-920 1.40e-64

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


:

Pssm-ID: 461219  Cd Length: 209  Bit Score: 215.86  E-value: 1.40e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 714 QIDENLVTFSGLPSSRWANLPDLALIKERNKPTDAVKKIKQAPFFLSASATLDGfEFETENIGDEMDGDSRYITSKrnLL 793
Cdd:pfam04192   2 QLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVG-DFASVEAQEEEEEEEEEERSR--LL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 794 EL-----ESSFTTLLRNAKTRDHLLDAFKTLQNMSLSAIDFQIRTLNP----KTIPIFFRMLLEVLKTKTNFELVQAYAA 864
Cdd:pfam04192  79 KLgslgfESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSLNSggplEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1845976620 865 TATKIHRTIMWNASEgasehEELTEVLEEMAQVQMESWNEMENLFVENMAVVQWIK 920
Cdd:pfam04192 159 VFLKLHGDVIHSNEE-----EELREALEEWKSVQEEEWERLDELVGYCSGVVGFLR 209
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 152-357 3.67e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 3.67e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 152 CHPSTYLNKIVVGSSTGRMKIINFRTGKVIHEFqRSFDSRITIIEQTTALDVVVVGLENGEVMLFNVKMDKIITSFR-HD 230
Cdd:cd00200    57 VAASADGTYLASGSSDKTIRLWDLETGECVRTL-TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHT 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 231 AKITNVAFRDDGeSTMVTADKNGTMAVWDLEKQELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLWifDSADGmp 310
Cdd:cd00200   136 DWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLW--DLSTG-- 209

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1845976620 311 RELVRLEGHSKPCASIKF-VGKDHVLSAGKDGSIRKYDVSSLTMRQKL 357
Cdd:cd00200   210 KCLGTLRGHENGVNSVAFsPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
WD40 COG2319
WD40 repeat [General function prediction only];
161-618 7.36e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 7.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 161 IVVGSSTGRMKIINFRTGKVIHEFQRSfDSRITIIEQTTALDVVVVGLENGEVMLFNVKMDKIITSFR-HDAKITNVAFR 239
Cdd:COG2319    51 LAAGAGDLTLLLLDAAAGALLATLLGH-TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFS 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 240 DDGeSTMVTADKNGTMAVWDLEKQELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLWifDSADGmpRELVRLEGH 319
Cdd:COG2319   130 PDG-KTLASGSADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLW--DLATG--KLLRTLTGH 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 320 SKPCASIKFV--GKdHVLSAGKDGSIRKYDVSSltmrqklgtvgqgvklNKEVQnvaemafgwqreaawnnvfcrqvndt 397
Cdd:COG2319   204 TGAVRSVAFSpdGK-LLASGSADGTVRLWDLAT----------------GKLLR-------------------------- 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 398 kittwqtrnntsgafTLEHDrfkkkvdfiDANATALCVSPCGNFVFIGYSTGHIDQFNAQSGRHVHSFTASTtvkkskks 477
Cdd:COG2319   241 ---------------TLTGH---------SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS-------- 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 478 knprkgptktngdihndtpaadSPITSLSVDQRGKELMSTDAQGHILFWSLSTKAInakmfkkdvrlgICAPCPSNSLVA 557
Cdd:COG2319   289 ----------------------GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL------------LRTLTGHTGAVR 334

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1845976620 558 LVAIAENGK--------ESVILVDTVCHRVARAFETVGNKVNAMTFSSDGKWLLVADNDSYIRVFDVAT 618
Cdd:COG2319   335 SVAFSPDGKtlasgsddGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 714-920 1.40e-64

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


Pssm-ID: 461219  Cd Length: 209  Bit Score: 215.86  E-value: 1.40e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 714 QIDENLVTFSGLPSSRWANLPDLALIKERNKPTDAVKKIKQAPFFLSASATLDGfEFETENIGDEMDGDSRYITSKrnLL 793
Cdd:pfam04192   2 QLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVG-DFASVEAQEEEEEEEEEERSR--LL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 794 EL-----ESSFTTLLRNAKTRDHLLDAFKTLQNMSLSAIDFQIRTLNP----KTIPIFFRMLLEVLKTKTNFELVQAYAA 864
Cdd:pfam04192  79 KLgslgfESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSLNSggplEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1845976620 865 TATKIHRTIMWNASEgasehEELTEVLEEMAQVQMESWNEMENLFVENMAVVQWIK 920
Cdd:pfam04192 159 VFLKLHGDVIHSNEE-----EELREALEEWKSVQEEEWERLDELVGYCSGVVGFLR 209
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 152-357 3.67e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 3.67e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 152 CHPSTYLNKIVVGSSTGRMKIINFRTGKVIHEFqRSFDSRITIIEQTTALDVVVVGLENGEVMLFNVKMDKIITSFR-HD 230
Cdd:cd00200    57 VAASADGTYLASGSSDKTIRLWDLETGECVRTL-TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHT 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 231 AKITNVAFRDDGeSTMVTADKNGTMAVWDLEKQELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLWifDSADGmp 310
Cdd:cd00200   136 DWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLW--DLSTG-- 209

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1845976620 311 RELVRLEGHSKPCASIKF-VGKDHVLSAGKDGSIRKYDVSSLTMRQKL 357
Cdd:cd00200   210 KCLGTLRGHENGVNSVAFsPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
WD40 COG2319
WD40 repeat [General function prediction only];
161-618 7.36e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 7.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 161 IVVGSSTGRMKIINFRTGKVIHEFQRSfDSRITIIEQTTALDVVVVGLENGEVMLFNVKMDKIITSFR-HDAKITNVAFR 239
Cdd:COG2319    51 LAAGAGDLTLLLLDAAAGALLATLLGH-TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFS 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 240 DDGeSTMVTADKNGTMAVWDLEKQELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLWifDSADGmpRELVRLEGH 319
Cdd:COG2319   130 PDG-KTLASGSADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLW--DLATG--KLLRTLTGH 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 320 SKPCASIKFV--GKdHVLSAGKDGSIRKYDVSSltmrqklgtvgqgvklNKEVQnvaemafgwqreaawnnvfcrqvndt 397
Cdd:COG2319   204 TGAVRSVAFSpdGK-LLASGSADGTVRLWDLAT----------------GKLLR-------------------------- 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 398 kittwqtrnntsgafTLEHDrfkkkvdfiDANATALCVSPCGNFVFIGYSTGHIDQFNAQSGRHVHSFTASTtvkkskks 477
Cdd:COG2319   241 ---------------TLTGH---------SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS-------- 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 478 knprkgptktngdihndtpaadSPITSLSVDQRGKELMSTDAQGHILFWSLSTKAInakmfkkdvrlgICAPCPSNSLVA 557
Cdd:COG2319   289 ----------------------GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL------------LRTLTGHTGAVR 334

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1845976620 558 LVAIAENGK--------ESVILVDTVCHRVARAFETVGNKVNAMTFSSDGKWLLVADNDSYIRVFDVAT 618
Cdd:COG2319   335 SVAFSPDGKtlasgsddGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
79-350 8.37e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 8.37e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620  79 FAAHGTNITSLAFCRDikdsidlgakikimtliGTQLIAVDISSGIHVIDTSEGGLQMSLlmEGSDDfEITAIC-HPSTy 157
Cdd:COG2319   158 LTGHSGAVTSVAFSPD-----------------GKLLASGSDDGTVRLWDLATGKLLRTL--TGHTG-AVRSVAfSPDG- 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 158 lNKIVVGSSTGRMKIINFRTGKVIHEFqRSFDSRITiieqttALDV------VVVGLENGEVMLFNVKMDKIITSFR-HD 230
Cdd:COG2319   217 -KLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVR------SVAFspdgrlLASGSADGTVRLWDLATGELLRTLTgHS 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 231 AKITNVAFRDDGEsTMVTADKNGTMAVWDLEKQELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLWifDSADGmp 310
Cdd:COG2319   289 GGVNSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLW--DLATG-- 362

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1845976620 311 RELVRLEGHSKPCASIKFV--GKdHVLSAGKDGSIRKYDVSS 350
Cdd:COG2319   363 ELLRTLTGHTGAVTSVAFSpdGR-TLASGSADGTVRLWDLAT 403
8prop_heme_binding_protein cd20718
eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; ...
 548-644 4.63e-07

eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; Members here contain an 8-bladed beta-propeller heme-binding domain in cytochrome cd1 (nitrite reductase) and similar proteins including NirN and NirF. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO(3-)-> NO(2-)-> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic nitrite reductase NirS via its maturation factor NirF. NirN and NirF form a stable complex with the nitrite reductase NirS during enzyme maturation. NirF is involved in heme d1 insertion.


Pssm-ID: 467720 [Multi-domain]  Cd Length: 380  Bit Score: 53.11  E-value: 4.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 548 APCPSNSLVALVAIAENGKESVILVDTVCHRVARAFETVGNKVNAMTFSSDGKWLLVADNDSYIRVFDVATSQLIDVLLF 627
Cdd:cd20718    19 VAYGIWDLENLMVVVERDAGSVLVIDGSTHEVLGRIDDGGAQVHVVVFSPDGRFAYVISRDGWLTKIDLYTLRPVASIRI 98

                          90
                  ....*....|....*..
gi 1845976620 628 SKPCISMSYNETGQYLA 644
Cdd:cd20718    99 GVNSRGIALSDDGKYVI 115
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 424-470 1.19e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.88  E-value: 1.19e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1845976620 424 DFIDANATALCVSPCGNFVFIGYSTGHIDQFNAQSGRHVHSFTASTT 470
Cdd:pfam12894  35 DKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSD 81
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 554-625 3.68e-04

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 43.49  E-value: 3.68e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1845976620 554 SLVALVAIAE-----NGKE-SVILVDTVCHRVARAFEtVGNKVNAMTFSSDGKWLLVADNDS-YIRVFDVATSQLIDVL 625
Cdd:TIGR03866   2 LLAAGSAAAEtayvsNEKDnTISVIDTATLKVTRTFP-VGQRPRGITFSKDGKLLYVCASDSdTIQVIDPATGEVLHTL 79
WD40 pfam00400
WD domain, G-beta repeat;
264-301 4.62e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.62e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1845976620 264 ELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLW 301
Cdd:pfam00400   2 KLLKTLEG-HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 262-301 4.93e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 4.93e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1845976620  262 KQELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLW 301
Cdd:smart00320   1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
Utp21 pfam04192
Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is ...
 714-920 1.40e-64

Utp21 specific WD40 associated putative domain; Utp21 is a subunit of U3 snoRNP, which is essential for synthesis of 18S rRNA.


Pssm-ID: 461219  Cd Length: 209  Bit Score: 215.86  E-value: 1.40e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 714 QIDENLVTFSGLPSSRWANLPDLALIKERNKPTDAVKKIKQAPFFLSASATLDGfEFETENIGDEMDGDSRYITSKrnLL 793
Cdd:pfam04192   2 QLSEDLVTLSLLPRSRWQTLLHLDLIKQRNKPKEAPKKPEKAPFFLPTLGGLVG-DFASVEAQEEEEEEEEEERSR--LL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 794 EL-----ESSFTTLLRNAKTRDHLLDAFKTLQNMSLSAIDFQIRTLNP----KTIPIFFRMLLEVLKTKTNFELVQAYAA 864
Cdd:pfam04192  79 KLgslgfESEFTKLLREGSETGDYTPFLEYLKSLSPSAIDLEIRSLNSggplEELVSFIRALTSRLKSNRDFELVQAYMA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1845976620 865 TATKIHRTIMWNASEgasehEELTEVLEEMAQVQMESWNEMENLFVENMAVVQWIK 920
Cdd:pfam04192 159 VFLKLHGDVIHSNEE-----EELREALEEWKSVQEEEWERLDELVGYCSGVVGFLR 209
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 152-357 3.67e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 3.67e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 152 CHPSTYLNKIVVGSSTGRMKIINFRTGKVIHEFqRSFDSRITIIEQTTALDVVVVGLENGEVMLFNVKMDKIITSFR-HD 230
Cdd:cd00200    57 VAASADGTYLASGSSDKTIRLWDLETGECVRTL-TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHT 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 231 AKITNVAFRDDGeSTMVTADKNGTMAVWDLEKQELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLWifDSADGmp 310
Cdd:cd00200   136 DWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLW--DLSTG-- 209

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1845976620 311 RELVRLEGHSKPCASIKF-VGKDHVLSAGKDGSIRKYDVSSLTMRQKL 357
Cdd:cd00200   210 KCLGTLRGHENGVNSVAFsPDGYLLASGSEDGTIRVWDLRTGECVQTL 257
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 229-645 6.53e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.80  E-value: 6.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 229 HDAKITNVAFRDDGEsTMVTADKNGTMAVWDLEKQELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLWIFDSadg 308
Cdd:cd00200     8 HTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLWDLET--- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 309 mPRELVRLEGHSKPCASIKFVGKDHVL-SAGKDGSIRKYDVSSLTMRQKLGTVGQGVklnkevqnvaemafgwqreaawn 387
Cdd:cd00200    83 -GECVRTLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWDVETGKCLTTLRGHTDWV----------------------- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 388 nvfcrqvndtkittwqtrnntsgaftlehdrfkkkvdfidanaTALCVSPCGNFVFIGYSTGHIDQFNAQSGRHVHSFTA 467
Cdd:cd00200   139 -------------------------------------------NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTG 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 468 sttvkkskksknprkgptktngdiHNDtpaadsPITSLSVDQRGKELMSTDAQGHILFWSLSTKAinakmfkkdvrlgic 547
Cdd:cd00200   176 ------------------------HTG------EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK--------------- 210

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 548 apcpsnslvalvaiaengkesvilvdtvCHRVARAFEtvgNKVNAMTFSSDGKWLLVADNDSYIRVFDVATSQLIDVL-L 626
Cdd:cd00200   211 ----------------------------CLGTLRGHE---NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLsG 259

                         410
                  ....*....|....*....
gi 1845976620 627 FSKPCISMSYNETGQYLAT 645
Cdd:cd00200   260 HTNSVTSLAWSPDGKRLAS 278
WD40 COG2319
WD40 repeat [General function prediction only];
161-618 7.36e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 7.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 161 IVVGSSTGRMKIINFRTGKVIHEFQRSfDSRITIIEQTTALDVVVVGLENGEVMLFNVKMDKIITSFR-HDAKITNVAFR 239
Cdd:COG2319    51 LAAGAGDLTLLLLDAAAGALLATLLGH-TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFS 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 240 DDGeSTMVTADKNGTMAVWDLEKQELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLWifDSADGmpRELVRLEGH 319
Cdd:COG2319   130 PDG-KTLASGSADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLW--DLATG--KLLRTLTGH 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 320 SKPCASIKFV--GKdHVLSAGKDGSIRKYDVSSltmrqklgtvgqgvklNKEVQnvaemafgwqreaawnnvfcrqvndt 397
Cdd:COG2319   204 TGAVRSVAFSpdGK-LLASGSADGTVRLWDLAT----------------GKLLR-------------------------- 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 398 kittwqtrnntsgafTLEHDrfkkkvdfiDANATALCVSPCGNFVFIGYSTGHIDQFNAQSGRHVHSFTASTtvkkskks 477
Cdd:COG2319   241 ---------------TLTGH---------SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS-------- 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 478 knprkgptktngdihndtpaadSPITSLSVDQRGKELMSTDAQGHILFWSLSTKAInakmfkkdvrlgICAPCPSNSLVA 557
Cdd:COG2319   289 ----------------------GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL------------LRTLTGHTGAVR 334

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1845976620 558 LVAIAENGK--------ESVILVDTVCHRVARAFETVGNKVNAMTFSSDGKWLLVADNDSYIRVFDVAT 618
Cdd:COG2319   335 SVAFSPDGKtlasgsddGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
79-350 8.37e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 8.37e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620  79 FAAHGTNITSLAFCRDikdsidlgakikimtliGTQLIAVDISSGIHVIDTSEGGLQMSLlmEGSDDfEITAIC-HPSTy 157
Cdd:COG2319   158 LTGHSGAVTSVAFSPD-----------------GKLLASGSDDGTVRLWDLATGKLLRTL--TGHTG-AVRSVAfSPDG- 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 158 lNKIVVGSSTGRMKIINFRTGKVIHEFqRSFDSRITiieqttALDV------VVVGLENGEVMLFNVKMDKIITSFR-HD 230
Cdd:COG2319   217 -KLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVR------SVAFspdgrlLASGSADGTVRLWDLATGELLRTLTgHS 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 231 AKITNVAFRDDGEsTMVTADKNGTMAVWDLEKQELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLWifDSADGmp 310
Cdd:COG2319   289 GGVNSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLW--DLATG-- 362

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1845976620 311 RELVRLEGHSKPCASIKFV--GKdHVLSAGKDGSIRKYDVSS 350
Cdd:COG2319   363 ELLRTLTGHTGAVTSVAFSpdGR-TLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
79-357 7.20e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.30  E-value: 7.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620  79 FAAHGTNITSLAFCRDikdsidlgakikimtliGTQLIAVDISSGIHVIDTSEGGLQMSLlmEGSDDfEITAIC-HP-ST 156
Cdd:COG2319   116 LTGHTGAVRSVAFSPD-----------------GKTLASGSADGTVRLWDLATGKLLRTL--TGHSG-AVTSVAfSPdGK 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 157 YLnkiVVGSSTGRMKIINFRTGKVIHEFQR----------SFDSRItiieqttaldvVVVGLENGEVMLFNVKMDKIITS 226
Cdd:COG2319   176 LL---ASGSDDGTVRLWDLATGKLLRTLTGhtgavrsvafSPDGKL-----------LASGSADGTVRLWDLATGKLLRT 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 227 FR-HDAKITNVAFRDDGEsTMVTADKNGTMAVWDLEKQELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLWifDS 305
Cdd:COG2319   242 LTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLW--DL 317

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1845976620 306 ADGmpRELVRLEGHSKPCASIKF--VGKdHVLSAGKDGSIRKYDVSSLTMRQKL 357
Cdd:COG2319   318 ATG--KLLRTLTGHTGAVRSVAFspDGK-TLASGSDDGTVRLWDLATGELLRTL 368
WD40 COG2319
WD40 repeat [General function prediction only];
161-645 2.12e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 2.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 161 IVVGSSTGRMKIINFRTGKVIHEFQRSFDSRITIIEQTTALDVVVVGLENGEVMLFNVKMDKIITSFRHDAKITNVAFRD 240
Cdd:COG2319     9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 241 DGEsTMVTADKNGTMAVWDLEKQELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLWifDSADGmpRELVRLEGHS 320
Cdd:COG2319    89 DGR-LLASASADGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSADGTVRLW--DLATG--KLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 321 KPCASIKFV--GKdHVLSAGKDGSIRKYDVSSLTMRQKLGTVGQGVklnkevqnvaemafgwqreaawnnvfcrqvndtk 398
Cdd:COG2319   163 GAVTSVAFSpdGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAV---------------------------------- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 399 ittwqtrnntsgaftlehdrfkkkvdfidanaTALCVSPCGNFVFIGYSTGHIDQFNAQSGRHVHSFTASTtvkkskksk 478
Cdd:COG2319   208 --------------------------------RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS--------- 246

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 479 nprkgptktngdihndtpaadSPITSLSVDQRGKELMSTDAQGHILFWSLSTKainakmfkkdvrlgicapcpsnslval 558
Cdd:COG2319   247 ---------------------GSVRSVAFSPDGRLLASGSADGTVRLWDLATG--------------------------- 278

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 559 vaiaengkesvilvdtvchRVARAFETVGNKVNAMTFSSDGKWLLVADNDSYIRVFDVATSQLIDVLL-FSKPCISMSYN 637
Cdd:COG2319   279 -------------------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFS 339


                  ....*...
gi 1845976620 638 ETGQYLAT 645
Cdd:COG2319   340 PDGKTLAS 347
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 159-301 2.40e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.62  E-value: 2.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 159 NKIVVGSST-GRMKIINFRTGKVIHEFqRSFDSRITIIEQTTALDVVVVGLENGEVMLFNVKMDKIITSFR-HDAKITNV 236
Cdd:cd00200   147 GTFVASSSQdGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSV 225

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1845976620 237 AFRDDGEsTMVTADKNGTMAVWDLEKQELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLW 301
Cdd:cd00200   226 AFSPDGY-LLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
496-649 7.99e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 7.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 496 PAADSPITSLSVDQRGKELMSTDAQGHILFWSLSTKAINAKMFkkdvrlgicapcPSNSLVALVAIAENGK--------E 567
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT------------GHTGAVRSVAFSPDGKtlasgsadG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 568 SVILVDTVCHRVARAFETVGNKVNAMTFSSDGKWLLVADNDSYIRVFDVATSQLIDVLLFSKPCI-SMSYNETGQYLATV 646
Cdd:COG2319   143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVrSVAFSPDGKLLASG 222


                  ...
gi 1845976620 647 HEG 649
Cdd:COG2319   223 SAD 225
WD40 COG2319
WD40 repeat [General function prediction only];
499-656 1.25e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.92  E-value: 1.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 499 DSPITSLSVDQRGKELMSTDAQGHILFWSLSTKainakmfkkdvRLGICAPCPSNSLVAlVAIAENGK--------ESVI 570
Cdd:COG2319   120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTS-VAFSPDGKllasgsddGTVR 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 571 LVDTVCHRVARAFETVGNKVNAMTFSSDGKWLLVADNDSYIRVFDVATSQLIDVLLFSKPCI-SMSYNETGQYLATVHEG 649
Cdd:COG2319   188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVrSVAFSPDGRLLASGSAD 267


                  ....*..
gi 1845976620 650 eRAVYTW 656
Cdd:COG2319   268 -GTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
495-656 3.31e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 3.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 495 TPAADSPITSLSVDQRGKELMSTDAQGHILFWSLSTKAINAKMFKKDVRLGICAPCPSNSLVALVAiaenGKESVILVDT 574
Cdd:COG2319    32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS----ADGTVRLWDL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 575 VCHRVARAFETVGNKVNAMTFSSDGKWLLVADNDSYIRVFDVATSQLIDVLLFSKPCI-SMSYNETGQYLATVHEGeRAV 653
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVtSVAFSPDGKLLASGSDD-GTV 186


                  ...
gi 1845976620 654 YTW 656
Cdd:COG2319   187 RLW 189
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
557-660 3.48e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.39  E-value: 3.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 557 ALVAIAENGkeSVILVDTVCHRVARAFeTVGNKVNAMTFSSDGKWLLVADNDS-----YIRVFDVATSQLIDVLLFSKPC 631
Cdd:COG3391   124 LYVADSGNG--RVSVIDTATGKVVATI-PVGAGPHGIAVDPDGKRLYVANSGSntvsvIVSVIDTATGKVVATIPVGGGP 200

                          90       100
                  ....*....|....*....|....*....
gi 1845976620 632 ISMSYNETGQYLATVHEGERAVYTWANKV 660
Cdd:COG3391   201 VGVAVSPDGRRLYVANRGSNTSNGGSNTV 229
8prop_heme_binding_protein cd20718
eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; ...
 548-644 4.63e-07

eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; Members here contain an 8-bladed beta-propeller heme-binding domain in cytochrome cd1 (nitrite reductase) and similar proteins including NirN and NirF. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO(3-)-> NO(2-)-> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic nitrite reductase NirS via its maturation factor NirF. NirN and NirF form a stable complex with the nitrite reductase NirS during enzyme maturation. NirF is involved in heme d1 insertion.


Pssm-ID: 467720 [Multi-domain]  Cd Length: 380  Bit Score: 53.11  E-value: 4.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 548 APCPSNSLVALVAIAENGKESVILVDTVCHRVARAFETVGNKVNAMTFSSDGKWLLVADNDSYIRVFDVATSQLIDVLLF 627
Cdd:cd20718    19 VAYGIWDLENLMVVVERDAGSVLVIDGSTHEVLGRIDDGGAQVHVVVFSPDGRFAYVISRDGWLTKIDLYTLRPVASIRI 98

                          90
                  ....*....|....*..
gi 1845976620 628 SKPCISMSYNETGQYLA 644
Cdd:cd20718    99 GVNSRGIALSDDGKYVI 115
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 424-470 1.19e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.88  E-value: 1.19e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1845976620 424 DFIDANATALCVSPCGNFVFIGYSTGHIDQFNAQSGRHVHSFTASTT 470
Cdd:pfam12894  35 DKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSD 81
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 550-634 2.10e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.11  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 550 CPSNSLVALVaiaeNGKESVILVDTVCHRV-ARAFETVGNKVNAMTFSSDGKWLLVADNDSYIRVFDVATSQLIDVLLFS 628
Cdd:pfam12894   4 CPTMDLIALA----TEDGELLLHRLNWQRVwTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAG 79


                  ....*.
gi 1845976620 629 KPCISM 634
Cdd:pfam12894  80 SDLITC 85
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
559-654 2.57e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.53  E-value: 2.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 559 VAIAENGKESVILVDTVCHRVARAFeTVGNKVNAMTFSSDGKWLLVAD-NDSYIRVFDVATSQLIDVLLFSKPCISMSYN 637
Cdd:COG3391    82 LYVANSGSGRVSVIDLATGKVVATI-PVGGGPRGLAVDPDGGRLYVADsGNGRVSVIDTATGKVVATIPVGAGPHGIAVD 160

                          90
                  ....*....|....*..
gi 1845976620 638 ETGQYLATVHEGERAVY 654
Cdd:COG3391   161 PDGKRLYVANSGSNTVS 177
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 554-625 3.68e-04

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 43.49  E-value: 3.68e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1845976620 554 SLVALVAIAE-----NGKE-SVILVDTVCHRVARAFEtVGNKVNAMTFSSDGKWLLVADNDS-YIRVFDVATSQLIDVL 625
Cdd:TIGR03866   2 LLAAGSAAAEtayvsNEKDnTISVIDTATLKVTRTFP-VGQRPRGITFSKDGKLLYVCASDSdTIQVIDPATGEVLHTL 79
WD40 pfam00400
WD domain, G-beta repeat;
264-301 4.62e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.62e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1845976620 264 ELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLW 301
Cdd:pfam00400   2 KLLKTLEG-HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 500-656 4.90e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 4.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 500 SPITSLSVDQRGKELMSTDAQGHILFWSLSTKAI-----NAKMFKKDVRLgicapCPSNSLVALVAiaENGkeSVILVDT 574
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELlrtlkGHTGPVRDVAA-----SADGTYLASGS--SDK--TIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845976620 575 VCHRVARAFETVGNKVNAMTFSSDGKWLLVADNDSYIRVFDVATSQLIDVLLF-SKPCISMSYNETGQYLATVHeGERAV 653
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASSS-QDGTI 159


                  ...
gi 1845976620 654 YTW 656
Cdd:cd00200   160 KLW 162
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 262-301 4.93e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 4.93e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1845976620  262 KQELIGKITGiHSDEINCLYFVPGEPIMLSASLDNSLRLW 301
Cdd:smart00320   1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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