NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1807799535|ref|NP_001365293|]
View 

DNA helicase MCM9 isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MCM super family cl28901
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 305-535 1.21e-151

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


The actual alignment was detected with superfamily member cd17760:

Pssm-ID: 475121 [Multi-domain]  Cd Length: 299  Bit Score: 453.16  E-value: 1.21e-151
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  305 VILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17760      1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  385 LTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 464
Cdd:cd17760     81 LTVTAVKDGGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  465 PQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILENK----------------------------------- 509
Cdd:cd17760    161 PNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFILENKgepskssklwsmekmrtyfcliknlrpvlsdeana 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1807799535  510 ---------------------------------AHARLMFRDTVTLEDAITVVSVMESS 535
Cdd:cd17760    241 illryyqlqrqsdcrnaarttirmleslirlaeAHARLMFRETVTEEDAITVVSVMESS 299
Mcm2 super family cl34204
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 2-536 9.34e-134

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1241:

Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 420.75  E-value: 9.34e-134
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535    2 NSDQVTLVGQVFESYVseyHKNDILLILkerdedAHYP----VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsa 77
Cdd:COG1241      2 ESDLVDKFEEFLRRYK---YRDEILELA------QEYPekrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALR--- 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   78 ltilQSLSQPEAVSMKQnLHARISGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIk 157
Cdd:COG1241     70 ----EIDLEPYDVSLGD-AHVRITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV- 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  158 adfEQYYT-FCRPSSCPSlesC----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILED 226
Cdd:COG1241    141 ---PQTGEkLQEPHECPG---CgrqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILED 201

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  227 DLVDSCKSGDDLTIYGIVMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEEVQKEFEDFweyyKSDPFAgRNVI 306
Cdd:COG1241    202 DLVGEVRPGDRVTVTGILRIEQRTSGRGKSTIFDLYLEANSIEVEEKEFEEIEITEEDEEKIKEL----SKDPDI-YEKI 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  307 LASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLT 386
Cdd:COG1241    277 IASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLT 356

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  387 VTAVKD---SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQ 462
Cdd:COG1241    357 AAAVRDdfgTGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKyGR 436

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1807799535  463 YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILenKAHARLMFRDTVTLEDAITVVSVMESSM 536
Cdd:COG1241    437 FDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHIL--KVHRAGELLEQEIEEETEEVKPEIDPDL 508
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 683-1045 1.72e-06

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 52.38  E-value: 1.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  683 HQSEPKNTVVVSPHPKTSGENMASKISNSTSQG----KEKSEPGQRSKVDIGLLPSPGETGVPWRADNVesNKKKRLALD 758
Cdd:PTZ00449   507 HDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKEsdepKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTL--SKKPEFPKD 584

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  759 SEaavSADKPDSVLTHHVPRNLQKLCKERAQKLcRNSTRVPAQCTVPSHPQStpvhsPDRmldSPKRKRPKSLAQVEEPA 838
Cdd:PTZ00449   585 PK---HPKDPEEPKKPKRPRSAQRPTRPKSPKL-PELLDIPKSPKRPESPKS-----PKR---PPPPQRPSSPERPEGPK 652

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  839 IenVKPPGSPVAKLAKFTFKQKSKLIHSFEDHShvspGATKIAVHSPKISQRRTRRDAALPVKRPGKLTSTPGNQISSQP 918
Cdd:PTZ00449   653 I--IKSPKPPKSPKPPFDPKFKEKFYDDYLDAA----AKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLP 726

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  919 QgeTKEVSQQPP-----EKHGPREKVMCAPEKRIIQPELElgNETGCAHLTCEGDKKEEVSgsnksgkvhactlarlanf 993
Cdd:PTZ00449   727 R--DEEFPFEPIgdpdaEQPDDIEFFTPPEEERTFFHETP--ADTPLPDILAEEFKEEDIH------------------- 783

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1807799535  994 cftppSESKSKSPPPERKNRGERGPSSPPTTTAPMRVSKRKSFQLRGSTEKL 1045
Cdd:PTZ00449   784 -----AETGEPDEAMKRPDSPSEHEDKPPGDHPSLPKKRHRLDGLALSTTDL 830
 
Name Accession Description Interval E-value
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 305-535 1.21e-151

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 453.16  E-value: 1.21e-151
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  305 VILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17760      1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  385 LTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 464
Cdd:cd17760     81 LTVTAVKDGGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  465 PQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILENK----------------------------------- 509
Cdd:cd17760    161 PNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFILENKgepskssklwsmekmrtyfcliknlrpvlsdeana 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1807799535  510 ---------------------------------AHARLMFRDTVTLEDAITVVSVMESS 535
Cdd:cd17760    241 illryyqlqrqsdcrnaarttirmleslirlaeAHARLMFRETVTEEDAITVVSVMESS 299
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 2-536 9.34e-134

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 420.75  E-value: 9.34e-134
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535    2 NSDQVTLVGQVFESYVseyHKNDILLILkerdedAHYP----VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsa 77
Cdd:COG1241      2 ESDLVDKFEEFLRRYK---YRDEILELA------QEYPekrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALR--- 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   78 ltilQSLSQPEAVSMKQnLHARISGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIk 157
Cdd:COG1241     70 ----EIDLEPYDVSLGD-AHVRITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV- 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  158 adfEQYYT-FCRPSSCPSlesC----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILED 226
Cdd:COG1241    141 ---PQTGEkLQEPHECPG---CgrqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILED 201

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  227 DLVDSCKSGDDLTIYGIVMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEEVQKEFEDFweyyKSDPFAgRNVI 306
Cdd:COG1241    202 DLVGEVRPGDRVTVTGILRIEQRTSGRGKSTIFDLYLEANSIEVEEKEFEEIEITEEDEEKIKEL----SKDPDI-YEKI 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  307 LASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLT 386
Cdd:COG1241    277 IASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLT 356

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  387 VTAVKD---SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQ 462
Cdd:COG1241    357 AAAVRDdfgTGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKyGR 436

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1807799535  463 YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILenKAHARLMFRDTVTLEDAITVVSVMESSM 536
Cdd:COG1241    437 FDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHIL--KVHRAGELLEQEIEEETEEVKPEIDPDL 508
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
9-507 6.75e-128

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 405.08  E-value: 6.75e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535    9 VGQVFESYVSEYHKNDILLILKERDED--AHYP--VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsaltILQSL 84
Cdd:NF040949     1 LGEKFKEFIRTFRDSFGNEKYKERIFEmiAMRKrsLVVDFNDLYMFDPELADLLIEKPDEVLPAASKALK-----EIVEE 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   85 SQPEAVSMKQNLHARISGLPvcpELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIKADFEQYY 164
Cdd:NF040949    76 EDPEYAEEVAKFHVRFRNLP---RTVPLRDLRSEYIGKLIAVEGIVTRTTPVKPRIVKAVFRCRDCGCEFEWPEEEEESY 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  165 TFC-RPSSCPSLEScdSSKFTCLSGLSssptRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 243
Cdd:NF040949   153 EIVePPTVCPVCGK--PGSFRLLQEKS----KFIDWQKIVVQERPEELPPGQLPRSIEVVLEDDLVDTARPGDRVTVTGI 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  244 V-MQRWKPFQQDVRCEVEIVLKANYIqvnnEQSSGIIMDEEVQKEFEDFWEYYKSDPFAgRNVILASLCPQVFGMYLVKL 322
Cdd:NF040949   227 LrIKPDSSLKKGSRPIFKNYIEANHI----EVSQKELEEVEITEEDEEKILELAKDPWI-REKIIASIAPSIYGHWEIKE 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  323 AVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEA 400
Cdd:NF040949   302 AIALLLFGGVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLAPRAVYTSGKGSTAAGLTAAVVRDklTGEYYLEA 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  401 GALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPQESVSVNIALGSPL 479
Cdd:NF040949   382 GALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLNARASVLAAGNPKfGRYDPNRSVAENIDLPPTI 461

                          490       500
                   ....*....|....*....|....*...
gi 1807799535  480 LSRFDLILVLLDTKNEDWDRIISSFILE 507
Cdd:NF040949   462 LSRFDLIFVIRDKPNEERDRRLARHILD 489
MCM smart00350
minichromosome maintenance proteins;
116-506 2.75e-118

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 373.91  E-value: 2.75e-118
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   116 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVfviKADFEQYYTFCRPSSCPSlESCDS-SKFTCLSGLSsspt 194
Cdd:smart00350    9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGAT---LGPEIQSGRETEPTVCPP-RECQSpTPFSLNHERS---- 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   195 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVmqRWKPFQ-----QDVRCEVEIVLKANYIQ 269
Cdd:smart00350   81 TFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGfklntVKGLPVFATYIEANHVR 158

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   270 VNNEQSSGIIMDEEVQK----EFEDFWEYYKSDPFAgrNVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGE 345
Cdd:smart00350  159 KLDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPDIY--ERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMKIRGD 236

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   346 SHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHD 423
Cdd:smart00350  237 INILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDpeTREFTLEAGALVLADNGVCCIDEFDKMDDSD 316

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   424 RTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIIS 502
Cdd:smart00350  317 RTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPiGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELA 396


                    ....
gi 1807799535   503 SFIL 506
Cdd:smart00350  397 KHVV 400
MCM pfam00493
MCM P-loop domain;
304-508 6.67e-99

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 311.39  E-value: 6.67e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  304 NVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:pfam00493   16 DKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAA 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  384 GLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK- 460
Cdd:pfam00493   96 GLTAAVVRDpvTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVATLNARCSILAAANPIf 175

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1807799535  461 GQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILEN 508
Cdd:pfam00493  176 GRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDL 223
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 140-508 5.71e-52

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 198.29  E-value: 5.71e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  140 EFERDYMCNKCKHvfviKADFEQYYTFCRPSS---CPSLESCDSSKFTCLSGLSSSPTRCRDYQEIKIQEQvqrlsvgsi 216
Cdd:PTZ00111   279 EVNEPLLCNECNS----KYTFELNHNMCVYSTkkiVKLLQSNSSLNNPDKDGLDNSVDNSGLNGEIYMKDN--------- 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  217 pRSMKVILEDDLVDSCKSGDDLTIYGIVMQ---RWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIM------------- 280
Cdd:PTZ00111   346 -EVINLNLYDDLIDSVKTGDRVTVVGILKVtpiRTSTTRRTLKSLYTYFVNVIHVKVINSTNANQPEkglkylgnendfs 424

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  281 DEEVQKEFEdfweyYKSDPFAGRnVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRV---------RGESHLLLV 351
Cdd:PTZ00111   425 DLQVYKILE-----LSRNPMIYR-ILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSPdacykvdnfRGIINVLLC 498

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  352 GDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVT-AVKDS--GEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIH 428
Cdd:PTZ00111   499 GDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASiKFNESdnGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLY 578

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  429 EAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILE 507
Cdd:PTZ00111   579 EVMEQQTVTIAKAGIVATLKAETAILASCNPiNSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAK 658


                   .
gi 1807799535  508 N 508
Cdd:PTZ00111   659 D 659
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 116-243 1.40e-24

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 99.86  E-value: 1.40e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  116 KTKDVGHFLSVTGTVIRTSLVK---VLEFerdYMCNKCKHVFVIKadfeqyytFCRPSSCPSlESCDS-SKFTclsgLSS 191
Cdd:pfam17207    6 RSEHIGKLVSVSGIVTRTSEVRpklKKAT---FTCRKCGHTVGVK--------ITEPTKCPN-PECGNkDPFK----LVH 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1807799535  192 SPTRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 243
Cdd:pfam17207   70 EKSKFVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGI 121
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 683-1045 1.72e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 52.38  E-value: 1.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  683 HQSEPKNTVVVSPHPKTSGENMASKISNSTSQG----KEKSEPGQRSKVDIGLLPSPGETGVPWRADNVesNKKKRLALD 758
Cdd:PTZ00449   507 HDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKEsdepKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTL--SKKPEFPKD 584

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  759 SEaavSADKPDSVLTHHVPRNLQKLCKERAQKLcRNSTRVPAQCTVPSHPQStpvhsPDRmldSPKRKRPKSLAQVEEPA 838
Cdd:PTZ00449   585 PK---HPKDPEEPKKPKRPRSAQRPTRPKSPKL-PELLDIPKSPKRPESPKS-----PKR---PPPPQRPSSPERPEGPK 652

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  839 IenVKPPGSPVAKLAKFTFKQKSKLIHSFEDHShvspGATKIAVHSPKISQRRTRRDAALPVKRPGKLTSTPGNQISSQP 918
Cdd:PTZ00449   653 I--IKSPKPPKSPKPPFDPKFKEKFYDDYLDAA----AKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLP 726

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  919 QgeTKEVSQQPP-----EKHGPREKVMCAPEKRIIQPELElgNETGCAHLTCEGDKKEEVSgsnksgkvhactlarlanf 993
Cdd:PTZ00449   727 R--DEEFPFEPIgdpdaEQPDDIEFFTPPEEERTFFHETP--ADTPLPDILAEEFKEEDIH------------------- 783

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1807799535  994 cftppSESKSKSPPPERKNRGERGPSSPPTTTAPMRVSKRKSFQLRGSTEKL 1045
Cdd:PTZ00449   784 -----AETGEPDEAMKRPDSPSEHEDKPPGDHPSLPKKRHRLDGLALSTTDL 830
 
Name Accession Description Interval E-value
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 305-535 1.21e-151

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 453.16  E-value: 1.21e-151
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  305 VILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17760      1 EILASLCPQVFGLYNVKLAVAMVLAGGVQRIDASGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSAG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  385 LTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 464
Cdd:cd17760     81 LTVTAVKDGGEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  465 PQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILENK----------------------------------- 509
Cdd:cd17760    161 PNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFILENKgepskssklwsmekmrtyfcliknlrpvlsdeana 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1807799535  510 ---------------------------------AHARLMFRDTVTLEDAITVVSVMESS 535
Cdd:cd17760    241 illryyqlqrqsdcrnaarttirmleslirlaeAHARLMFRETVTEEDAITVVSVMESS 299
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 2-536 9.34e-134

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 420.75  E-value: 9.34e-134
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535    2 NSDQVTLVGQVFESYVseyHKNDILLILkerdedAHYP----VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsa 77
Cdd:COG1241      2 ESDLVDKFEEFLRRYK---YRDEILELA------QEYPekrsLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALR--- 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   78 ltilQSLSQPEAVSMKQnLHARISGLPVCPELvrEHIPkTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIk 157
Cdd:COG1241     70 ----EIDLEPYDVSLGD-AHVRITNLPETVPI--RDIR-SDHIGKLISVEGIVRKATEVKPKITEAAFECPRCGTETYV- 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  158 adfEQYYT-FCRPSSCPSlesC----------DSSKFTclsglsssptrcrDYQEIKIQEQVQRLSVGSIPRSMKVILED 226
Cdd:COG1241    141 ---PQTGEkLQEPHECPG---CgrqgpfkllpEKSEFI-------------DAQKIRIQEPPEDLPGGQQPQSIDVILED 201

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  227 DLVDSCKSGDDLTIYGIVMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIMDEEVQKEFEDFweyyKSDPFAgRNVI 306
Cdd:COG1241    202 DLVGEVRPGDRVTVTGILRIEQRTSGRGKSTIFDLYLEANSIEVEEKEFEEIEITEEDEEKIKEL----SKDPDI-YEKI 276

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  307 LASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLT 386
Cdd:COG1241    277 IASIAPSIYGYEEIKEAIALQLFGGVPKVLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARLAPRGVYTSGKGSTAAGLT 356

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  387 VTAVKD---SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQ 462
Cdd:COG1241    357 AAAVRDdfgTGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVATLNARCSVLAAANPKyGR 436

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1807799535  463 YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILenKAHARLMFRDTVTLEDAITVVSVMESSM 536
Cdd:COG1241    437 FDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHIL--KVHRAGELLEQEIEEETEEVKPEIDPDL 508
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
9-507 6.75e-128

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 405.08  E-value: 6.75e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535    9 VGQVFESYVSEYHKNDILLILKERDED--AHYP--VVVNAMTLFETNMEIGEYFNMFPSEVLTIFDSALRrsaltILQSL 84
Cdd:NF040949     1 LGEKFKEFIRTFRDSFGNEKYKERIFEmiAMRKrsLVVDFNDLYMFDPELADLLIEKPDEVLPAASKALK-----EIVEE 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   85 SQPEAVSMKQNLHARISGLPvcpELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIKADFEQYY 164
Cdd:NF040949    76 EDPEYAEEVAKFHVRFRNLP---RTVPLRDLRSEYIGKLIAVEGIVTRTTPVKPRIVKAVFRCRDCGCEFEWPEEEEESY 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  165 TFC-RPSSCPSLEScdSSKFTCLSGLSssptRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 243
Cdd:NF040949   153 EIVePPTVCPVCGK--PGSFRLLQEKS----KFIDWQKIVVQERPEELPPGQLPRSIEVVLEDDLVDTARPGDRVTVTGI 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  244 V-MQRWKPFQQDVRCEVEIVLKANYIqvnnEQSSGIIMDEEVQKEFEDFWEYYKSDPFAgRNVILASLCPQVFGMYLVKL 322
Cdd:NF040949   227 LrIKPDSSLKKGSRPIFKNYIEANHI----EVSQKELEEVEITEEDEEKILELAKDPWI-REKIIASIAPSIYGHWEIKE 301

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  323 AVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEA 400
Cdd:NF040949   302 AIALLLFGGVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLAPRAVYTSGKGSTAAGLTAAVVRDklTGEYYLEA 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  401 GALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYDPQESVSVNIALGSPL 479
Cdd:NF040949   382 GALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATLNARASVLAAGNPKfGRYDPNRSVAENIDLPPTI 461

                          490       500
                   ....*....|....*....|....*...
gi 1807799535  480 LSRFDLILVLLDTKNEDWDRIISSFILE 507
Cdd:NF040949   462 LSRFDLIFVIRDKPNEERDRRLARHILD 489
MCM smart00350
minichromosome maintenance proteins;
116-506 2.75e-118

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 373.91  E-value: 2.75e-118
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   116 KTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVfviKADFEQYYTFCRPSSCPSlESCDS-SKFTCLSGLSsspt 194
Cdd:smart00350    9 RADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGAT---LGPEIQSGRETEPTVCPP-RECQSpTPFSLNHERS---- 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   195 RCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVmqRWKPFQ-----QDVRCEVEIVLKANYIQ 269
Cdd:smart00350   81 TFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIY--RNVPYGfklntVKGLPVFATYIEANHVR 158

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   270 VNNEQSSGIIMDEEVQK----EFEDFWEYYKSDPFAgrNVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGE 345
Cdd:smart00350  159 KLDYKRSFEDSSFSVQSlsdeEEEEIRKLSKDPDIY--ERLARSLAPSIYGHEDIKKAILLLLFGGVHKNLPDGMKIRGD 236

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   346 SHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHD 423
Cdd:smart00350  237 INILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDpeTREFTLEAGALVLADNGVCCIDEFDKMDDSD 316

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   424 RTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIIS 502
Cdd:smart00350  317 RTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPiGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELA 396


                    ....
gi 1807799535   503 SFIL 506
Cdd:smart00350  397 KHVV 400
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 306-511 3.33e-104

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 329.30  E-value: 3.33e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGL 385
Cdd:cd17706      2 LADSIAPSIYGHEDVKKAVLLQLFGGVQKILEDGTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAGL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  386 TVTAVKDS--GEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQ- 462
Cdd:cd17706     82 TAAVVRDSetGEWYLEAGALVLADGGVCCIDEFDKMKELDRTALHEAMEQQTISIAKAGIVTTLNARCSILAAANPKGGr 161

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1807799535  463 YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILENKAH 511
Cdd:cd17706    162 YNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDLHRG 210
MCM pfam00493
MCM P-loop domain;
304-508 6.67e-99

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 311.39  E-value: 6.67e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  304 NVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:pfam00493   16 DKLADSIAPSIYGHEDVKKAILLQLFGGVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAPRAVYTSGKGSSAA 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  384 GLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK- 460
Cdd:pfam00493   96 GLTAAVVRDpvTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVATLNARCSILAAANPIf 175

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1807799535  461 GQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILEN 508
Cdd:pfam00493  176 GRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDL 223
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 306-507 5.01e-83

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 272.02  E-value: 5.01e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGL 385
Cdd:cd17761      3 IISSIAPSIYGHEDVKEAIALQLFGGVPKVLPDGTRIRGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAAGL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  386 TVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQ 462
Cdd:cd17761     83 TAAVVRDegTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGIVATLNARAAVLAAANPKfGR 162

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1807799535  463 YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILE 507
Cdd:cd17761    163 FDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILD 207
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
 306-506 3.87e-80

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 264.23  E-value: 3.87e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGL 385
Cdd:cd17757      2 LVRSIAPSIYGHEEVKKGILLMLLGGVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAGL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  386 TVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQ 462
Cdd:cd17757     82 TAAVVRDeeTGDFVIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPvGGR 161

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1807799535  463 YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFIL 506
Cdd:cd17757    162 YDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHIV 205
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 308-523 6.74e-76

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 252.33  E-value: 6.74e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  308 ASLCPQVFGMYLVKLAVAMVLAGGIQRTdATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTV 387
Cdd:cd17758      4 ASIAPEIYGHEDVKKALLLLLVGGVDKR-GDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGLTA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  388 TAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQYD 464
Cdd:cd17758     83 AVMKDpvTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAyGRYN 162

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1807799535  465 PQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILENKAHARLMFRDTVTLE 523
Cdd:cd17758    163 PRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTYVHQHNKQPDSDFEPLD 221
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
 306-513 3.21e-75

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 251.21  E-value: 3.21e-75
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGL 385
Cdd:cd17753      2 IINSIAPSIYGHDDIKTAIALALFGGVAKNPGGKHRIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVGL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  386 TVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-GQ 462
Cdd:cd17753     82 TASVRKDpvTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIgGR 161

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1807799535  463 YDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILENkaHAR 513
Cdd:cd17753    162 YNPTLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFVVGS--HVR 210
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
 305-513 1.38e-70

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 238.05  E-value: 1.38e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  305 VILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAG 384
Cdd:cd17756      1 IISKSIAPSIYGNEDIKKAIACLLFGGSRKRLPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  385 LTVTAVKDS--GEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK-G 461
Cdd:cd17756     81 LTASVMRDPstREFYLEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRTSVLAAANPVfG 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1807799535  462 QYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILENKAHAR 513
Cdd:cd17756    161 RYDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINIHASAR 212
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 306-527 1.50e-68

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 232.33  E-value: 1.50e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  306 ILA-SLCPQVFGMYLVKLAVAMVLAGGIQRTDAT-GTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:cd17755      1 RLArSIAPSIYELEDVKKGILLQLFGGTRKDFTKtGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  384 GLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKG 461
Cdd:cd17755     81 GLTAYVTRDpdTKQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIITTLNARTSILASANPIG 160

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1807799535  462 -QYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDR-----IISSFILENKAHARLMFRDTVTLEDAIT 527
Cdd:cd17755    161 sRYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRrlakhLVSLYLEDTPEHIQDEVLDVEVLTDYIS 232
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 309-515 2.61e-66

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 225.42  E-value: 2.61e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  309 SLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLT-- 386
Cdd:cd17754      5 SLAPSIYGHEYIKKAILLMLLGGVEKNLENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVGLTaa 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  387 VTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDP 465
Cdd:cd17754     85 VTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPvYGRYDV 164

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1807799535  466 QESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILENKAHARLM 515
Cdd:cd17754    165 YKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRYIKFL 214
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 306-503 4.53e-62

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 213.16  E-value: 4.53e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  306 ILASLCPQVFGMYLVKLAVAMVLAGGIQRT--DATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSA 383
Cdd:cd17759      2 IVNSLCPAIYGHELVKAGLLLSLFGGKQKYadDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTTS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  384 GLTVTAVKD--SGEWNLEAGALVLADAGLCCIDEFNSL-KEHdrTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK 460
Cdd:cd17759     82 GLTVTLTKDgrSGDFALEAGALVLGDQGICGIDEFDKMgSQH--QALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPV 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1807799535  461 -GQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISS 503
Cdd:cd17759    160 gGHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDHLLSE 203
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 140-508 5.71e-52

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 198.29  E-value: 5.71e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  140 EFERDYMCNKCKHvfviKADFEQYYTFCRPSS---CPSLESCDSSKFTCLSGLSSSPTRCRDYQEIKIQEQvqrlsvgsi 216
Cdd:PTZ00111   279 EVNEPLLCNECNS----KYTFELNHNMCVYSTkkiVKLLQSNSSLNNPDKDGLDNSVDNSGLNGEIYMKDN--------- 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  217 pRSMKVILEDDLVDSCKSGDDLTIYGIVMQ---RWKPFQQDVRCEVEIVLKANYIQVNNEQSSGIIM------------- 280
Cdd:PTZ00111   346 -EVINLNLYDDLIDSVKTGDRVTVVGILKVtpiRTSTTRRTLKSLYTYFVNVIHVKVINSTNANQPEkglkylgnendfs 424

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  281 DEEVQKEFEdfweyYKSDPFAGRnVILASLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRV---------RGESHLLLV 351
Cdd:PTZ00111   425 DLQVYKILE-----LSRNPMIYR-ILLDSFAPSIKARNNVKIGLLCQLFSGNKNSSDFNKSPdacykvdnfRGIINVLLC 498

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  352 GDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVT-AVKDS--GEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIH 428
Cdd:PTZ00111   499 GDPGTAKSQLLHYTHLLSPRSIYTSGKSSSSVGLTASiKFNESdnGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLY 578

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  429 EAMEQQTISVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILE 507
Cdd:PTZ00111   579 EVMEQQTVTIAKAGIVATLKAETAILASCNPiNSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIAK 658


                   .
gi 1807799535  508 N 508
Cdd:PTZ00111   659 D 659
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 116-243 1.40e-24

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 99.86  E-value: 1.40e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  116 KTKDVGHFLSVTGTVIRTSLVK---VLEFerdYMCNKCKHVFVIKadfeqyytFCRPSSCPSlESCDS-SKFTclsgLSS 191
Cdd:pfam17207    6 RSEHIGKLVSVSGIVTRTSEVRpklKKAT---FTCRKCGHTVGVK--------ITEPTKCPN-PECGNkDPFK----LVH 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1807799535  192 SPTRCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGI 243
Cdd:pfam17207   70 EKSKFVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGI 121
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 347-483 2.01e-08

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 53.84  E-value: 2.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  347 HLLLVGDPGTGKSQFLK-YAAKITPRSVLTTGIgstSAGLTVTAVKdsGEWNLEAGALVLADAGL---------CCIDEF 416
Cdd:pfam07728    1 GVLLVGPPGTGKTELAErLAAALSNRPVFYVQL---TRDTTEEDLF--GRRNIDPGGASWVDGPLvraaregeiAVLDEI 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1807799535  417 NSLKEHDRTSIHEAMEQQTISVAKAG-LVCKLNTRTTILAATNPkgqydPQESVSVniaLGSPLLSRF 483
Cdd:pfam07728   76 NRANPDVLNSLLSLLDERRLLLPDGGeLVKAAPDGFRLIATMNP-----LDRGLNE---LSPALRSRF 135
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 683-1045 1.72e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 52.38  E-value: 1.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  683 HQSEPKNTVVVSPHPKTSGENMASKISNSTSQG----KEKSEPGQRSKVDIGLLPSPGETGVPWRADNVesNKKKRLALD 758
Cdd:PTZ00449   507 HDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKEsdepKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTL--SKKPEFPKD 584

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  759 SEaavSADKPDSVLTHHVPRNLQKLCKERAQKLcRNSTRVPAQCTVPSHPQStpvhsPDRmldSPKRKRPKSLAQVEEPA 838
Cdd:PTZ00449   585 PK---HPKDPEEPKKPKRPRSAQRPTRPKSPKL-PELLDIPKSPKRPESPKS-----PKR---PPPPQRPSSPERPEGPK 652

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  839 IenVKPPGSPVAKLAKFTFKQKSKLIHSFEDHShvspGATKIAVHSPKISQRRTRRDAALPVKRPGKLTSTPGNQISSQP 918
Cdd:PTZ00449   653 I--IKSPKPPKSPKPPFDPKFKEKFYDDYLDAA----AKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLP 726

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  919 QgeTKEVSQQPP-----EKHGPREKVMCAPEKRIIQPELElgNETGCAHLTCEGDKKEEVSgsnksgkvhactlarlanf 993
Cdd:PTZ00449   727 R--DEEFPFEPIgdpdaEQPDDIEFFTPPEEERTFFHETP--ADTPLPDILAEEFKEEDIH------------------- 783

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1807799535  994 cftppSESKSKSPPPERKNRGERGPSSPPTTTAPMRVSKRKSFQLRGSTEKL 1045
Cdd:PTZ00449   784 -----AETGEPDEAMKRPDSPSEHEDKPPGDHPSLPKKRHRLDGLALSTTDL 830
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 346-489 1.84e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 45.99  E-value: 1.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  346 SHLLLVGDPGTGKSQFLKYAAKITPRSVLTTgIGSTSAGLTVTAVKDS--GEWNLEAGALVLADAGLCC--IDEFNSLKE 421
Cdd:cd00009     20 KNLLLYGPPGTGKTTLARAIANELFRPGAPF-LYLNASDLLEGLVVAElfGHFLVRLLFELAEKAKPGVlfIDEIDSLSR 98

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1807799535  422 HDRTSIHEAMEQQTISVakaglvcKLNTRTTILAATNPKGQYDPQEsvsvnialgsPLLSRFDLILVL 489
Cdd:cd00009     99 GAQNALLRVLETLNDLR-------IDRENVRVIGATNRPLLGDLDR----------ALYDRLDIRIVI 149
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 347-491 6.54e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 41.20  E-value: 6.54e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535   347 HLLLVGDPGTGKSQFLKYAAKITPR---SVLTTGIGSTSAGLTVTAVKDSGEWNLEAG------ALVLADA-----GLCC 412
Cdd:smart00382    4 VILIVGPPGSGKTTLARALARELGPpggGVIYIDGEDILEEVLDQLLLIIVGGKKASGsgelrlRLALALArklkpDVLI 83

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1807799535   413 IDEFNSLKEHDRtsiheAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPqesvsvnialgSPLLSRFDLILVLLD 491
Cdd:smart00382   84 LDEITSLLDAEQ-----EALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGP-----------ALLRRRFDRRIVLLL 146
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 348-487 8.06e-03

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 37.57  E-value: 8.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1807799535  348 LLLVGDPGTGKSQFLKYAAKITPRSVLTT---GIGSTSAGLTVTAVKDsgewnleagALVLADAGLCC---IDEFNSL-K 420
Cdd:pfam00004    1 LLLYGPPGTGKTTLAKAVAKELGAPFIEIsgsELVSKYVGESEKRLRE---------LFEAAKKLAPCvifIDEIDALaG 71

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1807799535  421 EHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPqesvsvnialgsPLLSRFDLIL 487
Cdd:pfam00004   72 SRGSGGDSESRRVVNQLLTELDGFTSSNSKVIVIAATNRPDKLDP------------ALLGRFDRII 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH