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Conserved domains on  [gi|1774222183|ref|NP_001363018|]
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calpain-7 isoform 4 [Homo sapiens]

Protein Classification

CysPc and calpain_III domain-containing protein( domain architecture ID 10119415)

protein containing domains MIT_calpain7_1, MIT, CysPc, and calpain_III

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CysPc cd00044
Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. ...
 214-538 1.12e-105

Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.


:

Pssm-ID: 238004 [Multi-domain]  Cd Length: 315  Bit Score: 324.67  E-value: 1.12e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 214 TTSKINGIEYVPFMNVDLRERFAYPMPFCdrwgklPLSPKQKTTFSKWVRPEDLTNN-----PTMIY-TVSSFSIKQTIV 287
Cdd:cd00044     1 TLLQICLLSGVLFEDPDFPPNDSSLGFDD------SLSNGQPKKVIEWKRPSEIFADdgnsnPRLFVnGASPSDVCQGIL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 288 SDCSFVASLAISAAYErrfnkKLITGIIYPqnkDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHkGELLCSYSNNK 367
Cdd:cd00044    75 GDCWFLAALAALAERP-----ELLKRVIPP---DQSFEENYAGIYHFRFWKNGEWVEVVIDDRLPTSN-GGLLFMHSRDR 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 368 SELWVSLIEKAYMKVMGGYDF-PGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYqRFHKGDVLITASTGMMTE 446
Cdd:cd00044   146 NELWVALLEKAYAKLHGSYEAlVGGNTAEALEDLTGGPTERIDLKSADASSGDNDLFALLL-SFLQGGSLIGCSTGSRSE 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 447 AEGEK-WGLVPTHAYAVLDIREFK--GLRFIQLKNPWSHLRWKGRYSENDVKNWTPELQkylnFDPRTAQKIDNGIFWIS 523
Cdd:cd00044   225 EEARTaNGLVKGHAYSVLDVREVQeeGLRLLRLRNPWGVGEWWGGWSDDSSEWWVIDAE----RKKLLLSGKDDGEFWMS 300

                         330
                  ....*....|....*
gi 1774222183 524 WDDLCQYYDVIYLSW 538
Cdd:cd00044   301 FEDFLRNFDGLYVCN 315
MIT super family cl00299
MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain ...
 85-159 1.47e-45

MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar sorting proteins and others. The molecular function of the MIT domain is unclear.


The actual alignment was detected with superfamily member cd02680:

Pssm-ID: 469712  Cd Length: 75  Bit Score: 156.70  E-value: 1.47e-45
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1774222183  85 LDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSEPLTKPVG 159
Cdd:cd02680     1 LDLERAHFLVTQAFDEDEKGNAEEAIELYTEAVELCINTSNETMDQALQTKLKQLARQALDRAEALKESMSKASS 75
calpain_III smart00720
calpain_III domain;
593-716 6.93e-38

calpain_III domain;


:

Pssm-ID: 214786  Cd Length: 143  Bit Score: 137.88  E-value: 6.93e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183  593 TLSKRINGKWS-GQSAGGCGNFQETHKNNPIYQFHIEKTGP----LLIEL----------RGPRQYSVGFEVVTV----S 653
Cdd:smart00720   1 WHTKSVQGSWTrGQTAGGCRNYPATFWTNPQFRITLEEPDDddctVLIALmqknrrrlrrKGADFLTIGFAVYKVpkelH 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1774222183  654 TLGDPGPHGFLRKSSGDYRCGFCYLELENIPSGIFNIIPSTFLPKQEGPFFLDFNSIIPIKIT 716
Cdd:smart00720  81 LRRDFFLSNAPRASSGDYINGREVSERFRLPPGEYVIVPSTFEPNQEGDFLLRVFSEGPFKLT 143
MIT_calpain7_1 cd02681
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 5-76 1.49e-36

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.


:

Pssm-ID: 239144  Cd Length: 76  Bit Score: 131.56  E-value: 1.49e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1774222183   5 ALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAEMAG----SSLENIQEKITEYLERVQALHSAVQSKSA 76
Cdd:cd02681     1 ALERDAVQFARLAVQRDQEGRYSEAVFYYKEAAQLLIYAEMAGtlndSHLKTIQEKSNEYLDRAQALHQLVQGQQG 76
 
Name Accession Description Interval E-value
CysPc cd00044
Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. ...
 214-538 1.12e-105

Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.


Pssm-ID: 238004 [Multi-domain]  Cd Length: 315  Bit Score: 324.67  E-value: 1.12e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 214 TTSKINGIEYVPFMNVDLRERFAYPMPFCdrwgklPLSPKQKTTFSKWVRPEDLTNN-----PTMIY-TVSSFSIKQTIV 287
Cdd:cd00044     1 TLLQICLLSGVLFEDPDFPPNDSSLGFDD------SLSNGQPKKVIEWKRPSEIFADdgnsnPRLFVnGASPSDVCQGIL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 288 SDCSFVASLAISAAYErrfnkKLITGIIYPqnkDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHkGELLCSYSNNK 367
Cdd:cd00044    75 GDCWFLAALAALAERP-----ELLKRVIPP---DQSFEENYAGIYHFRFWKNGEWVEVVIDDRLPTSN-GGLLFMHSRDR 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 368 SELWVSLIEKAYMKVMGGYDF-PGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYqRFHKGDVLITASTGMMTE 446
Cdd:cd00044   146 NELWVALLEKAYAKLHGSYEAlVGGNTAEALEDLTGGPTERIDLKSADASSGDNDLFALLL-SFLQGGSLIGCSTGSRSE 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 447 AEGEK-WGLVPTHAYAVLDIREFK--GLRFIQLKNPWSHLRWKGRYSENDVKNWTPELQkylnFDPRTAQKIDNGIFWIS 523
Cdd:cd00044   225 EEARTaNGLVKGHAYSVLDVREVQeeGLRLLRLRNPWGVGEWWGGWSDDSSEWWVIDAE----RKKLLLSGKDDGEFWMS 300

                         330
                  ....*....|....*
gi 1774222183 524 WDDLCQYYDVIYLSW 538
Cdd:cd00044   301 FEDFLRNFDGLYVCN 315
CysPc smart00230
Calpain-like thiol protease family; Calpain-like thiol protease family (peptidase family C2). ...
 223-545 2.07e-85

Calpain-like thiol protease family; Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit).


Pssm-ID: 128526  Cd Length: 318  Bit Score: 272.28  E-value: 2.07e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183  223 YVPFMNVDLRERFAYPMP-FCDRWGKLPLSPKQKTtFSKWVRPEDLTNNPTMIY-TVSSFSIKQTIVSDCSFVASLAISA 300
Cdd:smart00230   1 YEALRQYCKESGTLFEDPlFPANNGSLFFSQRQRK-FVVWKRPHEIFENPPFIVgGASRTDICQGVLGDCWLLAALASLT 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183  301 AYErrfnkKLITgIIYPQNKDGEPeyNPCGKYMVKLHLNGVPRKVIIDDQLPVDhKGELLCSYSNNKSELWVSLIEKAYM 380
Cdd:smart00230  80 LRE-----KLLD-RVIPHDQEFSE--NYAGIFHFRFWRFGKWVDVVIDDRLPTY-NGELVFMHSNSRNEFWSALLEKAYA 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183  381 KVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDSQTfsKDNSFRMLYQRFHKGdVLITASTGMMTEAEGE---KWGLVP 456
Cdd:smart00230 151 KLNGCYEALKGGSTTEaLEDLTGGVAESIDLKEASKD--PDNLFEDLFKAFERG-SLMGCSIGAGTAVEEEeqkDCGLVK 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183  457 THAYAVLDIRE--FKGLRFIQLKNPWSHLRWKGRYSEnDVKNWT---PELQKYLNFDPRtaqkiDNGIFWISWDDLCQYY 531
Cdd:smart00230 228 GHAYSVTDVREvqGRRQELLRLRNPWGQVEWNGPWSD-DSPEWRsvsASEKKNLGLTFD-----DDGEFWMSFEDFLRHF 301

                          330
                   ....*....|....*
gi 1774222183  532 -DVIYLSWNPGLFKE 545
Cdd:smart00230 302 dKVEICNLNPDSLEE 316
Peptidase_C2 pfam00648
Calpain family cysteine protease;
249-532 3.98e-48

Calpain family cysteine protease;


Pssm-ID: 459889 [Multi-domain]  Cd Length: 295  Bit Score: 171.53  E-value: 3.98e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 249 PLSPKQKTTFsKWVRPEDLTNNPTMI-YTVSSFSIKQTIVSDCSFVASLAISAAYERRFNKklitgIIYPqnkDGEPEYN 327
Cdd:pfam00648  16 PPSPPPPRGV-EWKRPKEICSNPQFIvDGASRFDICQGELGDCWLLAAIASLTLNPKLLER-----VVPP---DQSFEEN 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 328 PCGKYMVKLHLNGVPRKVIIDDQLPVdHKGELLCSYSNNKSELWVSLIEKAYMKVMGGY-DFPGSNSNIDLHALTGWIPE 406
Cdd:pfam00648  87 YAGIFHFRFWRFGEWVDVVIDDRLPT-RNGKLLFVHSRDKNEFWSALLEKAYAKLHGSYeALKGGSTSEALEDFTGGVAE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 407 RIAMHSdsqtfSKDNSFRMLyQRFHKGDVLITASTGMMTEAEGEKW---GLVPTHAYAVLDIRE----FKGLRFIQLKNP 479
Cdd:pfam00648 166 SYDLKE-----PPPNLFEIL-LKALERGSLMGCSIDATSAAEEEARtpnGLVKGHAYSVTGVRKvnlkGGKVRLIRLRNP 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1774222183 480 WSHLRWKGRYSENDvKNW---TPELQKYLNFdprtaQKIDNGIFWISWDDLCQYYD 532
Cdd:pfam00648 240 WGEVEWNGAWSDGS-PEWqtvSPEEKEELGL-----TKKDDGEFWMSFEDFLKYFT 289
MIT_calpain7_2 cd02680
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 85-159 1.47e-45

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.


Pssm-ID: 239143  Cd Length: 75  Bit Score: 156.70  E-value: 1.47e-45
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1774222183  85 LDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSEPLTKPVG 159
Cdd:cd02680     1 LDLERAHFLVTQAFDEDEKGNAEEAIELYTEAVELCINTSNETMDQALQTKLKQLARQALDRAEALKESMSKASS 75
calpain_III smart00720
calpain_III domain;
593-716 6.93e-38

calpain_III domain;


Pssm-ID: 214786  Cd Length: 143  Bit Score: 137.88  E-value: 6.93e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183  593 TLSKRINGKWS-GQSAGGCGNFQETHKNNPIYQFHIEKTGP----LLIEL----------RGPRQYSVGFEVVTV----S 653
Cdd:smart00720   1 WHTKSVQGSWTrGQTAGGCRNYPATFWTNPQFRITLEEPDDddctVLIALmqknrrrlrrKGADFLTIGFAVYKVpkelH 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1774222183  654 TLGDPGPHGFLRKSSGDYRCGFCYLELENIPSGIFNIIPSTFLPKQEGPFFLDFNSIIPIKIT 716
Cdd:smart00720  81 LRRDFFLSNAPRASSGDYINGREVSERFRLPPGEYVIVPSTFEPNQEGDFLLRVFSEGPFKLT 143
MIT_calpain7_1 cd02681
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 5-76 1.49e-36

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.


Pssm-ID: 239144  Cd Length: 76  Bit Score: 131.56  E-value: 1.49e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1774222183   5 ALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAEMAG----SSLENIQEKITEYLERVQALHSAVQSKSA 76
Cdd:cd02681     1 ALERDAVQFARLAVQRDQEGRYSEAVFYYKEAAQLLIYAEMAGtlndSHLKTIQEKSNEYLDRAQALHQLVQGQQG 76
Calpain_III cd00214
Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, ...
 591-718 1.87e-35

Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are separated by C2-like domain III. Domain III plays an important role in calcium-induced activation of calpain involving electrostatic interactions with subdomain II. Proposed to mediate calpain's interaction with phospholipids and translocation to cytoplasmic/nuclear membranes. CD includes subdomain III of typical and atypical calpains.


Pssm-ID: 238132  Cd Length: 150  Bit Score: 131.27  E-value: 1.87e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 591 PYTLSKRINGKWS-GQSAGGCGNFQETHKNNPIYQFHIEKTG------PLLIELR----------GPRQYSVGFEVVTVS 653
Cdd:cd00214     1 RKWHTKSFNGEWRrGQTAGGCRNNPDTFWTNPQFRIRVPEPDddegkcTVLIALMqknrrhlrkkGLDLLTIGFHVYKVP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1774222183 654 T-LGDPGPHGFLRK-----SSGDYRCGFCYLELEnIPSGIFNIIPSTFLPKQEGPFFLDFNSIIPIKITQL 718
Cdd:cd00214    81 GeNRHLRRDFFLHKaprarSSTFINTREVSLRFR-LPPGEYVIVPSTFEPGEEGEFLLRVFSEKSIKSSEL 150
MIT smart00745
Microtubule Interacting and Trafficking molecule domain;
87-155 1.71e-16

Microtubule Interacting and Trafficking molecule domain;


Pssm-ID: 197854  Cd Length: 77  Bit Score: 74.65  E-value: 1.71e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1774222183   87 LERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSEPLT 155
Cdd:smart00745   5 LSKAKELISKALKADEAGNYEEALELYKKAIEYLLEGIKVESDSKRREALKAKAAEYLDRAEEIKKSLL 73
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 87-152 5.97e-15

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 69.88  E-value: 5.97e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1774222183  87 LERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSE 152
Cdd:pfam04212   1 LSKALELVKKAVEEDNAGNYEEALELYKEALDYLLLALKETKNEERRELLRAKIAEYLERAEELKE 66
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 10-69 5.69e-10

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 55.62  E-value: 5.69e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1774222183  10 AVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYA---EMAGSSLENIQEKITEYLERVQALHS 69
Cdd:pfam04212   4 ALELVKKAVEEDNAGNYEEALELYKEALDYLLLAlkeTKNEERRELLRAKIAEYLERAEELKE 66
Calpain_III pfam01067
Calpain large subunit, domain III; The function of the domain III and I are currently unknown. ...
 599-705 3.96e-09

Calpain large subunit, domain III; The function of the domain III and I are currently unknown. Domain II is a cysteine protease and domain IV is a calcium binding domain. Calpains are believed to participate in intracellular signaling pathways mediated by calcium ions.


Pssm-ID: 460050  Cd Length: 136  Bit Score: 55.63  E-value: 3.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 599 NGKW-SGQSAGGCGNFQETHKNNPIYQFHIEKTGP--------LLIEL----------RGPRQYSVGFEV--VTVSTLGD 657
Cdd:pfam01067   2 EGRWvRGSTAGGCRNYPDTFWTNPQYRFTLTEPDDdddegectVLVSLmqknrrkqrrLGENLLTIGFAIykVPVELNRK 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1774222183 658 PGPHGFLRKS----SGDY---RCGFCYLELeniPSGIFNIIPSTFLPKQEGPFFL 705
Cdd:pfam01067  82 LRKHFFLTNQpvarSSTYinsREVSLRFRL---PPGEYVIVPSTFEPNEEGEFLL 133
MIT smart00745
Microtubule Interacting and Trafficking molecule domain;
4-74 4.75e-06

Microtubule Interacting and Trafficking molecule domain;


Pssm-ID: 197854  Cd Length: 77  Bit Score: 44.99  E-value: 4.75e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1774222183    4 TALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQAL---IYAEMAGSSLENIQEKITEYLERVQALHSAVQSK 74
Cdd:smart00745   2 RDYLSKAKELISKALKADEAGNYEEALELYKKAIEYLlegIKVESDSKRREALKAKAAEYLDRAEEIKKSLLER 75
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 5-150 1.07e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.72  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183   5 ALERDAVQF-ARLAVQRDH--EGRYSEAVFYYKEAAQALIYAEMAGSSLENIQEKITEYLERVQALHSAVQsksadplks 81
Cdd:COG2956    68 LLERDPDRAeALLELAQDYlkAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLK--------- 138

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1774222183  82 khqLDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDL---CLKTSYETADKVLQNKLKQLARQALDRAEAL 150
Cdd:COG2956   139 ---LGPENAHAYCELAELYLEQGDYDEAIEALEKALKLdpdCARALLLLAELYLEQGDYEEAIAALERALEQ 207
 
Name Accession Description Interval E-value
CysPc cd00044
Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. ...
 214-538 1.12e-105

Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.


Pssm-ID: 238004 [Multi-domain]  Cd Length: 315  Bit Score: 324.67  E-value: 1.12e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 214 TTSKINGIEYVPFMNVDLRERFAYPMPFCdrwgklPLSPKQKTTFSKWVRPEDLTNN-----PTMIY-TVSSFSIKQTIV 287
Cdd:cd00044     1 TLLQICLLSGVLFEDPDFPPNDSSLGFDD------SLSNGQPKKVIEWKRPSEIFADdgnsnPRLFVnGASPSDVCQGIL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 288 SDCSFVASLAISAAYErrfnkKLITGIIYPqnkDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHkGELLCSYSNNK 367
Cdd:cd00044    75 GDCWFLAALAALAERP-----ELLKRVIPP---DQSFEENYAGIYHFRFWKNGEWVEVVIDDRLPTSN-GGLLFMHSRDR 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 368 SELWVSLIEKAYMKVMGGYDF-PGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYqRFHKGDVLITASTGMMTE 446
Cdd:cd00044   146 NELWVALLEKAYAKLHGSYEAlVGGNTAEALEDLTGGPTERIDLKSADASSGDNDLFALLL-SFLQGGSLIGCSTGSRSE 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 447 AEGEK-WGLVPTHAYAVLDIREFK--GLRFIQLKNPWSHLRWKGRYSENDVKNWTPELQkylnFDPRTAQKIDNGIFWIS 523
Cdd:cd00044   225 EEARTaNGLVKGHAYSVLDVREVQeeGLRLLRLRNPWGVGEWWGGWSDDSSEWWVIDAE----RKKLLLSGKDDGEFWMS 300

                         330
                  ....*....|....*
gi 1774222183 524 WDDLCQYYDVIYLSW 538
Cdd:cd00044   301 FEDFLRNFDGLYVCN 315
CysPc smart00230
Calpain-like thiol protease family; Calpain-like thiol protease family (peptidase family C2). ...
 223-545 2.07e-85

Calpain-like thiol protease family; Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit).


Pssm-ID: 128526  Cd Length: 318  Bit Score: 272.28  E-value: 2.07e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183  223 YVPFMNVDLRERFAYPMP-FCDRWGKLPLSPKQKTtFSKWVRPEDLTNNPTMIY-TVSSFSIKQTIVSDCSFVASLAISA 300
Cdd:smart00230   1 YEALRQYCKESGTLFEDPlFPANNGSLFFSQRQRK-FVVWKRPHEIFENPPFIVgGASRTDICQGVLGDCWLLAALASLT 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183  301 AYErrfnkKLITgIIYPQNKDGEPeyNPCGKYMVKLHLNGVPRKVIIDDQLPVDhKGELLCSYSNNKSELWVSLIEKAYM 380
Cdd:smart00230  80 LRE-----KLLD-RVIPHDQEFSE--NYAGIFHFRFWRFGKWVDVVIDDRLPTY-NGELVFMHSNSRNEFWSALLEKAYA 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183  381 KVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDSQTfsKDNSFRMLYQRFHKGdVLITASTGMMTEAEGE---KWGLVP 456
Cdd:smart00230 151 KLNGCYEALKGGSTTEaLEDLTGGVAESIDLKEASKD--PDNLFEDLFKAFERG-SLMGCSIGAGTAVEEEeqkDCGLVK 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183  457 THAYAVLDIRE--FKGLRFIQLKNPWSHLRWKGRYSEnDVKNWT---PELQKYLNFDPRtaqkiDNGIFWISWDDLCQYY 531
Cdd:smart00230 228 GHAYSVTDVREvqGRRQELLRLRNPWGQVEWNGPWSD-DSPEWRsvsASEKKNLGLTFD-----DDGEFWMSFEDFLRHF 301

                          330
                   ....*....|....*
gi 1774222183  532 -DVIYLSWNPGLFKE 545
Cdd:smart00230 302 dKVEICNLNPDSLEE 316
Peptidase_C2 pfam00648
Calpain family cysteine protease;
249-532 3.98e-48

Calpain family cysteine protease;


Pssm-ID: 459889 [Multi-domain]  Cd Length: 295  Bit Score: 171.53  E-value: 3.98e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 249 PLSPKQKTTFsKWVRPEDLTNNPTMI-YTVSSFSIKQTIVSDCSFVASLAISAAYERRFNKklitgIIYPqnkDGEPEYN 327
Cdd:pfam00648  16 PPSPPPPRGV-EWKRPKEICSNPQFIvDGASRFDICQGELGDCWLLAAIASLTLNPKLLER-----VVPP---DQSFEEN 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 328 PCGKYMVKLHLNGVPRKVIIDDQLPVdHKGELLCSYSNNKSELWVSLIEKAYMKVMGGY-DFPGSNSNIDLHALTGWIPE 406
Cdd:pfam00648  87 YAGIFHFRFWRFGEWVDVVIDDRLPT-RNGKLLFVHSRDKNEFWSALLEKAYAKLHGSYeALKGGSTSEALEDFTGGVAE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 407 RIAMHSdsqtfSKDNSFRMLyQRFHKGDVLITASTGMMTEAEGEKW---GLVPTHAYAVLDIRE----FKGLRFIQLKNP 479
Cdd:pfam00648 166 SYDLKE-----PPPNLFEIL-LKALERGSLMGCSIDATSAAEEEARtpnGLVKGHAYSVTGVRKvnlkGGKVRLIRLRNP 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1774222183 480 WSHLRWKGRYSENDvKNW---TPELQKYLNFdprtaQKIDNGIFWISWDDLCQYYD 532
Cdd:pfam00648 240 WGEVEWNGAWSDGS-PEWqtvSPEEKEELGL-----TKKDDGEFWMSFEDFLKYFT 289
MIT_calpain7_2 cd02680
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 85-159 1.47e-45

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.


Pssm-ID: 239143  Cd Length: 75  Bit Score: 156.70  E-value: 1.47e-45
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1774222183  85 LDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSEPLTKPVG 159
Cdd:cd02680     1 LDLERAHFLVTQAFDEDEKGNAEEAIELYTEAVELCINTSNETMDQALQTKLKQLARQALDRAEALKESMSKASS 75
calpain_III smart00720
calpain_III domain;
593-716 6.93e-38

calpain_III domain;


Pssm-ID: 214786  Cd Length: 143  Bit Score: 137.88  E-value: 6.93e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183  593 TLSKRINGKWS-GQSAGGCGNFQETHKNNPIYQFHIEKTGP----LLIEL----------RGPRQYSVGFEVVTV----S 653
Cdd:smart00720   1 WHTKSVQGSWTrGQTAGGCRNYPATFWTNPQFRITLEEPDDddctVLIALmqknrrrlrrKGADFLTIGFAVYKVpkelH 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1774222183  654 TLGDPGPHGFLRKSSGDYRCGFCYLELENIPSGIFNIIPSTFLPKQEGPFFLDFNSIIPIKIT 716
Cdd:smart00720  81 LRRDFFLSNAPRASSGDYINGREVSERFRLPPGEYVIVPSTFEPNQEGDFLLRVFSEGPFKLT 143
MIT_calpain7_1 cd02681
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 5-76 1.49e-36

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.


Pssm-ID: 239144  Cd Length: 76  Bit Score: 131.56  E-value: 1.49e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1774222183   5 ALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAEMAG----SSLENIQEKITEYLERVQALHSAVQSKSA 76
Cdd:cd02681     1 ALERDAVQFARLAVQRDQEGRYSEAVFYYKEAAQLLIYAEMAGtlndSHLKTIQEKSNEYLDRAQALHQLVQGQQG 76
Calpain_III cd00214
Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, ...
 591-718 1.87e-35

Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are separated by C2-like domain III. Domain III plays an important role in calcium-induced activation of calpain involving electrostatic interactions with subdomain II. Proposed to mediate calpain's interaction with phospholipids and translocation to cytoplasmic/nuclear membranes. CD includes subdomain III of typical and atypical calpains.


Pssm-ID: 238132  Cd Length: 150  Bit Score: 131.27  E-value: 1.87e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 591 PYTLSKRINGKWS-GQSAGGCGNFQETHKNNPIYQFHIEKTG------PLLIELR----------GPRQYSVGFEVVTVS 653
Cdd:cd00214     1 RKWHTKSFNGEWRrGQTAGGCRNNPDTFWTNPQFRIRVPEPDddegkcTVLIALMqknrrhlrkkGLDLLTIGFHVYKVP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1774222183 654 T-LGDPGPHGFLRK-----SSGDYRCGFCYLELEnIPSGIFNIIPSTFLPKQEGPFFLDFNSIIPIKITQL 718
Cdd:cd00214    81 GeNRHLRRDFFLHKaprarSSTFINTREVSLRFR-LPPGEYVIVPSTFEPGEEGEFLLRVFSEKSIKSSEL 150
MIT cd02656
MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain ...
 86-157 2.40e-19

MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar sorting proteins and others. The molecular function of the MIT domain is unclear.


Pssm-ID: 239121  Cd Length: 75  Bit Score: 82.74  E-value: 2.40e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1774222183  86 DLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSEPLTKP 157
Cdd:cd02656     2 LLQQAKELIKQAVKEDEDGNYEEALELYKEALDYLLQALKAEKEPKLRKLLRKKVKEYLDRAEFLKELLKKQ 73
MIT smart00745
Microtubule Interacting and Trafficking molecule domain;
87-155 1.71e-16

Microtubule Interacting and Trafficking molecule domain;


Pssm-ID: 197854  Cd Length: 77  Bit Score: 74.65  E-value: 1.71e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1774222183   87 LERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSEPLT 155
Cdd:smart00745   5 LSKAKELISKALKADEAGNYEEALELYKKAIEYLLEGIKVESDSKRREALKAKAAEYLDRAEEIKKSLL 73
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 87-152 5.97e-15

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 69.88  E-value: 5.97e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1774222183  87 LERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSE 152
Cdd:pfam04212   1 LSKALELVKKAVEEDNAGNYEEALELYKEALDYLLLALKETKNEERRELLRAKIAEYLERAEELKE 66
MIT cd02656
MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain ...
 5-76 1.09e-12

MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar sorting proteins and others. The molecular function of the MIT domain is unclear.


Pssm-ID: 239121  Cd Length: 75  Bit Score: 63.87  E-value: 1.09e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1774222183   5 ALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAEMAGSS---LENIQEKITEYLERVQALHSAVQSKSA 76
Cdd:cd02656     1 ELLQQAKELIKQAVKEDEDGNYEEALELYKEALDYLLQALKAEKEpklRKLLRKKVKEYLDRAEFLKELLKKQKQ 75
MIT pfam04212
MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric ...
 10-69 5.69e-10

MIT (microtubule interacting and transport) domain; The MIT domain forms an asymmetric three-helix bundle and binds ESCRT-III (endosomal sorting complexes required for transport) substrates.


Pssm-ID: 461228  Cd Length: 66  Bit Score: 55.62  E-value: 5.69e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1774222183  10 AVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYA---EMAGSSLENIQEKITEYLERVQALHS 69
Cdd:pfam04212   4 ALELVKKAVEEDNAGNYEEALELYKEALDYLLLAlkeTKNEERRELLRAKIAEYLERAEELKE 66
Calpain_III pfam01067
Calpain large subunit, domain III; The function of the domain III and I are currently unknown. ...
 599-705 3.96e-09

Calpain large subunit, domain III; The function of the domain III and I are currently unknown. Domain II is a cysteine protease and domain IV is a calcium binding domain. Calpains are believed to participate in intracellular signaling pathways mediated by calcium ions.


Pssm-ID: 460050  Cd Length: 136  Bit Score: 55.63  E-value: 3.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183 599 NGKW-SGQSAGGCGNFQETHKNNPIYQFHIEKTGP--------LLIEL----------RGPRQYSVGFEV--VTVSTLGD 657
Cdd:pfam01067   2 EGRWvRGSTAGGCRNYPDTFWTNPQYRFTLTEPDDdddegectVLVSLmqknrrkqrrLGENLLTIGFAIykVPVELNRK 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1774222183 658 PGPHGFLRKS----SGDY---RCGFCYLELeniPSGIFNIIPSTFLPKQEGPFFL 705
Cdd:pfam01067  82 LRKHFFLTNQpvarSSTYinsREVSLRFRL---PPGEYVIVPSTFEPNEEGEFLL 133
MIT_VPS4 cd02678
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 87-156 2.42e-07

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.


Pssm-ID: 239141  Cd Length: 75  Bit Score: 48.42  E-value: 2.42e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1774222183  87 LERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKT-SYETadkvlQNKLKQLAR----QALDRAEALSEPLTK 156
Cdd:cd02678     3 LQKAIELVKKAIEEDNAGNYEEALRLYQHALEYFMHAlKYEK-----NPKSKESIRakctEYLDRAEKLKEYLAK 72
MIT smart00745
Microtubule Interacting and Trafficking molecule domain;
4-74 4.75e-06

Microtubule Interacting and Trafficking molecule domain;


Pssm-ID: 197854  Cd Length: 77  Bit Score: 44.99  E-value: 4.75e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1774222183    4 TALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQAL---IYAEMAGSSLENIQEKITEYLERVQALHSAVQSK 74
Cdd:smart00745   2 RDYLSKAKELISKALKADEAGNYEEALELYKKAIEYLlegIKVESDSKRREALKAKAAEYLDRAEEIKKSLLER 75
MIT_VPS4 cd02678
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 10-76 7.89e-06

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.


Pssm-ID: 239141  Cd Length: 75  Bit Score: 44.18  E-value: 7.89e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183  10 AVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYA---EMAGSSLENIQEKITEYLERVQALHSAVQSKSA 76
Cdd:cd02678     6 AIELVKKAIEEDNAGNYEEALRLYQHALEYFMHAlkyEKNPKSKESIRAKCTEYLDRAEKLKEYLAKKEK 75
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 5-150 1.07e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.72  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1774222183   5 ALERDAVQF-ARLAVQRDH--EGRYSEAVFYYKEAAQALIYAEMAGSSLENIQEKITEYLERVQALHSAVQsksadplks 81
Cdd:COG2956    68 LLERDPDRAeALLELAQDYlkAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLK--------- 138

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1774222183  82 khqLDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDL---CLKTSYETADKVLQNKLKQLARQALDRAEAL 150
Cdd:COG2956   139 ---LGPENAHAYCELAELYLEQGDYDEAIEALEKALKLdpdCARALLLLAELYLEQGDYEEAIAALERALEQ 207
MIT_AAA_Arch cd02682
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 6-76 2.24e-04

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in mostly archaebacterial AAA-ATPases. The molecular function of the MIT domain is unclear.


Pssm-ID: 239145  Cd Length: 75  Bit Score: 40.20  E-value: 2.24e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1774222183   6 LERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQAL---IYAEMAGSSLENIQEKITEYLERVQALHSAVQSKSA 76
Cdd:cd02682     2 LEEMARKYAINAVKAEKEGNAEDAITNYKKAIEVLsqiVKNYPDSPTRLIYEQMINEYKRRIEVLEKQNPASSA 75
MIT_2 cd02684
MIT: domain contained within Microtubule Interacting and Trafficking molecules. This ...
 87-150 1.33e-03

MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.


Pssm-ID: 239147  Cd Length: 75  Bit Score: 37.88  E-value: 1.33e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1774222183  87 LERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEAL 150
Cdd:cd02684     3 LEKAIALVVQAVKKDQRGDAAAALSLYCSALQYFVPALHYETDAQRKEALRQKVLQYVSRAEEL 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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