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Conserved domains on  [gi|1393428042|ref|NP_001350692|]
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cyclin-dependent kinase inhibitor 2A isoform 6 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
4-82 1.50e-08

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.34  E-value: 1.50e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1393428042   4 GSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAA 82
Cdd:COG0666   131 GNLEIVKLLLEAGADVNAQDNDGNT-PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-82 1.50e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.34  E-value: 1.50e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1393428042   4 GSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAA 82
Cdd:COG0666   131 GNLEIVKLLLEAGADVNAQDNDGNT-PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 4-105 9.79e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 9.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428042   4 GSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLraaa 83
Cdd:PTZ00322   93 GDAVGARILLTGGADPNCRDYDGRT-PLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL---- 167

                          90       100
                  ....*....|....*....|..
gi 1393428042  84 ggtrgSNHARIDAAEGPSDIPD 105
Cdd:PTZ00322  168 -----SRHSQCHFELGANAKPD 184
Ank_2 pfam12796
Ankyrin repeats (3 copies);
4-79 2.63e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.33  E-value: 2.63e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1393428042   4 GSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHrAGARLDVRDAwGRLPVDLAEELGHRDVARYL 79
Cdd:pfam12796   8 GNLELVKLLLENGADANLQDKNGRT-ALHLAAKNGHLEIVKLLL-EHADVNLKDN-GRTALHYAARSGHLEIVKLL 80
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-82 1.50e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.34  E-value: 1.50e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1393428042   4 GSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAA 82
Cdd:COG0666   131 GNLEIVKLLLEAGADVNAQDNDGNT-PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-97 2.65e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.57  E-value: 2.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428042   4 GSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAA 83
Cdd:COG0666   164 GNLEIVKLLLEAGADVNARDNDGET-PLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242

                          90
                  ....*....|....
gi 1393428042  84 GGTRGSNHARIDAA 97
Cdd:COG0666   243 ADLNAKDKDGLTAL 256
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 4-105 9.79e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 9.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428042   4 GSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLraaa 83
Cdd:PTZ00322   93 GDAVGARILLTGGADPNCRDYDGRT-PLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL---- 167

                          90       100
                  ....*....|....*....|..
gi 1393428042  84 ggtrgSNHARIDAAEGPSDIPD 105
Cdd:PTZ00322  168 -----SRHSQCHFELGANAKPD 184
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-79 1.34e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.94  E-value: 1.34e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1393428042   2 MMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 79
Cdd:COG0666    96 RNGDLEIVKLLLEAGADVNARDKDGET-PLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
4-79 2.63e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.33  E-value: 2.63e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1393428042   4 GSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHrAGARLDVRDAwGRLPVDLAEELGHRDVARYL 79
Cdd:pfam12796   8 GNLELVKLLLENGADANLQDKNGRT-ALHLAAKNGHLEIVKLLL-EHADVNLKDN-GRTALHYAARSGHLEIVKLL 80
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 7-67 2.83e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.02  E-value: 2.83e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1393428042   7 RVAELLLLHGAEPNCADpATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLA 67
Cdd:PHA02878  182 RLTELLLSYGANVNIPD-KTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS 241
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
11-82 6.22e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 40.32  E-value: 6.22e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1393428042  11 LLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAA 82
Cdd:COG0666    71 LLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-97 2.68e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 38.40  E-value: 2.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1393428042   2 MMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRA 81
Cdd:COG0666   195 ENGHLEIVKLLLEAGADVNAKDNDGKT-ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273

                          90
                  ....*....|....*.
gi 1393428042  82 AAGGTRGSNHARIDAA 97
Cdd:COG0666   274 ALLLLAAALLDLLTLL 289
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 2-79 9.52e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 36.77  E-value: 9.52e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1393428042   2 MMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 79
Cdd:PLN03192  534 STGNAALLEELLKAKLDPDIGDSKGRT-PLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL 610
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 4-79 1.26e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 36.48  E-value: 1.26e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1393428042   4 GSARVAELLLLHGAEPNCADPATlTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 79
Cdd:PHA02874  135 GDLESIKMLFEYGADVNIEDDNG-CYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLL 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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