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Conserved domains on  [gi|1372261749|ref|NP_001348907|]
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arylsulfatase G isoform 4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ALP_like super family cl23718
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ...
5-48 9.09e-18

alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.


The actual alignment was detected with superfamily member cd16161:

Pssm-ID: 474031 [Multi-domain]  Cd Length: 383  Bit Score: 74.43  E-value: 9.09e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1372261749   5 GGSPTKQTTWEGGHRVPALAYWPGRVPANVTSTALLRCYST-PTV 48
Cdd:cd16161   243 GGSVAKASTWEGGHREPAIVYWPGRIPANSTSAALVSTLDIfPTV 287
 
Name Accession Description Interval E-value
ARSG cd16161
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ...
5-48 9.09e-18

arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.


Pssm-ID: 293780 [Multi-domain]  Cd Length: 383  Bit Score: 74.43  E-value: 9.09e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1372261749   5 GGSPTKQTTWEGGHRVPALAYWPGRVPANVTSTALLRCYST-PTV 48
Cdd:cd16161   243 GGSVAKASTWEGGHREPAIVYWPGRIPANSTSAALVSTLDIfPTV 287
AslA COG3119
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
10-39 6.19e-10

Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 442353 [Multi-domain]  Cd Length: 393  Bit Score: 52.19  E-value: 6.19e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 1372261749  10 KQTTWEGGHRVPALAYWPGRVPANVTSTAL 39
Cdd:COG3119   250 KGTLYEGGIRVPLIVRWPGKIKAGSVSDAL 279
 
Name Accession Description Interval E-value
ARSG cd16161
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ...
5-48 9.09e-18

arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.


Pssm-ID: 293780 [Multi-domain]  Cd Length: 383  Bit Score: 74.43  E-value: 9.09e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1372261749   5 GGSPTKQTTWEGGHRVPALAYWPGRVPANVTSTALLRCYST-PTV 48
Cdd:cd16161   243 GGSVAKASTWEGGHREPAIVYWPGRIPANSTSAALVSTLDIfPTV 287
GALNS_like cd16026
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ...
5-40 1.53e-13

galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.


Pssm-ID: 293750 [Multi-domain]  Cd Length: 399  Bit Score: 62.58  E-value: 1.53e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1372261749   5 GGSPT-----KQTTWEGGHRVPALAYWPGRVPANVTSTALL 40
Cdd:cd16026   258 GGSAGplrggKGTTWEGGVRVPFIAWWPGVIPAGTVSDELA 298
ARS_like cd16142
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ...
5-36 2.88e-10

uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293761 [Multi-domain]  Cd Length: 372  Bit Score: 53.31  E-value: 2.88e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1372261749   5 GGSP---TKQTTWEGGHRVPALAYWPGRVPANVTS 36
Cdd:cd16142   228 GYTPfrgEKGTTWEGGVRVPAIVRWPGKIKPGRVS 262
spARS_like cd16160
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ...
5-37 4.49e-10

sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293779 [Multi-domain]  Cd Length: 445  Bit Score: 52.82  E-value: 4.49e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1372261749   5 GGSPT-----KQTTWEGGHRVPALAYWPGRVPANVTST 37
Cdd:cd16160   269 GGSTGglkggKGNSWEGGIRVPFIAYWPGTIKPRVSHE 306
AslA COG3119
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
10-39 6.19e-10

Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 442353 [Multi-domain]  Cd Length: 393  Bit Score: 52.19  E-value: 6.19e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 1372261749  10 KQTTWEGGHRVPALAYWPGRVPANVTSTAL 39
Cdd:COG3119   250 KGTLYEGGIRVPLIVRWPGKIKAGSVSDAL 279
ARS_like cd16143
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ...
1-39 8.54e-10

uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293762 [Multi-domain]  Cd Length: 395  Bit Score: 51.82  E-value: 8.54e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1372261749   1 MIKIGGSPT------KQTTWEGGHRVPALAYWPGRVPANVTSTAL 39
Cdd:cd16143   249 LEKFGHDPSgplrgmKADIYEGGHRVPFIVRWPGKIPAGSVSDQL 293
GALNS cd16157
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ...
10-45 1.87e-08

galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.


Pssm-ID: 293776 [Multi-domain]  Cd Length: 466  Bit Score: 48.23  E-value: 1.87e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1372261749  10 KQTTWEGGHRVPALAYWPGRVPANVTS---TALLRCYST 45
Cdd:cd16157   282 KQTTFEGGMREPAIAWWPGHIKPGQVShqlGSLMDLFTT 320
sulfatase_like cd16022
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ...
10-39 5.43e-08

sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293746 [Multi-domain]  Cd Length: 236  Bit Score: 46.66  E-value: 5.43e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 1372261749  10 KQTTWEGGHRVPALAYWPGRVPANVTSTAL 39
Cdd:cd16022   181 KGSLYEGGIRVPFIVRWPGKIPAGQVSDAL 210
ARS_like cd16145
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ...
10-36 6.28e-08

uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293764 [Multi-domain]  Cd Length: 415  Bit Score: 46.82  E-value: 6.28e-08
                          10        20
                  ....*....|....*....|....*..
gi 1372261749  10 KQTTWEGGHRVPALAYWPGRVPANVTS 36
Cdd:cd16145   293 KRSLYEGGIRVPFIARWPGKIPAGSVS 319
ARS_like cd16144
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ...
10-39 1.93e-07

uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293763 [Multi-domain]  Cd Length: 421  Bit Score: 45.23  E-value: 1.93e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1372261749  10 KQTTWEGGHRVPALAYWPGRVPANVTSTAL 39
Cdd:cd16144   280 KGSLYEGGIRVPLIVRWPGVIKPGSVSDVP 309
ARS_like cd16146
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ...
9-39 2.87e-07

uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293765 [Multi-domain]  Cd Length: 409  Bit Score: 44.85  E-value: 2.87e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1372261749   9 TKQTTWEGGHRVPALAYWPGRVPANVTSTAL 39
Cdd:cd16146   262 KKGSVYEGGHRVPFFIRWPGKILAGKDVDTL 292
ARSA cd16158
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ...
10-36 3.29e-07

Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.


Pssm-ID: 293777 [Multi-domain]  Cd Length: 479  Bit Score: 44.74  E-value: 3.29e-07
                          10        20
                  ....*....|....*....|....*..
gi 1372261749  10 KQTTWEGGHRVPALAYWPGRVPANVTS 36
Cdd:cd16158   283 KGTTYEGGVREPAIAYWPGRIKPGVTH 309
ES cd16159
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ...
2-33 5.91e-05

Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.


Pssm-ID: 293778 [Multi-domain]  Cd Length: 521  Bit Score: 38.42  E-value: 5.91e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1372261749   2 IKIGGsptKQTTWEGGHRVPALAYWPGRVPAN 33
Cdd:cd16159   336 IYGGK---KMGGWEGGIRVPTIVRWPGVIPPG 364
sulfatase_like cd16151
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
10-39 6.71e-05

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293770 [Multi-domain]  Cd Length: 377  Bit Score: 37.96  E-value: 6.71e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1372261749  10 KQTTWEGGHRVPALAYWPGRVPANVTSTAL 39
Cdd:cd16151   261 KGKTTDAGTHVPLIVNWPGLIPAGGVSDDL 290
SGSH cd16027
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ...
10-39 1.33e-04

N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.


Pssm-ID: 293751 [Multi-domain]  Cd Length: 373  Bit Score: 37.10  E-value: 1.33e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1372261749  10 KQTTWEGGHRVPALAYWPGRVPANVTSTAL 39
Cdd:cd16027   234 KGTLYDSGLRVPLIVRWPGKIKPGSVSDAL 263
PAS_like cd16025
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ...
9-32 4.46e-04

Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293749 [Multi-domain]  Cd Length: 402  Bit Score: 35.88  E-value: 4.46e-04
                          10        20
                  ....*....|....*....|....
gi 1372261749   9 TKQTTWEGGHRVPALAYWPGRVPA 32
Cdd:cd16025   275 YKQASHEGGIRTPLIVSWPKGIKA 298
G6S_like cd16031
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ...
10-39 7.50e-03

unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.


Pssm-ID: 293755 [Multi-domain]  Cd Length: 429  Bit Score: 32.50  E-value: 7.50e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1372261749  10 KQTTWEGGHRVPALAYWPGRVPANVTSTAL 39
Cdd:cd16031   286 KRLMYEESIRVPLIIRDPRLIKAGTVVDAL 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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