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Conserved domains on  [gi|1159731393|ref|NP_001336377|]
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kynurenine--oxoglutarate transaminase 3 isoform 1 [Homo sapiens]

Protein Classification

pyridoxal phosphate-dependent aminotransferase( domain architecture ID 11418212)

pyridoxal phosphate (PLP)-dependent aminotransferase catalyzes the reversible exchange of an amino group from one molecule with a keto group from another molecule, an important reaction in the synthesis or degradation of amino acids

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AspB COG0436
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ...
35-449 2.30e-130

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


:

Pssm-ID: 440205 [Multi-domain]  Cd Length: 387  Bit Score: 381.79  E-value: 2.30e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  35 MSLkftnAKRIEGLDSNVWIEFTKL-----AADPSVVNLGQGFPDISPPTYVKEELskIAAI-DSLNQYTRGFGHPSLVK 108
Cdd:COG0436     1 MKL----SSRLARLPPSPIREVSALaaelkAAGEDVIDLGIGEPDFPTPDHIREAA--IEALdDGVTGYTPSAGIPELRE 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 109 ALSYLYEKLYQKQIDSNkEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPvygkrw 188
Cdd:COG0436    75 AIAAYYKRRYGVDLDPD-EILVTNGAKEALALALLALLNPGDEVLVPDPGYPSYRAAVRLAGGKPVPVPLDEEN------ 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 189 sssDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGM 268
Cdd:COG0436   148 ---GFLPDPEALEAAITPRTKAIVLNSPNNPTGAVYSREELEALAELAREHDLLVISDEIYEELVYDGAEHVSILSLPGL 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 269 WERTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFwidikrmDDPECYFNSLPKELEV 348
Cdd:COG0436   225 KDRTIVINSFSKSYAMTGWRIGYAVGPPELIAALLKLQSNLTSCAPTPAQYAAAAAL-------EGPQDYVEEMRAEYRR 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 349 KRDRMVRLLESVGLKPIVPDGGYFIIADVSLLDPDlsdmknnepyDYKFVKWMTKHKKLSAIPVSAFCnsetkSQFEKFV 428
Cdd:COG0436   298 RRDLLVEGLNEIGLSVVKPEGAFYLFADVPELGLD----------SEEFAERLLEEAGVAVVPGSAFG-----PAGEGYV 362
                         410       420
                  ....*....|....*....|.
gi 1159731393 429 RFCFIKKDSTLDAAEEIIKAW 449
Cdd:COG0436   363 RISYATSEERLEEALERLARF 383
 
Name Accession Description Interval E-value
AspB COG0436
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ...
35-449 2.30e-130

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440205 [Multi-domain]  Cd Length: 387  Bit Score: 381.79  E-value: 2.30e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  35 MSLkftnAKRIEGLDSNVWIEFTKL-----AADPSVVNLGQGFPDISPPTYVKEELskIAAI-DSLNQYTRGFGHPSLVK 108
Cdd:COG0436     1 MKL----SSRLARLPPSPIREVSALaaelkAAGEDVIDLGIGEPDFPTPDHIREAA--IEALdDGVTGYTPSAGIPELRE 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 109 ALSYLYEKLYQKQIDSNkEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPvygkrw 188
Cdd:COG0436    75 AIAAYYKRRYGVDLDPD-EILVTNGAKEALALALLALLNPGDEVLVPDPGYPSYRAAVRLAGGKPVPVPLDEEN------ 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 189 sssDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGM 268
Cdd:COG0436   148 ---GFLPDPEALEAAITPRTKAIVLNSPNNPTGAVYSREELEALAELAREHDLLVISDEIYEELVYDGAEHVSILSLPGL 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 269 WERTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFwidikrmDDPECYFNSLPKELEV 348
Cdd:COG0436   225 KDRTIVINSFSKSYAMTGWRIGYAVGPPELIAALLKLQSNLTSCAPTPAQYAAAAAL-------EGPQDYVEEMRAEYRR 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 349 KRDRMVRLLESVGLKPIVPDGGYFIIADVSLLDPDlsdmknnepyDYKFVKWMTKHKKLSAIPVSAFCnsetkSQFEKFV 428
Cdd:COG0436   298 RRDLLVEGLNEIGLSVVKPEGAFYLFADVPELGLD----------SEEFAERLLEEAGVAVVPGSAFG-----PAGEGYV 362
                         410       420
                  ....*....|....*....|.
gi 1159731393 429 RFCFIKKDSTLDAAEEIIKAW 449
Cdd:COG0436   363 RISYATSEERLEEALERLARF 383
PRK07777 PRK07777
putative succinyldiaminopimelate transaminase DapC;
44-449 1.36e-116

putative succinyldiaminopimelate transaminase DapC;


Pssm-ID: 236095 [Multi-domain]  Cd Length: 387  Bit Score: 346.64  E-value: 1.36e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  44 RIEGLDSNVWIEFTKLAADPSVVNLGQGFPDISPPTYVKEELSKiAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQID 123
Cdd:PRK07777    5 RLRPFGTTIFAEMSALAVRTGAVNLGQGFPDEDGPPEMLEAAQE-AIAGGVNQYPPGPGIPELRAAIAAQRRRRYGLEYD 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 124 SNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSkpvygkrwSSSDWTLDPQELESK 203
Cdd:PRK07777   84 PDTEVLVTVGATEAIAAAVLGLVEPGDEVLLIEPYYDSYAAVIAMAGAHRVPVPLVP--------DGRGFALDLDALRAA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 204 FNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFS 283
Cdd:PRK07777  156 VTPRTRALIVNSPHNPTGTVLTAAELAAIAELAVEHDLLVITDEVYEHLVFDGARHLPLATLPGMRERTVTISSAAKTFN 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 284 VTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAfwidikrMDDPECYFNSLPKELEVKRDRMVRLLESVGLK 363
Cdd:PRK07777  236 VTGWKIGWACGPAPLIAAVRAAKQYLTYVGGAPFQPAVAHA-------LDHEDAWVAALRDSLQAKRDRLAAGLAEAGFE 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 364 PIVPDGGYFIIADVSLLDPDLSdmknnepydYKFVKWMTKHKKLSAIPVSAFCNSEtkSQFEKFVRFCFIKKDSTLDAAE 443
Cdd:PRK07777  309 VHDSAGTYFLCADPRPLGYDDG---------TEFCRALPERVGVAAIPMSVFYDPA--DAWNHLVRFAFCKRDDTLDEAI 377

                  ....*.
gi 1159731393 444 EIIKAW 449
Cdd:PRK07777  378 RRLRAL 383
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
66-448 6.18e-95

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 290.01  E-value: 6.18e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  66 VNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNkEILVTVGAYGSLFNTIQAL 145
Cdd:cd00609     1 IDLSIGEPDFPPPPEVLEALAAAALRAGLLGYYPDPGLPELREAIAEWLGRRGGVDVPPE-EIVVTNGAQEALSLLLRAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 146 IDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKpvygkrwssSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYN 225
Cdd:cd00609    80 LNPGDEVLVPDPTYPGYEAAARLAGAEVVPVPLDEE---------GGFLLDLELLEAAKTPKTKLLYLNNPNNPTGAVLS 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 226 REELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLkIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPN-HLIKHLQT 304
Cdd:cd00609   151 EEELEELAELAKKHGILIISDEAYAELVYDGEPPP-ALALLDAYERVIVLRSFSKTFGLPGLRIGYLIAPPeELLERLKK 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 305 VQQNTIYTCATPLQEALAQAfwidikrMDDPECYFNSLPKELEVKRDRMVRLLESVG-LKPIVPDGGYFIIADVSlldpd 383
Cdd:cd00609   230 LLPYTTSGPSTLSQAAAAAA-------LDDGEEHLEELRERYRRRRDALLEALKELGpLVVVKPSGGFFLWLDLP----- 297
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1159731393 384 lsdmknnEPYDYKFVKWMTKHKKLSAIPVSAFCnsetkSQFEKFVRFCFIKKDSTLDAAEEIIKA 448
Cdd:cd00609   298 -------EGDDEEFLERLLLEAGVVVRPGSAFG-----EGGEGFVRLSFATPEEELEEALERLAE 350
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
65-432 1.95e-53

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 182.50  E-value: 1.95e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  65 VVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGSLFNTIQA 144
Cdd:pfam00155   3 KINLGSNEYLGDTLPAVAKAEKDALAGGTRNLYGPTDGHPELREALAKFLGRSPVLKLDREAAVVFGSGAGANIEALIFL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 145 LIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLrskpvygkrWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVY 224
Cdd:pfam00155  83 LANPGDAILVPAPTYASYIRIARLAGGEVVRYPL---------YDSNDFHLDFDALEAALKEKPKVVLHTSPHNPTGTVA 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 225 NREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATF--PGMWerTITIGSAGKTFSVTGWKLGWSIGPNHLIKHL 302
Cdd:pfam00155 154 TLEELEKLLDLAKEHNILLLVDEAYAGFVFGSPDAVATRALlaEGPN--LLVVGSFSKAFGLAGWRVGYILGNAAVISQL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 303 QTVQQNTIYTcaTPLQEALAQAfwidikrMDDPE---CYFNSLPKELEVKRDRMVRLLESVGLKPIVPDGGYFiiadvSL 379
Cdd:pfam00155 232 RKLARPFYSS--THLQAAAAAA-------LSDPLlvaSELEEMRQRIKERRDYLRDGLQAAGLSVLPSQAGFF-----LL 297
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1159731393 380 LDPDLSDMKnnepydyKFVKWMTKHKKLSAIPVSAFCNSEtksqfekFVRFCF 432
Cdd:pfam00155 298 TGLDPETAK-------ELAQVLLEEVGVYVTPGSSPGVPG-------WLRITV 336
C_S_lyase_PatB TIGR04350
putative C-S lyase; Members of this subfamily are probable C-S lyases from a family of ...
101-385 4.97e-34

putative C-S lyase; Members of this subfamily are probable C-S lyases from a family of pyridoxal phosphate-dependent enzymes that tend to be (mis)annotated as probable aminotransferases. One member is PatB of Bacillus subtilis, a proven C-S-lyase. Another is the virulence factor cystalysin from Treponema denticola, whose hemolysin activity may stem from H2S production. Members of the seed alignment occur next to examples of the enzyme 5-histidylcysteine sulfoxide synthase, from ovothiol A biosynthesis, and would be expected to perform a C-S cleavage of 5-histidylcysteine sulfoxide to leave 1-methyl-4-mercaptohistidine (ovothiol A).


Pssm-ID: 275146  Cd Length: 384  Bit Score: 131.29  E-value: 4.97e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 101 FGHP----SLVKALSYLYEKLYQKQIDsNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFI 176
Cdd:TIGR04350  56 FGYTlppdSLYAAVINWLAQRHGWQID-PEDIVFLPGVVPSLFAAVRALTAPGEGVIVQTPVYPPFLSAVKSNGRELVLN 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 177 PLRskpvygkrWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSG 256
Cdd:TIGR04350 135 PLK--------LDEGRYRFDLEDLEDAITEKARLLLLCSPHNPVGRVWTREELTRLAELCLRHNVVVVSDEIHADLVYPP 206
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 257 NKHLKIAT-FPGMWERTITIGSAGKTFSVTGWKLGWSIGPNH-LIKHLQTVQQNTIYTCATPLQEALAQAFWidikrmDD 334
Cdd:TIGR04350 207 NKHIPLASlSPEPAERTVTLLSPGKTFNIAGLNISFAIIPNPeLRRAFQEAAQRVHIQHGNLFGYVAFEAAY------RD 280
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1159731393 335 PECYFNSLPKELEVKRDRMVRLL--ESVGLKPIVPDGGYFIIADVSLL---DPDLS 385
Cdd:TIGR04350 281 GEPWLDALLAYLRGNRDLVEEFIakRLPQIRVRPPEATYLAWLDCRALgldDADLR 336
 
Name Accession Description Interval E-value
AspB COG0436
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ...
35-449 2.30e-130

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440205 [Multi-domain]  Cd Length: 387  Bit Score: 381.79  E-value: 2.30e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  35 MSLkftnAKRIEGLDSNVWIEFTKL-----AADPSVVNLGQGFPDISPPTYVKEELskIAAI-DSLNQYTRGFGHPSLVK 108
Cdd:COG0436     1 MKL----SSRLARLPPSPIREVSALaaelkAAGEDVIDLGIGEPDFPTPDHIREAA--IEALdDGVTGYTPSAGIPELRE 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 109 ALSYLYEKLYQKQIDSNkEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPvygkrw 188
Cdd:COG0436    75 AIAAYYKRRYGVDLDPD-EILVTNGAKEALALALLALLNPGDEVLVPDPGYPSYRAAVRLAGGKPVPVPLDEEN------ 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 189 sssDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGM 268
Cdd:COG0436   148 ---GFLPDPEALEAAITPRTKAIVLNSPNNPTGAVYSREELEALAELAREHDLLVISDEIYEELVYDGAEHVSILSLPGL 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 269 WERTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFwidikrmDDPECYFNSLPKELEV 348
Cdd:COG0436   225 KDRTIVINSFSKSYAMTGWRIGYAVGPPELIAALLKLQSNLTSCAPTPAQYAAAAAL-------EGPQDYVEEMRAEYRR 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 349 KRDRMVRLLESVGLKPIVPDGGYFIIADVSLLDPDlsdmknnepyDYKFVKWMTKHKKLSAIPVSAFCnsetkSQFEKFV 428
Cdd:COG0436   298 RRDLLVEGLNEIGLSVVKPEGAFYLFADVPELGLD----------SEEFAERLLEEAGVAVVPGSAFG-----PAGEGYV 362
                         410       420
                  ....*....|....*....|.
gi 1159731393 429 RFCFIKKDSTLDAAEEIIKAW 449
Cdd:COG0436   363 RISYATSEERLEEALERLARF 383
PRK07777 PRK07777
putative succinyldiaminopimelate transaminase DapC;
44-449 1.36e-116

putative succinyldiaminopimelate transaminase DapC;


Pssm-ID: 236095 [Multi-domain]  Cd Length: 387  Bit Score: 346.64  E-value: 1.36e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  44 RIEGLDSNVWIEFTKLAADPSVVNLGQGFPDISPPTYVKEELSKiAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQID 123
Cdd:PRK07777    5 RLRPFGTTIFAEMSALAVRTGAVNLGQGFPDEDGPPEMLEAAQE-AIAGGVNQYPPGPGIPELRAAIAAQRRRRYGLEYD 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 124 SNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSkpvygkrwSSSDWTLDPQELESK 203
Cdd:PRK07777   84 PDTEVLVTVGATEAIAAAVLGLVEPGDEVLLIEPYYDSYAAVIAMAGAHRVPVPLVP--------DGRGFALDLDALRAA 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 204 FNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFS 283
Cdd:PRK07777  156 VTPRTRALIVNSPHNPTGTVLTAAELAAIAELAVEHDLLVITDEVYEHLVFDGARHLPLATLPGMRERTVTISSAAKTFN 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 284 VTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAfwidikrMDDPECYFNSLPKELEVKRDRMVRLLESVGLK 363
Cdd:PRK07777  236 VTGWKIGWACGPAPLIAAVRAAKQYLTYVGGAPFQPAVAHA-------LDHEDAWVAALRDSLQAKRDRLAAGLAEAGFE 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 364 PIVPDGGYFIIADVSLLDPDLSdmknnepydYKFVKWMTKHKKLSAIPVSAFCNSEtkSQFEKFVRFCFIKKDSTLDAAE 443
Cdd:PRK07777  309 VHDSAGTYFLCADPRPLGYDDG---------TEFCRALPERVGVAAIPMSVFYDPA--DAWNHLVRFAFCKRDDTLDEAI 377

                  ....*.
gi 1159731393 444 EIIKAW 449
Cdd:PRK07777  378 RRLRAL 383
PRK08912 PRK08912
aminotransferase;
59-449 2.54e-116

aminotransferase;


Pssm-ID: 181580  Cd Length: 387  Bit Score: 346.19  E-value: 2.54e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  59 LAADPSVVNLGQGFPDISPPTYVKEELSKiAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGSL 138
Cdd:PRK08912   22 LAREHGAINLGQGFPDDPGPEDVRRAAAD-ALLDGSNQYPPMMGLPELRQAVAAHYARFQGLDLDPETEVMVTSGATEAL 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 139 FNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLrsKPvygkrwssSDWTLDPQELESKFNSKTKAIILNTPHN 218
Cdd:PRK08912  101 AAALLALVEPGDEVVLFQPLYDAYLPLIRRAGGVPRLVRL--EP--------PHWRLPRAALAAAFSPRTKAVLLNNPLN 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 219 PLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHL 298
Cdd:PRK08912  171 PAGKVFPREELALLAEFCQRHDAVAICDEVWEHVVFDGRRHIPLMTLPGMRERTVKIGSAGKIFSLTGWKVGFVCAAPPL 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 299 IKHLQTVQQNTIYTCATPLQEALAQAfwidikrMDDPECYFNSLPKELEVKRDRMVRLLESVGLkPIVPDGG-YFIIADV 377
Cdd:PRK08912  251 LRVLAKAHQFLTFTTPPNLQAAVAYG-------LGKPDDYFEGMRADLARSRDRLAAGLRRIGF-PVLPSQGtYFLTVDL 322
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1159731393 378 SLLDPDLSDMknnepydyKFVKWMTKHKKLSAIPVSAFcnsetksqFEK-----FVRFCFIKKDSTLDAAEEIIKAW 449
Cdd:PRK08912  323 APLGLAEDDV--------AFCRRLVEEAGVAAIPVSAF--------YEEdpvtsVVRFCFAKRDATLDEAVERLAAA 383
PLN00175 PLN00175
aminotransferase family protein; Provisional
42-447 2.53e-106

aminotransferase family protein; Provisional


Pssm-ID: 215089 [Multi-domain]  Cd Length: 413  Bit Score: 321.43  E-value: 2.53e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  42 AKRIEGLDSNVWIEFTKLAADPSVVNLGQGFPDISPPTYVKEelSKIAAI-DSLNQYTRGFGHPSLVKALSYLYEKLYQK 120
Cdd:PLN00175   33 AKRLEKFKTTIFTQMSSLAIKHGAINLGQGFPNFDGPDFVKE--AAIQAIrDGKNQYARGFGVPELNSAIAERFKKDTGL 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 121 QIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKpvygkrwsssDWTLDPQEL 200
Cdd:PLN00175  111 VVDPEKEVTVTSGCTEAIAATILGLINPGDEVILFAPFYDSYEATLSMAGAKIKTVTLRPP----------DFAVPEDEL 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 201 ESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNkHLKIATFPGMWERTITIGSAGK 280
Cdd:PLN00175  181 KAAFTSKTRAILINTPHNPTGKMFTREELELIASLCKENDVLAFTDEVYDKLAFEGD-HISMASLPGMYERTVTMNSLGK 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 281 TFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAfwidikrMDDPECYFNSLPKELEVKRDRMVRLLESV 360
Cdd:PLN00175  260 TFSLTGWKIGWAIAPPHLTWGVRQAHSFLTFATATPMQWAAVAA-------LRAPESYYEELKRDYSAKKDILVEGLKEV 332
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 361 GLKPIVPDGGYFIIADVSLLdpdlsDMKNnepyDYKFVKWMTKHKKLSAIPVSAF-CNSEtksQFEKFVRFCFIKKDSTL 439
Cdd:PLN00175  333 GFKVYPSSGTYFVMVDHTPF-----GFEN----DIAFCEYLIEEVGVAAIPPSVFyLNPE---DGKNLVRFAFCKDEETL 400

                  ....*...
gi 1159731393 440 DAAEEIIK 447
Cdd:PLN00175  401 RAAVERMK 408
PRK09082 PRK09082
methionine aminotransferase; Validated
56-444 1.02e-102

methionine aminotransferase; Validated


Pssm-ID: 181642 [Multi-domain]  Cd Length: 386  Bit Score: 311.08  E-value: 1.02e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  56 FT---KLAADPSVVNLGQGFPDISPPTYVKEELSKiAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTV 132
Cdd:PRK09082   20 FTvmsALAAEHGAINLSQGFPDFDGPPYLVEALAY-AMAAGHNQYPPMTGVAALREAIAAKTARLYGRQYDADSEITVTA 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 133 GAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSkPVYgkrwsSSDWtldpQELESKFNSKTKAII 212
Cdd:PRK09082   99 GATEALFAAILALVRPGDEVIVFDPSYDSYAPAIELAGGRAVRVALQP-PDF-----RVDW----QRFAAAISPRTRLII 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 213 LNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWS 292
Cdd:PRK09082  169 LNTPHNPSGTVWSAADMRALWQLIAGTDIYVLSDEVYEHIVFDGAGHASVLRHPELRERAFVVSSFGKTYHVTGWKVGYC 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 293 IGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFwidikrMDDPECYfNSLPKELEVKRDRMVRLLESVGLKPIVPDGGYF 372
Cdd:PRK09082  249 VAPAALSAEFRKVHQYNTFTVNTPAQLALADYL------RAEPEHY-LELPAFYQAKRDRFRAALANSRFKLLPCEGTYF 321
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1159731393 373 IIADVSLLdPDLSDMknnepydyKFVKWMTKHKKLSAIPVSAFCNSetkSQFEKFVRFCFIKKDSTLDAAEE 444
Cdd:PRK09082  322 QLVDYSAI-SDLDDV--------EFCQWLTREHGVAAIPLSVFYAD---PFPHRLVRLCFAKQEETLDAAAE 381
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
66-448 6.18e-95

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 290.01  E-value: 6.18e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  66 VNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNkEILVTVGAYGSLFNTIQAL 145
Cdd:cd00609     1 IDLSIGEPDFPPPPEVLEALAAAALRAGLLGYYPDPGLPELREAIAEWLGRRGGVDVPPE-EIVVTNGAQEALSLLLRAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 146 IDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKpvygkrwssSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYN 225
Cdd:cd00609    80 LNPGDEVLVPDPTYPGYEAAARLAGAEVVPVPLDEE---------GGFLLDLELLEAAKTPKTKLLYLNNPNNPTGAVLS 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 226 REELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLkIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPN-HLIKHLQT 304
Cdd:cd00609   151 EEELEELAELAKKHGILIISDEAYAELVYDGEPPP-ALALLDAYERVIVLRSFSKTFGLPGLRIGYLIAPPeELLERLKK 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 305 VQQNTIYTCATPLQEALAQAfwidikrMDDPECYFNSLPKELEVKRDRMVRLLESVG-LKPIVPDGGYFIIADVSlldpd 383
Cdd:cd00609   230 LLPYTTSGPSTLSQAAAAAA-------LDDGEEHLEELRERYRRRRDALLEALKELGpLVVVKPSGGFFLWLDLP----- 297
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1159731393 384 lsdmknnEPYDYKFVKWMTKHKKLSAIPVSAFCnsetkSQFEKFVRFCFIKKDSTLDAAEEIIKA 448
Cdd:cd00609   298 -------EGDDEEFLERLLLEAGVVVRPGSAFG-----EGGEGFVRLSFATPEEELEEALERLAE 350
PRK05764 PRK05764
aspartate aminotransferase; Provisional
42-449 8.07e-88

aspartate aminotransferase; Provisional


Pssm-ID: 235596  Cd Length: 393  Bit Score: 273.15  E-value: 8.07e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  42 AKRIEGLDSNVWIEFTKLAA-------DpsVVNLGQGFPDISPPTYVKEelskiAAIDSLNQ----YTRGFGHPSLVKAL 110
Cdd:PRK05764    5 SKRVSRVTPSATLAVTAKAKelkaqgrD--VISLGAGEPDFDTPEHIKE-----AAIEALDDgktkYTPAAGIPELREAI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 111 SYLYEKLYQKQIDSNkEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSkpvygkrwsS 190
Cdd:PRK05764   78 AAKLKRDNGLDYDPS-QVIVTTGAKQALYNAFMALLDPGDEVIIPAPYWVSYPEMVKLAGGVPVFVPTGE---------E 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 191 SDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATF-PGMW 269
Cdd:PRK05764  148 NGFKLTVEQLEAAITPKTKALILNSPSNPTGAVYSPEELEAIADVAVEHDIWVLSDEIYEKLVYDGAEFTSIASLsPELR 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 270 ERTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTiYTCATplqeALAQafWIDIKRMDDPECYFNSLPKELEVK 349
Cdd:PRK05764  228 DRTITVNGFSKAYAMTGWRLGYAAGPKELIKAMSKLQSHS-TSNPT----SIAQ--YAAVAALNGPQDEVEEMRQAFEER 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 350 RDRMVRLLESV-GLKPIVPDGGYFIIADVSlldpdlSDMKNNEPYDYKFVKWMTKHKKLSAIPVSAFCNSEtksqfekFV 428
Cdd:PRK05764  301 RDLMVDGLNEIpGLECPKPEGAFYVFPNVS------KLLGKSITDSLEFAEALLEEAGVAVVPGIAFGAPG-------YV 367
                         410       420
                  ....*....|....*....|.
gi 1159731393 429 RFCFIKKDSTLDAAEEIIKAW 449
Cdd:PRK05764  368 RLSYATSLEDLEEGLERIERF 388
PRK12414 PRK12414
putative aminotransferase; Provisional
58-439 7.36e-71

putative aminotransferase; Provisional


Pssm-ID: 183514  Cd Length: 384  Bit Score: 229.29  E-value: 7.36e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  58 KLAADPSVVNLGQGFPDISPPTYVKEELSKiAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGS 137
Cdd:PRK12414   24 QLAAQHDALNLSQGAPNFAPDPALVEGVAR-AMRDGHNQYAPMAGIAALREALAEKTERLYGARYDPASEVTVIASASEG 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 138 LFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLrskpvygkrwSSSDWTLDPQELESKFNSKTKAIILNTPH 217
Cdd:PRK12414  103 LYAAISALVHPGDEVIYFEPSFDSYAPIVRLQGATPVAIKL----------SPEDFRVNWDEVAAAITPRTRMIIVNTPH 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 218 NPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNH 297
Cdd:PRK12414  173 NPSATVFSAADLARLAQLTRNTDIVILSDEVYEHVVFDGARHHSMARHRELAERSVIVSSFGKSYHVTGWRVGYCLAPAE 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 298 LIKHLQTVQQNTIYTCATPLQEALAQAfwidikrMDDPECYFnSLPKELEVKRDRMVRLLESVGLKPIVPDGGYFIIADV 377
Cdd:PRK12414  253 LMDEIRKVHQFMVFSADTPMQHAFAEA-------LAEPASYL-GLGAFYQRKRDLLARELAGSRFELLPSEGSFFMLARF 324
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1159731393 378 SlldpDLSDMKNNEpydykFVKWMTKHKKLSAIPVSAFCNSETKSqfeKFVRFCFIKKDSTL 439
Cdd:PRK12414  325 R----HFSDESDSD-----FVLRLIRDARVATIPLSAFYTDGTDT---GLIRLSFSKDDATL 374
PRK07309 PRK07309
pyridoxal phosphate-dependent aminotransferase;
63-415 6.44e-60

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 235985  Cd Length: 391  Bit Score: 200.72  E-value: 6.44e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  63 PSVVNLGQGFPDISPPTYVKEelSKIAAIDSlNQ--YTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGSLFN 140
Cdd:PRK07309   30 PGILKLTLGEPDFTTPDHVKE--AAKRAIDA-NQshYTGMAGLLELRQAAADFVKEKYNLDYAPENEILVTIGATEALSA 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 141 TIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSkpvygkrwssSDWTLDPQELES---KFNSKTKAIILNTPH 217
Cdd:PRK07309  107 SLTAILEPGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTE----------NDFVLTPEMLEKailEQGDKLKAVILNYPA 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 218 NPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFpgMWERTITIGSAGKTFSVTGWKLGWSIGPNH 297
Cdd:PRK07309  177 NPTGVTYSREQIKALADVLKKYDIFVISDEVYSELTYTGEPHVSIAEY--LPDQTILINGLSKSHAMTGWRIGLIFAPAE 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 298 LIKHLQTVQQNTIYTCATPLQEALAQAFwidIKRMDDPEcyfnSLPKELEVKRDRMVRLLESVGLKPIVPDGGYFIIADV 377
Cdd:PRK07309  255 FTAQLIKSHQYLVTAATTMAQFAAVEAL---TNGKDDAL----PMKKEYIKRRDYIIEKMTDLGFKIIKPDGAFYIFAKI 327
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1159731393 378 slldPDlsdmkNNEPYDYKFVKWMTKHKKLSAIPVSAF 415
Cdd:PRK07309  328 ----PA-----GYNQDSFKFLQDFARKKAVAFIPGAAF 356
PRK07683 PRK07683
aminotransferase A; Validated
55-432 3.61e-59

aminotransferase A; Validated


Pssm-ID: 236075  Cd Length: 387  Bit Score: 198.79  E-value: 3.61e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  55 EFTKLAAD-PSVVNLGQGFPDISPPTYVKEelSKIAAID-SLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTV 132
Cdd:PRK07683   19 QFSNMVQNyDNLISLTIGQPDFPTPSHVKE--AAKRAITeNYTSYTHNAGLLELRKAACNFVKDKYDLHYSPESEIIVTI 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 133 GAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRskpvygkrwsSSDWTLDPQELESKFNSKTKAII 212
Cdd:PRK07683   97 GASEAIDIAFRTILEPGTEVILPAPIYPGYEPIIRLCGAKPVFIDTR----------STGFRLTAEALENAITEKTRCVV 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 213 LNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGnKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWS 292
Cdd:PRK07683  167 LPYPSNPTGVTLSKEELQDIADVLKDKNIFVLSDEIYSELVYEQ-PHTSIAHFPEMREKTIVINGLSKSHSMTGWRIGFL 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 293 IGPNHLIKHLQTVQQNTIyTCATPLQ-----EALAQAFwidikrmDDPECYFNSLPKELEVKRDRMVrlleSVGLKPIVP 367
Cdd:PRK07683  246 FAPSYLAKHILKVHQYNV-TCASSISqyaalEALTAGK-------DDAKMMRHQYKKRRDYVYNRLI----SMGLDVEKP 313
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1159731393 368 DGGYFIIadvslldPDLSDMKNNEpydYKFVKWMTKHKKLSAIPVSAFcnsetkSQF-EKFVRFCF 432
Cdd:PRK07683  314 TGAFYLF-------PSIGHFTMSS---FDFALDLVEEAGLAVVPGSAF------SEYgEGYVRLSY 363
PRK06348 PRK06348
pyridoxal phosphate-dependent aminotransferase;
35-415 1.62e-56

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180537  Cd Length: 384  Bit Score: 191.47  E-value: 1.62e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  35 MSLKFTnAKRIEGLDSNVWIEFTKLAAD-PSVVNLGQGFPDIspPTyvKEELSKIAAIDSLNQYTR---GFGHPSLVKAL 110
Cdd:PRK06348    1 MKNKFL-AKKYQQMEVNIMAEIATLAKKfPDIIDLSLGDPDL--IT--DESIINAAFEDAKKGHTRytdSGGDVELIEEI 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 111 SYLYEKLYQKQIDSNkEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKpvygkrwss 190
Cdd:PRK06348   76 IKYYSKNYDLSFKRN-EIMATVGACHGMYLALQSILDPGDEVIIHEPYFTPYKDQIEMVGGKPIILETYEE--------- 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 191 SDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSgNKHLKIATFPGMWE 270
Cdd:PRK06348  146 DGFQINVKKLEALITSKTKAIILNSPNNPTGAVFSKETLEEIAKIAIEYDLFIISDEVYDGFSFY-EDFVPMATLAGMPE 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 271 RTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFwidikRMDDpecyfNSLPKELEVKR 350
Cdd:PRK06348  225 RTITFGSFSKDFAMTGWRIGYVIAPDYIIETAKIINEGICFSAPTISQRAAIYAL-----KHRD-----TIVPLIKEEFQ 294
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1159731393 351 DRMVRLLESVGLKP----IVPDGGYFIIADVSllDPDLSDMknnepydyKFVKWMTKHKKLSAIPVSAF 415
Cdd:PRK06348  295 KRLEYAYKRIESIPnlslHPPKGSIYAFINIK--KTGLSSV--------EFCEKLLKEAHVLVIPGKAF 353
PRK07682 PRK07682
aminotransferase;
56-372 6.79e-54

aminotransferase;


Pssm-ID: 181082 [Multi-domain]  Cd Length: 378  Bit Score: 184.55  E-value: 6.79e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  56 FTKLAAD-PSVVNLGQGFPDISPPTYVKEelskiAAIDSLNQ----YTRGFGHPSLVKALS-YLYEKlYQKQIDSNKEIL 129
Cdd:PRK07682   12 FFDLAANmEGVISLGVGEPDFVTPWNVRE-----ASIRSLEQgytsYTANAGLLELRQEIAkYLKKR-FAVSYDPNDEII 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 130 VTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKpvygkrwssSDWTLDPQELESKFNSKTK 209
Cdd:PRK07682   86 VTVGASQALDVAMRAIINPGDEVLIVEPSFVSYAPLVTLAGGVPVPVATTLE---------NEFKVQPAQIEAAITAKTK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 210 AIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGnKHLKIATFPGMWERTITIGSAGKTFSVTGWKL 289
Cdd:PRK07682  157 AILLCSPNNPTGAVLNKSELEEIAVIVEKHDLIVLSDEIYAELTYDE-AYTSFASIKGMRERTILISGFSKGFAMTGWRL 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 290 GWSIGPNHLIKHLQTVQQNTIYTCATPLQ----EALAQAfwidikrMDDPECYFNSLPKelevKRDRMVRLLESVGLKPI 365
Cdd:PRK07682  236 GFIAAPVYFSEAMLKIHQYSMMCAPTMAQfaalEALRAG-------NDDVIRMRDSYRK----RRNFFVTSFNEIGLTCH 304

                  ....*..
gi 1159731393 366 VPDGGYF 372
Cdd:PRK07682  305 VPGGAFY 311
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
65-432 1.95e-53

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 182.50  E-value: 1.95e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  65 VVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGSLFNTIQA 144
Cdd:pfam00155   3 KINLGSNEYLGDTLPAVAKAEKDALAGGTRNLYGPTDGHPELREALAKFLGRSPVLKLDREAAVVFGSGAGANIEALIFL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 145 LIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLrskpvygkrWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVY 224
Cdd:pfam00155  83 LANPGDAILVPAPTYASYIRIARLAGGEVVRYPL---------YDSNDFHLDFDALEAALKEKPKVVLHTSPHNPTGTVA 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 225 NREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATF--PGMWerTITIGSAGKTFSVTGWKLGWSIGPNHLIKHL 302
Cdd:pfam00155 154 TLEELEKLLDLAKEHNILLLVDEAYAGFVFGSPDAVATRALlaEGPN--LLVVGSFSKAFGLAGWRVGYILGNAAVISQL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 303 QTVQQNTIYTcaTPLQEALAQAfwidikrMDDPE---CYFNSLPKELEVKRDRMVRLLESVGLKPIVPDGGYFiiadvSL 379
Cdd:pfam00155 232 RKLARPFYSS--THLQAAAAAA-------LSDPLlvaSELEEMRQRIKERRDYLRDGLQAAGLSVLPSQAGFF-----LL 297
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1159731393 380 LDPDLSDMKnnepydyKFVKWMTKHKKLSAIPVSAFCNSEtksqfekFVRFCF 432
Cdd:pfam00155 298 TGLDPETAK-------ELAQVLLEEVGVYVTPGSSPGVPG-------WLRITV 336
PRK08361 PRK08361
aspartate aminotransferase; Provisional
56-450 5.28e-51

aspartate aminotransferase; Provisional


Pssm-ID: 236248 [Multi-domain]  Cd Length: 391  Bit Score: 177.38  E-value: 5.28e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  56 FTKLAADPSVVNLGQGFPDISPPTYVKEElSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNkEILVTVGAY 135
Cdd:PRK08361   26 FERASKMENVISLGIGEPDFDTPKNIKEA-AKRALDEGWTHYTPNAGIPELREAIAEYYKKFYGVDVDVD-NVIVTAGAY 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 136 GSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKpvygkrwssSDWTLDPQELESKFNSKTKAIILNT 215
Cdd:PRK08361  104 EATYLAFESLLEEGDEVIIPDPAFVCYVEDAKIAEAKPIRIPLREE---------NEFQPDPDELLELITKRTRMIVINY 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 216 PHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGmwERTITIGSAGKTFSVTGWKLGWSIGP 295
Cdd:PRK08361  175 PNNPTGATLDKEVAKAIADIAEDYNIYILSDEPYEHFLYEGAKHYPMIKYAP--DNTILANSFSKTFAMTGWRLGFVIAP 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 296 NHLIKHLQTVQQNTIYTCATPLQ----EAL-AQAFWIDIKRMddpecyfnslpKELEVKRDRMV--RLLESVGLKPIVPD 368
Cdd:PRK08361  253 EQVIKDMIKLHAYIIGNVASFVQiagiEALrSKESWKAVEEM-----------RKEYNERRKLVlkRLKEMPHIKVFEPK 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 369 GGYFIIADVSLLdpdlsDMKNNEpydykFVKWMTKHKKLSAIPVSAFcnsetKSQFEKFVRFCF-IKKDSTLDAAEEIIK 447
Cdd:PRK08361  322 GAFYVFANIDET-----GMSSED-----FAEWLLEKARVVVIPGTAF-----GKAGEGYIRISYaTSKEKLIEAMERMEK 386

                  ...
gi 1159731393 448 AWS 450
Cdd:PRK08361  387 ALE 389
PRK07568 PRK07568
pyridoxal phosphate-dependent aminotransferase;
67-448 1.87e-46

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 181036  Cd Length: 397  Bit Score: 165.41  E-value: 1.87e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  67 NLGQgfPDISPPTYVKEELSKIAaiDSLNQYTRGFGHPSLVKALSYLYEKLyqkQIDSNKE-ILVTVGAYGSLFNTIQAL 145
Cdd:PRK07568   36 NIGQ--PDIKTPEVFFEAIKNYD--EEVLAYSHSQGIPELREAFAKYYKKW---GIDVEPDeILITNGGSEAILFAMMAI 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 146 IDEGDEVILIVPFYDCYEPMVRMAGATPVfiPLRSKPVYGKRWSSsdwtldPQELESKFNSKTKAIILNTPHNPLGKVYN 225
Cdd:PRK07568  109 CDPGDEILVPEPFYANYNGFATSAGVKIV--PVTTKIEEGFHLPS------KEEIEKLITPKTKAILISNPGNPTGVVYT 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 226 REELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPN-HLIKHLQT 304
Cdd:PRK07568  181 KEELEMLAEIAKKHDLFLISDEVYREFVYDGLKYTSALSLEGLEDRVIIIDSVSKRYSACGARIGCLISKNkELIAAAMK 260
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 305 VQQNTIyTCATPLQEALAQAfwidikrMDDPECYFNSLPKELEVKRDRMVRLLESV-GLKPIVPDGGYFIIADVSLLDPD 383
Cdd:PRK07568  261 LCQARL-SPPTLEQIGAAAL-------LDTPESYFDEVREEYKKRRDILYEELNKIpGVVCEKPKGAFYIIAKLPVDDAE 332
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 384 lsdmknnepydyKFVKWMTKH-----KKLSAIPVSAFCNSETKSQFEkfVRFCFIKKDSTLDAAEEIIKA 448
Cdd:PRK07568  333 ------------DFAKWLLTDfnyngETVMVAPASGFYATPGLGKNE--IRIAYVLNEEDLKRAMEILKE 388
PRK06107 PRK06107
aspartate transaminase;
60-373 9.60e-44

aspartate transaminase;


Pssm-ID: 180403  Cd Length: 402  Bit Score: 158.36  E-value: 9.60e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  60 AADPSVVNLGQGFPDISPPTYVKEelSKIAAIDS-LNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNkEILVTVGAYGSL 138
Cdd:PRK06107   30 AAGRSIVDLTVGEPDFDTPDHIKQ--AAVAAIERgETKYTLVNGTPALRKAIIAKLERRNGLHYADN-EITVGGGAKQAI 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 139 FNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSkpvygkrwsSSDWTLDPQELESKFNSKTKAIILNTPHN 218
Cdd:PRK06107  107 FLALMATLEAGDEVIIPAPYWVSYPDMVLANDGTPVIVACPE---------EQGFKLTPEALEAAITPRTRWLILNAPSN 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 219 PLGKVYNREELQVIADLCIKY-DTLCISDEVYEWLVYSG--NKHLkIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGP 295
Cdd:PRK06107  178 PTGAVYSRAELRALADVLLRHpHVLVLTDDIYDHIRFDDepTPHL-LAAAPELRDRVLVTNGVSKTYAMTGWRIGYAAGP 256
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1159731393 296 NHLIKHLQTVQQNTIYTCATPLQEALAQAFWIDikrmddpECYFNSLPKELEVKRDRMVRLLESV-GLKPIVPDGGYFI 373
Cdd:PRK06107  257 ADLIAAINKLQSQSSSCPSSISQAAAAAALNGD-------QSFVTESVAVYKQRRDYALALLNAIpGLSCLVPDGAFYL 328
PRK05957 PRK05957
pyridoxal phosphate-dependent aminotransferase;
59-313 3.65e-43

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 235654  Cd Length: 389  Bit Score: 156.39  E-value: 3.65e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  59 LAADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSylyEKLYQK---QIDSNKEILVTVGAY 135
Cdd:PRK05957   23 IRENPGTISLGQGVVSYPPPPEAIEALNNFLANPENHKYQAVQGIPPLLEAIT---QKLQQDngiELNNEQAIVVTAGSN 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 136 GSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPlrskpvygkrwSSSDWTLDPQELESKFNSKTKAIILNT 215
Cdd:PRK05957  100 MAFMNAILAITDPGDEIILNTPYYFNHEMAITMAGCQPILVP-----------TDDNYQLQPEAIEQAITPKTRAIVTIS 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 216 PHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGP 295
Cdd:PRK05957  169 PNNPTGVVYPEALLRAVNQICAEHGIYHISDEAYEYFTYDGVKHFSPGSIPGSGNHTISLYSLSKAYGFASWRIGYMVIP 248
                         250
                  ....*....|....*...
gi 1159731393 296 NHLIKHLQTVqQNTIYTC 313
Cdd:PRK05957  249 IHLLEAIKKI-QDTILIC 265
PRK06108 PRK06108
pyridoxal phosphate-dependent aminotransferase;
59-449 1.02e-42

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180404  Cd Length: 382  Bit Score: 154.72  E-value: 1.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  59 LAADPS----VVNLGQGFPDISP----------PTYVKEelskiAAIDSLNQ----YTRGFGHPSLVKALSYLYEKLYQK 120
Cdd:PRK06108    6 RALPESgireVANAGRGREGVLPlwfgesdlptPDFIRD-----AAAAALADgetfYTHNLGIPELREALARYVSRLHGV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 121 QIDSnKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRskpvYGkrwsSSDWTLDPQEL 200
Cdd:PRK06108   81 ATPP-ERIAVTSSGVQALMLAAQALVGPGDEVVAVTPLWPNLVAAPKILGARVVCVPLD----FG----GGGWTLDLDRL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 201 ESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGN----KHLKIATfPGmwERTITIG 276
Cdd:PRK06108  152 LAAITPRTRALFINSPNNPTGWTASRDDLRAILAHCRRHGLWIVADEVYERLYYAPGgrapSFLDIAE-PD--DRIIFVN 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 277 SAGKTFSVTGWKLGWSIGPNHLIKHL-QTVQQNTiyTC-ATPLQEALAQAfwidikrMDDPECYFNSLPKELEVKRDRMV 354
Cdd:PRK06108  229 SFSKNWAMTGWRLGWLVAPPALGQVLeKLIEYNT--SCvAQFVQRAAVAA-------LDEGEDFVAELVARLRRSRDHLV 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 355 RLLESV-GLKPIVPDGGYFIIADVslldPDLSDMKnnepydyKFVKWMTKHKKLSAIPVSAFcnsetKSQFEKFVRFCFI 433
Cdd:PRK06108  300 DALRALpGVEVAKPDGAMYAFFRI----PGVTDSL-------ALAKRLVDEAGLGLAPGTAF-----GPGGEGFLRWCFA 363
                         410
                  ....*....|....*.
gi 1159731393 434 KKDSTLDAAEEIIKAW 449
Cdd:PRK06108  364 RDPARLDEAVERLRRF 379
PRK07337 PRK07337
pyridoxal phosphate-dependent aminotransferase;
60-432 9.67e-39

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180937  Cd Length: 388  Bit Score: 144.43  E-value: 9.67e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  60 AADPSVVNLGQGFPDISPPTYVKEELSKiAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKeILVTVGAYGSLF 139
Cdd:PRK07337   27 RAGRDIIHMGIGEPDFTAPEPVVEAAAR-ALRRGVTQYTSALGLAPLREAIAAWYARRFGLDVAPER-IVVTAGASAALL 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 140 NTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPlrSKPVygKRWSssdwtLDPQELESKFNSKTKAIILNTPHNP 219
Cdd:PRK07337  105 LACLALVERGDEVLMPDPSYPCNRHFVAAAEGRPVLVP--SGPA--ERFQ-----LTAADVEAAWGERTRGVLLASPSNP 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 220 LGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIAtfpgMWERTITIGSAGKTFSVTGWKLGWSIGPNHLI 299
Cdd:PRK07337  176 TGTSIAPDELRRIVEAVRARGGFTIVDEIYQGLSYDAAPVSALS----LGDDVITINSFSKYFNMTGWRLGWLVVPEALV 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 300 KHLQTVQQNtIYTCATPL-QEALAQAFwidikrmdDPECY--FNSLPKELEVKRDRMVRLLESVGLK-PIVPDGGYFIIA 375
Cdd:PRK07337  252 GTFEKLAQN-LFICASALaQHAALACF--------EPDTLaiYERRRAEFKRRRDFIVPALESLGFKvPVMPDGAFYVYA 322
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1159731393 376 DVS-LLDPDLSDmknnepyDYKFVKWMTKHKKLSAIPVSAFCNSETksqfEKFVRFCF 432
Cdd:PRK07337  323 DCRgVAHPAAGD-------SAALTQAMLHDAGVVLVPGRDFGPHAP----RDYIRLSY 369
PRK07681 PRK07681
LL-diaminopimelate aminotransferase;
37-448 2.64e-38

LL-diaminopimelate aminotransferase;


Pssm-ID: 181081  Cd Length: 399  Bit Score: 143.41  E-value: 2.64e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  37 LKFTNAKRIEGLDSNVWIEFT-----KLAADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGfGHPSLVKALS 111
Cdd:PRK07681    1 MTYTLATRMKAFQSSIFSELGaykkeKIAAGHKMIDLSIGNPDMPPADFVREEMVHTANQKESYGYTLS-GIQEFHEAVT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 112 YLYEKLYQKQIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKpvygkrwssS 191
Cdd:PRK07681   80 EYYNNTHNVILNADKEVLLLMGSQDGLVHLPMVYANPGDIILVPDPGYTAYETGIQMAGATSYYMPLKKE---------N 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 192 DWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWER 271
Cdd:PRK07681  151 DFLPDLELIPEEIADKAKMMILNFPGNPVPAMAHEDFFKEVIAFAKKHNIIVVHDFAYAEFYFDGNKPISFLSVPGAKEV 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 272 TITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFwidikRMDDPECYFNslpKEL-EVKR 350
Cdd:PRK07681  231 GVEINSLSKSYSLAGSRIGYMIGNEEIVRALTQFKSNTDYGVFLPIQKAACAAL-----RNGAAFCEKN---RGIyQERR 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 351 DRMVRLLESVGLKPIVPDGGYFIIADVslldPDLSDmknnepyDYKFVKWMTKHKKLSAIPVSAFcnsetKSQFEKFVRF 430
Cdd:PRK07681  303 DTLVDGFRTFGWNVDKPAGSMFVWAEI----PKGWT-------SLSFAYALMDRANVVVTPGHAF-----GPHGEGFVRI 366
                         410
                  ....*....|....*...
gi 1159731393 431 CFIKKDSTLDAAEEIIKA 448
Cdd:PRK07681  367 ALVQDEEVLQQAVENIRN 384
PRK08363 PRK08363
alanine aminotransferase; Validated
65-373 4.21e-36

alanine aminotransferase; Validated


Pssm-ID: 181402  Cd Length: 398  Bit Score: 137.25  E-value: 4.21e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  65 VVNLGQGFP---DISPPTYVKEELSKiAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSnKEILVTVGAYGSLFNT 141
Cdd:PRK08363   32 VIRLNIGDPvkfDFQPPEHMKEAYCR-AIKEGHNYYGPSEGLPELREAIVKREKRKNGVDITP-DDVRVTAAVTEALQLI 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 142 IQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIplrskpvygKRWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLG 221
Cdd:PRK08363  110 FGALLDPGDEILIPGPSYPPYTGLVKFYGGVPVEY---------RTIEEEGWQPDIDDIRKKITEKTKAIAVINPNNPTG 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 222 KVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGnKHLKIATFPGMwERTITIGSAGKTFSVTGWKLGWS--IGPNhli 299
Cdd:PRK08363  181 ALYEKKTLKEILDIAGEHDLPVISDEIYDLMTYEG-KHVSPGSLTKD-VPVIVMNGLSKVYFATGWRLGYIyfVDPE--- 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 300 KHLQTVQQNT-----IYTCA-TPLQEALAQAFwidIKRMDdpecYFNSLPKELEVKRDRMV-RLLESVGLKPIVPDGGYF 372
Cdd:PRK08363  256 GKLAEVREAIdklarIRLCPnTPAQFAAIAGL---TGPMD----YLEEYMKKLKERRDYIYkRLNEIPGISTTKPQGAFY 328

                  .
gi 1159731393 373 I 373
Cdd:PRK08363  329 I 329
MalY COG1168
Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor ...
97-296 1.25e-35

Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440782  Cd Length: 387  Bit Score: 135.60  E-value: 1.25e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  97 YTrgFGHPSLVKALSYLYEKLYQKQIDsnKE-ILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVF 175
Cdd:COG1168    62 YT--APPDEYYEAIIDWLKRRHGWEID--PEwIVFTPGVVPGLALAIRAFTEPGDGVLIQTPVYPPFFKAIENNGRELVE 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 176 IPLRskpvygkrWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYS 255
Cdd:COG1168   138 NPLI--------LEDGRYRIDFDDLEAKLDPGVKLLLLCNPHNPTGRVWTREELERLAELCERHDVLVISDEIHADLVLP 209
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1159731393 256 GNKHLKIATF-PGMWERTITIGSAGKTFSVTGWKLGWSIGPN 296
Cdd:COG1168   210 GHKHTPFASLsEEAADRTITLTSPSKTFNLAGLKASYAIIPN 251
PRK06836 PRK06836
pyridoxal phosphate-dependent aminotransferase;
71-415 2.60e-35

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180720  Cd Length: 394  Bit Score: 134.94  E-value: 2.60e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  71 GFPDISPPTYVKEELSKIA--AIDSLNQYTRGFGHPSLVKALSylyEKLYQKQ-IDSNKE-ILVTVGAYGSLFNTIQALI 146
Cdd:PRK06836   41 GNPSVPPPAAVKEALRELAeeEDPGLHGYMPNAGYPEVREAIA---ESLNRRFgTPLTADhIVMTCGAAGALNVALKAIL 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 147 DEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKpvygkrwsssDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNR 226
Cdd:PRK06836  118 NPGDEVIVFAPYFVEYRFYVDNHGGKLVVVPTDTD----------TFQPDLDALEAAITPKTKAVIINSPNNPTGVVYSE 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 227 EELQVIADL----CIKYDT--LCISDEVYEWLVYSGnkhLKIATFPGMWERTITIGSAGKTFSVTGWKLGWsIGPNHLIK 300
Cdd:PRK06836  188 ETLKALAALleekSKEYGRpiYLISDEPYREIVYDG---AEVPYIFKYYDNSIVVYSFSKSLSLPGERIGY-IAVNPEME 263
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 301 HLQT-----VQQNTI--YTCATPL-QEALAQAfwIDIKRmdDPECYfnslpkelEVKRDRMVRLLESVGLKPIVPDGGYF 372
Cdd:PRK06836  264 DADDlvaalVFANRIlgFVNAPALmQRVVAKC--LDATV--DVSIY--------KRNRDLLYDGLTELGFECVKPQGAFY 331
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1159731393 373 IIadVSLLDPDlsdmknnepyDYKFVKWMTKHKKLsAIPVSAF 415
Cdd:PRK06836  332 LF--PKSPEED----------DVAFCEKAKKHNLL-LVPGSGF 361
C_S_lyase_PatB TIGR04350
putative C-S lyase; Members of this subfamily are probable C-S lyases from a family of ...
101-385 4.97e-34

putative C-S lyase; Members of this subfamily are probable C-S lyases from a family of pyridoxal phosphate-dependent enzymes that tend to be (mis)annotated as probable aminotransferases. One member is PatB of Bacillus subtilis, a proven C-S-lyase. Another is the virulence factor cystalysin from Treponema denticola, whose hemolysin activity may stem from H2S production. Members of the seed alignment occur next to examples of the enzyme 5-histidylcysteine sulfoxide synthase, from ovothiol A biosynthesis, and would be expected to perform a C-S cleavage of 5-histidylcysteine sulfoxide to leave 1-methyl-4-mercaptohistidine (ovothiol A).


Pssm-ID: 275146  Cd Length: 384  Bit Score: 131.29  E-value: 4.97e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 101 FGHP----SLVKALSYLYEKLYQKQIDsNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFI 176
Cdd:TIGR04350  56 FGYTlppdSLYAAVINWLAQRHGWQID-PEDIVFLPGVVPSLFAAVRALTAPGEGVIVQTPVYPPFLSAVKSNGRELVLN 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 177 PLRskpvygkrWSSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSG 256
Cdd:TIGR04350 135 PLK--------LDEGRYRFDLEDLEDAITEKARLLLLCSPHNPVGRVWTREELTRLAELCLRHNVVVVSDEIHADLVYPP 206
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 257 NKHLKIAT-FPGMWERTITIGSAGKTFSVTGWKLGWSIGPNH-LIKHLQTVQQNTIYTCATPLQEALAQAFWidikrmDD 334
Cdd:TIGR04350 207 NKHIPLASlSPEPAERTVTLLSPGKTFNIAGLNISFAIIPNPeLRRAFQEAAQRVHIQHGNLFGYVAFEAAY------RD 280
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1159731393 335 PECYFNSLPKELEVKRDRMVRLL--ESVGLKPIVPDGGYFIIADVSLL---DPDLS 385
Cdd:TIGR04350 281 GEPWLDALLAYLRGNRDLVEEFIakRLPQIRVRPPEATYLAWLDCRALgldDADLR 336
PRK08960 PRK08960
pyridoxal phosphate-dependent aminotransferase;
60-383 1.15e-33

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 181595  Cd Length: 387  Bit Score: 130.17  E-value: 1.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  60 AADPSVVNLGQGFPDISPPTYVKEelSKIAAIDSLN-QYTRGFGHPSLVKALSYLYEKLYQKQIDSNKeILVTVGAYGSL 138
Cdd:PRK08960   29 AAGHDVIHLEIGEPDFTTAEPIVA--AGQAALAAGHtRYTAARGLPALREAIAGFYAQRYGVDVDPER-ILVTPGGSGAL 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 139 FNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSkpvygkrwsSSDWTLDPQELESKFNSKTKAIILNTPHN 218
Cdd:PRK08960  106 LLASSLLVDPGKHWLLADPGYPCNRHFLRLVEGAAQLVPVGP---------DSRYQLTPALVERHWNADTVGALVASPAN 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 219 PLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSgnkhLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHL 298
Cdd:PRK08960  177 PTGTLLSRDELAALSQALRARGGHLVVDEIYHGLTYG----VDAASVLEVDDDAFVLNSFSKYFGMTGWRLGWLVAPPAA 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 299 IKHLQTVQQNTIYTCATPLQEALAQAFwidikrmdDPECY--FNSLPKELEVKRDRMVRLLESVGLK-PIVPDGGYFIIA 375
Cdd:PRK08960  253 VPELEKLAQNLYISASTPAQHAALACF--------EPETLaiLEARRAEFARRRDFLLPALRELGFGiAVEPQGAFYLYA 324

                  ....*...
gi 1159731393 376 DVSLLDPD 383
Cdd:PRK08960  325 DISAFGGD 332
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
59-432 1.13e-31

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 126.10  E-value: 1.13e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  59 LAADPSVVNLGQGFPDIS--PPTYVKEELSKIAAID--SLNQYTRGFGHPSLVKALSylyEKLYQKQID-SNKEILVTVG 133
Cdd:COG1167   102 LEAAPGVIDLGSGAPDPDlfPLAALRRALRRALRRLppALLGYGDPQGLPELREAIA---RYLARRGVPaSPDQILITSG 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 134 AYGSLFNTIQALIDEGDEVILIVPfydCYEPMV---RMAGATPVFIPLRSkpvYGkrwsssdwtLDPQELESKF-NSKTK 209
Cdd:COG1167   179 AQQALDLALRALLRPGDTVAVESP---TYPGALaalRAAGLRLVPVPVDE---DG---------LDLDALEAALrRHRPR 243
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 210 AIILnTP--HNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMwERTITIGSAGKTFSvTGW 287
Cdd:COG1167   244 AVYV-TPshQNPTGATMSLERRRALLELARRHGVPIIEDDYDSELRYDGRPPPPLAALDAP-GRVIYIGSFSKTLA-PGL 320
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 288 KLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQafWID-------IKRMddpecyfnslPKELEVKRDRMVRLLESV 360
Cdd:COG1167   321 RLGYLVAPGRLIERLARLKRATDLGTSPLTQLALAE--FLEsghydrhLRRL----------RREYRARRDLLLAALARH 388
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1159731393 361 ---GLKPIVPDGGYFIIADvslLDPDLSDMknnepydyKFVKWMTKHkKLSAIPVSAFCNSEtksQFEKFVRFCF 432
Cdd:COG1167   389 lpdGLRVTGPPGGLHLWLE---LPEGVDAE--------ALAAAALAR-GILVAPGSAFSADG---PPRNGLRLGF 448
tyr_nico_aTase TIGR01265
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal ...
56-448 4.95e-30

tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley.


Pssm-ID: 188123  Cd Length: 403  Bit Score: 120.52  E-value: 4.95e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  56 FTKLAADPSVVNLGQGFPDISP--PTYVKEELSKIAAIDS--LNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNkEILVT 131
Cdd:TIGR01265  24 KVKPNPEKPVIPLSHGDPSVFGnlRTDPEAEEAVKDALRSgkFNGYAPSVGALAAREAVAEYLSSDLPGKLTAD-DVVLT 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 132 VGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGatpvfIPLRskpvYGKRWSSSDWTLDPQELESKFNSKTKAI 211
Cdd:TIGR01265 103 SGCSQAIEICIEALANPGANILVPRPGFPLYDTRAAFSG-----LEVR----LYDLLPEKDWEIDLDGLESLADEKTVAI 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 212 ILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERtITIGSAGKTFSVTGWKLGW 291
Cdd:TIGR01265 174 VVINPSNPCGSVFSRDHLQKIAEVAEKLGIPIIADEIYGHMVFGDAPFIPMASFASIVPV-LSLGGISKRWVVPGWRLGW 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 292 SI--GPNHLIKH--LQTVQQNTIYTC--ATPLQEALAqafwiDIKRmDDPECYFNSLPKELevKRDRMV---RLLESVGL 362
Cdd:TIGR01265 253 IIihDPHGIFRDtvLQGLKNLLQRILgpATIVQGALP-----DILE-NTPQEFFDGKISVL--KSNAELcyeELKDIPGL 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 363 KPIVPDGGYFIIADVSL-LDPDLSDmknnepyDYKFVKWMTKHKKLSAIPVSAFcnsetksQFEKFVRFCFIKKDSTLDA 441
Cdd:TIGR01265 325 VCPKPEGAMYLMVKLELeLFPEIKD-------DVDFCEKLAREESVICLPGSAF-------GLPNWVRITITVPESMLEE 390

                  ....*..
gi 1159731393 442 AEEIIKA 448
Cdd:TIGR01265 391 ACSRIKE 397
PRK09276 PRK09276
LL-diaminopimelate aminotransferase; Provisional
38-377 1.77e-29

LL-diaminopimelate aminotransferase; Provisional


Pssm-ID: 181749  Cd Length: 385  Bit Score: 118.48  E-value: 1.77e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  38 KFTNAKRIEGLDSNVWIEFTKLAADP-----SVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSY 112
Cdd:PRK09276    1 MMKLADRIKNLPPYLFAEIDKKKAEKiargvDVISLGIGDPDLPTPDHIIEAMCKAVEDPENHQYPSYEGMLEFRKAVAD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 113 LYEKLYQKQIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRS----KPvygkrw 188
Cdd:PRK09276   81 WYKRRFGVELDPETEVISLIGSKEGIAHIPLAFVNPGDVVLVPDPGYPVYKIGTIFAGGEPYFMPLKEengfLP------ 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 189 sssDWTLDPQELESKfnskTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGM 268
Cdd:PRK09276  155 ---DLDAIPEDVAKK----AKLMFINYPNNPTGAVADLEFFEEVVDFAKKYDIIVCHDAAYSEIAYDGYKPPSFLEVPGA 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 269 WERTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEAlaqafwiDIKRMDDPECYFNSLPKELEV 348
Cdd:PRK09276  228 KDVGIEFHSLSKTYNMTGWRIGFAVGNADLIAGLGKVKSNVDSGVFQAIQEA-------GIAALNGPQEVVEELRKIYQE 300
                         330       340
                  ....*....|....*....|....*....
gi 1159731393 349 KRDRMVRLLESVGLKPIVPDGGYFIIADV 377
Cdd:PRK09276  301 RRDILVEGLRKLGLEVEPPKATFYVWAPV 329
PTZ00433 PTZ00433
tyrosine aminotransferase; Provisional
77-388 1.97e-28

tyrosine aminotransferase; Provisional


Pssm-ID: 185613  Cd Length: 412  Bit Score: 116.04  E-value: 1.97e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  77 PPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQkQIDSNKE------ILVTVGAYGSLFNTIQALIDEGD 150
Cdd:PTZ00433   51 TPAIQTKALVEAVDSQECNGYPPTVGSPEAREAVATYWRNSFV-HKESLKStikkdnVVLCSGVSHAILMALTALCDEGD 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 151 EVILIVPFYDCYEPMVRMAGATPVFIPLRSkpvygkrwsSSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQ 230
Cdd:PTZ00433  130 NILVPAPGFPHYETVCKAYGIEMRFYNCRP---------EKDWEADLDEIRRLVDDRTKALIMTNPSNPCGSNFSRKHVE 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 231 VIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAgKTFSVTGWKLGWSI-------GPNhLIKHLQ 303
Cdd:PTZ00433  201 DIIRLCEELRLPLISDEIYAGMVFNGATFTSVADFDTTVPRVILGGTA-KNLVVPGWRLGWLLlvdphgnGGD-FLDGMK 278
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 304 TVQQNTIYTCATpLQEALAQAFwidikrMDDPECYFNSLPKELEVKRDRMVRLLES-VGLKPIVPDGGYFIIA--DVSLL 380
Cdd:PTZ00433  279 RLGMLVCGPCSV-VQAALGEAL------LNTPQEHLEQIVAKLEEGAMVLYNHIGEcIGLSPTMPRGSMFLMSrlDLEKF 351

                  ....*...
gi 1159731393 381 DPDLSDMK 388
Cdd:PTZ00433  352 RDIKSDVE 359
tyr_amTase_E TIGR01264
tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found ...
62-415 1.07e-27

tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found in animals and Trypanosoma cruzi. It is the first enzyme of a pathway of tyrosine degradation via homogentisate. Several plant enzyme designated as probable tyrosine aminotransferases are very closely related to an experimentally demonstrated nicotianamine aminotransferase, an enzyme in a siderophore (iron uptake chelator) biosynthesis pathway. These plant sequences are excluded from the model seed and score between the trusted an noise cutoffs. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273529 [Multi-domain]  Cd Length: 401  Bit Score: 113.72  E-value: 1.07e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  62 DPSVvnlgqgFPDISPPTYVKEELSKiaAIDS--LNQYTRGFGHPSLVKALSYLYEKLyQKQIDSNkEILVTVGAYGSLF 139
Cdd:TIGR01264  40 DPTV------FGNLPTDPEVMQAMKD--SLDSgkYNGYAPTVGALSAREAIASYYHNP-DGPIEAD-DVVLCSGCSHAIE 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 140 NTIQALIDEGDEVILIVPFYDCYEPMVRMAGatpvfipLRSKPvYGKRwSSSDWTLDPQELESKFNSKTKAIILNTPHNP 219
Cdd:TIGR01264 110 MCIAALANAGQNILVPRPGFPLYETLAESMG-------IEVKL-YNLL-PDKSWEIDLKQLESLIDEKTAALIVNNPSNP 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 220 LGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERtITIGSAGKTFSVTGWKLGWSIGPNH-- 297
Cdd:TIGR01264 181 CGSVFSRQHLEEILAVAERQCLPIIADEIYGDMVFSGATFEPLASLSSTVPI-LSCGGLAKRWLVPGWRLGWIIIHDRrg 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 298 ----LIKHLQTVQQNTIYTCaTPLQEALAQAFwidikrMDDPECYFNSLPKELEVKRDRMVRLL-ESVGLKPIVPDGGYF 372
Cdd:TIGR01264 260 ilrdIRDGLVKLSQRILGPC-TIVQGALPSIL------LRTPQEYFDGTLSVLESNAMLCYGALaAVPGLRPVMPSGAMY 332
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1159731393 373 IIADVSLldPDLSDMKNnepyDYKFVKWMTKHKKLSAIPVSAF 415
Cdd:TIGR01264 333 MMVGIEM--EHFPEFKN----DVEFTERLVAEQSVFCLPGSCF 369
PRK07550 PRK07550
aminotransferase;
60-372 5.17e-26

aminotransferase;


Pssm-ID: 181026 [Multi-domain]  Cd Length: 386  Bit Score: 108.89  E-value: 5.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  60 AADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSnKEILVTVGAYGSLF 139
Cdd:PRK07550   26 GADGPLIDLSQAVPGYPPPPELLRALAEAAADPAAHLYGPVEGLPELREAYAAHYSRLYGAAISP-EQVHITSGCNQAFW 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 140 NTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPvygkrwsssDWTLDPQELESKFNSKTKAIILNTPHNP 219
Cdd:PRK07550  105 AAMVTLAGAGDEVILPLPWYFNHKMWLDMLGIRPVYLPCDEGP---------GLLPDPAAAEALITPRTRAIALVTPNNP 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 220 LGKVYNREELQVIADLCIKYDTLCISDEVY-EWLVYSGNKHLKIATfPGmWERT-ITIGSAGKTFSVTGWKLGWSIGPNH 297
Cdd:PRK07550  176 TGVVYPPELLHELYDLARRHGIALILDETYrDFDSGGGAPHDLFAD-PD-WDDTlVHLYSFSKSYALTGHRVGAVVASPA 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 298 LIKHLQTVqQNTIYTCATPL-QEALAQAF-----WIDIKRMddpecyfnslpkELEVKRDRMVRLLESVGLKPIVPDGGY 371
Cdd:PRK07550  254 RIAEIEKF-MDTVAICAPRIgQIAVAWGLpnladWRAGNRA------------EIARRRDAFRAVFARLPGWELLASGAY 320

                  .
gi 1159731393 372 F 372
Cdd:PRK07550  321 F 321
PRK08068 PRK08068
transaminase; Reviewed
57-372 5.89e-26

transaminase; Reviewed


Pssm-ID: 181219  Cd Length: 389  Bit Score: 108.86  E-value: 5.89e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  57 TKLAADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYG 136
Cdd:PRK08068   26 KKVAEGHDVINLGQGNPDQPTPEHIVEALQEAAENPANHKYSPFRGYPFLKEAAADFYKREYGVTLDPETEVAILFGGKA 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 137 SLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKpvygkrwssSDWTLDPQELESKFNSKTKAIILNTP 216
Cdd:PRK08068  106 GLVELPQCLMNPGDTILVPDPGYPDYLSGVALARAQFETMPLIAE---------NNFLPDYTKIPEEVAEKAKLMYLNYP 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 217 HNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPN 296
Cdd:PRK08068  177 NNPTGAVATKAFFEETVAFAKKHNIGVVHDFAYGAIGFDGQKPVSFLQTPGAKDVGIELYTLSKTFNMAGWRVAFAVGNE 256
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1159731393 297 HLIKHLQTVQQNTIYTCATPLQEALAQAFwidikrMDDPECyFNSLPKELEVKRDRMVRLLESVGLKPIVPDGGYF 372
Cdd:PRK08068  257 SVIEAINLLQDHLFVSLFGAIQDAAIEAL------LSDQSC-VAELVARYESRRNAFISACREIGWEVDAPKGSFF 325
PRK07324 PRK07324
transaminase; Validated
102-322 1.45e-24

transaminase; Validated


Pssm-ID: 235989  Cd Length: 373  Bit Score: 104.63  E-value: 1.45e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 102 GHPSLVKALSylyeKLYQKQIDSNkeILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSK 181
Cdd:PRK07324   63 GSPEFKEAVA----SLYQNVKPEN--ILQTNGATGANFLVLYALVEPGDHVISVYPTYQQLYDIPESLGAEVDYWQLKEE 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 182 pvygkrwssSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNkhlk 261
Cdd:PRK07324  137 ---------NGWLPDLDELRRLVRPNTKLICINNANNPTGALMDRAYLEEIVEIARSVDAYVLSDEVYRPLDEDGS---- 203
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1159731393 262 IATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQ-NTIytCATPLQEALA 322
Cdd:PRK07324  204 TPSIADLYEKGISTNSMSKTYSLPGIRVGWIAANEEVIDILRKYRDyTMI--CAGVFDDMLA 263
PRK06207 PRK06207
pyridoxal phosphate-dependent aminotransferase;
122-386 6.25e-24

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 235742  Cd Length: 405  Bit Score: 103.31  E-value: 6.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 122 IDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPVygkrwsSSDWTLDPQELE 201
Cdd:PRK06207   99 VDAADELIITPGTQGALFLAVAATVARGDKVAIVQPDYFANRKLVEFFEGEMVPVQLDYLSA------DKRAGLDLDQLE 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 202 SKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKT 281
Cdd:PRK06207  173 EAFKAGVRVFLFSNPNNPAGVVYSAEEIAQIAALARRYGATVIVDQLYSRLLYDGTSYTHLRALPIDPENVITIMGPSKT 252
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 282 FSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFwidikrmDDPECYFNSLPKELEVKRDRMVRLLESV- 360
Cdd:PRK06207  253 ESLSGYRLGVAFGSPAIIDRMEKLQAIVSLRAAGYSQAVLRTWF-------SEPDGWMKDRIARHQAIRDDLLRVLRGVe 325
                         250       260
                  ....*....|....*....|....*.
gi 1159731393 361 GLKPIVPDGGYFIIADVSLLDPDLSD 386
Cdd:PRK06207  326 GVFVRAPQAGSYLFPRLPRLAVSLHD 351
HisC COG0079
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ...
77-377 3.34e-23

Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 439849 [Multi-domain]  Cd Length: 341  Bit Score: 99.82  E-value: 3.34e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  77 PPTYVKEELSkiAAIDSLNQYTRGfGHPSLVKALS-YLyeklyqkQIDSNkEILVTVGAYGSLFNTIQALIDEGDEVILI 155
Cdd:COG0079    27 PPPKVLEAIA--AALDALNRYPDP-DATALREALAeYY-------GVPPE-QVLVGNGSDELIQLLARAFLGPGDEVLVP 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 156 VPFYDCYEPMVRMAGATPVFIPLRSkpvygkrwsssDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADL 235
Cdd:COG0079    96 EPTFSEYPIAARAAGAEVVEVPLDE-----------DFSLDLDALLAAITERTDLVFLCNPNNPTGTLLPREELEALLEA 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 236 CiKYDTLCISDEVY-EwlvYSGNKH----LkIATFPGMwertITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQntI 310
Cdd:COG0079   165 L-PADGLVVVDEAYaE---FVPEEDsalpL-LARYPNL----VVLRTFSKAYGLAGLRLGYAIASPELIAALRRVRG--P 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1159731393 311 YTCATPLQEALAQAfwidikrMDDPEcYFNSLPKELEVKRDRMVRLLESVGLKPiVPDGGYFIIADV 377
Cdd:COG0079   234 WNVNSLAQAAALAA-------LEDRA-YLEETRARLRAERERLAAALRALGLTV-YPSQANFVLVRV 291
PRK09148 PRK09148
LL-diaminopimelate aminotransferase;
60-324 3.75e-23

LL-diaminopimelate aminotransferase;


Pssm-ID: 181674 [Multi-domain]  Cd Length: 405  Bit Score: 100.91  E-value: 3.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  60 AADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGSLF 139
Cdd:PRK09148   27 AAGADIIDLGMGNPDLPTPQHIVDKLCETAQDPRTHRYSASKGIPGLRRAQAAYYARRFGVKLNPDTQVVATLGSKEGFA 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 140 NTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPVYgkrwsssdwtLDPQELESKFN-SKTKAIILNTPHN 218
Cdd:PRK09148  107 NMAQAITAPGDVILCPNPSYPIHAFGFIMAGGVIRSVPAEPDEEF----------FPALERAVRHSiPKPIALIVNYPSN 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 219 PLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHL 298
Cdd:PRK09148  177 PTAYVADLDFYKDVVAFAKKHDIIILSDLAYSEIYFDGNPPPSVLQVPGAKDVTVEFTSMSKTFSMAGWRMGFAVGNERL 256
                         250       260
                  ....*....|....*....|....*.
gi 1159731393 299 IKHLQTVQQNTIYTCATPLQEALAQA 324
Cdd:PRK09148  257 IAALTRVKSYLDYGAFTPIQVAATAA 282
PRK08175 PRK08175
aminotransferase; Validated
65-448 4.51e-23

aminotransferase; Validated


Pssm-ID: 181268 [Multi-domain]  Cd Length: 395  Bit Score: 100.56  E-value: 4.51e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  65 VVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGSLFNTIQA 144
Cdd:PRK08175   31 IIDFSMGNPDGPTPPHIVEKLCEVAQRPDTHGYSTSRGIPRLRRAISRWYQDRYDVDIDPESEAIVTIGSKEGLAHLMLA 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 145 LIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLrskpVYGKRWSSsdwtldpqELESKFNS---KTKAIILNTPHNPLG 221
Cdd:PRK08175  111 TLDHGDTVLVPNPSYPIHIYGAVIAGAQVRSVPL----VEGVDFFN--------ELERAIREsypKPKMMILGFPSNPTA 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 222 KVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHLIKH 301
Cdd:PRK08175  179 QCVELEFFEKVVALAKRYDVLVVHDLAYADIVYDGWKAPSIMQVPGAKDVAVEFFTLSKSYNMAGWRIGFMVGNPELVSA 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 302 LQTVQQNTIYTCATPLQEAlaqafwiDIKRMDDPECYFNSLPKELEVKRDRMVRLLESVGLKPIVPDGGYFIIADVSlld 381
Cdd:PRK08175  259 LARIKSYHDYGTFTPLQVA-------AIAALEGDQQCVRDIAEQYKRRRDVLVKGLHEAGWMVEMPKASMYVWAKIP--- 328
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1159731393 382 pdlsdmknnEPY----DYKFVKWMTKHKKLSAIPVSAFcnsetKSQFEKFVRFCFIKKDSTLDAAEEIIKA 448
Cdd:PRK08175  329 ---------EPYaamgSLEFAKKLLNEAKVCVSPGIGF-----GDYGDTHVRFALIENRDRIRQAIRGIKA 385
PRK09265 PRK09265
aminotransferase AlaT; Validated
141-300 6.40e-23

aminotransferase AlaT; Validated


Pssm-ID: 181738  Cd Length: 404  Bit Score: 100.27  E-value: 6.40e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 141 TIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFipLRSKPvygkrwsSSDWTLDPQELESKFNSKTKAIILNTPHNPL 220
Cdd:PRK09265  111 AMQALLNNGDEVLVPAPDYPLWTAAVSLSGGKPVH--YLCDE-------EAGWFPDLDDIRSKITPRTKAIVIINPNNPT 181
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 221 GKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATF-PGMWerTITIGSAGKTFSVTGWKLGWSI--GPNH 297
Cdd:PRK09265  182 GAVYSKELLEEIVEIARQHNLIIFADEIYDKILYDGAVHISIASLaPDLL--CVTFNGLSKAYRVAGFRVGWMVlsGPKK 259

                  ...
gi 1159731393 298 LIK 300
Cdd:PRK09265  260 HAK 262
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
141-293 8.98e-23

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 100.97  E-value: 8.98e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 141 TIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKpvygkrwssSDWTLDPQELESKFNSKTKAIILNTPHNPL 220
Cdd:PRK13355  224 SMSALLDDGDEVLIPSPDYPLWTACVNLAGGTAVHYRCDEQ---------SEWYPDIDDIRSKITSRTKAIVIINPNNPT 294
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1159731393 221 GKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATF-PGMWerTITIGSAGKTFSVTGWKLGWSI 293
Cdd:PRK13355  295 GALYPREVLQQIVDIAREHQLIIFSDEIYDRLVMDGLEHTSIASLaPDLF--CVTFSGLSKSHMIAGYRIGWMI 366
PRK05942 PRK05942
aspartate aminotransferase; Provisional
35-361 1.07e-22

aspartate aminotransferase; Provisional


Pssm-ID: 180317  Cd Length: 394  Bit Score: 99.41  E-value: 1.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  35 MSLKFTN-AKRIEGLDSNVWIEFTKLAADP-----SVVNLGQGFPDISPPTYVKEelskiAAIDSL-NQYTRGF----GH 103
Cdd:PRK05942    1 MSLDWITpADRLQALPPYVFARLDELKARAreqglDLIDLGMGNPDGAAPQPVIE-----AAIAALaDPQNHGYppfeGT 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 104 PSLVKALSYLYEKLYQKQIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCY--EPMVrmAGATPVFIPLRSK 181
Cdd:PRK05942   76 ASFRQAITDWYHRRYGVELDPDSEALPLLGSKEGLTHLALAYVNPGDVVLVPSPAYPAHfrGPLI--AGAQIYPIILKPE 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 182 pvygkrwssSDWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLK 261
Cdd:PRK05942  154 ---------NDWLIDLSSIPEEVAQQAKILYFNYPSNPTTATAPREFFEEIVAFARKYEIMLVHDLCYAELAFDGYQPTS 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 262 IATFPGMWERTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAFWIdikrmddPECYFNS 341
Cdd:PRK05942  225 LLEIPGAKDIGVEFHTLSKTYNMAGWRVGFVVGNRHIIQGLRTLKTNLDYGIFSALQKAAETALQL-------PDSYLQQ 297
                         330       340
                  ....*....|....*....|
gi 1159731393 342 LPKELEVKRDRMVRLLESVG 361
Cdd:PRK05942  298 VQERYRTRRDFLIQGLGELG 317
PRK06290 PRK06290
LL-diaminopimelate aminotransferase;
54-447 7.28e-22

LL-diaminopimelate aminotransferase;


Pssm-ID: 235772  Cd Length: 410  Bit Score: 97.03  E-value: 7.28e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  54 IEFTKLAA-----DPSVVNLGQGFPDISPPTYVKEELSKIAAIDSlnqyTRGF---GHPSLVKALSYLYEKLYQ-KQIDS 124
Cdd:PRK06290   30 IKRAKRAAkekhpDMELIDMGVGEPDEMADESVVEVLCEEAKKPE----NRGYadnGIQEFKEAAARYMEKVFGvKDIDP 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 125 NKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKpvygkrwssSDWTLDPQELESKF 204
Cdd:PRK06290  106 VTEVIHSIGSKPALAMLPSCFINPGDVTLMTVPGYPVTGTHTKYYGGEVYNLPLLEE---------NNFLPDLDSIPKDI 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 205 NSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGnKHLKIATFPGMWERTITIGSAGKTFSV 284
Cdd:PRK06290  177 KEKAKLLYLNYPNNPTGAVATKEFYEEVVDFAKENNIIVVQDAAYAALTFDG-KPLSFLSVPGAKEVGVEIHSLSKAYNM 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 285 TGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAfwidikrMDDPEcyfnsLPKELEVKRDR----MVRLLESV 360
Cdd:PRK06290  256 TGWRLAFVVGNELIVKAFATVKDNNDSGQFIAIQKAGIYA-------LDHPE-----ITEKIREKYSRrldkLVKILNEV 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 361 GLKPIVPDGGYFIIADVSLLDPDLSDMKNNEpydyKFVKWMTKHKKLSAIPVSAFCNsetksqfekFVRF--CFIKKDst 438
Cdd:PRK06290  324 GFKAEMPGGTFYLYVKAPKGTKSGIKFENAE----EFSQYLIKEKLISTVPWDDAGH---------FLRFsvTFEAKD-- 388

                  ....*....
gi 1159731393 439 LDAAEEIIK 447
Cdd:PRK06290  389 EEEEDRILE 397
PLN00145 PLN00145
tyrosine/nicotianamine aminotransferase; Provisional
65-387 1.38e-17

tyrosine/nicotianamine aminotransferase; Provisional


Pssm-ID: 215074 [Multi-domain]  Cd Length: 430  Bit Score: 84.44  E-value: 1.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  65 VVNLGQGFPDISP--PTYVKEELSKIAAIDS--LNQYTRGFGHPSLVKALS-YLYEKL-YQKQIDsnkEILVTVGAYGSL 138
Cdd:PLN00145   54 VLPLGHGDPSAFPcfRTAPEAEDAVAAALRSgkYNSYSTCVGLLPARRAIAeYLSRDLpYELSTD---DIYLTAGCAQAI 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 139 FNTIQALIDEGDEVILIVPFYDCYEpmvrmagATPVFIPLRSKpvYGKRWSSSDWTLDPQELESKFNSKTKAIILNTPHN 218
Cdd:PLN00145  131 EIIMSVLAQPGANILLPRPGYPLYE-------ARAVFSGLEVR--HFDLLPERGWEVDLEGVEALADENTVAMVIINPNN 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 219 PLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFpGMWERTITIGSAGKTFSVTGWKLGW--SIGPN 296
Cdd:PLN00145  202 PCGSVYSYEHLAKIAETARKLGILVIADEVYDHLTFGSKPFVPMGVF-GEVAPVLTLGSISKRWVVPGWRLGWiaTCDPN 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 297 HLIKHLQTVQ--QNTIYTCATP---LQEALAQAfwidIKRMDDPecYFNSLPKELEVKRDRMVRLLESV-GLK-PIVPDG 369
Cdd:PLN00145  281 GILKETKVVDsiRNYLNISTDPatfVQGAIPQI----IANTKEE--FFTKTLGLLKETADICYEKIKEIkCITcPHKPEG 354
                         330       340
                  ....*....|....*....|
gi 1159731393 370 GYFIIA--DVSLLDPDLSDM 387
Cdd:PLN00145  355 SMFVMVklDLSCLSGIKDDM 374
PRK06225 PRK06225
pyridoxal phosphate-dependent aminotransferase;
55-378 4.40e-17

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 235749 [Multi-domain]  Cd Length: 380  Bit Score: 82.49  E-value: 4.40e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  55 EFTKLAADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLvKALSYLYEKLyqkqidSNKEILVTVGA 134
Cdd:PRK06225   20 FFDYVFKDKEMIWMGQNTNHLGPHEEVREAMIRCIEEGEYCKYPPPEGFPEL-RELILKDLGL------DDDEALITAGA 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 135 YGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATpvfipLRSKPVYGkrwSSSDWTLDPQELESKFNSKTKAIILN 214
Cdd:PRK06225   93 TESLYLVMRAFLSPGDNAVTPDPGYLIIDNFASRFGAE-----VIEVPIYS---EECNYKLTPELVKENMDENTRLIYLI 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 215 TPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEwlVYSGNKHLKIATFPgmwERTITIGSAGKTFSVTGWKLGWSIG 294
Cdd:PRK06225  165 DPLNPLGSSYTEEEIKEFAEIARDNDAFLLHDCTYR--DFAREHTLAAEYAP---EHTVTSYSFSKIFGMAGLRIGAVVA 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 295 PNHLIKHLQTVQQNTIYTCATPLQEALA----QAFWID-IKRmddpECYFNslpKELeVKrdRMVRLLESVGLkPIVPDG 369
Cdd:PRK06225  240 TPDLIEVVKSIVINDLGTNVIAQEAAIAglkvKDEWIDrIRR----TTFKN---QKL-IK--EAVDEIEGVFL-PVYPSH 308

                  ....*....
gi 1159731393 370 GYFIIADVS 378
Cdd:PRK06225  309 GNMMVIDIS 317
PRK05839 PRK05839
succinyldiaminopimelate transaminase;
68-351 6.49e-16

succinyldiaminopimelate transaminase;


Pssm-ID: 180281  Cd Length: 374  Bit Score: 78.96  E-value: 6.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  68 LGQGFPDISPPTYVKEELSKIAAidSLNQYTRGFGHPSLVKALSYLYEKLYQKQIDSNkEILVTVGAYGSLFNTIQ-ALI 146
Cdd:PRK05839   29 LTIGEPQFETPKFIQDALKNNAH--LLNKYPKSAGEESLREAQRGFFKRRFKIELKEN-ELIPTFGTREVLFNFPQfVLF 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 147 DEGDEVILIV-PFYDCYEPMVRMAGATPVFIPLRSkpvygkrwsSSDWT--LDPQELeskfnSKTKAIILNTPHNPLGKV 223
Cdd:PRK05839  106 DKQNPTIAYPnPFYQIYEGAAIASRAKVLLMPLTK---------ENDFTpsLNEKEL-----QEVDLVILNSPNNPTGRT 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 224 YNREELQVIADLCIKYDTLCISDEVY-------------EWLVYSGNKHLKiatfpgmweRTITIGSAGKTFSVTGWKLG 290
Cdd:PRK05839  172 LSLEELIEWVKLALKHDFILINDECYseiyentpppsllEASILVGNESFK---------NVLVINSISKRSSAPGLRSG 242
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1159731393 291 WSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAfWIDikrMDDPECYFNSLPKELEVKRD 351
Cdd:PRK05839  243 FIAGDASILKKYKAYRTYLGCASPLPLQKAAAVA-WLD---DEHAEFFRNIYAKNLKLARE 299
PLN02656 PLN02656
tyrosine transaminase
64-291 4.76e-15

tyrosine transaminase


Pssm-ID: 178262 [Multi-domain]  Cd Length: 409  Bit Score: 76.50  E-value: 4.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  64 SVVNLGQGFPDISP---PTYVKEElskiAAIDSL-----NQYTRGFGHPSLVKALS-YLYEKLYQKQidSNKEILVTVGA 134
Cdd:PLN02656   32 RVISLGMGDPTAYScfhTTHVAQE----AVVDALqsnkfNGYAPTVGLPQARRAIAeYLSRDLPYKL--SLDDVFITSGC 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 135 YGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRskPVYGkrwsssdWTLDPQELESKFNSKTKAIILN 214
Cdd:PLN02656  106 TQAIDVALSMLARPGANILLPRPGFPIYELCAAFRHLEVRYVDLL--PEKG-------WEVDLDAVEALADQNTVALVII 176
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1159731393 215 TPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFpGMWERTITIGSAGKTFSVTGWKLGW 291
Cdd:PLN02656  177 NPGNPCGNVYSYQHLKKIAETAEKLKILVIADEVYGHLAFGSNPFVPMGVF-GSIVPVLTLGSLSKRWIVPGWRLGW 252
PLN00143 PLN00143
tyrosine/nicotianamine aminotransferase; Provisional
124-411 5.72e-15

tyrosine/nicotianamine aminotransferase; Provisional


Pssm-ID: 165711 [Multi-domain]  Cd Length: 409  Bit Score: 76.59  E-value: 5.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 124 SNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMvrmagATPVFIPLRSKPVYGKRwsssDWTLDPQELESK 203
Cdd:PLN00143   96 SPDDVYLTLGCKHAAEIIIKVLARPEANILLPRPGFPDVETY-----AIFHHLEIRHFDLLPEK----GWEVDLDAVEAI 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 204 FNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFpGMWERTITIGSAGKTFS 283
Cdd:PLN00143  167 ADENTIAMVIINPGNPCGSVYSYEHLNKIAETARKLGILVIADEVYGHIVFGSKPFVPMGLF-ASIVPVITLGSISKRWM 245
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 284 VTGWKLGWSI--GPNHLIKHLQTVQQNTIYTCATPLQEALAQAFWIDIKRMDDPECY---FNSLPKELEVKRDRMVRLle 358
Cdd:PLN00143  246 IPGWGLGWLVtcDPSGLLQICEIADSIKKALNPAPFPPTFIQAAIPEILEKTTEDFFsktINILRAALAFCYDKLKEI-- 323
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1159731393 359 SVGLKPIVPDGGYFIIADVSLLdpDLSDMKNnepyDYKFVKWMTKHKKLSAIP 411
Cdd:PLN00143  324 PCIMCPQKAEGAFFALVKLNLL--LLEDIED----DMEFCLKLAKEESLIILP 370
PRK08636 PRK08636
LL-diaminopimelate aminotransferase;
44-375 3.43e-14

LL-diaminopimelate aminotransferase;


Pssm-ID: 236316  Cd Length: 403  Bit Score: 73.97  E-value: 3.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  44 RIEGLDSNVWIEFT--KLA---ADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEKLY 118
Cdd:PRK08636    9 KIKRLPKYVFAEVNelKMAarrAGEDIIDFSMGNPDGPTPQHIIDKLCESAQKPKTHGYSVSKGIYKLRLAICNWYKRKY 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 119 QKQIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRskpvygkrwSSSDWTLDPQ 198
Cdd:PRK08636   89 NVDLDPETEVVATMGSKEGYVHLVQAITNPGDVAIVPDPAYPIHSQAFILAGGNVHKMPLE---------YNEDFELDED 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 199 E----LESKFNS---KTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWER 271
Cdd:PRK08636  160 QffenLEKALREsspKPKYVVVNFPHNPTTATVEKSFYERLVALAKKERFYIISDIAYADITFDGYKTPSILEVEGAKDV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 272 TITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNTIYTCATPLQEALAQAfwidikrMDDPECYFNSLPKELEVKRD 351
Cdd:PRK08636  240 AVESYTLSKSYNMAGWRVGFVVGNKKLVGALKKIKSWLDYGMFTPIQVAATIA-------LDGDQSCVEEIRETYRKRRD 312
                         330       340
                  ....*....|....*....|....
gi 1159731393 352 RMVRLLESVGLKPIVPDGGYFIIA 375
Cdd:PRK08636  313 VLIESFANAGWELQKPRASMFVWA 336
PRK09147 PRK09147
succinyldiaminopimelate transaminase; Provisional
56-249 6.67e-14

succinyldiaminopimelate transaminase; Provisional


Pssm-ID: 236393  Cd Length: 396  Bit Score: 72.98  E-value: 6.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  56 FTKLA---------ADPSVVNLGQGFPDISPPTYVKEELskIAAIDSLNQYTRGFGHPSLVKALSYLYEKLYQKQ-IDSN 125
Cdd:PRK09147   13 FEKLRalfagvtppADLPPISLSIGEPKHPTPAFIKDAL--AANLDGLASYPTTAGLPALREAIAAWLERRYGLPaLDPA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 126 KEILVTVGAYGSLFNTIQALIDEGDEVILIV---PFYDCYEPMVRMAGATPVFIPlrSKPvygKRWSSSDWTLDPQELEs 202
Cdd:PRK09147   91 TQVLPVNGSREALFAFAQTVIDRDGPGPLVVcpnPFYQIYEGAALLAGAEPYFLN--CDP---ANNFAPDFDAVPAEVW- 164
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1159731393 203 kfnSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVY 249
Cdd:PRK09147  165 ---ARTQLLFVCSPGNPTGAVLPLDDWKKLFALSDRYGFVIASDECY 208
PLN02187 PLN02187
rooty/superroot1
62-321 6.74e-13

rooty/superroot1


Pssm-ID: 215119 [Multi-domain]  Cd Length: 462  Bit Score: 70.14  E-value: 6.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  62 DPSVVNLGQGFPDISP--PTYVKEELSKIAAIDSL--NQYTRGFG-HPSLVKALSYLYEKLYQKQidSNKEILVTVGAYG 136
Cdd:PLN02187   65 NKTILPLGHGDPSVYPcfRTCIEAEDAVVDVLRSGkgNSYGPGAGiLPARRAVADYMNRDLPHKL--TPEDIFLTAGCNQ 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 137 SLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGatpvfIPLRSKPVYGKRwsssDWTLDPQELESKFNSKTKAIILNTP 216
Cdd:PLN02187  143 GIEIVFESLARPNANILLPRPGFPHYDARAAYSG-----LEVRKFDLLPEK----EWEIDLEGIEAIADENTVAMVVINP 213
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 217 HNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATFPGMWErTITIGSAGKTFSVTGWKLGWSI--- 293
Cdd:PLN02187  214 NNPCGNVYSHDHLKKVAETARKLGIMVISDEVYDRTIFGDNPFVSMGKFASIVP-VLTLAGISKGWVVPGWKIGWIAlnd 292
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1159731393 294 --GPNHLIKHLQTVQQNTIYT--CATPLQEAL 321
Cdd:PLN02187  293 peGVFETTKVLQSIKQNLDVTpdPATIIQAAL 324
PRK07366 PRK07366
LL-diaminopimelate aminotransferase;
42-306 1.57e-12

LL-diaminopimelate aminotransferase;


Pssm-ID: 180947  Cd Length: 388  Bit Score: 68.94  E-value: 1.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  42 AKRIEGLDSNVWIEFTK-----LAADPSVVNLGQGFPDISPPTYVKEELSKIAAIDSLNQYTRGFGHPSLVKALSYLYEK 116
Cdd:PRK07366    4 AQRLQPLQSNVFADMDRakaqaRAAGKELIDLSLGSSDLPAPAHALEAIAQSLHDPSTHGYLLFHGTLDFREAAAQWYEQ 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 117 LYQKQIDSNKEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSK----PVygkrwsssd 192
Cdd:PRK07366   84 RFGLAVDPETEVLPLIGSQEGTAHLPLAVLNPGDFALLLDPGYPSHAGGVYLAGGQIYPMPLRAEndflPV--------- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 193 WTLDPQELESKfnskTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKiATFPGMWERT 272
Cdd:PRK07366  155 FADIPTEVLAQ----ARLMVLSYPHNPTTAIAPLSFFQEAVAFCQQHDLVLVHDFPYVDLVFDGEVEPP-SILQADPEKS 229
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1159731393 273 ITIG--SAGKTFSVTGWKLGWSIGPNHLIKHLQTVQ 306
Cdd:PRK07366  230 VSIEffTLSKSYNMGGFRIGFAIGNAQLIQALRQVK 265
PRK06855 PRK06855
pyridoxal phosphate-dependent aminotransferase;
192-291 1.45e-11

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180734  Cd Length: 433  Bit Score: 66.13  E-value: 1.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 192 DWTLDPQELES--KFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIATF---- 265
Cdd:PRK06855  154 NWYPDLDDLENkvKYNPSIAGILLINPDNPTGAVYPKEILREIVDIAREYDLFIICDEIYNNIVYNGKKTVPLSEVigdv 233
                          90       100
                  ....*....|....*....|....*.
gi 1159731393 266 PGMWERTITigsagKTFSVTGWKLGW 291
Cdd:PRK06855  234 PGIALKGIS-----KELPWPGSRCGW 254
PTZ00377 PTZ00377
alanine aminotransferase; Provisional
97-258 1.28e-10

alanine aminotransferase; Provisional


Pssm-ID: 240391 [Multi-domain]  Cd Length: 481  Bit Score: 63.06  E-value: 1.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  97 YTRGFGHPSLVKALSYLYEKL--YQKQIDSnkeILVTVGAYGSLFNTIQALI-DEGDEVILIVPFYDCYEPMVRMAGATP 173
Cdd:PTZ00377  111 YTDSAGYPFVRKAVAAFIERRdgVPKDPSD---IFLTDGASSGIKLLLQLLIgDPSDGVMIPIPQYPLYSAAITLLGGKQ 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 174 VFIPLRSkpvygkrwsSSDWTLDPQELESKF------NSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDE 247
Cdd:PTZ00377  188 VPYYLDE---------EKGWSLDQEELEEAYeqavrnGITPRALVVINPGNPTGQVLTRDVMEEIIKFCYEKGIVLMADE 258
                         170
                  ....*....|.
gi 1159731393 248 VYEWLVYSGNK 258
Cdd:PTZ00377  259 VYQENIYDGEK 269
PLN03026 PLN03026
histidinol-phosphate aminotransferase; Provisional
104-378 6.90e-09

histidinol-phosphate aminotransferase; Provisional


Pssm-ID: 178597  Cd Length: 380  Bit Score: 57.40  E-value: 6.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 104 PSLVKALS-----YLYEKLYQKQI------DSNKE---ILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVRMA 169
Cdd:PLN03026   68 PEVLEALGnmkfpYVYPDPESRRLraalaeDSGLEsenILVGCGADELIDLLMRCVLDPGDKIIDCPPTFGMYVFDAAVN 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 170 GATPVFIPLrskpvygkrwsSSDWTLD-PQELESKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIkydtLCISDEV 248
Cdd:PLN03026  148 GAEVIKVPR-----------TPDFSLDvPRIVEAVETHKPKLLFLTSPNNPDGSIISDDDLLKILELPI----LVVLDEA 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 249 YewLVYSGNK-HLKIATfpgMWERTITIGSAGKTFSVTGWKLGWSIGPNHLIKHLQTVQQNtiYTCATPLQEALAQAFwi 327
Cdd:PLN03026  213 Y--IEFSTQEsRMKWVK---KYDNLIVLRTFSKRAGLAGLRVGYGAFPLSIIEYLWRAKQP--YNVSVAAEVAACAAL-- 283
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1159731393 328 dikrmDDPEcYFNSLPKELEVKRDRMVRLLESVG-LKPIvPDGGYFIIADVS 378
Cdd:PLN03026  284 -----SNPK-YLEDVKNALVEERERLFGLLKEVPfLEPY-PSDANFILCRVT 328
PLN02607 PLN02607
1-aminocyclopropane-1-carboxylate synthase
102-290 9.80e-09

1-aminocyclopropane-1-carboxylate synthase


Pssm-ID: 215327 [Multi-domain]  Cd Length: 447  Bit Score: 57.21  E-value: 9.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 102 GHPSLVKALSYLYEKLY--QKQIDSNKeILVTVGAYGS--LFNTIqaLIDEGDEVILIVPFYDCYEPMVRMAGATPVfIP 177
Cdd:PLN02607   96 GLKSFRQAMASFMEQIRggKARFDPDR-IVLTAGATAAneLLTFI--LADPGDALLVPTPYYPGFDRDLRWRTGVKI-VP 171
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 178 LRSKpvygkrwSSSDWTLDPQELESKF------NSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEW 251
Cdd:PLN02607  172 IHCD-------SSNNFQVTPQALEAAYqeaeaaNIRVRGVLITNPSNPLGATVQRSVLEDILDFVVRKNIHLVSDEIYSG 244
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1159731393 252 LVYSGNKHLKIAT------FPGMWERTITIGSAGKTFSVTGWKLG 290
Cdd:PLN02607  245 SVFSASEFVSVAEiveargYKGVAERVHIVYSLSKDLGLPGFRVG 289
PLN02368 PLN02368
alanine transaminase
94-254 1.18e-07

alanine transaminase


Pssm-ID: 177996 [Multi-domain]  Cd Length: 407  Bit Score: 53.65  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  94 LNQYTRGFGHPSLVKALSYLYEKlyQKQIDSNKE-ILVTVGAYGSLFNTIQALI-DEGDEVILIVPFYDCYEPMVRMAGA 171
Cdd:PLN02368  100 LGAYSDSRGLPGVRKEVAEFIER--RDGYPSDPElIFLTDGASKGVMQILNAVIrGEKDGVLVPVPQYPLYSATISLLGG 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 172 TPVfiplrskPVYGKRwsSSDWTLDPQELESKFNSK------TKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCIS 245
Cdd:PLN02368  178 TLV-------PYYLEE--SENWGLDVNNLRQSVAQArskgitVRAMVIINPGNPTGQCLSEANLREILKFCYQERLVLLG 248

                  ....*....
gi 1159731393 246 DEVYEWLVY 254
Cdd:PLN02368  249 DEVYQQNIY 257
PRK03321 PRK03321
putative aminotransferase; Provisional
130-229 1.53e-07

putative aminotransferase; Provisional


Pssm-ID: 179559  Cd Length: 352  Bit Score: 53.05  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 130 VTVGAyGS---LFNTIQALIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRskpvygkrwssSDWTLDPQELESKFNS 206
Cdd:PRK03321   77 VAVGC-GSvalCQQLVQATAGPGDEVIFAWRSFEAYPILVQVAGATPVQVPLT-----------PDHTHDLDAMAAAITD 144
                          90       100
                  ....*....|....*....|...
gi 1159731393 207 KTKAIILNTPHNPLGKVYNREEL 229
Cdd:PRK03321  145 RTRLIFVCNPNNPTGTVVTPAEL 167
PLN02376 PLN02376
1-aminocyclopropane-1-carboxylate synthase
126-263 3.34e-07

1-aminocyclopropane-1-carboxylate synthase


Pssm-ID: 178004 [Multi-domain]  Cd Length: 496  Bit Score: 52.39  E-value: 3.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 126 KEILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVR-MAGATPVFIPLRSKPVYGKRWSSSDWTLDPQElESkf 204
Cdd:PLN02376  120 ERVVMSGGATGANETIMFCLADPGDVFLIPSPYYAAFDRDLRwRTGVEIIPVPCSSSDNFKLTVDAADWAYKKAQ-ES-- 196
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1159731393 205 NSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHLKIA 263
Cdd:PLN02376  197 NKKVKGLILTNPSNPLGTMLDKDTLTNLVRFVTRKNIHLVVDEIYAATVFAGGDFVSVA 255
PLN02231 PLN02231
alanine transaminase
127-277 5.05e-07

alanine transaminase


Pssm-ID: 177876 [Multi-domain]  Cd Length: 534  Bit Score: 51.86  E-value: 5.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 127 EILVTVGAYGSLFNTIQALI-DEGDEVILIVPFYDCYEPMVRMAGATPVfiplrskPVYGKRwsSSDWTLDPQELESKF- 204
Cdd:PLN02231  193 DIFLTDGASPAVHMMMQLLIrSEKDGILCPIPQYPLYSASIALHGGTLV-------PYYLDE--ATGWGLEISELKKQLe 263
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 205 NSKTK-----AIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYSGNKHL----KIATFPGMWERTITI 275
Cdd:PLN02231  264 DARSKgitvrALVVINPGNPTGQVLAEENQRDIVEFCKQEGLVLLADEVYQENVYVPDKKFhsfkKVARSMGYGEKDISL 343

                  ..
gi 1159731393 276 GS 277
Cdd:PLN02231  344 VS 345
WecE COG0399
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
142-212 2.16e-06

dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440168  Cd Length: 364  Bit Score: 49.68  E-value: 2.16e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1159731393 142 IQAL-IDEGDEVIliVP---FYDCYEPmVRMAGATPVFI---PlrskpvygkrwssSDWTLDPQELESKFNSKTKAII 212
Cdd:COG0399    62 LRALgIGPGDEVI--TPaftFVATANA-ILYVGATPVFVdidP-------------DTYNIDPEALEAAITPRTKAII 123
PRK08354 PRK08354
putative aminotransferase; Provisional
93-294 5.73e-06

putative aminotransferase; Provisional


Pssm-ID: 169399  Cd Length: 311  Bit Score: 48.19  E-value: 5.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393  93 SLNQYTRGFGHPSLVKALSYLYEKLYQKQIDS------NKEILVTVGAYGSLFnTIQALIDEGDEVILIVPFYDCYEPMV 166
Cdd:PRK08354   16 SVNPYPPEWLDEMFERAKEISGRYTYYEWLEEefsklfGEPIVITAGITEALY-LIGILALRDRKVIIPRHTYGEYERVA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 167 RMAGAtpvfiplrsKPVYGKrwsssdwtLDPQELEsKFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISD 246
Cdd:PRK08354   95 RFFAA---------RIIKGP--------NDPEKLE-ELVERNSVVFFCNPNNPDGKFYNFKELKPLLDAVEDRNALLILD 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1159731393 247 EVYEWLVYSGNKhlkiatFPGmwERTITIGSAGKTFSVTGWKLGWSIG 294
Cdd:PRK08354  157 EAFIDFVKKPES------PEG--ENIIKLRTFTKSYGLPGIRVGYVKG 196
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
138-246 1.89e-05

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 46.46  E-value: 1.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 138 LFNTIQALIDEGDEVILIvpfYDCYEPMVRM-------AGATPVFIPlrskpvygkrwsssdwTLDPQELESKFNSKTKA 210
Cdd:pfam01053  75 ITAAILALLKAGDHIVAT---DDLYGGTYRLfnkvlprFGIEVTFVD----------------TSDPEDLEAAIKPNTKA 135
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1159731393 211 IILNTPHNPLGKVYnreELQVIADLCIKYDTLCISD 246
Cdd:pfam01053 136 VYLETPTNPLLKVV---DIEAIAKLAKKHGILVVVD 168
AHBA_syn cd00616
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal ...
146-246 2.19e-05

3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.


Pssm-ID: 99740 [Multi-domain]  Cd Length: 352  Bit Score: 46.38  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 146 IDEGDEVIliVPfydcyePM--------VRMAGATPVFI---PlrskpvygkrwssSDWTLDPQELESKFNSKTKAIIln 214
Cdd:cd00616    55 IGPGDEVI--VP------SFtfvatanaILLLGATPVFVdidP-------------DTYNIDPELIEAAITPRTKAII-- 111
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1159731393 215 tPHNPLGKVYNREELQVIADlciKYDTLCISD 246
Cdd:cd00616   112 -PVHLYGNPADMDAIMAIAK---RHGLPVIED 139
PRK09275 PRK09275
bifunctional aspartate transaminase/aspartate 4-decarboxylase;
138-290 7.00e-05

bifunctional aspartate transaminase/aspartate 4-decarboxylase;


Pssm-ID: 236444  Cd Length: 527  Bit Score: 45.24  E-value: 7.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 138 LFNTIQA--LIDEGDEVILIVPFYDCYEPMVRMAGATPVFIPLRSKPvygkrwsSSDWTLDPQELESKFNSKTKAIILNT 215
Cdd:PRK09275  177 IFDSLKEngLLKAGDKIALMTPIFTPYLEIPELPRYDLEVVHINADE-------ENEWQYPDSELEKLRDPSIKALFLVN 249
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 216 PHNPLGKVYNREELQVIADLCIKY--DTLCISDEVYewlvysgnkhlkiATF-PGMweRTI-------TIG--SAGKTFS 283
Cdd:PRK09275  250 PSNPPSVAMSDESLEKIADIVNEKrpDLMIITDDVY-------------GTFvDDF--RSLfavlpynTILvySFSKYFG 314

                  ....*..
gi 1159731393 284 VTGWKLG 290
Cdd:PRK09275  315 ATGWRLG 321
PLN02450 PLN02450
1-aminocyclopropane-1-carboxylate synthase
102-255 1.02e-04

1-aminocyclopropane-1-carboxylate synthase


Pssm-ID: 178069 [Multi-domain]  Cd Length: 468  Bit Score: 44.36  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 102 GHPSLVKALSYLYEKL--YQKQIDSNKeILVTVGAYGSLFNTIQALIDEGDEVILIVPFYDCYEPMVR-MAGATPVfiPL 178
Cdd:PLN02450   87 GLPAFKNALAEFMSEIrgNKVTFDPNK-LVLTAGATSANETLMFCLAEPGDAFLLPTPYYPGFDRDLKwRTGVEIV--PI 163
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1159731393 179 RSKPVYGKRWSSSdwTLDPQELES-KFNSKTKAIILNTPHNPLGKVYNREELQVIADLCIKYDTLCISDEVYEWLVYS 255
Cdd:PLN02450  164 HCSSSNGFQITES--ALEEAYQQAqKLNLKVKGVLITNPSNPLGTTTTRTELNLLVDFITAKNIHLISDEIYSGTVFD 239
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
124-249 1.13e-04

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 42.75  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 124 SNKEILVTVGAYGSLFNTIQALIDEGDEVILIVP-FYDCYEPMVRMAGATPVFIPlrsKPVYGKRwsssdwTLDPQELES 202
Cdd:cd01494    16 GNDKAVFVPSGTGANEAALLALLGPGDEVIVDANgHGSRYWVAAELAGAKPVPVP---VDDAGYG------GLDVAILEE 86
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1159731393 203 KFNSK-TKAIILNTPHNPLGKVYNREElqvIADLCIKYDTLCISDEVY 249
Cdd:cd01494    87 LKAKPnVALIVITPNTTSGGVLVPLKE---IRKIAKEYGILLLVDAAS 131
PRK08247 PRK08247
methionine biosynthesis PLP-dependent protein;
180-246 2.32e-04

methionine biosynthesis PLP-dependent protein;


Pssm-ID: 181320 [Multi-domain]  Cd Length: 366  Bit Score: 43.15  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 180 SKPVYG----------KRWSSS---DWTLDPQELESKFNSKTKAIILNTPHNPLGKVYNreeLQVIADLCIKYDTLCISD 246
Cdd:PRK08247   96 SSDLYGgtyrlfeehwKKWNVRfvyVNTASLKAIEQAITPNTKAIFIETPTNPLMQETD---IAAIAKIAKKHGLLLIVD 172
DegT_DnrJ_EryC1 pfam01041
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all ...
143-246 4.28e-04

DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.


Pssm-ID: 395827  Cd Length: 360  Bit Score: 42.27  E-value: 4.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159731393 143 QAL-IDEGDEVILiVPF-YDCYEPMVRMAGATPVFIPLrsKPVygkrwsssDWTLDPQELESKFNSKTKAIIlntPHNPL 220
Cdd:pfam01041  57 RALgVGPGDEVIT-PSFtFVATANAALRLGAKPVFVDI--DPD--------TYNIDPEAIEAAITPRTKAII---PVHLY 122
                          90       100
                  ....*....|....*....|....*.
gi 1159731393 221 GKVYnreELQVIADLCIKYDTLCISD 246
Cdd:pfam01041 123 GQPA---DMDAIRAIAARHGLPVIED 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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