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Conserved domains on  [gi|1063732508|ref|NP_001332508|]
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calcium exchanger 7 [Arabidopsis thaliana]

Protein Classification

cation/calcium exchanger( domain architecture ID 1004073)

cation/calcium exchanger belonging to the Ca(2+):cation antiporter (CaCA) family, such as mitochondrial sodium/calcium exchanger protein, an antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion

Gene Ontology:  GO:0015368|GO:0016020|GO:0070588
PubMed:  23685453
SCOP:  3002205
TCDB:  2.A.19

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03151 super family cl33648
cation/calcium exchanger; Provisional
 30-531 2.77e-161

cation/calcium exchanger; Provisional


The actual alignment was detected with superfamily member PLN03151:

Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 473.48  E-value: 2.77e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508  30 FASQTPPPSGSIQTLNSFAGGDSDSCSGgLASLDDHRSKCSYIRSQSKCGPQGYIDYLKIFFCIFGQSPVLGHLVLSAWL 109
Cdd:PLN03151   69 RLSDIDVNSSYFSDNSSLSGDSPVLCSG-LHEHEGYADQCEFLKAHPICSSGGFFDYLKFFYCSCEDFRILGYAVLGVWL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 110 FVLFYLLGDTAASYFCPSLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSFTRSNNGDFGLNSILGGAFFVSSFVVG 189
Cdd:PLN03151  148 VALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFASIAAFVGKDAGEVGLNSVLGGAVFVTCVVVG 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 190 TICVLIGSRDVAIDRNSFIRDVVFLLVALCCLGLIIFIGK------------------------ILR------------- 232
Cdd:PLN03151  228 IVSLCVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKvtvggaiafvsiyvvyaflvaaneILRkharrlkldvvtp 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 233 -----------SREDLAEMGVSLLGYIAEEKLA-----LPE---------KTTQEFKIVFEDSPK-------------RH 274
Cdd:PLN03151  308 llpvqgsifspSVEEDESMYSPLLESDTESDVPrlqtsLPQwmwasnvaiYSNHFAKGSVHDEERppwgwtdegaeveSS 387

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 275 RSCFSVLVSIIGLPLYLPRRLTIPVVCEEKWSKPCAVVSTAIAPVLLTELYCSHYS-GSQRNLILYIISGSIGLIVGILA 353
Cdd:PLN03151  388 LFSCSKLFSLLEMPLTIPRRLTIPIVEEDRWSKTYAVASASLAPVLLAFLWSSQDDvSLQARIAAYFIGVAIGSTLGFLA 467

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 354 YLTTEKSHPPKKFSLVWLLGGFTMSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGn 433
Cdd:PLN03151  468 YKYTEPDRPPRRFLIPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGG- 546

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 434 DGAQIALSGCYAGPLFNTVIGLGVPLVISSLAEYPGVYIIPSDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLL 513
Cdd:PLN03151  547 DGVQIAMSGCYAGPMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLI 626

                         570
                  ....*....|....*...
gi 1063732508 514 AIYLCFLSLRLARVFGVL 531
Cdd:PLN03151  627 ALYLIFLTFRVSTAMGFI 644
 
Name Accession Description Interval E-value
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 30-531 2.77e-161

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 473.48  E-value: 2.77e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508  30 FASQTPPPSGSIQTLNSFAGGDSDSCSGgLASLDDHRSKCSYIRSQSKCGPQGYIDYLKIFFCIFGQSPVLGHLVLSAWL 109
Cdd:PLN03151   69 RLSDIDVNSSYFSDNSSLSGDSPVLCSG-LHEHEGYADQCEFLKAHPICSSGGFFDYLKFFYCSCEDFRILGYAVLGVWL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 110 FVLFYLLGDTAASYFCPSLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSFTRSNNGDFGLNSILGGAFFVSSFVVG 189
Cdd:PLN03151  148 VALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFASIAAFVGKDAGEVGLNSVLGGAVFVTCVVVG 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 190 TICVLIGSRDVAIDRNSFIRDVVFLLVALCCLGLIIFIGK------------------------ILR------------- 232
Cdd:PLN03151  228 IVSLCVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKvtvggaiafvsiyvvyaflvaaneILRkharrlkldvvtp 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 233 -----------SREDLAEMGVSLLGYIAEEKLA-----LPE---------KTTQEFKIVFEDSPK-------------RH 274
Cdd:PLN03151  308 llpvqgsifspSVEEDESMYSPLLESDTESDVPrlqtsLPQwmwasnvaiYSNHFAKGSVHDEERppwgwtdegaeveSS 387

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 275 RSCFSVLVSIIGLPLYLPRRLTIPVVCEEKWSKPCAVVSTAIAPVLLTELYCSHYS-GSQRNLILYIISGSIGLIVGILA 353
Cdd:PLN03151  388 LFSCSKLFSLLEMPLTIPRRLTIPIVEEDRWSKTYAVASASLAPVLLAFLWSSQDDvSLQARIAAYFIGVAIGSTLGFLA 467

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 354 YLTTEKSHPPKKFSLVWLLGGFTMSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGn 433
Cdd:PLN03151  468 YKYTEPDRPPRRFLIPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGG- 546

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 434 DGAQIALSGCYAGPLFNTVIGLGVPLVISSLAEYPGVYIIPSDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLL 513
Cdd:PLN03151  547 DGVQIAMSGCYAGPMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLI 626

                         570
                  ....*....|....*...
gi 1063732508 514 AIYLCFLSLRLARVFGVL 531
Cdd:PLN03151  627 ALYLIFLTFRVSTAMGFI 644
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 370-524 2.41e-20

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 87.66  E-value: 2.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 370 WLLGGFTMSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYAGPLF 449
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPD---LALGNVIGSNIF 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063732508 450 NTVIGLGVPLVISSLAEYPGVYIIPSDNSLLETLGFLMVGLLWALVImpkkKMRLDKLVGGGLLAIYLCFLSLRL 524
Cdd:pfam01699  78 NILLVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLVLLLLYIVYLVFQI 148
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
127-522 1.38e-16

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 80.18  E-value: 1.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 127 SLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSfTRSNNGDFGLNSILGGAFFVSSFVVGtICVLIgsRDVAIDRNS 206
Cdd:COG0530     7 GADALARRLGISPLVIGLTIVAFGTSLPELAVSVTA-ALDGSPDIAVGNVVGSNIANILLILG-LAALI--RPLAVDRRV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 207 FIRDVVFLLVALCCLGLIIFIGKILRSredlaeMGVSLLGyiaeeklalpekttqefkivfedspkrhrscfsVLVSIIG 286
Cdd:COG0530    83 LRRDLPFLLLASLLLLALLLDGTLSRI------DGVILLL---------------------------------LYVLYLY 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 287 LPLYLPRRLTIPVVCEEKWSKpcavvstaiapvlltelycsHYSGSQRNLILYIISGSIGLIVGilaylttekshppkkf 366
Cdd:COG0530   124 YLIRRARKEPAWEEVEEELEE--------------------KPKMSLWKALLLLVLGLALLVVG---------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 367 slvwllggftmsvtwtymiAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYAG 446
Cdd:COG0530   168 -------------------ARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDD---LAVGNIIGS 225

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063732508 447 PLFNTVIGLGVPLVISSlaeypgvyiIPSDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLLAIYLCFLSL 522
Cdd:COG0530   226 NIFNILLVLGIGALITP---------IPVDPAVLSFDLPVMLAATLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 364-535 1.54e-13

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 73.49  E-value: 1.54e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508  364 KKFSLVWLLGgftmSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGC 443
Cdd:TIGR00927  931 RKFFVITFLG----SIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGD---MAVSSS 1003

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508  444 YAGPLFNTVIGLGVPLVISSLAEypGVYIIP-SDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLLAIYLCFLsl 522
Cdd:TIGR00927 1004 VGSNIFDITVGLPVPWLLFSLIN--GLQPVPvSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFL-- 1079

                          170
                   ....*....|...
gi 1063732508  523 rlarVFGVLDTDR 535
Cdd:TIGR00927 1080 ----IISVMLEDR 1088
 
Name Accession Description Interval E-value
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 30-531 2.77e-161

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 473.48  E-value: 2.77e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508  30 FASQTPPPSGSIQTLNSFAGGDSDSCSGgLASLDDHRSKCSYIRSQSKCGPQGYIDYLKIFFCIFGQSPVLGHLVLSAWL 109
Cdd:PLN03151   69 RLSDIDVNSSYFSDNSSLSGDSPVLCSG-LHEHEGYADQCEFLKAHPICSSGGFFDYLKFFYCSCEDFRILGYAVLGVWL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 110 FVLFYLLGDTAASYFCPSLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSFTRSNNGDFGLNSILGGAFFVSSFVVG 189
Cdd:PLN03151  148 VALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFASIAAFVGKDAGEVGLNSVLGGAVFVTCVVVG 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 190 TICVLIGSRDVAIDRNSFIRDVVFLLVALCCLGLIIFIGK------------------------ILR------------- 232
Cdd:PLN03151  228 IVSLCVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKvtvggaiafvsiyvvyaflvaaneILRkharrlkldvvtp 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 233 -----------SREDLAEMGVSLLGYIAEEKLA-----LPE---------KTTQEFKIVFEDSPK-------------RH 274
Cdd:PLN03151  308 llpvqgsifspSVEEDESMYSPLLESDTESDVPrlqtsLPQwmwasnvaiYSNHFAKGSVHDEERppwgwtdegaeveSS 387

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 275 RSCFSVLVSIIGLPLYLPRRLTIPVVCEEKWSKPCAVVSTAIAPVLLTELYCSHYS-GSQRNLILYIISGSIGLIVGILA 353
Cdd:PLN03151  388 LFSCSKLFSLLEMPLTIPRRLTIPIVEEDRWSKTYAVASASLAPVLLAFLWSSQDDvSLQARIAAYFIGVAIGSTLGFLA 467

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 354 YLTTEKSHPPKKFSLVWLLGGFTMSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGn 433
Cdd:PLN03151  468 YKYTEPDRPPRRFLIPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGG- 546

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 434 DGAQIALSGCYAGPLFNTVIGLGVPLVISSLAEYPGVYIIPSDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLL 513
Cdd:PLN03151  547 DGVQIAMSGCYAGPMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLI 626

                         570
                  ....*....|....*...
gi 1063732508 514 AIYLCFLSLRLARVFGVL 531
Cdd:PLN03151  627 ALYLIFLTFRVSTAMGFI 644
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 370-524 2.41e-20

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 87.66  E-value: 2.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 370 WLLGGFTMSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYAGPLF 449
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPD---LALGNVIGSNIF 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063732508 450 NTVIGLGVPLVISSLAEYPGVYIIPSDNSLLETLGFLMVGLLWALVImpkkKMRLDKLVGGGLLAIYLCFLSLRL 524
Cdd:pfam01699  78 NILLVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLVLLLLYIVYLVFQI 148
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
127-522 1.38e-16

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 80.18  E-value: 1.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 127 SLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSfTRSNNGDFGLNSILGGAFFVSSFVVGtICVLIgsRDVAIDRNS 206
Cdd:COG0530     7 GADALARRLGISPLVIGLTIVAFGTSLPELAVSVTA-ALDGSPDIAVGNVVGSNIANILLILG-LAALI--RPLAVDRRV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 207 FIRDVVFLLVALCCLGLIIFIGKILRSredlaeMGVSLLGyiaeeklalpekttqefkivfedspkrhrscfsVLVSIIG 286
Cdd:COG0530    83 LRRDLPFLLLASLLLLALLLDGTLSRI------DGVILLL---------------------------------LYVLYLY 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 287 LPLYLPRRLTIPVVCEEKWSKpcavvstaiapvlltelycsHYSGSQRNLILYIISGSIGLIVGilaylttekshppkkf 366
Cdd:COG0530   124 YLIRRARKEPAWEEVEEELEE--------------------KPKMSLWKALLLLVLGLALLVVG---------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 367 slvwllggftmsvtwtymiAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYAG 446
Cdd:COG0530   168 -------------------ARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDD---LAVGNIIGS 225

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063732508 447 PLFNTVIGLGVPLVISSlaeypgvyiIPSDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLLAIYLCFLSL 522
Cdd:COG0530   226 NIFNILLVLGIGALITP---------IPVDPAVLSFDLPVMLAATLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 105-249 3.73e-16

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 75.72  E-value: 3.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 105 LSAWLFVLFYLLGDTAASYFCPSLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSFtRSNNGDFGLNSILGGAFFVS 184
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAA-LRGEPDLALGNVIGSNIFNI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063732508 185 SFVVGTICVLIGsrdVAIDRNSFIRDV-VFLLVALCCLGLIIFIGKILRSREDLAEMGVSLLGYIA 249
Cdd:pfam01699  80 LLVLGLSALIGP---VKVDSLLLKLDLgVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIV 142
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 364-535 1.54e-13

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 73.49  E-value: 1.54e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508  364 KKFSLVWLLGgftmSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGC 443
Cdd:TIGR00927  931 RKFFVITFLG----SIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGD---MAVSSS 1003

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508  444 YAGPLFNTVIGLGVPLVISSLAEypGVYIIP-SDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLLAIYLCFLsl 522
Cdd:TIGR00927 1004 VGSNIFDITVGLPVPWLLFSLIN--GLQPVPvSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFL-- 1079

                          170
                   ....*....|...
gi 1063732508  523 rlarVFGVLDTDR 535
Cdd:TIGR00927 1080 ----IISVMLEDR 1088
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 109-519 1.56e-09

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 59.26  E-value: 1.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 109 LFVLFYLLGDTAASYFCPSLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSFTRSNNgDFGLNSILGGAFFVSSFVV 188
Cdd:TIGR00367   6 YLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQP-DIGVGNVIGSNIFNILLIL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 189 GtICVLIgsRDVAIDRNSFIRDVVFLLVALCCLGLIIFIGKILRsredlaemgvsllgyiaeeklalpekttqefkivfe 268
Cdd:TIGR00367  85 G-LSAIF--SPIIVDKDWLRRDILFYLLVSILLLFFGLDGQISR------------------------------------ 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 269 dspkrhrscFSVLVSIIGLPLYLPRrltipVVCEEKWSKPCAVvstaiapvllTELYCSHYSgsQRNLILyiisgsigli 348
Cdd:TIGR00367 126 ---------IDGVVLLILYIVYLLF-----LVKNERWVKYDTY----------TEENLDENN--RRPQIF---------- 169

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 349 vgilaylttekshppkkFSLVWLLGGFTMSVTWTYMiaqeLVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVA 428
Cdd:TIGR00367 170 -----------------FSLVLLIIGLIGLVVGSRL----LVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAA 228

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 429 FHGGNDgaqIALSGCYAGPLFNTVIGLGVPLVIsslaeypgvYIIPSDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLV 508
Cdd:TIGR00367 229 RKGLGD---IAVGNVIGSNIFNILVGLGVPSLF---------MPIPVEPLAYNLDAPVMVIVTLLLMLFFKTSMKLGRWE 296

                         410
                  ....*....|.
gi 1063732508 509 GGGLLAIYLCF 519
Cdd:TIGR00367 297 GILLLALYIAY 307
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 96-226 3.18e-09

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 59.62  E-value: 3.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508   96 QSPVLGHLVLSAWLFVLFYLLGDtaaSYFCPSLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSFTRSNNgDFGLNS 175
Cdd:TIGR00927  454 QGWVVLHIFGMMYVFVALAIVCD---EYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHS-NVGIGT 529

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1063732508  176 ILGGAFFVSSFVVGTiCVLIGSRDVAIDRNSFIRDVVFLLVALccLGLIIF 226
Cdd:TIGR00927  530 IVGSAVFNILFVIGT-CALFSREILNLTWWPLFRDVSFYILDL--MMLILF 577
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
389-520 9.01e-08

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 53.60  E-value: 9.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 389 LVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYAGPLFNTVIGLGVPLVISSLAeyp 468
Cdd:COG0530     4 LVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPD---IAVGNVVGSNIANILLILGLAALIRPLA--- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063732508 469 gvyiIPSDNSLLETLGFLMVGLLWALVIMPkkkMRLDKLVGGGLLAIYLCFL 520
Cdd:COG0530    78 ----VDRRVLRRDLPFLLLASLLLLALLLD---GTLSRIDGVILLLLYVLYL 122
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 396-522 2.06e-06

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 49.64  E-value: 2.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 396 LGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYAGPLFNTVIGLGVPLVISSLAEYPGVYiiPS 475
Cdd:PRK10734  200 LANYFAISELTIGLTVIAIGTSLPELATAIAGARKGEND---IAVGNIIGSNIFNIVIVLGLPALISPGEINPLAF--SR 274

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063732508 476 DNSLLetlgfLMVGLLWALVIMpKKKMRLDKLVGGGLLAIYLCFLSL 522
Cdd:PRK10734  275 DYWVM-----LLVSVIFALLCW-RRKRRIGRGAGALLLGGFIVWLAM 315
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
103-249 2.40e-06

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 49.36  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 103 LVLSAWLFVlfyllgdtaasyfcPSLDSLSKVLKLSPTMAGVTLLSLGNGAPDLFSSVVSfTRSNNGDFGLNSILGGAFF 182
Cdd:COG0530   164 LVVGARLLV--------------DGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVA-ARKGEDDLAVGNIIGSNIF 228

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063732508 183 VSSFVVGtICVLIgsRDVAIDRNSFIRDVVFLL-VALCCLGLIIFIGKILRsredlAEMGVSLLGYIA 249
Cdd:COG0530   229 NILLVLG-IGALI--TPIPVDPAVLSFDLPVMLaATLLLLGLLRTGGRIGR-----WEGLLLLALYLA 288
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 371-520 5.78e-03

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 38.84  E-value: 5.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 371 LLGGFTMSVTWTYMIAQELVSLLISLGNIFGISPSVLGLTVLAWGNSLGDLIANVTVAFHGGNDgaqIALSGCYAGPLFN 450
Cdd:TIGR00367   3 LIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPD---IGVGNVIGSNIFN 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063732508 451 TVIGLGVPLVISSLaeypgvyIIPSDNSLLETLGFLMVGLLWALVIMPKKKMRLDKLVGGGLLAIYLCFL 520
Cdd:TIGR00367  80 ILLILGLSAIFSPI-------IVDKDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFL 142
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 140-195 9.29e-03

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 39.00  E-value: 9.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063732508 140 TMAGVTLLSLGNGAPDLFSSVVSFTRSN--NGDFGLNSILGGAFFvSSFVVGTICVLI 195
Cdd:TIGR00845 130 TVSNLTLMALGSSAPEILLSVIEVCGHNfeAGDLGPSTIVGSAAF-NMFIIIAICVYV 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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