NCBI Conserved Domain Search

Conserved domains on [gi|1057503148|ref|NP_001317122|]

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ribonucleoside-diphosphate reductase large subunit isoform 4 [Homo sapiens]

Protein Classification

glycyl radical enzyme family protein( domain architecture ID 1562547)

glycyl radical enzyme family protein such as ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL), which have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.

CATH: 3.20.70.20

PubMed: 10574800

SCOP: 3001069

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

RNR_PFL super family

cl38938

Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ...

1-570

0e+00

Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.

The actual alignment was detected with superfamily member PLN02437:

Pssm-ID: 476821 [Multi-domain] Cd Length: 813 Bit Score: 1144.48 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   1 MKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLE 80
Cdd:PLN02437  223 MKDDSIEGIYDTLKECAVISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLE 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  81 PWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRK 160
Cdd:PLN02437  303 PWHADIFEFLDLRKNHGKEEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKK 382

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 161 VVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSE---- 236
Cdd:PLN02437  383 VVQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVREKgvpl 462

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 237 ---------------HTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAE 301
Cdd:PLN02437  463 eshpsklvgslgsknRYFDFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPE 542

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 302 AQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMP 381
Cdd:PLN02437  543 AQQLNKDIFETIYYHALKASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMP 622

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 382 TASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTV 461
Cdd:PLN02437  623 TASTSQILGNNECFEPYTSNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTV 702

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 462 WEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKV 541
Cdd:PLN02437  703 WEIKQRTLVDMAADRGCYIDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASLKPSATG 782

                         570       580       590
                  ....*....|....*....|....*....|.
gi 1057503148 542 SKEEEEKERNT--AAMVCSLENRDECLMCGS 570
Cdd:PLN02437  783 VAAPEEEDVETkmAQMVCSLDNREECLACGS 813

Name

Accession

Description

Interval

E-value

PLN02437

ribonucleoside--diphosphate reductase large subunit

1-570

0e+00

ribonucleoside--diphosphate reductase large subunit

Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1144.48 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   1 MKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLE 80
Cdd:PLN02437  223 MKDDSIEGIYDTLKECAVISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLE 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  81 PWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRK 160
Cdd:PLN02437  303 PWHADIFEFLDLRKNHGKEEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKK 382

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 161 VVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSE---- 236
Cdd:PLN02437  383 VVQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVREKgvpl 462

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 237 ---------------HTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAE 301
Cdd:PLN02437  463 eshpsklvgslgsknRYFDFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPE 542

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 302 AQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMP 381
Cdd:PLN02437  543 AQQLNKDIFETIYYHALKASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMP 622

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 382 TASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTV 461
Cdd:PLN02437  623 TASTSQILGNNECFEPYTSNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTV 702

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 462 WEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKV 541
Cdd:PLN02437  703 WEIKQRTLVDMAADRGCYIDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASLKPSATG 782

                         570       580       590
                  ....*....|....*....|....*....|.
gi 1057503148 542 SKEEEEKERNT--AAMVCSLENRDECLMCGS 570
Cdd:PLN02437  783 VAAPEEEDVETkmAQMVCSLDNREECLACGS 813

Ribonuc_red_lgC

pfam02867

Ribonucleotide reductase, barrel domain;

1-516

0e+00

Ribonucleotide reductase, barrel domain;

Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 744.41 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   1 MKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLE 80
Cdd:pfam02867   7 SVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGG-KRRGAAAVYLE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  81 PWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKL-YASYEKQGRVR 159
Cdd:pfam02867  86 VWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYEREENEGIRK 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 160 KVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTY 239
Cdd:pfam02867 166 KTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKFVEFGGTF 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 240 DFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALE 319
Cdd:pfam02867 246 DFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKIFETMYYYALK 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 320 ASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTD------LWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNE 393
Cdd:pfam02867 326 ASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFApkasktREDWEELREDIKKYGLRNSQLTAIAPTGSISQIAGATE 405

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 394 SIEPYTSNIYTRRVLSgefqivnphllkdlterglwheemknqiiacngsiqsipeipDDLKQLYKTVWEISQKTVLKMA 473
Cdd:pfam02867 406 SIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYDIDQKAHIDMA 443

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 1057503148 474 AERGAFIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTGMYY 516
Cdd:pfam02867 444 AARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487

NrdA

COG0209

Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ...

3-532

0e+00

Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage

Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 738.15 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:COG0209   136 EDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGG-KRRGANMVYLRVW 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVV 162
Cdd:COG0209   215 HPDIEEFLDLKKNNGDERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTI 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 KAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTsEHTYDFK 242
Cdd:COG0209   295 KARELWRKILESAWETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLLPYESEDASCNLGSINLAKFVK-DGEFDWE 373

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 243 KLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASC 322
Cdd:COG0209   374 KLEETVRTAVRFLDNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASA 453

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 323 DLAKEQGPYETYEGSPVSKGILQYDMW--NVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTS 400
Cdd:COG0209   454 ELAKERGAFPAFEGSKYAKGILPFDKYldDLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFS 533

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 401 NIYTRRVLS-GEFQIVNPHLLKDLTERGLWHEEMKNQIIAcNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAF 479
Cdd:COG0209   534 LVYVRKVLDgGEFTVVNPYLVRALKELGLWDEELVEKIKE-DGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKH 612

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1057503148 480 IDQSQSLNIHIA-EPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPIQFTLNK 532
Cdd:COG0209   613 VDQAISKTLNLPnDATVEDLAELYLLAWKLGLKG-IYYYRDGSRTGQVLSTGKK 665

RNR_I

cd01679

Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ...

3-519

0e+00

Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.

Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 672.72 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:cd01679    58 DDSLESIYDTIKECAQLSKIGGGIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGG-QRKGAGAVYLEIW 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVEtnqdwslmcpnecpgldevwgeefeklyasyekqgrvrkvv 162
Cdd:cd01679   137 HPDIEEFLDLKKNNGDERRRARDLFYGVWIPDLFMERVE----------------------------------------- 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 kaQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSK-----DEVAVCNLASLALNMYVTseh 237
Cdd:cd01679   176 --RDLWRKILESQFETGYPYILFKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINLGNFVT--- 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 238 tydFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGA 317
Cdd:cd01679   251 ---FEKLEEVVKLAVRALDNVIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYA 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 318 LEASCDLAKEQGpyetyegspvskgilqydmwnvtptdlwdwkvlkekiakyGIRNSLLIAPMPTASTAQILGNNESIEP 397
Cdd:cd01679   328 LKASCELAKERG----------------------------------------GLRNSLLLAIAPTASISQILGATPSIEP 367

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 398 YTSNIYTRRVLSGEFQIVNPHLLKDLTERGlwheemknqiiacngsiqsipeipddlkqLYKTVWEISQKTVLKMAAERG 477
Cdd:cd01679   368 ITSNIYVRRVLSGEFPVVNPHLEKDLWEYG-----------------------------LYKTAYEIDQRWLIDLAADRQ 418

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1057503148 478 AFIDQSQSLNIHIAEP-NYGKLTSMHFYGWKQGLKTGmYYLRT 519
Cdd:cd01679   419 KHIDQGQSLNLFLTPPaTTRDLNSLYFYAWKKGLKTL-YYLRT 460

NrdE_NrdA

TIGR02506

ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ...

3-520

0e+00

ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]

Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 658.30 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:TIGR02506  88 DDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG-KRPGAAAVYLEVW 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRK-- 160
Cdd:TIGR02506 167 HPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKDVEARKki 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 161 -VVKAQQLWYAIIESQTETGTPYMLYKDSCNRK-SNQQNLGTIKCSNLCTEIVEYTSKD---EVAVCNLASLALNMYVTS 235
Cdd:TIGR02506 247 rKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDShkgETAVCNLASVNLANFVME 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 236 EhTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYY 315
Cdd:TIGR02506 327 D-KFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDLNDRIFEAIYY 405

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 316 GALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLW-------DWKVLKEKIAKYGIRNSLLIAPMPTASTAQI 388
Cdd:TIGR02506 406 YAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTALMPTASSSQL 485

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 389 LGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKT 468
Cdd:TIGR02506 486 TGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKYKTAYELDQEA 565

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1057503148 469 VLKMAAERGAFIDQSQSLNIHIAE-PNYGKLTSMHFYGWKQGLKTgMYYLRTR 520
Cdd:TIGR02506 566 LIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT-MYYCRSR 617

Name

Accession

Description

Interval

E-value

PLN02437

ribonucleoside--diphosphate reductase large subunit

1-570

0e+00

ribonucleoside--diphosphate reductase large subunit

Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1144.48 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   1 MKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLE 80
Cdd:PLN02437  223 MKDDSIEGIYDTLKECAVISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLE 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  81 PWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRK 160
Cdd:PLN02437  303 PWHADIFEFLDLRKNHGKEEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKK 382

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 161 VVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSE---- 236
Cdd:PLN02437  383 VVQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVREKgvpl 462

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 237 ---------------HTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAE 301
Cdd:PLN02437  463 eshpsklvgslgsknRYFDFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPE 542

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 302 AQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMP 381
Cdd:PLN02437  543 AQQLNKDIFETIYYHALKASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMP 622

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 382 TASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTV 461
Cdd:PLN02437  623 TASTSQILGNNECFEPYTSNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTV 702

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 462 WEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKV 541
Cdd:PLN02437  703 WEIKQRTLVDMAADRGCYIDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASLKPSATG 782

                         570       580       590
                  ....*....|....*....|....*....|.
gi 1057503148 542 SKEEEEKERNT--AAMVCSLENRDECLMCGS 570
Cdd:PLN02437  783 VAAPEEEDVETkmAQMVCSLDNREECLACGS 813

Ribonuc_red_lgC

pfam02867

Ribonucleotide reductase, barrel domain;

1-516

0e+00

Ribonucleotide reductase, barrel domain;

Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 744.41 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   1 MKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLE 80
Cdd:pfam02867   7 SVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGG-KRRGAAAVYLE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  81 PWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKL-YASYEKQGRVR 159
Cdd:pfam02867  86 VWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYEREENEGIRK 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 160 KVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTY 239
Cdd:pfam02867 166 KTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKFVEFGGTF 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 240 DFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALE 319
Cdd:pfam02867 246 DFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKIFETMYYYALK 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 320 ASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTD------LWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNE 393
Cdd:pfam02867 326 ASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFApkasktREDWEELREDIKKYGLRNSQLTAIAPTGSISQIAGATE 405

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 394 SIEPYTSNIYTRRVLSgefqivnphllkdlterglwheemknqiiacngsiqsipeipDDLKQLYKTVWEISQKTVLKMA 473
Cdd:pfam02867 406 SIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYDIDQKAHIDMA 443

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 1057503148 474 AERGAFIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTGMYY 516
Cdd:pfam02867 444 AARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487

NrdA

COG0209

Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ...

3-532

0e+00

Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage

Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 738.15 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:COG0209   136 EDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGG-KRRGANMVYLRVW 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVV 162
Cdd:COG0209   215 HPDIEEFLDLKKNNGDERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTI 294

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 KAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTsEHTYDFK 242
Cdd:COG0209   295 KARELWRKILESAWETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLLPYESEDASCNLGSINLAKFVK-DGEFDWE 373

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 243 KLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASC 322
Cdd:COG0209   374 KLEETVRTAVRFLDNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASA 453

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 323 DLAKEQGPYETYEGSPVSKGILQYDMW--NVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTS 400
Cdd:COG0209   454 ELAKERGAFPAFEGSKYAKGILPFDKYldDLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFS 533

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 401 NIYTRRVLS-GEFQIVNPHLLKDLTERGLWHEEMKNQIIAcNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAF 479
Cdd:COG0209   534 LVYVRKVLDgGEFTVVNPYLVRALKELGLWDEELVEKIKE-DGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKH 612

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1057503148 480 IDQSQSLNIHIA-EPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPIQFTLNK 532
Cdd:COG0209   613 VDQAISKTLNLPnDATVEDLAELYLLAWKLGLKG-IYYYRDGSRTGQVLSTGKK 665

RNR_I

cd01679

Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ...

3-519

0e+00

Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 672.72 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:cd01679    58 DDSLESIYDTIKECAQLSKIGGGIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGG-QRKGAGAVYLEIW 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVEtnqdwslmcpnecpgldevwgeefeklyasyekqgrvrkvv 162
Cdd:cd01679   137 HPDIEEFLDLKKNNGDERRRARDLFYGVWIPDLFMERVE----------------------------------------- 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 kaQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSK-----DEVAVCNLASLALNMYVTseh 237
Cdd:cd01679   176 --RDLWRKILESQFETGYPYILFKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINLGNFVT--- 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 238 tydFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGA 317
Cdd:cd01679   251 ---FEKLEEVVKLAVRALDNVIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYA 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 318 LEASCDLAKEQGpyetyegspvskgilqydmwnvtptdlwdwkvlkekiakyGIRNSLLIAPMPTASTAQILGNNESIEP 397
Cdd:cd01679   328 LKASCELAKERG----------------------------------------GLRNSLLLAIAPTASISQILGATPSIEP 367

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 398 YTSNIYTRRVLSGEFQIVNPHLLKDLTERGlwheemknqiiacngsiqsipeipddlkqLYKTVWEISQKTVLKMAAERG 477
Cdd:cd01679   368 ITSNIYVRRVLSGEFPVVNPHLEKDLWEYG-----------------------------LYKTAYEIDQRWLIDLAADRQ 418

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1057503148 478 AFIDQSQSLNIHIAEP-NYGKLTSMHFYGWKQGLKTGmYYLRT 519
Cdd:cd01679   419 KHIDQGQSLNLFLTPPaTTRDLNSLYFYAWKKGLKTL-YYLRT 460

NrdE_NrdA

TIGR02506

ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ...

3-520

0e+00

Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 658.30 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:TIGR02506  88 DDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG-KRPGAAAVYLEVW 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRK-- 160
Cdd:TIGR02506 167 HPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKDVEARKki 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 161 -VVKAQQLWYAIIESQTETGTPYMLYKDSCNRK-SNQQNLGTIKCSNLCTEIVEYTSKD---EVAVCNLASLALNMYVTS 235
Cdd:TIGR02506 247 rKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDShkgETAVCNLASVNLANFVME 326

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 236 EhTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYY 315
Cdd:TIGR02506 327 D-KFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDLNDRIFEAIYY 405

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 316 GALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLW-------DWKVLKEKIAKYGIRNSLLIAPMPTASTAQI 388
Cdd:TIGR02506 406 YAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTALMPTASSSQL 485

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 389 LGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKT 468
Cdd:TIGR02506 486 TGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKYKTAYELDQEA 565

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1057503148 469 VLKMAAERGAFIDQSQSLNIHIAE-PNYGKLTSMHFYGWKQGLKTgMYYLRTR 520
Cdd:TIGR02506 566 LIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT-MYYCRSR 617

PRK07207

ribonucleoside-diphosphate reductase subunit alpha;

4-568

0e+00

ribonucleoside-diphosphate reductase subunit alpha;

Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 558.81 E-value: 0e+00

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   4 DSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWH 83
Cdd:PRK07207  381 DDLDGIYEAIKDNALLSKFAGGLGNDWTPVRALGSHIKGTNGKSQGVVPFLKVVNDTAVAVNQGG-KRKGAVCAYLETWH 459

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  84 LDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQG-----RV 158
Cdd:PRK07207  460 LDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTLFSPSEVPDLHDLFGKAFEEAYTAYEAKAargeiKL 539

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 159 RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHT 238
Cdd:PRK07207  540 FKKIPAVDLWRKMLSMLFETGHPWITFKDPCNLRSPQQHVGVVHSSNLCTEITLNTSDDEIAVCNLGSVNLVAHIKDGAK 619

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 239 YDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL 318
Cdd:PRK07207  620 LDHEKLKRTVSTAMRMLDNVIDINYYAVPKARNSNLRHRPVGLGIMGFQDALYLLRIPYASDEAVEFADRSMEAVSYYAI 699

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 319 EASCDLAKEQGPYETYEGSPVSKGILQYD-----------MWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQ 387
Cdd:PRK07207  700 WASTELAEERGRYSSYEGSLWSRGILPIDslkllaearggYLEVDRSSTLDWDALRARIKKHGMRNSNCMAIAPTATISN 779

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 388 ILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQK 467
Cdd:PRK07207  780 IIGVSQSIEPTYQNLYVKSNLSGEFTVVNPYLVRDLKARGLWDEVMVNDLKYFDGSLQRIDRIPADLKALYATAFEVDPR 859

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 468 TVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPIQFTLNKEKL------KDKEKV 541
Cdd:PRK07207  860 WLVEAASRRQKWIDQAQSLNLYMAGASGKKLDETYKLAWLRGLKT-TYYLRTLGATHVEKSTVNTGALnavssgGGGAGG 938

                         570       580
                  ....*....|....*....|....*..
gi 1057503148 542 SKEEEEKERNTAAMVCSLENRDeCLMC 568
Cdd:PRK07207  939 AAAAAAAPPAADPKACSIDDPD-CEAC 964

PRK12365

ribonucleoside-diphosphate reductase subunit alpha;

4-522

3.14e-155

ribonucleoside-diphosphate reductase subunit alpha;

Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 471.35 E-value: 3.14e-155

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148    4 DSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWH 83
Cdd:PRK12365   464 DDLVHIYKVISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGG-KRKGAVCVYLEVWH 542

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   84 LDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQ---GRVR- 159
Cdd:PRK12365   543 LDYEDFLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVPGLHEAYGEEFEKLYEEYERKvdtGEIRl 622

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  160 -KVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHT 238
Cdd:PRK12365   623 yKKVEAEDLWRKMLSMLYETGHPWMTFKDPSNIRSAQDHKGVVRCSNLCTEILLNCSETETAVCNLGSINLVEHIVNDGL 702

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  239 yDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL 318
Cdd:PRK12365   703 -DEEKLSETISIAIRILDNVIDINFYPTKEAKEANLAHRAIGLGVMGFQDALYKLNISYASQEAVEFADYSSELIAYYAI 781

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  319 EASCDLAKEQGPYETYEGSPVSKGILQYDMWN------------VTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTA 386
Cdd:PRK12365   782 LASSLLAKERGTYSSYKGSKWDRGYLPIDTIEllkeyrgeanllMDTSSRKDWEPVRSLIKEYGMRNSQLMAIAPTATIS 861

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  387 QILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQ 466
Cdd:PRK12365   862 NIIGVTQSIEPTYKHLFVKSNLSGEFTIPNVYLIEKLKKLGIWDADMLDDLKYFDGSLLEIERIPDHLKKIFLTAFEIEP 941

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1057503148  467 KTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYLRTRPA 522
Cdd:PRK12365   942 EWIIECASRRQKWIDMGQSLNLYLAEPDGKKLSNMYLTAWKKGLKT-TYYLRSSAA 996

PRK06539

ribonucleoside-diphosphate reductase subunit alpha;

1-534

6.34e-135

ribonucleoside-diphosphate reductase subunit alpha;

Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 412.39 E-value: 6.34e-135

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   1 MKDDsIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLE 80
Cdd:PRK06539  232 MQDD-IEHIAKTTRDVMWLTKGTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRGG-KKFGALCFYME 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  81 PWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQ---GR 157
Cdd:PRK06539  310 NWHMDFPEFLDLRQNSGDPYRRTRTANTAVWISDEFMKRVQNDEDWYLFDPLETPDLNELYGKAFSKRYAQYVEQaeaGR 389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 158 VR--KVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTS 235
Cdd:PRK06539  390 IRmfKRITAREQFRAILMSLQTTSHPWLTWKDTINNRALNNNTGTIHLSNLCTEICLPQDRDNVSVCNLASINLSRHLAD 469

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 236 EHTyDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYY 315
Cdd:PRK06539  470 GEL-DWAQLEESTRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIMEHISY 548

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 316 GALEASCDLAKEQGPYETYEGSPVSKGILQYDMW-----------NVTPTDLWDWKVLKEKIaKYGIRNSLLIAPMPTAS 384
Cdd:PRK06539  549 AAIDESADLAAERGAYPNFEGSRWSRGMVPVDSIalleadrgvpvDVNRTTRLDWDALRAKV-RGGMRNATLMAIAPTAS 627

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 385 TAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWhEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEI 464
Cdd:PRK06539  628 IGLVAGTTPGLDPQFSQIFSRSTSSGKFLEVNRNLVADLKELGLW-ETVREEILRSQGDIQEIAAIPDEIKALYRTSFQL 706

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 465 SQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPIQFTLNKEK 534
Cdd:PRK06539  707 SPYAFLEVAARAQKWVDQAISRNMYLESRDIGDMMDIYTAAWEMGVKT-TYYLHMKPRHTAEQSTVKVNK 775

PRK08447

ribonucleoside-diphosphate reductase subunit alpha;

4-519

6.10e-123

ribonucleoside-diphosphate reductase subunit alpha;

Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 380.23 E-value: 6.10e-123

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   4 DSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNkRPGAFAIYLEPWH 83
Cdd:PRK08447  223 DNIEGIFDSYKEMALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGT-RKGAIAVYLEPWH 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  84 LDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRK-VV 162
Cdd:PRK08447  302 MDISDFIDLRKNSGEERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKDLTELYGEEFEKRYLEYEKDEKIIKeYI 381

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 KAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEI------------VEYTSKDEV----------- 219
Cdd:PRK08447  382 NAKELWKKILTNYFETGLPFLCFKDNANRANPNAHAGIIRSSNLCTEIfqntapnhykikIEFEDGSIEffeeeelvtvd 461

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 220 ---------------------------------AVCNLASLALNMYVTSEhtydfkKLAEVTKVVVRNLNKIIDINYYPV 266
Cdd:PRK08447  462 sgitkkakkitsldslkgkkiyivekekkdgktAVCNLASINLSKINTKE------DIERVVPIAIRMLDNVIDLNFYPN 535

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 267 PEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQY 346
Cdd:PRK08447  536 RKVKATNLKSRAIGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKGVYPDFEGSNWSKGIFPI 615

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 347 DMWN------VTPTDLW----DWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPytsnIYTRRvlsgefqivn 416
Cdd:PRK08447  616 DKANeeakklVERGGLFdsacDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEP----VYKRK---------- 681

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 417 phllkdlterglWHEEMKNQIIACngsiqSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIA-EPNY 495
Cdd:PRK08447  682 ------------WFEENLSGLIPV-----VVPNLSPETWQYYTPAYDLDQKDLIKAAAVRQKWIDQGQSLNIFLSlDKAS 744

                         570       580
                  ....*....|....*....|....*
gi 1057503148 496 GK-LTSMHFYGWKQGLKTgMYYLRT 519
Cdd:PRK08447  745 GKyLNEIYTLAWKLGLKS-TYYLRS 768

PRK09209

ribonucleoside-diphosphate reductase subunit alpha;

3-520

8.81e-117

ribonucleoside-diphosphate reductase subunit alpha;

Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 363.66 E-value: 8.81e-117

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:PRK09209  243 DDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWIKQLNNTAVSVDQLG-QRKGAIAVYLDVW 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECP-----GLDEVWGEE-----FEKLYASY 152
Cdd:PRK09209  322 HKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDPHEVKkvmgwYLEDFYDEKkgdgsFREKYEEC 401

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 153 EKQGRV-RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIV----------EYTSKDEV-- 219
Cdd:PRK09209  402 VADERLsRKTVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPNKHEGMIYSSNLCTEIMqnmsptvmiqEIISGGQIvi 481

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 220 -------AVCNLASLALNMYVTSEhtydfkKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFIL 292
Cdd:PRK09209  482 tkqpgdfVVCNLSSINLGRAVTAD------VLERLIPIQVRMLDNVIDLNQLPVPQATITNQKYRAIGLGTFGWHHLLAL 555

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 293 MRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGilQY-DMWNVTPTdlwDWKVLKEKIAKYGI 371
Cdd:PRK09209  556 KGIAWESEEAVQYADELYERINYLTIQASMELAKEKGAYPVFKGSDWQTG--EYfERRGYNSP---QWDELAAQVAENGV 630

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 372 RNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPhllkDLTERGLWHEEmknqiiacngsiqsipeip 451
Cdd:PRK09209  631 RNAYLMAVAPNMSTAQIAGSTASIDPIYSAFYYEEKKDYRRPVTAP----DLSLDTWPYYE------------------- 687

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1057503148 452 ddlkqlyKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIaePN---YGKLTSMHFYGWKQGLKTgMYYLRTR 520
Cdd:PRK09209  688 -------KGAYKVDQFWSIRQNAARQRHVDQSISFNFYV--PStirASELLDLHMTAWKEGLKT-TYYVRST 749

PRK09102

ribonucleoside-diphosphate reductase subunit alpha;

3-523

1.07e-110

ribonucleoside-diphosphate reductase subunit alpha;

Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 343.09 E-value: 1.07e-110

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIaGTNGNSNGLVPMLRVYNNTARYVDQGGNKRpGAFAIYLEPW 82
Cdd:PRK09102   97 EDSLEGIVNTWNENVWLAKRGGGIGSYWGNVRSIGEPI-RNNGKSSGIIPFIKVMDSLTLAISQGSLRR-GSFAVYLDIE 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPnecpgldevwgeefeklyasyeKQGRVRKVV 162
Cdd:PRK09102  175 HPEIEEFLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISP----------------------KDKSVIRTV 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 KAQQLWYAIIESQTETGTPYMLYKDSCNRK--SNQQNLG-TIKCSNLCTEI-----VEYTSKDEVAVCNLASLALNMYVT 234
Cdd:PRK09102  233 KARDLWAKILETRIETGEPYLLFIDNVNRAlpEVYKDLGlKVKASNLCSEItlptgIDHLGEDRTAVCCLSSLNLEYYDE 312

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 235 SEHTYDFkklaevTKVVVRNLNKIID--INYYP--VPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIF 310
Cdd:PRK09102  313 WKDTDAF------IEDLMRFLDNVLQdfIDKAPdeMERAKYSAMRERSVGLGVMGFHSYLQSKMIPFESVMAKQWNKKIF 386

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 311 ETIYYGALEASCDLAKEQGPyetyegspvskgilqydmwnvtPTDLwdwkvlkekiAKYGI--RNSLLIAPMPTASTAQI 388
Cdd:PRK09102  387 KHIREQADKASKELAKEKGE----------------------CPDA----------AGYGVmrRFSTKMAIAPTASISII 434

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 389 LGN-NESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQK 467
Cdd:PRK09102  435 LGNtSPGIEPIAANYYTHKTLKGSFTVKNKYLEKLLEEKGKDTDEVWSSILTNEGSVQHLDFLSEEEKDVFKTAFEIDQR 514

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1057503148 468 TVLKMAAERGAFIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAA 523
Cdd:PRK09102  515 WIIELAADRQKYIDQAQSLNLFLpANVPKRDLNKLHFEAWKKGVKS-LYYQRSKSVQ 570

PRK12364

ribonucleoside-diphosphate reductase subunit alpha;

4-520

1.56e-108

ribonucleoside-diphosphate reductase subunit alpha;

Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 344.04 E-value: 1.56e-108

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   4 DSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWH 83
Cdd:PRK12364  323 DSLDGIYRSIDNFAQVSKFGGGMGLYFGKVRAVGSNIRGFQGVAGGVIRWIKLANDTAVAVDQLG-MRQGAVAVYLDVWH 401

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  84 LDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVE--TNQDWSLMCPNECP-----GLDEVWGEEFEKLYASYEKQG 156
Cdd:PRK12364  402 KDIPEFLQLRTNNGDDRMKAHDVFPAVCYPDLFWKMVRddINQSWYLFCPHEILtvkgyALEDYYGEEWEKRYLDCVNDA 481

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 157 RV-RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEI-----------------------VE 212
Cdd:PRK12364  482 RIsKRSIPIKDLVRLILKSAVETGTPFTFNRDTVNRANPNKHKGMIYCSNLCTEIaqnmsaietvsteietedgdtvvVT 561

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 213 YTSKDEVAVCNLASLAL-NMYVTSEHtydfkKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFI 291
Cdd:PRK12364  562 TTRPGDFVVCNLASLSLgNIDLEDEE-----ELEEVVRTVVRALDNVIDLNFYPVPYAQITNKRYRSIGLGVSGYHHALA 636

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 292 LMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILqYDMWNVTPTdlwDWKVLKEKIAKYGI 371
Cdd:PRK12364  637 KNGIRWESEEHLEFADRVFERINYAAIKASMEIAKEKGAYGYFEGSDWQTGAY-FRKRGYTSE---EWQRLAREVAENGM 712

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 372 RNSLLIAPMPTASTAQILGNNESIEPytsniytrrvlsgefqIVNPHLLkdlterglwhEEMKNQIIAcngsiQSIPEIP 451
Cdd:PRK12364  713 RNAYLLAVAPTSSTSIIAGTTAGVDP----------------VMKRYFL----------EEKKGALMP-----RVAPELS 761

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 452 DDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIA-EPNYGKLTSMHFYGWKQGLKTgMYYLRTR 520
Cdd:PRK12364  762 DKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQAQSVNLYITnEFTMRQVLDLYLLAWEEGVKT-IYYVRSK 830

PRK07088

ribonucleoside-diphosphate reductase subunit alpha;

3-520

7.67e-104

ribonucleoside-diphosphate reductase subunit alpha;

Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 329.85 E-value: 7.67e-104

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:PRK07088  245 DDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKLYNDTAIAVDQLG-KRKGGAAITLDIW 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  83 HLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGL---------DEVWGEEFEKLYASYE 153
Cdd:PRK07088  324 HKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRLEKRENWSLFDPHEIKKVkgysledyyDEEDRKEFTKKYLECE 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 154 KQGRV-RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVA------------ 220
Cdd:PRK07088  404 EDTNIpRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHKGMIYSSNLCHEIAQNMSESELLeeeiidengyye 483

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 221 -----------VCNLASLALNmyvtsehTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADA 289
Cdd:PRK07088  484 vvqkikagdmvTCNLNSIVLG-------NVDDEELEEVIPTQIRMLDNVISLNYYPVPEAEITSDKYRAIGLGTSGYHHM 556

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 290 FILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGilqyDMWNVTPTDLWDWKVLKEKIAKY 369
Cdd:PRK07088  557 LANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGSYPAFKGSEWETG----KYFERRGYNSERWKKLKEEIKKY 632

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 370 GIRNSLLIAPMPTASTAQILGNNESIEPytsnIYTRrvlsgefqivnphllkdltergLWHEEMKnqiiacnGSIqsIPE 449
Cdd:PRK07088  633 GMRNGYITAVAPTGSTSNIANTTAGIDP----VFKR----------------------FFMEEKK-------GSF--TPK 677

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1057503148 450 IPDDLKQ----LYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAePNYGKLTSMHFY--GWKQGLKTgMYYLRTR 520
Cdd:PRK07088  678 TAPDLNEenfwYYKEAHTIDQQWSIKACGVRQRHIDQAQSFNLYIT-PEYKAKQILNLYieAWKQGVKT-IYYVRNK 752

NrdJ_Z

TIGR02504

ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ...

3-511

4.50e-89

ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]

Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 286.14 E-value: 4.50e-89

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:TIGR02504  85 EDSMEDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGG-TRRGAQMGILDVW 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  83 HLDIFEFLDLKKNTGKEEQrardlF-FALWIPDLFMKRVETNQDWSLMCPNEcpgldevwgeefeklyasyekqgRVRKV 161
Cdd:TIGR02504 164 HPDIEEFIEAKAKEGKLQN-----FnISVGVTDEFMEAVENDEEYELRNPRT-----------------------GEYKE 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 162 VKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEI--VEYTSkdevavCNLASLALNMYV----TS 235
Cdd:TIGR02504 216 VDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPYGGRINATNPCGEQplLPYES------CNLGSINLAKFVkndfGD 289

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 236 EHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYY 315
Cdd:TIGR02504 290 EASFDFERLREVVRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEARELAEEVMEFIAD 369

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 316 GALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVT-PTDLWDWkvlkekIAKYGIRNSLLIAPMPTASTAQILGNNES 394
Cdd:TIGR02504 370 AAYRASAELAKERGAFPLYDASKYPMGRAMGARIPSAlPAEIREA------IRKYGIRNAQLTTIAPTGTISLIAGTSSG 443

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 395 IEPYTSNIYTRRVL-SGEFQIVNPHLLKDLTERGLWHEEmKNQIIACNGSIQSIPEiPDDLKQLYKTVWEISQKTVLKMA 473
Cdd:TIGR02504 444 IEPVFALVYFRNVTvGGELLEVNPLVELALRELGYYSDE-IVKYVDEKGTVEGAPG-PEELPKVFVTAMDISPEDHVLMQ 521

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 1057503148 474 AERGAFIDQSQSLNIHIaePN----------YgkltsmhFYGWKQGLK 511
Cdd:TIGR02504 522 AAIQPWVDSSISKTINM--PSdatvedvkavY-------LEAWKLGLK 560

RNR_II_dimer

cd02888

Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ...

1-398

2.67e-86

Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.

Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 275.27 E-value: 2.67e-86

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   1 MKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLE 80
Cdd:cd02888    39 VEDDSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKSTGGVASGPVSFMRVFDAATGVIKQGG-TRRGANMGVLD 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  81 PWHLDIFEFLDLKKntgKEEQRARDLFFAL--WIPDLFMKRVETNQDWSLMCPNECPGldevwgeefeklyasyekqGRV 158
Cdd:cd02888   118 VDHPDIEEFIDAKM---KEEKTVVLQNFNIsvAVTDAFMEAVENDEPWELRNPREPDT-------------------GKV 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 159 RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIV--EYTSkdevavCNLASLALNMYV--- 233
Cdd:cd02888   176 YRTVPARELWDKIVEAAWDSADPGVLFIDTINRWNPLPGLGRINATNPCGEQPllPYES------CNLGSINLSKFVknp 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 234 TSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETI 313
Cdd:cd02888   250 FGGASFDFERLREAVRLAVRFLDNVIDVNRYPLPEIAEETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFI 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 314 YYGALEASCDLAKEQGPYETYEGSpvskgilQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNE 393
Cdd:cd02888   330 RDAAYRASAELAKERGPFPLFDAS-------RYLMLKVIVNAKELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSS 402


                  ....*
gi 1057503148 394 SIEPY 398
Cdd:cd02888   403 GIEPI 407

nrdA

PHA02572

ribonucleoside-diphosphate reductase subunit alpha; Provisional

3-534

1.42e-75

ribonucleoside-diphosphate reductase subunit alpha; Provisional

Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 254.64 E-value: 1.42e-75

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTLKQCA-LISKSAGgIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEP 81
Cdd:PHA02572  229 GDSLDSINKTAMAIVkYISKRAG-IGINAGMIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGG-IRGGAATAYYPI 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  82 WHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGldEVWG------EEFEKLYASYEKQ 155
Cdd:PHA02572  307 WHLEVEDLLVLKNNKGVEENRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGG--ELYDayfadqDRFRELYEALEKD 384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 156 GRVR-KVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNqqNLGTIKCSNLCTEIVEYTS-------KDEVAVCNLASL 227
Cdd:PHA02572  385 PSVRkKRIKAQELFLLLLKERSETGRIYIMFIDHCNNHSP--FKDPIRQSNLCCEIALPTKplnhidgEGEIALCTLSAI 462

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 228 ALNMYVtsehtyDFKKLAEVTKVVVRNLNKIIDINYYPVPEAcLSNKRHRPIGIGVQGLAdAFILMRY-PFESAEAQLLN 306
Cdd:PHA02572  463 VLGNFE------DQDEIEELAEVAVRALDNLLDYQDYPVPAA-LKAKKRRSLGVGVTNYA-HYLAKNFaSYEDANADLVH 534

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 307 KqIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWN------VTPTDLWDWKVLKEKIAKYGIRNSLLIAPM 380
Cdd:PHA02572  535 E-LFERLQYYLIKASNKLAKEKGACEYFSDTKYSRGELPIDWYKkkvdelVAPKYNCDWESLREDLKKYGIRNSTLSALM 613

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 381 PTASTAQILGNNESIEPYTSNIYTRRVLSGEFqivnphllkdlterglwheemkNQIiacngsiqsIPEIpDDLKQLYKT 460
Cdd:PHA02572  614 PCESSSQVSNSTNGIEPPRGPVSIKKSKEGPF----------------------NQV---------VPNV-ETLKDLYDL 661

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 461 VWEISQKT---VLKMAAERGAFIDQSQSLNIHIAEPNY--GKL-TSMHF----YGWKQGLKTgMYYLRTRPAANPIQFTL 530
Cdd:PHA02572  662 LWDLAKKGnkgYLTQVAIMQKFVDQAISANTSYDPENYpnGKVpMSVMLddllYFYYYGGKT-LYYHNTRDGKGTEDYEI 740


                  ....
gi 1057503148 531 NKEK 534
Cdd:PHA02572  741 ETPK 744

PRK08665

vitamin B12-dependent ribonucleotide reductase;

3-479

1.90e-65

vitamin B12-dependent ribonucleotide reductase;

Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 227.12 E-value: 1.90e-65

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIyLEPW 82
Cdd:PRK08665  103 GDSIEEIFDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRRGANMGI-LRVD 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  83 HLDIFEFLDLKKNTGKeeqrARDLFFALWIPDLFMKRVETNQDWSLMCPNEcpgldevwgeefeklyasyekqGRVRKVV 162
Cdd:PRK08665  182 HPDIMEFITCKEDNGE----LTNFNISVAITEAFMEAVEADEEYDLINPRT----------------------GEVVGRL 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 KAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTE--IVEYTSkdevavCNLASLALNMYVTsEHTYD 240
Cdd:PRK08665  236 NAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPHLGEIESTNPCGEqpLLPYES------CNLGSINLSKMVK-NGDVD 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 241 FKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEA 320
Cdd:PRK08665  309 WEKLREVVHLAVRFLDNVIDANKYPLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEAVELAEKVMKFIQDEAHAA 388

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 321 SCDLAKEQGPYETYEGSpvskgilqydmwnvtptdLWDwkvlKEKIAKYgiRNSLL--IAPMPTAStaqILGNNES-IEP 397
Cdd:PRK08665  389 SRELAEERGPFPNYEGS------------------IYD----KDGLGPM--RNATVttIAPTGTIS---IIAGCSSgIEP 441

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 398 YTSNIYTRRVLSGEFQI-VNPHLLKDLTERGLWHEE-MKNqiIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAe 475
Cdd:PRK08665  442 LFALSFTRNVMDGERLVeVNPVFEAAAKEEGFYSEElMEK--IAEKGSIQDIDEVPEDVRRVFVTAHDISPEWHVRMQA- 518


                  ....
gi 1057503148 476 rgAF 479
Cdd:PRK08665  519 --AF 520

PRK06406

vitamin B12-dependent ribonucleotide reductase;

3-490

2.73e-64

vitamin B12-dependent ribonucleotide reductase;

Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 224.34 E-value: 2.73e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPW 82
Cdd:PRK06406  258 PDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPKDDIVASTKGVASGPLSFMRIFDVTTDVIKQGG-KRRGANMGILSYH 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  83 HLDIFEFLDLKKNtgkEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPnecpgldevwgeefeklyasyeKQGRVRKVV 162
Cdd:PRK06406  337 HPDIMEFITSKDS---ENKVLSNFNISVAVTDEFFDKLDNDDYYPLRNP----------------------RNGKEVKRI 391

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 163 KAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTE--IVEYTSkdevavCNLASLALNMYVTsEHTYD 240
Cdd:PRK06406  392 KARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKNLGEIESTNPCGEqpLLPYES------CNLGSINLSKFVE-NGKID 464

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 241 FKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEA 320
Cdd:PRK06406  465 WDRLRETVHIATRFLDNVIDANKFPVPQIKEMTRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRA 544

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 321 SCDLAKEQGPYETYEGSpvskgilqydmwnvtptdlwDWKvlKEKIAkygIRNSLLIAPMPTASTAQILGNNESIEPYTS 400
Cdd:PRK06406  545 SQKLAEERGVFPAWYGS--------------------EWE--KKGIK---MRNSTTTTIAPTGTISIIAGCSSSIEPLFA 599

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 401 NIYTRRVLSGEFQI-VNPHLLKDLTERGLWHEEMKNQiIACNGSIQSIpEIPDDLKQLYKTVWEISQKTVLKMAAERGAF 479
Cdd:PRK06406  600 IAFVRHVLNGQELLeVNPLFEEITRKRGLYSEELMRK-VAETGNLQNI-DVPEDIKRIFVTAHEIDPQWHVLMQATFQRY 677

                         490
                  ....*....|.
gi 1057503148 480 IDQSQSLNIHI 490
Cdd:PRK06406  678 CDSGVSKTINL 688

PRK09103

ribonucleoside-diphosphate reductase subunit alpha;

3-527

1.55e-59

ribonucleoside-diphosphate reductase subunit alpha;

Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 211.00 E-value: 1.55e-59

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTlkQCALI---SKSAGgIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYL 79
Cdd:PRK09103  228 GDSLDSINAT--SSAIVkyvSQRAG-IGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGG-VRGGAATLFY 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  80 EPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVW---GEEFEKLYASYEKQG 156
Cdd:PRK09103  304 PIWHLEVESLLVLKNNRGVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFfadQDEFERLYTKYEQDD 383

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 157 RVRK-VVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSN-QQNLGTIKCSNLCTEIVEYT--------SKDEVAVCNLAS 226
Cdd:PRK09103  384 SIRKkRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPKVAPVRQSNLCLEIALPTkplndvndENGEIALCTLSA 463

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 227 LALNmyvTSEHTYDFKKLAEvtkVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLadAFIL----MRYPFESAEA 302
Cdd:PRK09103  464 FNLG---AINSLDELEELAD---LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINF--AYYLakngVRYSDGSANN 535

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 303 qlLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMW-----NVTPTDL-WDWKVLKEKIAKYGIRNSLL 376
Cdd:PRK09103  536 --LTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAQGILPIDTYkkdldAICNEPLhYDWETLREEIKTHGLRNSTL 613

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 377 IAPMPTASTAQILGNNESIEPytsniytrrvlsgefqivnPhllkdlteRGLWH-EEMKNQIIAcngsiQSIPEIpDDLK 455
Cdd:PRK09103  614 SALMPSETSSQISNATNGIEP-------------------P--------RGYVSiKASKDGILK-----QVVPDY-ERLK 660

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 456 QLYKTVWEI-SQKTVLKMAAERGAFIDQSQSLNIHIaEPN---YGKLTSMHF-----YGWKQGLKTgMYYLRTRPAANPI 526
Cdd:PRK09103  661 DAYELLWEMpNNDGYLQLVGIMQKFVDQSISANTNY-DPSrfpSGKVPMKQLlkdllTAYKFGVKT-LYYHNTRDGAEDA 738


                  .
gi 1057503148 527 Q 527
Cdd:PRK09103  739 Q 739

PRK08115

vitamin B12-dependent ribonucleotide reductase;

4-432

9.93e-42

vitamin B12-dependent ribonucleotide reductase;

Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 161.16 E-value: 9.93e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   4 DSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRpGAFAIYLEPWH 83
Cdd:PRK08115  197 DSREGISEHRKQVMEIMSRGGGVGTNGSTLRPRNTLARGVNGKSSGSVSWLDDIAKLTHLVEQGGSRR-GAQMIMLADWH 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  84 LDIFEFLD-----------LKKNTGKEE------------------------------------------QRARDLF--- 107
Cdd:PRK08115  276 PDILEFIIskmqnprilryLLENTEDEQikrlvkeklkftplseveeamyqaivnykniegqggfdtkviKEAENKLrtg 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 108 --FALWIPDL-------------FMKRVETNQDWSLMCPN-------ECPGLDEVWGE-----EFEKLyaSYEKqgRVRK 160
Cdd:PRK08115  356 gtYTVNNPEFltganisvcltkeFMEAVENDEEYELRFPDvenyteeEMEIYNEEWHEvgdvrEWEKM--GYPV--RTYR 431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 161 VVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLG-TIKCSNLCTE--IVEYTskdevaVCNLASLAL-NMYVTSE 236
Cdd:PRK08115  432 KIKAKELWNLINICATYSAEPGIFFIDNANEMTNAKAYGqKVVATNPCGEqpLAPYS------VCNLAAINLaNMADKET 505

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 237 HTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYG 316
Cdd:PRK08115  506 KTVDYEKLKRTVEVGVRMQDNVIDATPYFLEENKKQALGERRVGLGVMGLHDLLIYCETVYGSEEGNQLVDQIFETIATT 585

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 317 ALEASCDLAKEQGPYETYEGSP------VSKGILQYDMWNVTPTDlwdwkvLKEKIAKYGIRNSLLIAPMPTASTAQILG 390
Cdd:PRK08115  586 AYRTSIELAKEKGSFPFLVGQTeeetakLREAFINTGYMKKMPED------IREDILKYGIRNSHLLTVAPTGSTGTMVG 659

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1057503148 391 NNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEE 432
Cdd:PRK08115  660 VSTGLEPYFSFSYYRSGRLGKFIEVKADIVQEYLDKHPEADE 701

PRK08332

vitamin B12-dependent ribonucleotide reductase;

204-464

4.49e-41

vitamin B12-dependent ribonucleotide reductase;

Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 159.93 E-value: 4.49e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  204 SNLCTE--IVEYTSkdevavCNLASLALNMYVTSEHT----YDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHR 277
Cdd:PRK08332  1294 SHNCGEepLYEYES------CNLASINLAKFVKYDENgkpyFDWDEYAYVIQKVAKYLDNAIDVNKFPLPEIDYNTKLTR 1367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  278 PIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGIL------QYDMWNV 351
Cdd:PRK08332  1368 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYEKTEYPKGELpvegfyHPEIWNL 1447

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  352 TptdlwdWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHE 431
Cdd:PRK08332  1448 P------WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKKRGLYSE 1521

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1057503148  432 EMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEI 464
Cdd:PRK08332  1522 ELLKKISDNYGSVQGLEEIPEDMQRVFVTALDI 1554

PRK06556

vitamin B12-dependent ribonucleotide reductase; Validated

3-453

2.71e-30

vitamin B12-dependent ribonucleotide reductase; Validated

Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 126.62 E-value: 2.71e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   3 DDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGtNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPW 82
Cdd:PRK06556  158 DDSMESILNWYKEEGMLFKGGSGTGTNLSRIRSSKELLSG-GGTASGPVSFMRGADASAGTIKSGGATRRAAKMVILDVD 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  83 HLDIFEFLDLKkntGKEEQRARDLFFALWIPDL----------------------FMKRVETNQDWSLMCpnecpgldev 140
Cdd:PRK06556  237 HPDIEEFIETK---AKEEDKIRALRDAGYDMDLggeayssvqyqnannsvrvsdeFMRAVENDGEFGLRA---------- 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 141 wgeefeklyasyEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEiveYTSKDEVA 220
Cdd:PRK06556  304 ------------RTDGEVIETVDAKELFRKIAEAAWECADPGIQYDDTINDWHTCPESGRINASNPCSE---YMFLDNSS 368

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 221 vCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESA 300
Cdd:PRK06556  369 -CNLASLNLMKFLRDDGTFDVESFRHAVELVITAMEISICFADFPTEKIARNTRAFRQLGLGYANLGALLMATGLPYDSD 447

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 301 EAQLLNKQIFETIYYGALEASCDLAKEQGPYETYE-----------------GSPVSKGILQYDMWNVTpTDLWDwKVLK 363
Cdd:PRK06556  448 GGRALAAAITSLMTGEAYRRSAELAGVVGPFEGYArnaephlrvmrkhaaanDAIRPLGEVDAALLEAA-KEAWD-DALE 525

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 364 EKiAKYGIRNS--LLIAP-------MPTASTaqilgnneSIEPYTSNI-YTRRVLSGEFQIVNPHLLKDLTERGlWHEEM 433
Cdd:PRK06556  526 LG-EKNGYRNAqaSVLAPtgtigfmMDCDTT--------GIEPDFALVkYKKLVGGGSMKIVNQTVPRALKKLG-YSEEQ 595

                         490       500
                  ....*....|....*....|...
gi 1057503148 434 KNQI---IACNGSIQSIPEIPDD 453
Cdd:PRK06556  596 IEAIveyIAEHGHIEGAPGLKPE 618

PRK06948

ribonucleotide reductase-like protein; Provisional

24-414

3.77e-30

ribonucleotide reductase-like protein; Provisional

Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 124.91 E-value: 3.77e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  24 GGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIyLEPWHLDIFEFLDLKKNtgkeeqRA 103
Cdd:PRK06948  121 GGIGYDFSAIPPADARPDADHPDSPGVCAALDRFDRICAALPFRDGRRGAQMAV-LRCDHPDLLAFVAAKRG------RA 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 104 RDLFF--ALWIPDLFMKRVETNQDWSLMCPNE--------CPGLDEVWgeefekLYASyekqgrvrkvVKAQQLWYAIIE 173
Cdd:PRK06948  194 RWTTFnlSVAVTDAFMQAVAQDLPWALRHRAPprraaggaLRGADGAW------TYAT----------VPARHLWREIVS 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 174 SQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTE--IVEYTSkdevavCNLASLALNMYVT------SEHTYDFKKLA 245
Cdd:PRK06948  258 AARDSAEPGLLFVDTIDAANPLREHERIDATNPCGEqpLPPYGS------CVLGPIDLSRFVRhpfgvgGEPRFDFAALA 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 246 EVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLA 325
Cdd:PRK06948  332 TAVRIQVRMLDNALDLTRWPLAAHAREARQKRRIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALA 411

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 326 KEQGPY-----ETYEGSPVSKGILQydmwnvtptdlwdwKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNES--IEPY 398
Cdd:PRK06948  412 AERGAYplcdpAAHLDALRAGPPLP--------------HAVCHAIARHGLRNSHLLSFAPVGSVSLAFGDNCSpgIEPA 477

                         410
                  ....*....|....*.
gi 1057503148 399 TSNIYTRRVLSGEFQI 414
Cdd:PRK06948  478 RAWIEHRPVRAGAGGA 493

RNR_PFL

cd00576

Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ...

17-343

2.50e-05

Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 46.76 E-value: 2.50e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  17 ALISKSAGGIGVAV--SCIRATGSYIAG-TNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY----LEPWHLDIFEF 89
Cdd:cd00576    62 AASNQNGGGVSFARasSILSPYGSRDYAkGSGTETDAVEAADAFNLALKEVGQGNGRTGAATGFIggvhKGKGDKISQEF 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  90 LDLKKNTGKEEQRardlffaLWIPDLFMKrvetnqdwslmcpnecpgldeVWGEEFEKLYASYEKQGRvrkvvkaqqlwy 169
Cdd:cd00576   142 LNLALANGGEGIP-------LNFPNLSVR---------------------VSSDKPGILVKAVELKQL------------ 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 170 aIIESQTETGTPYMLYKDSCNrksnqqnLGTIkcsnlcteiveytskdevavcNLASLALNMYVTSEHTYDfKKLAEVTK 249
Cdd:cd00576   182 -IAEEARKTGSPGIFNDELCN-------LVSL---------------------NLARIMEKAINGSMDVVL-EELEELAF 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148 250 VVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPF-ESAEAQLLNKQIFETIYYGALEASCDL--AK 326
Cdd:cd00576   232 LAVRALDCVIDSHDERIPTIELGGDERRTVGLGIAGVADLLIKLGLEKvGDPEADDLAAELVDQLKKHLVKATNERgfNF 311

                         330       340
                  ....*....|....*....|
gi 1057503148 327 EQG--PYETY-EGSPVSKGI 343
Cdd:cd00576   312 LLGlsPSESNsSGAPATNGV 331

PRK08332

vitamin B12-dependent ribonucleotide reductase;

27-207

2.46e-04

vitamin B12-dependent ribonucleotide reductase;

Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 44.37 E-value: 2.46e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148   27 GVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIyLEPWHLDIFEFLDLK-KNTGKEEQRARD 105
Cdd:PRK08332   757 GLNFSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGI-LEIWHPDIEKFIHAKeKNIGTNVLSNFN 835

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503148  106 LFFALWipDLFMKRVETNQDWSLMCPnecpgldevwgeefeklyasyeKQGRVRKVVKAQQLWYAIIESQTETGTPYMLY 185
Cdd:PRK08332   836 ISVGIW--EDFWEALKEGKKYPLINP----------------------RTGEVVKEIDPKSLFEELAYMAWAKADPGVIF 891

                          170       180
                   ....*....|....*....|....
gi 1057503148  186 KDSCNRKS--NQQNLGTIKCSNLC 207
Cdd:PRK08332   892 FDVINRRNvlKEAKGGPIRATNPC 915

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01