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Conserved domains on  [gi|1027855826|ref|NP_001311601|]
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guanine nucleotide-binding protein subunit beta-2 [Capsicum annuum]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-369 1.86e-76

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 238.00  E-value: 1.86e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826  57 CCRILQGHTGKVYSLDWTPEKNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPSGQSVACGGLDSACSIFNL 136
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 137 NSPidkdgnhPVSRMLSGHKGYVSSCQYVPdeDTHLITSSG-DQTCVLWDITTGLRTSVFggefqSGHTADVLSVSISSS 215
Cdd:cd00200    81 ETG-------ECVRTLTGHTSYVSSVAFSP--DGRILSSSSrDKTIKVWDVETGKCLTTL-----RGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 216 NPRLfVSGSCDTTARLWDTRvASRAQRTFHGHEGDVNTVKFFPDGNRFGTGSDDGTCRLFDIRTGHQLQVyYQPHGDSdi 295
Cdd:cd00200   147 GTFV-ASSSQDGTIKLWDLR-TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT-LRGHENG-- 221

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1027855826 296 phVTSMAFSISGRLLFVGYSNADCYVWDTLLAKVVLNLGAvqnsHEGRISCLGLSADGSALCTGSWDTNLKIWA 369
Cdd:cd00200   222 --VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-369 1.86e-76

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 238.00  E-value: 1.86e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826  57 CCRILQGHTGKVYSLDWTPEKNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPSGQSVACGGLDSACSIFNL 136
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 137 NSPidkdgnhPVSRMLSGHKGYVSSCQYVPdeDTHLITSSG-DQTCVLWDITTGLRTSVFggefqSGHTADVLSVSISSS 215
Cdd:cd00200    81 ETG-------ECVRTLTGHTSYVSSVAFSP--DGRILSSSSrDKTIKVWDVETGKCLTTL-----RGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 216 NPRLfVSGSCDTTARLWDTRvASRAQRTFHGHEGDVNTVKFFPDGNRFGTGSDDGTCRLFDIRTGHQLQVyYQPHGDSdi 295
Cdd:cd00200   147 GTFV-ASSSQDGTIKLWDLR-TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT-LRGHENG-- 221

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1027855826 296 phVTSMAFSISGRLLFVGYSNADCYVWDTLLAKVVLNLGAvqnsHEGRISCLGLSADGSALCTGSWDTNLKIWA 369
Cdd:cd00200   222 --VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
57-368 4.70e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 196.67  E-value: 4.70e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826  57 CCRILQGHTGKVYSLDWTPEKNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPSGQSVACGGLDSACSIFNL 136
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 137 NSPidkdgnhPVSRMLSGHKGYVSSCQYVPDeDTHLITSSGDQTCVLWDITTGLRTSVFGgefqsGHTADVLSVSISSSN 216
Cdd:COG2319   192 ATG-------KLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLWDLATGKLLRTLT-----GHSGSVRSVAFSPDG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 217 PRLfVSGSCDTTARLWDTRvASRAQRTFHGHEGDVNTVKFFPDGNRFGTGSDDGTCRLFDIRTGHQLQVyYQPHGDSdip 296
Cdd:COG2319   259 RLL-ASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTGA--- 332

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1027855826 297 hVTSMAFSISGRLLFVGYSNADCYVWDTLLAKVVLNLGAvqnsHEGRISCLGLSADGSALCTGSWDTNLKIW 368
Cdd:COG2319   333 -VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 242-276 1.38e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.38e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1027855826  242 RTFHGHEGDVNTVKFFPDGNRFGTGSDDGTCRLFD 276
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 110-364 1.12e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 110 VMTCAFSPSGQSVACGGLDSACSIFNLNSPID--KDGNHPVSRMLSGHKgyVSSCQYVPDEDTHLITSSGDQTCVLWDIT 187
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKdgRDIHYPVVELASRSK--LSGICWNSYIKSQVASSNFEGVVQVWDVA 563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 188 -TGLRTSVfggefqSGHTADVLSVSISSSNPRLFVSGSCDTTARLWDTR--VASRAQRTfhghEGDVNTVKFFPD-GNRF 263
Cdd:PLN00181  564 rSQLVTEM------KEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINqgVSIGTIKT----KANICCVQFPSEsGRSL 633

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 264 GTGSDDGTCRLFDIRT---------GHQLQVYYQPHGDSDiphvTSMAFSISGRLlfvgysnadcYVWDTLLAKVVLNLG 334
Cdd:PLN00181  634 AFGSADHKVYYYDLRNpklplctmiGHSKTVSYVRFVDSS----TLVSSSTDNTL----------KLWDLSMSISGINET 699

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1027855826 335 AVQN--SHEGRISCLGLSADGSALCTGSwDTN 364
Cdd:PLN00181  700 PLHSfmGHTNVKNFVGLSVSDGYIATGS-ETN 730
WD40 pfam00400
WD domain, G-beta repeat;
241-276 1.20e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.20e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1027855826 241 QRTFHGHEGDVNTVKFFPDGNRFGTGSDDGTCRLFD 276
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-369 1.86e-76

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 238.00  E-value: 1.86e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826  57 CCRILQGHTGKVYSLDWTPEKNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPSGQSVACGGLDSACSIFNL 136
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 137 NSPidkdgnhPVSRMLSGHKGYVSSCQYVPdeDTHLITSSG-DQTCVLWDITTGLRTSVFggefqSGHTADVLSVSISSS 215
Cdd:cd00200    81 ETG-------ECVRTLTGHTSYVSSVAFSP--DGRILSSSSrDKTIKVWDVETGKCLTTL-----RGHTDWVNSVAFSPD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 216 NPRLfVSGSCDTTARLWDTRvASRAQRTFHGHEGDVNTVKFFPDGNRFGTGSDDGTCRLFDIRTGHQLQVyYQPHGDSdi 295
Cdd:cd00200   147 GTFV-ASSSQDGTIKLWDLR-TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT-LRGHENG-- 221

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1027855826 296 phVTSMAFSISGRLLFVGYSNADCYVWDTLLAKVVLNLGAvqnsHEGRISCLGLSADGSALCTGSWDTNLKIWA 369
Cdd:cd00200   222 --VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
57-368 4.70e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 196.67  E-value: 4.70e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826  57 CCRILQGHTGKVYSLDWTPEKNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPSGQSVACGGLDSACSIFNL 136
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 137 NSPidkdgnhPVSRMLSGHKGYVSSCQYVPDeDTHLITSSGDQTCVLWDITTGLRTSVFGgefqsGHTADVLSVSISSSN 216
Cdd:COG2319   192 ATG-------KLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLWDLATGKLLRTLT-----GHSGSVRSVAFSPDG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 217 PRLfVSGSCDTTARLWDTRvASRAQRTFHGHEGDVNTVKFFPDGNRFGTGSDDGTCRLFDIRTGHQLQVyYQPHGDSdip 296
Cdd:COG2319   259 RLL-ASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTGA--- 332

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1027855826 297 hVTSMAFSISGRLLFVGYSNADCYVWDTLLAKVVLNLGAvqnsHEGRISCLGLSADGSALCTGSWDTNLKIW 368
Cdd:COG2319   333 -VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
59-324 4.37e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.48  E-value: 4.37e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826  59 RILQGHTGKVYSLDWTPEKNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPSGQSVACGGLDSACSIFNLNS 138
Cdd:COG2319   156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 139 PidkdgnhPVSRMLSGHKGYVSSCQYVPDeDTHLITSSGDQTCVLWDITTGLRTSVFGgefqsGHTADVLSVSIsSSNPR 218
Cdd:COG2319   236 G-------KLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGELLRTLT-----GHSGGVNSVAF-SPDGK 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 219 LFVSGSCDTTARLWDTRvASRAQRTFHGHEGDVNTVKFFPDGNRFGTGSDDGTCRLFDIRTGHQLQVyYQPHGDSdiphV 298
Cdd:COG2319   302 LLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT-LTGHTGA----V 375

                         250       260
                  ....*....|....*....|....*.
gi 1027855826 299 TSMAFSISGRLLFVGYSNADCYVWDT 324
Cdd:COG2319   376 TSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
57-279 1.24e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.54  E-value: 1.24e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826  57 CCRILQGHTGKVYSLDWTPEKNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPSGQSVACGGLDSACSIFNL 136
Cdd:COG2319   196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 137 NSPidkdgnhPVSRMLSGHKGYVSSCQYVPDeDTHLITSSGDQTCVLWDITTGLRTSVFggefqSGHTADVLSVSISSSN 216
Cdd:COG2319   276 ATG-------ELLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGKLLRTL-----TGHTGAVRSVAFSPDG 342

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1027855826 217 PRLfVSGSCDTTARLWDTRvASRAQRTFHGHEGDVNTVKFFPDGNRFGTGSDDGTCRLFDIRT 279
Cdd:COG2319   343 KTL-ASGSDDGTVRLWDLA-TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 202-376 7.78e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.41  E-value: 7.78e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 202 GHTADVLSVSISSSNPRLfVSGSCDTTARLWDTRVaSRAQRTFHGHEGDVNTVKFFPDGNRFGTGSDDGTCRLFDIRTGH 281
Cdd:cd00200     7 GHTGGVTCVAFSPDGKLL-ATGSGDGTIKVWDLET-GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 282 QLQVYyqpHGDSDipHVTSMAFSISGRLLFVGYSNADCYVWDTLLAKVVLNLgavqNSHEGRISCLGLSADGSALCTGSW 361
Cdd:cd00200    85 CVRTL---TGHTS--YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL----RGHTDWVNSVAFSPDGTFVASSSQ 155

                         170
                  ....*....|....*
gi 1027855826 362 DTNLKIWAFGGHRSV 376
Cdd:cd00200   156 DGTIKLWDLRTGKCV 170
WD40 COG2319
WD40 repeat [General function prediction only];
175-368 2.00e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.04  E-value: 2.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 175 SSGDQTCVLWDITTGLRTSVFGGEFQSGHTADVLSVSISSSNPRLFVSGSCDTTARLWDTRvASRAQRTFHGHEGDVNTV 254
Cdd:COG2319     6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAA-AGALLATLLGHTAAVLSV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 255 KFFPDGNRFGTGSDDGTCRLFDIRTGHQLQVyYQPHGDSdiphVTSMAFSISGRLLFVGYSNADCYVWDTLLAKVVLNLg 334
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRT-LTGHTGA----VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL- 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1027855826 335 avqNSHEGRISCLGLSADGSALCTGSWDTNLKIW 368
Cdd:COG2319   159 ---TGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 242-276 1.38e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.38e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1027855826  242 RTFHGHEGDVNTVKFFPDGNRFGTGSDDGTCRLFD 276
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 57-93 4.62e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 4.62e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1027855826   57 CCRILQGHTGKVYSLDWTPEKNRIVSASQDGRLIVWN 93
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 110-364 1.12e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 110 VMTCAFSPSGQSVACGGLDSACSIFNLNSPID--KDGNHPVSRMLSGHKgyVSSCQYVPDEDTHLITSSGDQTCVLWDIT 187
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKdgRDIHYPVVELASRSK--LSGICWNSYIKSQVASSNFEGVVQVWDVA 563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 188 -TGLRTSVfggefqSGHTADVLSVSISSSNPRLFVSGSCDTTARLWDTR--VASRAQRTfhghEGDVNTVKFFPD-GNRF 263
Cdd:PLN00181  564 rSQLVTEM------KEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINqgVSIGTIKT----KANICCVQFPSEsGRSL 633

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 264 GTGSDDGTCRLFDIRT---------GHQLQVYYQPHGDSDiphvTSMAFSISGRLlfvgysnadcYVWDTLLAKVVLNLG 334
Cdd:PLN00181  634 AFGSADHKVYYYDLRNpklplctmiGHSKTVSYVRFVDSS----TLVSSSTDNTL----------KLWDLSMSISGINET 699

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1027855826 335 AVQN--SHEGRISCLGLSADGSALCTGSwDTN 364
Cdd:PLN00181  700 PLHSfmGHTNVKNFVGLSVSDGYIATGS-ETN 730
WD40 pfam00400
WD domain, G-beta repeat;
241-276 1.20e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.20e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1027855826 241 QRTFHGHEGDVNTVKFFPDGNRFGTGSDDGTCRLFD 276
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 61-187 1.75e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 1.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826  61 LQGHTGKVYSLDWTP-EKNRIVSASQDGRLIVWNALTSQKTHAIKLPcAWVMTCAF-SPSGQSVACGGLDSACSIFNLNS 138
Cdd:PLN00181  571 MKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQFpSESGRSLAFGSADHKVYYYDLRN 649

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1027855826 139 PidkdgNHPVSRMLsGHKGYVSSCQYVpdEDTHLITSSGDQTCVLWDIT 187
Cdd:PLN00181  650 P-----KLPLCTMI-GHSKTVSYVRFV--DSSTLVSSSTDNTLKLWDLS 690
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-93 5.32e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 5.32e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1027855826  56 VCCRILQGHTGKVYSLDWTPEKNRIVSASQDGRLIVWN 93
Cdd:cd00200   252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
57-93 5.40e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 5.40e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1027855826  57 CCRILQGHTGKVYSLDWTPEKNRIVSASQDGRLIVWN 93
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
52-94 6.91e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 6.91e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1027855826  52 PTDLVCCRILQGHTGKVYSLDWTPEKNRIVSASQDGRLIVWNA 94
Cdd:COG2319   359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
PTZ00421 PTZ00421
coronin; Provisional
 151-280 2.48e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 2.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 151 MLSGHKGYVSSCQYVPDEDTHLITSSGDQTCVLWDI-TTGLRTSVFGG--EFQsGHTADVLSVSISSSNPRLFVSGSCDT 227
Cdd:PTZ00421   70 ILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpEEGLTQNISDPivHLQ-GHTKKVGIVSFHPSAMNVLASAGADM 148

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1027855826 228 TARLWDTRvASRAQRTFHGHEGDVNTVKFFPDGNRFGTGSDDGTCRLFDIRTG 280
Cdd:PTZ00421  149 VVNVWDVE-RGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 pfam00400
WD domain, G-beta repeat;
201-233 1.37e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.37e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1027855826 201 SGHTADVLSVSISSSNpRLFVSGSCDTTARLWD 233
Cdd:pfam00400   8 EGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 150-185 1.50e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.50e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1027855826  150 RMLSGHKGYVSSCQYVPDeDTHLITSSGDQTCVLWD 185
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 319-368 1.96e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.67  E-value: 1.96e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1027855826 319 CYVWDTLLAKVVLNLGAVQNS---HEGRISCLGLSADGSALCTGSWDTNLKIW 368
Cdd:pfam20426  99 CGNWENSFQVISLNDGRMVQSirqHKDVVSCVAVTSDGSILATGSYDTTVMVW 151
WD40 pfam00400
WD domain, G-beta repeat;
340-368 2.30e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.30e-03
                          10        20
                  ....*....|....*....|....*....
gi 1027855826 340 HEGRISCLGLSADGSALCTGSWDTNLKIW 368
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
150-185 2.39e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1027855826 150 RMLSGHKGYVSSCQYVPDeDTHLITSSGDQTCVLWD 185
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-233 2.45e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.45e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1027855826  201 SGHTADVLSVSISSSNpRLFVSGSCDTTARLWD 233
Cdd:smart00320   9 KGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 203-359 4.22e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 4.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 203 HTADVLSVSISSSNPRLFVSGSCDTTARLWD---TRVASRAQRT----------------FH---GHEgDVNTVKFFP-D 259
Cdd:pfam20426 122 QHKDVVSCVAVTSDGSILATGSYDTTVMVWEvlrGRSSEKRSRNtqtefprkdhviaetpFHilcGHD-DIITCLYVSvE 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1027855826 260 GNRFGTGSDDGTCRLFDIRTGHQLQVYYQPHGDSdiphVTSMAFSISGRLLFvgYSNADcyvwdtllakVVLNLGAVQNS 339
Cdd:pfam20426 201 LDIVISGSKDGTCIFHTLREGRYVRSIRHPSGCP----LSKLVASRHGRIVL--YADDD----------LSLHLYSINGK 264

                         170       180
                  ....*....|....*....|....*..
gi 1027855826 340 H------EGRISCLGLSADGSAL-CTG 359
Cdd:pfam20426 265 HiassesNGRLNCIELSSCGEFLvCAG 291
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 335-368 4.70e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 4.70e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1027855826  335 AVQNSHEGRISCLGLSADGSALCTGSWDTNLKIW 368
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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