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Conserved domains on  [gi|1021311959|ref|NP_001310490|]
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cardiolipin synthase (CMP-forming) isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN02794 super family cl28682
cardiolipin synthase
1-177 1.23e-29

cardiolipin synthase


The actual alignment was detected with superfamily member PLN02794:

Pssm-ID: 178391  Cd Length: 341  Bit Score: 111.47  E-value: 1.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021311959   1 MLSMTRIGLAPVLGYLIIEEDFNIALGVFALAGLTDLLDGFIARNwANQRSALGSALDPLADKILISILYVSLTYADLIP 80
Cdd:PLN02794  147 LISISRLVSGPVIGWMIVNEMYLSAFVGLAISGASDWLDGYVARK-MGINSVVGSYLDPLADKVLIGCVALAMVEKDLLH 225
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021311959  81 VPLTYMIISRDVMLIAAVFYVRYRTLPTP-RTLAKYFN-PCYATARLKPTFISKVNTAVQLILVAASLAAPVFNYADSI- 157
Cdd:PLN02794  226 PGLVGLVVLRDVALVGGAVYKRASSLGWKwNSWSDFFNlDGTRPEKVEPLFISKVNTVFQLMLVAAALLQPEFGTEETQn 305
                         170       180
                  ....*....|....*....|
gi 1021311959 158 YLQILWCFTAFTTAASAYSY 177
Cdd:PLN02794  306 YITYLSWLVASTTVASTAAY 325
 
Name Accession Description Interval E-value
PLN02794 PLN02794
cardiolipin synthase
1-177 1.23e-29

cardiolipin synthase


Pssm-ID: 178391  Cd Length: 341  Bit Score: 111.47  E-value: 1.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021311959   1 MLSMTRIGLAPVLGYLIIEEDFNIALGVFALAGLTDLLDGFIARNwANQRSALGSALDPLADKILISILYVSLTYADLIP 80
Cdd:PLN02794  147 LISISRLVSGPVIGWMIVNEMYLSAFVGLAISGASDWLDGYVARK-MGINSVVGSYLDPLADKVLIGCVALAMVEKDLLH 225
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021311959  81 VPLTYMIISRDVMLIAAVFYVRYRTLPTP-RTLAKYFN-PCYATARLKPTFISKVNTAVQLILVAASLAAPVFNYADSI- 157
Cdd:PLN02794  226 PGLVGLVVLRDVALVGGAVYKRASSLGWKwNSWSDFFNlDGTRPEKVEPLFISKVNTVFQLMLVAAALLQPEFGTEETQn 305
                         170       180
                  ....*....|....*....|
gi 1021311959 158 YLQILWCFTAFTTAASAYSY 177
Cdd:PLN02794  306 YITYLSWLVASTTVASTAAY 325
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
1-183 9.69e-23

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 89.53  E-value: 9.69e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021311959   1 MLSMTRIGLAPVLGYLIIEEDFN-IALGVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILISILYVSLTYADLI 79
Cdd:COG0558    14 QLTLLRILLVPVFALLLLLGGALlLALVLFLLAGLTDALDGYLARRL-GQVSRFGAFLDPVADKLLDAAALLGLVLLGLL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021311959  80 PVPLTYMIISRDVMliaaVFYVRYRtlptprtlakyfnpcYATARLKPTFISKVNTAVQLILVAASLAAPVFnyadsiyL 159
Cdd:COG0558    93 PAWLALLILLRELL----VSYLRAR---------------AAALGVVASYLGKAKTVLQLVAILLLLLGLPL-------L 146
                         170       180
                  ....*....|....*....|....
gi 1021311959 160 QILWCFTAFTTAASAYSYYHYGRK 183
Cdd:COG0558   147 GVLLWLAAVLTLLSGIQYLVAARR 170
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
1-110 1.25e-18

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 78.37  E-value: 1.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021311959   1 MLSMTRIGLAPVLGYLIIE-EDFNIALGVFALAGLTDLLDGFIARnWANQRSALGSALDPLADKILISILYVSLTYADLI 79
Cdd:pfam01066   6 LLTLLRILLVPVFVVLLLGpGNRILAAVVFALAALTDFLDGKIAR-KLNQVTDFGKFLDPLADKLLVAAALIALSILGLL 84
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1021311959  80 PVPLTYMIISRDVMLIAAVFYVRYRTLPTPR 110
Cdd:pfam01066  85 PWWFVVVILVRELGVTLLRFNVARKGVVIPA 115
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
2-94 1.30e-10

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 57.75  E-value: 1.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021311959   2 LSMTRIGLAPVLGYLIIEEDFNIAL------GVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILISILYVSLTY 75
Cdd:TIGR00560   7 LTLFRIIALPIFILFFLENVLPIQVspfigaLLFIFAAVTDWLDGYLARKW-NQVSNFGKFLDPLADKVLVLAVLIILVY 85
                          90
                  ....*....|....*....
gi 1021311959  76 ADLIPVPLTYMIISRDVML 94
Cdd:TIGR00560  86 HGYVPAWFVIVIIAREIVI 104
 
Name Accession Description Interval E-value
PLN02794 PLN02794
cardiolipin synthase
1-177 1.23e-29

cardiolipin synthase


Pssm-ID: 178391  Cd Length: 341  Bit Score: 111.47  E-value: 1.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021311959   1 MLSMTRIGLAPVLGYLIIEEDFNIALGVFALAGLTDLLDGFIARNwANQRSALGSALDPLADKILISILYVSLTYADLIP 80
Cdd:PLN02794  147 LISISRLVSGPVIGWMIVNEMYLSAFVGLAISGASDWLDGYVARK-MGINSVVGSYLDPLADKVLIGCVALAMVEKDLLH 225
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021311959  81 VPLTYMIISRDVMLIAAVFYVRYRTLPTP-RTLAKYFN-PCYATARLKPTFISKVNTAVQLILVAASLAAPVFNYADSI- 157
Cdd:PLN02794  226 PGLVGLVVLRDVALVGGAVYKRASSLGWKwNSWSDFFNlDGTRPEKVEPLFISKVNTVFQLMLVAAALLQPEFGTEETQn 305
                         170       180
                  ....*....|....*....|
gi 1021311959 158 YLQILWCFTAFTTAASAYSY 177
Cdd:PLN02794  306 YITYLSWLVASTTVASTAAY 325
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
1-183 9.69e-23

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 89.53  E-value: 9.69e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021311959   1 MLSMTRIGLAPVLGYLIIEEDFN-IALGVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILISILYVSLTYADLI 79
Cdd:COG0558    14 QLTLLRILLVPVFALLLLLGGALlLALVLFLLAGLTDALDGYLARRL-GQVSRFGAFLDPVADKLLDAAALLGLVLLGLL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021311959  80 PVPLTYMIISRDVMliaaVFYVRYRtlptprtlakyfnpcYATARLKPTFISKVNTAVQLILVAASLAAPVFnyadsiyL 159
Cdd:COG0558    93 PAWLALLILLRELL----VSYLRAR---------------AAALGVVASYLGKAKTVLQLVAILLLLLGLPL-------L 146
                         170       180
                  ....*....|....*....|....
gi 1021311959 160 QILWCFTAFTTAASAYSYYHYGRK 183
Cdd:COG0558   147 GVLLWLAAVLTLLSGIQYLVAARR 170
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
1-110 1.25e-18

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 78.37  E-value: 1.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021311959   1 MLSMTRIGLAPVLGYLIIE-EDFNIALGVFALAGLTDLLDGFIARnWANQRSALGSALDPLADKILISILYVSLTYADLI 79
Cdd:pfam01066   6 LLTLLRILLVPVFVVLLLGpGNRILAAVVFALAALTDFLDGKIAR-KLNQVTDFGKFLDPLADKLLVAAALIALSILGLL 84
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1021311959  80 PVPLTYMIISRDVMLIAAVFYVRYRTLPTPR 110
Cdd:pfam01066  85 PWWFVVVILVRELGVTLLRFNVARKGVVIPA 115
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
2-94 1.30e-10

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 57.75  E-value: 1.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1021311959   2 LSMTRIGLAPVLGYLIIEEDFNIAL------GVFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILISILYVSLTY 75
Cdd:TIGR00560   7 LTLFRIIALPIFILFFLENVLPIQVspfigaLLFIFAAVTDWLDGYLARKW-NQVSNFGKFLDPLADKVLVLAVLIILVY 85
                          90
                  ....*....|....*....
gi 1021311959  76 ADLIPVPLTYMIISRDVML 94
Cdd:TIGR00560  86 HGYVPAWFVIVIIAREIVI 104
PRK10832 PRK10832
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
28-71 6.32e-06

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


Pssm-ID: 182763 [Multi-domain]  Cd Length: 182  Bit Score: 44.45  E-value: 6.32e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1021311959  28 VFALAGLTDLLDGFIARNWaNQRSALGSALDPLADKILISILYV 71
Cdd:PRK10832   38 IFCVAAVTDWFDGFLARRW-NQSTRFGAFLDPVADKVMVAIAMV 80
PLN02558 PLN02558
CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase
28-96 1.47e-03

CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase


Pssm-ID: 166199  Cd Length: 203  Bit Score: 38.09  E-value: 1.47e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1021311959  28 VFALAGLTDLLDGFIARNwANQRSALGSALDPLADKILIS---ILYVS--LTYADLIPVPLTYM-----IISRDVMLIA 96
Cdd:PLN02558   44 IFIAAAITDWLDGYLARK-MKLGTAFGAFLDPVADKLMVAaalILLCSrpLEVAVLGEVPWLFTvpaiaIIGREITMSA 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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