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Conserved domains on  [gi|1012282623|ref|NP_001308617|]
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eIF5-mimic protein 2 isoform 1 [Homo sapiens]

Protein Classification

BZW family protein( domain architecture ID 10184010)

BZW family protein similar to human basic leucine zipper and W2 domain-containing protein 1 that enhances histone H4 gene transcription but does not seem to bind DNA directly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 217-406 1.44e-105

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


:

Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 310.30  E-value: 1.44e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282623 217 ELFPANKQSVEHFTKYFTEAGLKELSEYVRNQQTIGARKELQKELQEQMSRGDPFKDIILYVKEEMKKNNIPEPVVIGIV 296
Cdd:cd11560     1 EFFPPNKRTEEHFAEHFKEEGLDELVEFYRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSSLPEHEVVGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282623 297 WSSVMSTVEWNKKEELVAEQAIKHLKQYSPLLAAFTTQGQSELTLLLKIQEYCYDNIHFMKAFQKIVVLFYKAEVLSEEP 376
Cdd:cd11560    81 WTALMDAVEWSKKEDQIAEQALRHLKKYAPLLAAFCTTARAELALLNKIQEYCYENMKFMKVFQKIVKLLYKADVLSEDA 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1012282623 377 ILKWYKDAHVAKGKSVFLEQMKKFVEWLKN 406
Cdd:cd11560   161 ILKWYKKGHSPKGKQVFLKQMEPFVEWLQE 190
 
Name Accession Description Interval E-value
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 217-406 1.44e-105

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 310.30  E-value: 1.44e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282623 217 ELFPANKQSVEHFTKYFTEAGLKELSEYVRNQQTIGARKELQKELQEQMSRGDPFKDIILYVKEEMKKNNIPEPVVIGIV 296
Cdd:cd11560     1 EFFPPNKRTEEHFAEHFKEEGLDELVEFYRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSSLPEHEVVGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282623 297 WSSVMSTVEWNKKEELVAEQAIKHLKQYSPLLAAFTTQGQSELTLLLKIQEYCYDNIHFMKAFQKIVVLFYKAEVLSEEP 376
Cdd:cd11560    81 WTALMDAVEWSKKEDQIAEQALRHLKKYAPLLAAFCTTARAELALLNKIQEYCYENMKFMKVFQKIVKLLYKADVLSEDA 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1012282623 377 ILKWYKDAHVAKGKSVFLEQMKKFVEWLKN 406
Cdd:cd11560   161 ILKWYKKGHSPKGKQVFLKQMEPFVEWLQE 190
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
325-406 2.19e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 101.21  E-value: 2.19e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282623  325 SPLLAAFTTQGQSELTLLLKIQEYCYDNIHFMKAFQKIVVLFYKAEVLSEEPILKWYKDAHVAKGKSVFLEQMKKFVEWL 404
Cdd:smart00515   1 GPLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAEGKKKVRKNAKPFVTWL 80


                   ..
gi 1012282623  405 KN 406
Cdd:smart00515  81 QE 82
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 338-406 3.53e-19

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 81.42  E-value: 3.53e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282623 338 ELTLLLKIQEYCYDNIHFMKAFQKIVVLFYKAEVLSEEPILKWYKDAH-VAKGKSVFLEQMKKFVEWLKN 406
Cdd:pfam02020   1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSsAEKGMKKVRKQAKPFVEWLEE 70
 
Name Accession Description Interval E-value
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 217-406 1.44e-105

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 310.30  E-value: 1.44e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282623 217 ELFPANKQSVEHFTKYFTEAGLKELSEYVRNQQTIGARKELQKELQEQMSRGDPFKDIILYVKEEMKKNNIPEPVVIGIV 296
Cdd:cd11560     1 EFFPPNKRTEEHFAEHFKEEGLDELVEFYRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSSLPEHEVVGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282623 297 WSSVMSTVEWNKKEELVAEQAIKHLKQYSPLLAAFTTQGQSELTLLLKIQEYCYDNIHFMKAFQKIVVLFYKAEVLSEEP 376
Cdd:cd11560    81 WTALMDAVEWSKKEDQIAEQALRHLKKYAPLLAAFCTTARAELALLNKIQEYCYENMKFMKVFQKIVKLLYKADVLSEDA 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1012282623 377 ILKWYKDAHVAKGKSVFLEQMKKFVEWLKN 406
Cdd:cd11560   161 ILKWYKKGHSPKGKQVFLKQMEPFVEWLQE 190
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
325-406 2.19e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 101.21  E-value: 2.19e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282623  325 SPLLAAFTTQGQSELTLLLKIQEYCYDNIHFMKAFQKIVVLFYKAEVLSEEPILKWYKDAHVAKGKSVFLEQMKKFVEWL 404
Cdd:smart00515   1 GPLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAEGKKKVRKNAKPFVTWL 80


                   ..
gi 1012282623  405 KN 406
Cdd:smart00515  81 QE 82
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 338-406 3.53e-19

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 81.42  E-value: 3.53e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282623 338 ELTLLLKIQEYCYDNIHFMKAFQKIVVLFYKAEVLSEEPILKWYKDAH-VAKGKSVFLEQMKKFVEWLKN 406
Cdd:pfam02020   1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSsAEKGMKKVRKQAKPFVEWLEE 70
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 254-381 2.39e-18

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 80.98  E-value: 2.39e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282623 254 RKELQKELQEQMSRgdpFKDIILYVKEEMKKNNIPEPVVIGIVWSSVMSTVEWNK-KEELVAEQAIKHLKQYSPLLA-AF 331
Cdd:cd11473     7 RDSLLKELEEDKSS---DVESVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESADsISLTQKEQLVLVLKKYGPVLReLL 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1012282623 332 TTQGQSELTLLLKIQEYCY--DNIHFMKAFQKIVVLFYKAEVLSEEPILKWY 381
Cdd:cd11473    84 KLIKKDQLYLLLKIEKLCLqlKLSELISLLEKILDLLYDADVLSEEAILSWF 135
W2_eIF2B_epsilon cd11558
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ...
 314-406 2.41e-15

C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211396  Cd Length: 169  Bit Score: 73.45  E-value: 2.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282623 314 AEQAIKHLKQYSPLLAAFTTQGQSELTLLLKIQEYCYDNIHFMKAFQKIVVLFYKAEVLSEEPILKWYK--DAHVAKGKS 391
Cdd:cd11558    69 LEALKKLLSKWGPLLENYVKSQDDQVELLLALEEFCLESEEGGPLFAKLLHALYDLDILEEEAILEWWEepDAGADEEMK 148

                          90
                  ....*....|....*
gi 1012282623 392 VFLEQMKKFVEWLKN 406
Cdd:cd11558   149 KVRELVKKFIEWLEE 163
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 310-406 1.46e-10

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 59.17  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282623 310 EELVAEQAIKHLKQYSPLLAAFTTQGQSELTLLLKIQEYCY-DNIHFMKAFQKIVVLFYKAEVLSEEPILKWYKDA---H 385
Cdd:cd11561    50 EVLFDENIVKEIKKRKALLLKLVTDEKAQKALLGGIERFCGkHSPELLKKVPLILKALYDNDILEEEVILKWYEKVskkY 129

                          90       100
                  ....*....|....*....|..
gi 1012282623 386 VAKGKS-VFLEQMKKFVEWLKN 406
Cdd:cd11561   130 VSKEKSkKVRKAAEPFVEWLEE 151
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 255-383 6.03e-05

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 42.66  E-value: 6.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1012282623 255 KELQKELQEQMSRGDPFKDIILYVKEEMKKNNIPEPVVIGIVWSSVmstVEWNKKEELVAEQAIKHLKQYSPLLAAF-TT 333
Cdd:cd11559     4 LRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAV---LKYAIEEKSLPEKEKALLEKYAPLLQKYlDD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1012282623 334 QGQSELTLLLKIQEYCYdNIHFMKAF-QKIVVLFYKAEVLSEEPILKWYKD 383
Cdd:cd11559    81 DEQLQLQALYALQALVH-TLEFPKGLlLRFFDALYDEDVIEEEAFLKWKED 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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