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Conserved domains on  [gi|985567547|ref|NP_001306611|]
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tectonic-1 isoform 8 [Homo sapiens]

Protein Classification

tectonic family protein( domain architecture ID 10405)

tectonic family protein, formerly called DUF1619 domain, similar to Homo sapiens tectonic proteins which are components of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes, and is required for hedgehog signaling transduction

Gene Ontology:  GO:0008589|GO:1904491
PubMed:  16357211|22179047

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TCTN_DUF1619 super family cl06690
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 22-153 9.99e-43

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


The actual alignment was detected with superfamily member pfam07773:

Pssm-ID: 462260  Cd Length: 315  Bit Score: 145.00  E-value: 9.99e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985567547   22 CVCDLSPAQCDINCCCDPDCSSVDFSVFSACSVPVVTGDSQFCSQKAVIYSLNFtanPPQRVFELV-DQINPSIFCIHIT 100
Cdd:pfam07773   1 CVCDLTAGACDVNCCCDPDCSSEDLSTFSSCLVGVVSGDSQLCSQKSAIFRSNL---PPQRLFGLVtDQINPDLFCVQSS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 985567547  101 -NYKPALSFINP--EVPDENNF-DTLMKTSDGFTLNAESYVSFTtkldipTAAKYEV 153
Cdd:pfam07773  78 nNNSPLGSFFQPptSVPTPSNFeDSLYKKFTGFSFASESDVSSS------TSSGYKV 128
 
Name Accession Description Interval E-value
TCTN_DUF1619 pfam07773
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 22-153 9.99e-43

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


Pssm-ID: 462260  Cd Length: 315  Bit Score: 145.00  E-value: 9.99e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985567547   22 CVCDLSPAQCDINCCCDPDCSSVDFSVFSACSVPVVTGDSQFCSQKAVIYSLNFtanPPQRVFELV-DQINPSIFCIHIT 100
Cdd:pfam07773   1 CVCDLTAGACDVNCCCDPDCSSEDLSTFSSCLVGVVSGDSQLCSQKSAIFRSNL---PPQRLFGLVtDQINPDLFCVQSS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 985567547  101 -NYKPALSFINP--EVPDENNF-DTLMKTSDGFTLNAESYVSFTtkldipTAAKYEV 153
Cdd:pfam07773  78 nNNSPLGSFFQPptSVPTPSNFeDSLYKKFTGFSFASESDVSSS------TSSGYKV 128
 
Name Accession Description Interval E-value
TCTN_DUF1619 pfam07773
Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) ...
 22-153 9.99e-43

Tectonic domain DUF1619; This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also known as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions. These proteins form a complex required for hedgehog signalling transduction.


Pssm-ID: 462260  Cd Length: 315  Bit Score: 145.00  E-value: 9.99e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985567547   22 CVCDLSPAQCDINCCCDPDCSSVDFSVFSACSVPVVTGDSQFCSQKAVIYSLNFtanPPQRVFELV-DQINPSIFCIHIT 100
Cdd:pfam07773   1 CVCDLTAGACDVNCCCDPDCSSEDLSTFSSCLVGVVSGDSQLCSQKSAIFRSNL---PPQRLFGLVtDQINPDLFCVQSS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 985567547  101 -NYKPALSFINP--EVPDENNF-DTLMKTSDGFTLNAESYVSFTtkldipTAAKYEV 153
Cdd:pfam07773  78 nNNSPLGSFFQPptSVPTPSNFeDSLYKKFTGFSFASESDVSSS------TSSGYKV 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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