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Conserved domains on  [gi|970259826|ref|NP_001305073|]
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aquaporin-3 isoform 2 [Homo sapiens]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  8849412|11473620|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 23-164 1.59e-48

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member cd00333:

Pssm-ID: 444743  Cd Length: 228  Bit Score: 159.34  E-value: 1.59e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  23 RQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLP 102
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 970259826 103 IYTLAQTLGAFLGAGIVFGLYYDAIWHFADnqlfvsGPNGTAGIFATYPSGHLDMINGFFDQ 164
Cdd:cd00333   81 PYIIAQLLGAILGAALLYGLYYGLYLEFLG------ANNIVAGIFGTYPSPGVSNGNAFFVE 136
 
Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 23-164 1.59e-48

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 159.34  E-value: 1.59e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  23 RQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLP 102
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 970259826 103 IYTLAQTLGAFLGAGIVFGLYYDAIWHFADnqlfvsGPNGTAGIFATYPSGHLDMINGFFDQ 164
Cdd:cd00333   81 PYIIAQLLGAILGAALLYGLYYGLYLEFLG------ANNIVAGIFGTYPSPGVSNGNAFFVE 136
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 21-164 5.75e-42

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 142.57  E-value: 5.75e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  21 LLRQALAECLGTLILVMFGCGSVAQVVLSRGThGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIK 100
Cdd:COG0580    2 LMKRLLAEFLGTFILVLLGCGVVAVLAGTKGG-IGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 970259826 101 LPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADnqlfvsgPNGTAGIFATYPSGHLDMINGFFDQ 164
Cdd:COG0580   81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATED-------GGAKLGVFATSPAIGYSLGAAFLTE 137
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 18-152 1.67e-35

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 127.55  E-value: 1.67e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  18 RYRL-LRQALAECLGTLILVMFGCGSVAQVVLSrGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLARE 96
Cdd:PTZ00016  45 EYRPnVREYVAEFLGTFVLLFFGEGVVATTHTV-GNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKF 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  97 PWIKLPIYTLAQTLGAFLGAGIVFGLYYDaiwHFADNQ----LFVSGPNGTAGIFATYPS 152
Cdd:PTZ00016 124 PWKKLPGYFVAQLLGAFVGAACVYGLYYG---FFKDHGipelPWETMANGFAGVFATYPR 180
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 27-147 2.39e-34

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 122.41  E-value: 2.39e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826   27 AECLGTLILVMFGCGSVAQVVLSRGTH----GGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLP 102
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGavggGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 970259826  103 IYTLAQTLGAFLGAGIVFGLYYDAI---WHFADNqlFVSGPNGTAGIF 147
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFpgnLAVNGS--ASAGVSSGQAFF 126
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 21-162 3.94e-25

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 98.54  E-value: 3.94e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826   21 LLRQALAECLGTLILVMFGCGSVAQV--VLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPW 98
Cdd:pfam00230   7 FLRAVIAEFLATLLFVFFGVGSALGVkkLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFSL 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 970259826   99 IKLPIYTLAQTLGAFLGAGIVFGLYYdaiwhfadnqlfvsgPNGTAGIFATYPSGHLDMINGFF 162
Cdd:pfam00230  87 LRAIFYIVAQLLGAIAGAALLYGVTV---------------GLQRAGLFANTLAPGVNAGQAFV 135
 
Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 23-164 1.59e-48

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 159.34  E-value: 1.59e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  23 RQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLP 102
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 970259826 103 IYTLAQTLGAFLGAGIVFGLYYDAIWHFADnqlfvsGPNGTAGIFATYPSGHLDMINGFFDQ 164
Cdd:cd00333   81 PYIIAQLLGAILGAALLYGLYYGLYLEFLG------ANNIVAGIFGTYPSPGVSNGNAFFVE 136
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 21-164 5.75e-42

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 142.57  E-value: 5.75e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  21 LLRQALAECLGTLILVMFGCGSVAQVVLSRGThGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIK 100
Cdd:COG0580    2 LMKRLLAEFLGTFILVLLGCGVVAVLAGTKGG-IGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 970259826 101 LPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADnqlfvsgPNGTAGIFATYPSGHLDMINGFFDQ 164
Cdd:COG0580   81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATED-------GGAKLGVFATSPAIGYSLGAAFLTE 137
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 18-152 1.67e-35

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 127.55  E-value: 1.67e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  18 RYRL-LRQALAECLGTLILVMFGCGSVAQVVLSrGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLARE 96
Cdd:PTZ00016  45 EYRPnVREYVAEFLGTFVLLFFGEGVVATTHTV-GNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKF 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  97 PWIKLPIYTLAQTLGAFLGAGIVFGLYYDaiwHFADNQ----LFVSGPNGTAGIFATYPS 152
Cdd:PTZ00016 124 PWKKLPGYFVAQLLGAFVGAACVYGLYYG---FFKDHGipelPWETMANGFAGVFATYPR 180
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 27-147 2.39e-34

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 122.41  E-value: 2.39e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826   27 AECLGTLILVMFGCGSVAQVVLSRGTH----GGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLP 102
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGavggGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 970259826  103 IYTLAQTLGAFLGAGIVFGLYYDAI---WHFADNqlFVSGPNGTAGIF 147
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFpgnLAVNGS--ASAGVSSGQAFF 126
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 21-162 3.94e-25

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 98.54  E-value: 3.94e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826   21 LLRQALAECLGTLILVMFGCGSVAQV--VLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPW 98
Cdd:pfam00230   7 FLRAVIAEFLATLLFVFFGVGSALGVkkLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFSL 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 970259826   99 IKLPIYTLAQTLGAFLGAGIVFGLYYdaiwhfadnqlfvsgPNGTAGIFATYPSGHLDMINGFF 162
Cdd:pfam00230  87 LRAIFYIVAQLLGAIAGAALLYGVTV---------------GLQRAGLFANTLAPGVNAGQAFV 135
PRK05420 PRK05420
aquaporin Z; Provisional
 21-120 3.70e-15

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 71.92  E-value: 3.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  21 LLRQALAECLGTLILVMFGCGSVaqvVLSRGTHG---GFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREP 97
Cdd:PRK05420   1 MFKKLAAEFFGTFWLVFGGCGSA---VLAAAFPElgiGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFP 77

                         90       100
                 ....*....|....*....|...
gi 970259826  98 WIKLPIYTLAQTLGAFLGAGIVF 120
Cdd:PRK05420  78 AKELVPYIIAQVVGGIAAAAVLY 100
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 22-114 3.95e-15

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 72.58  E-value: 3.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  22 LRQALAECLGTLILVMFGCGSVAQVVLSRGtHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKL 101
Cdd:PLN00183  45 ARMVLAEMVGTFILMFCVCGIIASTQLSGG-EVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKV 123

                         90
                 ....*....|...
gi 970259826 102 PIYTLAQTLGAFL 114
Cdd:PLN00183 124 PLYITAQTVGSVL 136
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 21-117 5.03e-14

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 69.55  E-value: 5.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  21 LLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGgFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIK 100
Cdd:PLN00182  41 LTQKLIAEMIGTYFIIFSGCGVVVVNVLYGGTIT-FPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQ 119

                         90
                 ....*....|....*..
gi 970259826 101 LPIYTLAQTLGAFLGAG 117
Cdd:PLN00182 120 VPLYIGAQLTGSLLASL 136
PLN00184 PLN00184
aquaporin NIP1; Provisional
 14-125 9.40e-13

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 66.20  E-value: 9.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  14 MLHIRYRLLRQALAECLGTLILVMFGCGSVAqVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFL 93
Cdd:PLN00184  46 LLSVSVPFLQKLIAEVLGTYFLVFTGCASVV-VNMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASC 124

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 970259826  94 AREPWIKLPIYTLAQTLGAFLGAG---IVFGLYYD 125
Cdd:PLN00184 125 GRFPLKQVPAYVISQVIGSTLAAAtlrLLFGLDHD 159
PLN00026 PLN00026
aquaporin NIP; Provisional
 21-124 1.75e-11

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 62.57  E-value: 1.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  21 LLRQALAECLGTLILVMFGcgsVAQVVLSRGTHGGFLTINLAF--GFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPW 98
Cdd:PLN00026  70 LTRKLGAEFVGTFILIFAA---TAGPIVNQKYDGAETLIGNAAcaGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPW 146

                         90       100
                 ....*....|....*....|....*.
gi 970259826  99 IKLPIYTLAQTLGAFLGAGIVFGLYY 124
Cdd:PLN00026 147 KHVPAYIAAQVSASICASFALKGVFH 172
PLN00166 PLN00166
aquaporin TIP2; Provisional
 22-112 4.89e-07

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 49.16  E-value: 4.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  22 LRQALAECLGTLILVMFGCGS-VAQVVLSRGTH---GGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREP 97
Cdd:PLN00166  18 LKAYLSEFIATLLFVFAGVGSaIAFAKLTSDAAldpAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNIT 97

                         90
                 ....*....|....*
gi 970259826  98 WIKLPIYTLAQTLGA 112
Cdd:PLN00166  98 IITGFFYWIAQCLGS 112
PLN00027 PLN00027
aquaporin TIP; Provisional
 22-112 6.95e-07

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 48.63  E-value: 6.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  22 LRQALAECLGTLILVMFGCGS-VAQVVLSRG---THGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREP 97
Cdd:PLN00027  20 LKAALAEFISTLIFVFAGEGSgMAFNKLTDNgstTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNIT 99

                         90
                 ....*....|....*
gi 970259826  98 WIKLPIYTLAQTLGA 112
Cdd:PLN00027 100 LLRGILYWIAQLLGS 114
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 22-116 4.38e-05

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 43.40  E-value: 4.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  22 LRQALAECLGTLILVMFGCGSVAQvvlSRGTHGGFLTiNLAFGFAVTLGILIAGQVSGAHLNPAVTFA---MCFLAREpW 98
Cdd:cd00333  130 GNAFFVEFIGTFILVLVVFATTDD---PNGPPPGGLA-PLAIGLLVAAIGLAGGPITGASMNPARSLGpalFTGLARH-W 204

                         90
                 ....*....|....*...
gi 970259826  99 IKLPIYTLAQTLGAFLGA 116
Cdd:cd00333  205 HYFWVYWVGPLIGAIAGA 222
PLN00167 PLN00167
aquaporin TIP5; Provisional
 22-114 4.46e-05

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 43.35  E-value: 4.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  22 LRQALAECLGTLILVMFGCGSV--AQVVLSRGTHG--GFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLARep 97
Cdd:PLN00167  22 LRSYLAEFISTFFFVFAAVGSAmsSRKLMPDAASDpsSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGH-- 99

                         90       100
                 ....*....|....*....|
gi 970259826  98 wIKLP---IYTLAQTLGAFL 114
Cdd:PLN00167 100 -ISVPtamFYWISQMLASVM 118
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 17-123 6.40e-05

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 42.81  E-value: 6.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  17 IRYRLLRQALAECLGTLILVM--FGCGSvaqvvlSRGTHGGFLTinLAFGFAVTLGILIAGQVSGAHLNPAVTFA---MC 91
Cdd:COG0580  126 IGYSLGAAFLTEIIGTFVLVFviLGITD------KRAAPGGLAP--LAIGLLVAAIGLSLGPLTGYAINPARDLGprlFH 197

                         90       100       110
                 ....*....|....*....|....*....|....
gi 970259826  92 FLAR--EPWIKLPIYTLAQTLGAFLGAGIVFGLY 123
Cdd:COG0580  198 ALGKggSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00026 PLN00026
aquaporin NIP; Provisional
 61-118 6.90e-05

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 42.93  E-value: 6.90e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 970259826  61 LAFGFAVTLGILIAGQVSGAHLNPAVTFAMCfLAREPWIKLPIYTLAQTLGAFLGAGI 118
Cdd:PLN00026 220 IAVGATVMLNILVAGPSTGGSMNPVRTLGPA-VAAGNYRAIWIYLVAPTLGALAGAGT 276
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 22-116 7.54e-04

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 39.59  E-value: 7.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826   22 LRQALAECLGTLILVMFGCGSVaqVVLSRGTHGGFLTinLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLARE-PWIK 100
Cdd:TIGR00861 122 GQAFFVEFIGTAILVLVIFATT--DDRNRVPRGGFAP--LAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLaGWGN 197

                          90
                  ....*....|....*.
gi 970259826  101 LPIYTLAQTLGAFLGA 116
Cdd:TIGR00861 198 HWVYWVGPIIGAILGA 213
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 35-116 7.88e-04

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 39.84  E-value: 7.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970259826  35 LVMFGCGSVAQVVLSRGTHGGFLtinlaFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREpWIKLPIYTLAQTLGAFL 114
Cdd:PLN00183 173 IVMFLAASLTSQPQSLGHLSGFV-----IGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWD-FKDIWIYITAPTIGAVA 246


                 ..
gi 970259826 115 GA 116
Cdd:PLN00183 247 GA 248
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 61-116 9.17e-03

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 36.14  E-value: 9.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 970259826   61 LAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREpWIKLPIYTLAQTLGAFLGA 116
Cdd:pfam00230 166 LAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWK-WDDHWVYWVGPFIGAALGA 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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