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Conserved domains on  [gi|4503035|ref|NP_001301|]
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cAMP-responsive element-binding protein-like 2 [Homo sapiens]

Protein Classification

bZIP transcription factor( domain architecture ID 10200381)

basic leucine zipper (bZIP) transcription factor binds to the promoter regions of genes to control their expression; similar to mammalian cAMP-responsive element-binding protein-like 2 and Drosophila melanogaster REPTOR-binding partner

CATH:  1.20.5.170
Gene Ontology:  GO:0006355|GO:0003700
PubMed:  23661758|7780801
SCOP:  4003836

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bZIP_CREBL2 cd14709
Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 ...
 25-80 1.88e-21

Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain; CREBL2 is a bZIP transcription factor that interacts with CREB and plays a critical role in adipogenesis and lipogenesis. Its overexpression upregulates the expression of PPARgamma and CEBPalpha to promote adipogenesis as well as accelerate lipogenesis by increasing GLUT1 and GLUT4. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


:

Pssm-ID: 269857 [Multi-domain]  Cd Length: 56  Bit Score: 80.45  E-value: 1.88e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4503035   25 DLKAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQWCMAMD 80
Cdd:cd14709   1 KKKAKLERNRQSARESRDRKKLRYQYLEQLVADREREILLLREELEMYKQWCEELD 56
 
Name Accession Description Interval E-value
bZIP_CREBL2 cd14709
Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 ...
 25-80 1.88e-21

Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain; CREBL2 is a bZIP transcription factor that interacts with CREB and plays a critical role in adipogenesis and lipogenesis. Its overexpression upregulates the expression of PPARgamma and CEBPalpha to promote adipogenesis as well as accelerate lipogenesis by increasing GLUT1 and GLUT4. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269857 [Multi-domain]  Cd Length: 56  Bit Score: 80.45  E-value: 1.88e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4503035   25 DLKAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQWCMAMD 80
Cdd:cd14709   1 KKKAKLERNRQSARESRDRKKLRYQYLEQLVADREREILLLREELEMYKQWCEELD 56
bZIP_2 pfam07716
Basic region leucine zipper;
27-75 1.10e-04

Basic region leucine zipper;


Pssm-ID: 462244 [Multi-domain]  Cd Length: 51  Bit Score: 37.20  E-value: 1.10e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 4503035     27 KAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQW 75
Cdd:pfam07716   3 RDRRRKNNEAAKRSREKKKQKEEELEERVKELERENAQLRQKVEQLEKE 51
 
Name Accession Description Interval E-value
bZIP_CREBL2 cd14709
Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 ...
 25-80 1.88e-21

Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain; CREBL2 is a bZIP transcription factor that interacts with CREB and plays a critical role in adipogenesis and lipogenesis. Its overexpression upregulates the expression of PPARgamma and CEBPalpha to promote adipogenesis as well as accelerate lipogenesis by increasing GLUT1 and GLUT4. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269857 [Multi-domain]  Cd Length: 56  Bit Score: 80.45  E-value: 1.88e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4503035   25 DLKAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQWCMAMD 80
Cdd:cd14709   1 KKKAKLERNRQSARESRDRKKLRYQYLEQLVADREREILLLREELEMYKQWCEELD 56
bZIP_2 pfam07716
Basic region leucine zipper;
27-75 1.10e-04

Basic region leucine zipper;


Pssm-ID: 462244 [Multi-domain]  Cd Length: 51  Bit Score: 37.20  E-value: 1.10e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 4503035     27 KAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQW 75
Cdd:pfam07716   3 RDRRRKNNEAAKRSREKKKQKEEELEERVKELERENAQLRQKVEQLEKE 51
bZIP_CREB1 cd14690
Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) ...
 27-73 1.10e-03

Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain; CREB1 is a Basic leucine zipper (bZIP) transcription factor that plays a role in propagating signals initiated by receptor activation through the induction of cAMP-responsive genes. Because it responds to many signal transduction pathways, CREB1 is implicated to function in many processes including learning, memory, circadian rhythm, immune response, and reproduction, among others. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269838 [Multi-domain]  Cd Length: 55  Bit Score: 34.53  E-value: 1.10e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 4503035   27 KAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYK 73
Cdd:cd14690   3 QLRLEKNREAARECRRKKKEYVKCLENRVAVLENENKELREELKILK 49
bZIP cd14686
Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and ...
 27-74 8.99e-03

Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain; Basic leucine zipper (bZIP) factors comprise one of the most important classes of enhancer-type transcription factors. They act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes including cell survival, learning and memory, lipid metabolism, and cancer progression, among others. They also play important roles in responses to stimuli or stress signals such as cytokines, genotoxic agents, or physiological stresses. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.


Pssm-ID: 269834 [Multi-domain]  Cd Length: 52  Bit Score: 32.13  E-value: 8.99e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 4503035   27 KAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQ 74
Cdd:cd14686   2 ERRRERNREAARRSRERKKERIEELEEEVEELEEENEELKAELEELRA 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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